Design, synthesis and biological activity evaluation of adenosine analogues

Yaoxue Xuebao

Volumn 48, Issue 6, 2013, Pages 881-886

  Wang, Dong Mei ^a   Liu, Xiao Hui ^a   Guo, Hui ^a   Huang, Jun Hua ^a   Wang, Lin ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Adenosine analogues; Brain protective; Cordyceps; Sedative hypnotic activity; Structure activity relationship

Indexed keywords

ADENINE; ADENOSINE DERIVATIVE; N6 (2 HYDROXYETHYL)ADENOSINE; RIBOSE; UNCLASSIFIED DRUG; ADENOSINE; HYPNOTIC SEDATIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CORDYCEPS; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; LOCOMOTION; MASS SPECTROMETRY; MOUSE; MYCELIUM; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MOTOR ACTIVITY; RANDOMIZATION; SYNTHESIS;

ADENOSINE; ANIMALS; HYPNOTICS AND SEDATIVES; MALE; MICE; MICE, INBRED ICR; MOLECULAR STRUCTURE; MOTOR ACTIVITY; RANDOM ALLOCATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882401436     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Baxter CA, Cleator E, Brands KM J, et al. The first large-scale synthesis of MK-4305: a dual orexin receptor antagonist for the treatment of sleep disorder [J], Org Proc Res, 2011, 15:367-375.
2. Passarella S, Duong MT. Diagnosis and treatment of insomnia [J], Am J Health-Syst Pharm, 2008, 65:927-934.
3. Dou W, Zhao ZX. The tolerance study progress of sedative and hypnotic drug [J], Chin J Neurol, 2004, 37:459-461.
4. Daley M, Morin CM, LeBlanc M, et al. Insomnia and its relationship to health-care utilization, work absenteeism, productivity and accidents [J], Sleep Med, 2009, 10:427-438.
5. Pan JY, Wang QL, Chang Q. The research progress of new sedative and hypnotic drugs [J], Guangdong Med J, 2011, 32:665-667.
6. Liu SC. Advances in the study of sedative and hypnotic drugs [J], Foreign Med Sci (Pharmarcy), 2000, 27:227-230.
7. Furuya T, Hirotani M, Matasuzawa M. N6-(2-hydroxyethyl) adenosine, a biologically active compound from cultured mycelia of Cordyceps and Isaria species [J], Phytochemistry, 1983, 22:2509-2512.
8. Durcan MJ, Morgan PF. Evidence for adenosine A2 receptor in movement in hypomobility effects of adenosine analogues in mice [J]. Eur J Pharmacol, 1989, 168:285-290.
9. Basheer R, Strecha RE, Takkar MM, et al. Adenosine and sleep-wake regulation [J]. Prog Neurobiol, 2004, 73:379-396.
10. Feldberg LA, Sherwood PD. Injection of drugs into the lateral ventricle of the cat [J]. J Physiol, 1954, 123:148-167.
11. Townsend LB, Tipson RS. Nucleic Acid Chemistry: Improved and New Synthetic Procedures, Methods, and Techniques [M], New York: John Wiley & Sons, 1978:611-614.
12. Robins MJ, Uznanski BU. Nucleic acid related compounds 33 conversations of adenosine and guanosine to 2, 6-dichloro, 2-amino-6-chloro and derived purine nucleosides [J], Can J Chem, 1981, 59:2601-2617.
13. Bendich A, Russell PJ Jr, Fox JJ. The synthesis and properties of 6-chloro-purine and purine [J], J Am Chem Soc, 1954, 76:6073-6077.
14. Holemes RE, Robins RK. Purine nucleosides. VII. Direct bromination of adenosine, deoxyadenosine, guanosine, and related purine nucleosides [J]. J Org Chem, 1964, 86:1942-1945.