Influence of heparin chemical modifications on its antiproliferative properties

Chemistry and Biology of Heparin and Heparan Sulfate

Volumn , Issue , 2005, Pages 513-532

  Garg, Hari G ^a,b   Linhardt, Robert J ^c   Hales, Charles A ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882507073     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-008044859-6/50019-8     Document Type: Chapter

References (55)

1. Geggel RL, Reid LM The structure basis of PPHN. Clin Perinatol 1985, 11:525-549.
2. Hales CA, Kradin RL, Branstetter RD, Zhu YJ Impairment of hypoxic pulmonary artery remodeling by heparin in mice. Am Rev Respir Dis 1983, 128:747-751.
3. Meyrick B, Reid L The effect of chronic hypoxia on pulmonary arteries in young rats. Exp Lung Res 1981, 2:257-271.
4. Hislop A, Reid L New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. Br J Exp Pathol 1976, 57:542-554.
5. Grotendorst GR, Seppa HEJ, Kleinman HK, Martin GR Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor. Proc Natl Acad Sci USA 1981, 78:3669-3672.
6. Ikeda M, Kohno M, Yasunari K, Yokokawa K, Horio T, Ueda M, Morisaki N, Yoshikawa J Natriuretic peptide as a novel antimigration factor of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 1997, 17:731-736.
7. Koyama N, Koshikawa T, Morisaki N, Saito Y, Yoshida S Bifunctional effects of transforming growth factor [3 on migration of cultured rat aortic smooth muscle cells. Biochem Biophys Res Commun 1990, 169:725-729.
8. Naito M, Hayashi T, Kuzuya M, Funaki C, Asai K, Kuzuya F Fibrogen in chemotactic for vascular smooth muscle cells. FEBS Lett 1989, 247:358-360.
9. Autio I, Jakkola O, Solakivi T, Nikkari T Oxidized low density lipoprotein in chemotactic for arterial smooth muscle cells in culture. FEBB Lett 1990, 277:247-249.
10. Kohno M, Yokokawa K, Yasunari K, Kano H, Minami M, Ueda M, Yoshikawa J Effect of natriuretic family on the oxidized LDL-induced migration of human coronary artery smooth muscle cells. Circ Res 1997, 81:585-590.
11. Dubey RK, Jackson EK, Lucher TF Nitric oxide inhibits angiotensin-II induced migration of rat aortic smooth muscle cells: role of cyclic nucleotides and angeotensin I receptors. J Clin Invest 1995, 96:141-149.
12. Kohno M, Yokokawa K, Kano H, Yasunari K, Minami M, Hanehara T, Yoshikawa J Adrenomedullin, is a potent inhibitor of angiotensin-II induced migration of human coronary artery smooth muscle cells. Hypertension 1997, 29:1309-1313.
13. Lee S-L, Wong W-W, Joseph PM, Hales CA, Fanburg BL Inhibitory effect of heparin on serotonin-induced hyperplasia and hypertrophy of smooth muscle cells. Am J Respir Cell Mol Biol 1997, 17:78-83.
14. Thomson BT, Spence CR, Janssens SP, Joseph PM, Hales CA Inhibition of hypoxic pulmonary hypertension by heparins of differing in vitro antiproliferative potency. Am J Respir Crit Care Med 1994, 149:1512-1517.
15. Hassoun PM, Thomson BT, Steigman D, Hales CA Effect of heparin and warfarin on chronic hypoxic pulmonary hypertension and vascular remodeling in the guinea pig. Am Rev Respir Dis 1994, 139:763-7681.
16. Garg HG, Linhardt RJ, Hales HA Heparin as a potential therapeutic agent to reverse vascular remodeling. Proteoglycans in Lung Disease 2002, 377-398. Marcel-Dekker, New York. H.G. Garg, P.J. Roughley, C.A. Hales (Eds.).
17. Garg HG, Joseph PAM, Yoshida K, Thompson BT, Hales CA Antiproliferative role of 3-O-sulfate glucosamine in heparin on cultured plumanary artery smooth muscle cells. Biochem Biophys Res Commun 1996, 224:468-473.
18. Capila I, Linhardt RJ Heparin-protein interactions. Angew Chem Int Ed 2002, 41:390-412.
19. Reid L. The pulmonary circulation: remodeling in growth and disease. J Burns Amberson Lecture. Am J Respir Dis 1979, 119:431-436.
20. Rabinovitch M Pulmonary vascular remodeling in hypoxic pulmonary hypertension. Hypoxic Pulmonary Vasoconstriction. Cellular and Molecular Molecular Mechanisms 2004, 403-418. Kulwar Academic Publisher, Boston. J. Yuan (Ed.).
21. Benitz WE, Lessler Ds, Coulson JD, Bernfield M Heparin inhibits proliferation of fetal vascular smooth muscle cells in the absence of platelet-derived growth factor. J Cell Physiol 1986, 127:1-7.
22. Castellot JJ, Favreau LV, Karnovsky MJ, Rosenberg RD Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase. J Biol Chem 1982, 257:11256-11260.
23. Castellot JJ, Cochran DL, Karnovsky MJ Effect of heparin on vascular smooth muscle cells. I. Cell metabolism. J Cell Physiol 1985, 124:21-28.
24. Castellot JJ, Wong K, Herman B, Hoover RL, Albertini DF, Wright TC, Caleb BL, Karnovsky MJ Binding and internalization of heparin by vascular smooth muscle cells. J Cell Physiol 1985, 124:13-20.
25. Castellot JJ, Choay J, Lormeau JC, Pettitou M, Sache E, Karnovsky MJ Structural determinants of the capacity of heparin to inhibit the proliferation of vascular smooth muscle cells. II. Evidence for a pentasaccharide sequence that contain a 3-O-sulfate group. J Cell Biol 1986, 102:1979-1984.
26. Reilly CF, Fritze MS, Rosenberg RD Heparin inhibition of smooth muscle cell proliferation: a cellular site of action. J Cell Physiol 1986, 129:11-19.
27. Reilly CF, Kindy MS, Brown KE, Rosenberg RD Heparin prevents vascular smooth muscle cell progression through the G1 phase of the cell cycle. J Biol Chem 1989, 264:6990-6995.
28. Jackson RL, Busch SJ, Cardin AD Glycosaminoglycans: Molecular properties, protein interactions and role in physiological processes. Physiol Rev 1991, 71:481-539.
29. Schwartz SM, Gajdusek CM, Owens GK Vessel growth and control. Pathology of the Endothelial Cell 1982, 63-78. Academic Press, New York. H.L. Nossel, H.T. Vogel (Eds.).
30. Jaques LB Heparins-anionic polyelectrolyte drugs. Pharmacol Rev 1980, 31:99-106.
31. Majesky MW, Schwartz SM, Clowes MM, Clowes AW Heparin regulates smooth muscle S phase entry in the injured rat carotid. Circ Res 1987, 61:296-300.
32. Castellot JJ, Pujac LA, Caleb BL, Wright TC, Karnovsky MJ Heparin selectively inhibits a protein kinase C-dependent mechanism of cell cycle progression in calf aortic smooth muscle cells. J Cell Biol 1989, 116:31-42.
33. Wright TC, Pukac LA, Castellot JJ, Karnovsky MJ, Levine RA, Kim-Park HY, Campisi J Heparin suppresses the inhibition of c-fos and c-myc RNA in murine fibroblasts by selective induction of protein kinase C-dependent pathway. Proc Natl Acad Sci USA 1989, 86:3199-3209.
34. Au YPT, Dobrowolska G, Morris DR, Clowes AW Heparin decreases activator protein-1 binding to DNA in part by posttranslational modification of junB. Circ Res 1994, 75:15-22.
35. Busch SJ, Martin GA, Barnhart RL, Mano M, Cardin AD, Jackson RL Trans-repressor activity of nuclear glycosaminoglycans of fos and jun/AP-1 on coprotein-mediated transcription. J Cell Biol 1992, 116:31-42.
36. Pukac LA, Castellot JJ, Wright TC, Caleb BL, Karnovsky MJ Heparin inhibits c-fos c-myc mRNA expression in vascular smooth muscle cells. Cell Regul 1990, 1:435-443.
37. Daum G, Hedin U, Wang Y, Wang T, Clowes AW Diverse effects of heparin on mitogen-activated protein kinase-dependent signal transduction in vascular smooth muscle cells. Circ Res 1997, 81:17-23.
38. Mishra-Goruk K, Castellot JJ Heparin rapidly and selectively regulates protein tyrosine phosphorylation in vascular smooth muscle cells. J Cell Physiol 1999, 178:205-215.
39. + exchange and growth factors in pulmonary artery smooth muscle cell proliferation. Am J Respir Cell Mol Biol 1996, 14:139-145.
40. + exchange and growth of PASMC. Am J Physiol Lung Cell Mol Physiol 1996, 270:L260-L265.
41. Garg HG, Joseph PAM, Yoshida K, Thompson BT, Hales CA Antiproliferative role of 3-O-sulfate glucosamine in heparin on cultured pulmonary artery smooth muscle cells. Biochem Biophys Res Commun 1996, 224:468-473.
42. Wright TC, Castellot JJ, Petitou M, Lormeau J-C, Choay J, Karnovsky MJ Structural determinants of heparin's growth inhibitory activity. Interdependence of oligosaccharide size and charge. J Biol Chem 1989, 264:1534-1542.
43. Castellot JJ, Beeler DL, Rosenberg RD, Karnovsky MJ Structural determinants of the capacity of heparin to inhibit the proliferation of vascular smooth muscle cells. J Cell Physiol 1984, 120:315-320.
44. Garg HG, Cindhuchao N, Quinn DA, Hales CA, Thanawiroon C, Capila I, Linhardt RJ Heparin oligosaccharide sequence and size essential for inhibition of pulmonary artery smooth muscle cell proliferation. Carbohydr Res 2002, 337:2359-2364.
45. Kazatchkine M, Fearon DT, Metcalfe DD, Rosenberg RD, Austen KF Structural determinants of the capacity of heparin to inhibit the formation of the human amplification C3 convertase. J Clin Invest 1981, 67:223-228.
46. Tiozzo R, Cingi MR, Reggiani D, Andreoli T, Calandra S, Milani MR, Piani S, Marchi E, Barbanti M Effect of the desulfation of heparin on its anticoagulant and anti-proliferative activity. Thromb Res 1993, 70:99-106.
47. Kariya Y, Yoshida K, Morikawa K, Tawada A, Miyazono H, Kikuchi H, Tokuyasu K Preparation of unsaturated disaccharides by eliminative cleavage of heparin and heparan sulfate with heparitinases. Comp Biochem Physiol 1992, 103B:473-479.
48. Joseph PAM, Garg HG, Thompson BT, Liu X, Hales CA Influence of molecular weight, protein core and charge of native heparin fractions on pulmonary artery smooth muscle cell proliferation. Biochem Biophys Res Commun 1997, 241:18-23.
49. Carlson DM Structures and immunochemical properties of oligosaccharides isolated from pig submaxillary mucins. J Biol Chem 1968, 243:616-626.
50. Maruyama T, Toida T, Imanari T, Yu G, Linhardt RJ Conformational changes and anticoagulant activity of chondroitin sulfate following its O-sulfonation. Carbohydr Res 1998, 306:35-43.
51. Garg HG, Joseph PAM, Thompson BT, Hales CA, Toida T, Imanhari T, Capila I, Linhardt RJ Effect of fully sulfated glycosaminoglycans on pulmonary artery smooth mucle cell proliferation. Arch Biochem Biophys 1999, 371:228-233.
52. Garg HG, Yu L, Hales CA, Toida T, Islam T, Linhardt RJ Sulfation patterns in heparin and heparan sulfate: effects on the proliferation of bovine plumanary artery smooth muscle cells. Biochim Biophys Acta 2003, 1639:225-231.
53. Longas MO, Garg HG, Trinkle-Pereira M, Hales CA Heparin antiproliferative activity on bovine pulmonary artery smooth muscle cells requires both N-acetylation and N-sulfonation. Carbohydr Res 2003, 338:251-256.
54. Underwood PA, Mitchell SM, Whitelock JM Heparin fails to inhibit the proliferation of human vascular smooth muscle cells in the presence of human serum. J Vas Res 1998, 35:449-460.
55. Cindhuchao N, Quinn DA, Garg HG, Hales CA Heparin inhibits SMC growth in the presence of human and fetal bovine serum. Biochem Biophys Res Commun 2003, 302:84-88.