-
1
-
-
23244460597
-
Crucial role of p53- dependent cellular senescence in suppression of Pten-deficient tumorigenesis
-
Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M et al. Crucial role of p53- dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 2005; 436: 725-730.
-
(2005)
Nature
, vol.436
, pp. 725-730
-
-
Chen, Z.1
Trotman, L.C.2
Shaffer, D.3
Lin, H.K.4
Dotan, Z.A.5
Niki, M.6
-
2
-
-
0027203921
-
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
-
Kemp CJ, Donehower LA, Bradley A, Balmain A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 1993; 74: 813-822.
-
(1993)
Cell
, vol.74
, pp. 813-822
-
-
Kemp, C.J.1
Donehower, L.A.2
Bradley, A.3
Balmain, A.4
-
3
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007; 445: 656-660.
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
Dickins, R.A.4
Hernando, E.5
Krizhanovsky, V.6
-
4
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L et al. Restoration of p53 function leads to tumour regression in vivo. Nature 2007; 445: 661-665.
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
Tuveson, D.A.4
Grimm, J.5
Lintault, L.6
-
5
-
-
0032510115
-
Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints
-
Xie G, Habbersett RC, Jia Y, Peterson SR, Lehnert BE, Bradbury EM et al. Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints. Oncogene 1998; 16: 721-736.
-
(1998)
Oncogene
, vol.16
, pp. 721-736
-
-
Xie, G.1
Habbersett, R.C.2
Jia, Y.3
Peterson, S.R.4
Lehnert, B.E.5
Bradbury, E.M.6
-
6
-
-
4944255743
-
Post-translational modification of p53 in tumorigenesis
-
Bode AM, Dong Z. Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 2004; 4: 793-805.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 793-805
-
-
Bode, A.M.1
Dong, Z.2
-
7
-
-
0035545996
-
Mammalian G1- and S-phase checkpoints in response to DNA damage
-
Bartek J, Lukas J. Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol 2001; 13: 738-747.
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 738-747
-
-
Bartek, J.1
Lukas, J.2
-
8
-
-
10444226461
-
The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: Lessons from mouse models
-
Attardi LD. The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: lessons from mouse models. Mutat Res 2005; 569: 145-157.
-
(2005)
Mutat Res
, vol.569
, pp. 145-157
-
-
Attardi, L.D.1
-
9
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery Jr CA , Butel JS et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992; 356: 215-221.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
McArthur, M.J.4
Montgomery Jr., C.A.5
Butel, J.S.6
-
10
-
-
20244385424
-
Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
-
Ollmann M, Young LM, Di Como CJ, Karim F, Belvin M, Robertson S et al. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell 2000; 101: 91-101.
-
(2000)
Cell
, vol.101
, pp. 91-101
-
-
Ollmann, M.1
Young, L.M.2
Di Como, C.J.3
Karim, F.4
Belvin, M.5
Robertson, S.6
-
11
-
-
0034737292
-
Drosophila p53 binds a damage response element at the reaper locus
-
Brodsky MH, Nordstrom W, Tsang G, Kwan E, Rubin GM, Abrams JM. Drosophila p53 binds a damage response element at the reaper locus. Cell 2000; 101: 103-113.
-
(2000)
Cell
, vol.101
, pp. 103-113
-
-
Brodsky, M.H.1
Nordstrom, W.2
Tsang, G.3
Kwan, E.4
Rubin, G.M.5
Abrams, J.M.6
-
12
-
-
0037447069
-
Drosophila p53 preserves genomic stability by regulating cell death
-
Sogame N, Kim M, Abrams JM. Drosophila p53 preserves genomic stability by regulating cell death. Proc Natl Acad Sci USA 2003; 100: 4696-4701.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4696-4701
-
-
Sogame, N.1
Kim, M.2
Abrams, J.M.3
-
13
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka S, Ballif BA, Smogorzewska A, McDonald 3rd ER , Hurov KE, Luo J et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007; 316: 1160-1166.
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald III, E.R.4
Hurov, K.E.5
Luo, J.6
-
14
-
-
46049120003
-
ATM-like kinases and regulation of telomerase: Lessons from yeast and mammals
-
Sabourin M, Zakian VA. ATM-like kinases and regulation of telomerase: lessons from yeast and mammals. Trends Cell Biol 2008; 18: 337-346.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 337-346
-
-
Sabourin, M.1
Zakian, V.A.2
-
15
-
-
4444339751
-
ATM and ataxia telangiectasia
-
McKinnon PJ. ATM and ataxia telangiectasia. EMBO Rep 2004; 5: 772-776.
-
(2004)
EMBO Rep
, vol.5
, pp. 772-776
-
-
McKinnon, P.J.1
-
16
-
-
4143134403
-
The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development
-
Song YH, Mirey G, Betson M, Haber DA, Settleman J. The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. Curr Biol 2004; 14: 1354-1359.
-
(2004)
Curr Biol
, vol.14
, pp. 1354-1359
-
-
Song, Y.H.1
Mirey, G.2
Betson, M.3
Haber, D.A.4
Settleman, J.5
-
17
-
-
4143075951
-
Telomere protection without a telomerase; The role of ATM and Mre11 in Drosophila telomere maintenance
-
Bi X, Wei SC, Rong YS. Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance. Curr Biol 2004; 14: 1348-1353.
-
(2004)
Curr Biol
, vol.14
, pp. 1348-1353
-
-
Bi, X.1
Wei, S.C.2
Rong, Y.S.3
-
18
-
-
4143123447
-
ATM is required for telomere maintenance and chromosome stability during Drosophila development
-
Silva E, Tiong S, Pedersen M, Homola E, Royou A, Fasulo B et al. ATM is required for telomere maintenance and chromosome stability during Drosophila development. Curr Biol 2004; 14: 1341-1347.
-
(2004)
Curr Biol
, vol.14
, pp. 1341-1347
-
-
Silva, E.1
Tiong, S.2
Pedersen, M.3
Homola, E.4
Royou, A.5
Fasulo, B.6
-
19
-
-
3543088493
-
Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect
-
Oikemus SR, McGinnis N, Queiroz-Machado J, Tukachinsky H, Takada S, Sunkel CE et al. Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. Genes Dev 2004; 18: 1850-1861.
-
(2004)
Genes Dev
, vol.18
, pp. 1850-1861
-
-
Oikemus, S.R.1
McGinnis, N.2
Queiroz-Machado, J.3
Tukachinsky, H.4
Takada, S.5
Sunkel, C.E.6
-
20
-
-
32844463934
-
Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells
-
Bi X, Jones T, Abbasi F, Lee H, Stultz B, Hursh DA et al. Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Oncogene 2005; 24: 8229-8239.
-
(2005)
Oncogene
, vol.24
, pp. 8229-8239
-
-
Bi, X.1
Jones, T.2
Abbasi, F.3
Lee, H.4
Stultz, B.5
Hursh, D.A.6
-
21
-
-
17744420558
-
Characterization of human colon cancer antigens recognized by autologous antibodies
-
Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD et al. Characterization of human colon cancer antigens recognized by autologous antibodies. Int J Cancer 1998; 76: 652-658.
-
(1998)
Int J Cancer
, vol.76
, pp. 652-658
-
-
Scanlan, M.J.1
Chen, Y.T.2
Williamson, B.3
Gure, A.O.4
Stockert, E.5
Gordan, J.D.6
-
22
-
-
0035342468
-
Upregulation of a novel mRNA (NY-CO-1) involved in the methyl 4-methoxy-3-(3- methyl-2-butenoyl) benzoate (VT1)-induced proliferation arrest of a non-small-cell lung carcinoma cell line (NSCLC-N6)
-
Carbonnelle D, Jacquot C, Lanco X, Le Dez G, Tomasoni C, Briand G et al. Upregulation of a novel mRNA (NY-CO-1) involved in the methyl 4-methoxy-3-(3- methyl-2-butenoyl) benzoate (VT1)-induced proliferation arrest of a non-small-cell lung carcinoma cell line (NSCLC-N6). Int J Cancer 2001; 92: 388-397.
-
(2001)
Int J Cancer
, vol.92
, pp. 388-397
-
-
Carbonnelle, D.1
Jacquot, C.2
Lanco, X.3
Le Dez, G.4
Tomasoni, C.5
Briand, G.6
-
23
-
-
78649355858
-
Azathioprine-induced carcinogenesis in mice according to Msh2 genotype
-
Chalastanis A, Penard-Lacronique V, Svrcek M, Defaweux V, Antoine N, Buhard O et al. Azathioprine-induced carcinogenesis in mice according to Msh2 genotype. J Natl Cancer Inst 2010; 102: 1731-1740.
-
(2010)
J Natl Cancer Inst
, vol.102
, pp. 1731-1740
-
-
Chalastanis, A.1
Penard-Lacronique, V.2
Svrcek, M.3
Defaweux, V.4
Antoine, N.5
Buhard, O.6
-
24
-
-
34547737565
-
P53 directs focused genomic responses in Drosophila
-
Abrams
-
Akdemir F, Christich A, Sogame N, Chapo J, Abrams JM. p53 directs focused genomic responses in Drosophila. Oncogene 2007; 26: 5184-5193.
-
(2007)
Oncogene
, vol.26
, pp. 5184-5193
-
-
Akdemir, F.1
Christich, A.2
Sogame, N.3
Chapo, J.4
-
25
-
-
0037418177
-
Ends-out or replacement, gene targeting in Drosophila
-
Gong WJ, Golic KG. Ends-out or replacement, gene targeting in Drosophila. Proc Natl Acad Sci USA 2003; 100: 2556-2561.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2556-2561
-
-
Gong, W.J.1
Golic, K.G.2
-
26
-
-
33745597607
-
Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster
-
Wichmann A, Jaklevic B, Su TT. Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster. Proc Natl Acad Sci USA 2006; 103: 9952-9957.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9952-9957
-
-
Wichmann, A.1
Jaklevic, B.2
Su, T.T.3
-
27
-
-
0142102536
-
In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila
-
Lee JH, Lee E, Park J, Kim E, Kim J, Chung J. In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. FEBS Lett 2003; 550: 5-10.
-
(2003)
FEBS Lett
, vol.550
, pp. 5-10
-
-
Lee, J.H.1
Lee, E.2
Park, J.3
Kim, E.4
Kim, J.5
Chung, J.6
-
28
-
-
19444386896
-
Apoptosis in Drosophila: Neither fish nor fowl (nor man, nor worm)
-
Part 9
-
Kornbluth S, White K. Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). J Cell Sci 2005; 118(Part 9): 1779-1787.
-
(2005)
J Cell Sci
, vol.118
, pp. 1779-1787
-
-
Kornbluth, S.1
White, K.2
-
29
-
-
45449093594
-
Regulation of apoptosis in Drosophila
-
Steller H. Regulation of apoptosis in Drosophila. Cell Death Differ 2008; 15: 1132-1138.
-
(2008)
Cell Death Differ
, vol.15
, pp. 1132-1138
-
-
Steller, H.1
-
30
-
-
68949221698
-
P53-Independent apoptosis limits DNA damageinduced aneuploidy
-
McNamee LM, Brodsky MH. p53-Independent apoptosis limits DNA damageinduced aneuploidy. Genetics 2009; 182: 423-435.
-
(2009)
Genetics
, vol.182
, pp. 423-435
-
-
McNamee, L.M.1
Brodsky, M.H.2
-
31
-
-
50849132549
-
E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage
-
Moon NS, Di Stefano L, Morris EJ, Patel R, White K, Dyson NJ. E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 2008; 4: e1000153.
-
(2008)
PLoS Genet
, vol.4
-
-
Moon, N.S.1
Di Stefano, L.2
Morris, E.J.3
Patel, R.4
White, K.5
Dyson, N.J.6
-
32
-
-
77952236938
-
Dual roles of Drosophila p53 in cell death and cell differentiation
-
Fan Y, Lee TV, Xu D, Chen Z, Lamblin AF, Steller H et al. Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ 2010; 17: 912-921.
-
(2010)
Cell Death Differ
, vol.17
, pp. 912-921
-
-
Fan, Y.1
Lee, T.V.2
Xu, D.3
Chen, Z.4
Lamblin, A.F.5
Steller, H.6
-
33
-
-
0036741796
-
GAL4 system in Drosophila: A fly geneticists Swiss army knife
-
Duffy JB. GAL4 system in Drosophila: a fly geneticists Swiss army knife. Genesis 2002; 34: 1-15.
-
(2002)
Genesis
, vol.34
, pp. 1-15
-
-
Duffy, J.B.1
-
34
-
-
34447628492
-
The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis
-
Baum JS, Arama E, Steller H, McCall K. The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Cell Death Differ 2007; 14: 1508-1517.
-
(2007)
Cell Death Differ
, vol.14
, pp. 1508-1517
-
-
Baum, J.S.1
Arama, E.2
Steller, H.3
McCall, K.4
-
35
-
-
0029056059
-
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
-
Xue D, Horvitz HR. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 1995; 377: 248-251.
-
(1995)
Nature
, vol.377
, pp. 248-251
-
-
Xue, D.1
Horvitz, H.R.2
-
36
-
-
34548171631
-
Baculovirus caspase inhibitors P49 and P35 block virus-induced apoptosis downstream of effector caspase DrICE activation in Drosophila melanogaster cells
-
Lannan E, Vandergaast R, Friesen PD. Baculovirus caspase inhibitors P49 and P35 block virus-induced apoptosis downstream of effector caspase DrICE activation in Drosophila melanogaster cells. J Virol 2007; 81: 9319-9330.
-
(2007)
J Virol
, vol.81
, pp. 9319-9330
-
-
Lannan, E.1
Vandergaast, R.2
Friesen, P.D.3
-
37
-
-
61849142815
-
Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster
-
Titen SW, Golic KG. Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster. Genetics 2008; 180: 1821-1832.
-
(2008)
Genetics
, vol.180
, pp. 1821-1832
-
-
Titen, S.W.1
Golic, K.G.2
-
38
-
-
0842346437
-
Principles of tumor suppression
-
Sherr CJ. Principles of tumor suppression. Cell 2004; 116: 235-246.
-
(2004)
Cell
, vol.116
, pp. 235-246
-
-
Sherr, C.J.1
-
39
-
-
77956402972
-
E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila
-
Wichmann A, Uyetake L, Su TT. E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila. Dev Biol 2010; 346: 80-89.
-
(2010)
Dev Biol
, vol.346
, pp. 80-89
-
-
Wichmann, A.1
Uyetake, L.2
Su, T.T.3
-
40
-
-
77955441579
-
New role for LEKTI in skin barrier formation: Label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI
-
Bennett K, Callard R, Heywood W, Harper J, Jayakumar A, LC G et al. New role for LEKTI in skin barrier formation: label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI. J Proteome Res 2010; 9: 4289-4294.
-
(2010)
J Proteome Res
, vol.9
, pp. 4289-4294
-
-
Bennett, K.1
Callard, R.2
Heywood, W.3
Harper, J.4
Jayakumar, A.5
-
41
-
-
79960724914
-
A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing
-
Long SW, Ooi JY, Yau PM, Jones PL. A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing. Biosci Rep 2011; 31: 333-343.
-
(2011)
Biosci Rep
, vol.31
, pp. 333-343
-
-
Long, S.W.1
Ooi, J.Y.2
Yau, P.M.3
Jones, P.L.4
-
42
-
-
77952317326
-
Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA
-
Squillaro T, Alessio N, Cipollaro M, Renieri A, Giordano A, Galderisi U. Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA. FASEB J 2010; 24: 1593-1603.
-
(2010)
FASEB J
, vol.24
, pp. 1593-1603
-
-
Squillaro, T.1
Alessio, N.2
Cipollaro, M.3
Renieri, A.4
Giordano, A.5
Galderisi, U.6
-
43
-
-
58249121980
-
Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells
-
Papait R, Magrassi L, Rigamonti D, Cattaneo E. Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells. Biochem Bioph Res Co 2009; 379: 434-439.
-
(2009)
Biochem Bioph Res Co
, vol.379
, pp. 434-439
-
-
Papait, R.1
Magrassi, L.2
Rigamonti, D.3
Cattaneo, E.4
-
44
-
-
84863474612
-
P53 binds to estrogen receptor 1 promoter in human breast cancer cells
-
Rasti M, Arabsolghar R, Khatooni Z, Mostafavi-Pour Z. p53 Binds to estrogen receptor 1 promoter in human breast cancer cells. Pathol Oncol Res 2011; 18: 169-175.
-
(2011)
Pathol Oncol Res
, vol.18
, pp. 169-175
-
-
Rasti, M.1
Arabsolghar, R.2
Khatooni, Z.3
-
45
-
-
0033867524
-
The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo
-
Deuring R, Fanti L, Armstrong JA, Sarte M, Papoulas O, Prestel M et al. The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo. Mol Cell 2000; 5: 355-365.
-
(2000)
Mol Cell
, vol.5
, pp. 355-365
-
-
Deuring, R.1
Fanti, L.2
Armstrong, J.A.3
Sarte, M.4
Papoulas, O.5
Prestel, M.6
-
46
-
-
33747061857
-
Decapentaplegic head capsule mutations disrupt novel peripodial expression controlling the morphogenesis of the Drosophila ventral head
-
Stultz BG, Lee H, Ramon K, Hursh DA. Decapentaplegic head capsule mutations disrupt novel peripodial expression controlling the morphogenesis of the Drosophila ventral head. Dev Biol 2006; 296: 329-339.
-
(2006)
Dev Biol
, vol.296
, pp. 329-339
-
-
Stultz, B.G.1
Lee, H.2
Ramon, K.3
Hursh, D.A.4
|