Acute Liver Failure

Comprehensive Clinical Hepatology

Volumn , Issue , 2006, Pages 517-536

  O'Grady, John G ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882491258     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-323-03675-7.50037-8     Document Type: Chapter

References (13)

1. O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. Lancet 1993, 342:273-275. This article discusses the very important role that definitions play in defining prognosis and the clinical course of acute liver failure.
2. Rolando N, Wade J, Davalos M, et al. The systemic inflammatory response syndrome in acute liver failure. Hepatology 2000, 32:734-739.
3. Bernal W, Donaldson N, Wyncoll D, et al. Blood lactate as an early indicator of outcome in paracetamol-induced acute liver failure. Lancet 2002, 359:558-563.
4. O'Grady JG, Alexander GJ, Hallyar KM, et al. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 1989, 97:439-445. This seminal article details a scheme to accurately determine prognosis using commonly available variables to rapidly identify which patients will likely need transplantation or not. The scheme has been repeatedly tested by other systems, and has still stood the test of time.
5. Blei AT, Olafsson S, Webster S, et al. Complications of intracranial pressure monitoring in fulminant hepatic failure. Lancet 1993, 16(341):157-158. An excellent review from most of liver transplant programs in the United States detailing the use of and complications from intracranial pressure monitoring in patients with fulminant hepatic failure, demonstrating primarily its relative safety.
6. Harry R, Auzinger G, Wendon J. The clinical importance of adrenal insufficiency in acute hepatic dysfunction. Hepatology 2002, 36:395-402.
7. Murphy N, Auzinger G, Bernel W, et al. The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure. Hepatology 2004, 39:464-470.
8. Strauss GI, Knudsen GM, Kondrup J, et al. Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure. Gastroenterology 2001, 121(5):1109-1119.
9. Demetriou AA, Brown RS, Busuttil RW, et al. Prospective, randomised, multicenter, controlled trial of a bioartificial liver in treating acute liver failure. Ann Surg 2002, 239:660-670. A report of the largest clinical trial of cell-based, liver support therapy in the treatment of patients with acute liver failure. It shows that such devices may play a role in the management of patients with acetaminophen-induced acute liver failure, and acute liver failure caused by hepatitis A and B. It also highlights the problems with performing studies with liver support devices.
10. Ellis AJ, Hughes RD, Wendon JA, et al. Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure. Hepatology 1996, 24:1446-1451.
11. Jalan R, Damink SW, Deutz NE, et al. Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure. Lancet 1992, 354:1164-1168.
12. O'Grady JG, Gimson AE, O'Brien CJ, et al. Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure. Gastroenterology 1988, 94:1186-1192.
13. Bernal B. Changing patterns of causation and the use of transplantation in the United Kingdom. Semin Liver Dis 2003, 23:227-237.