Adipocytokines and aging: Adiponectin and leptin

Minerva Endocrinologica

Volumn 38, Issue 2, 2013, Pages 203-210

  Gulcelik, N E ^a   Haul, M ^a   Ariogul, S ^a   Usman, A ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Adipokines; Adiponectin; Aged, 80 and over; Aging; Leptin

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; C REACTIVE PROTEIN; CALRETICULIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ADVERSE OUTCOME; AGING; ALZHEIMER DISEASE; ANGIOGENESIS; BODY MASS; CORONARY ARTERY DISEASE; DISEASE COURSE; GENOTYPE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MACROPHAGE; MORTALITY; MULTIINFARCT DEMENTIA; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; REVIEW; SARCOPENIA; TELOMERE;

ADIPONECTIN; AGING; HUMANS; LEPTIN;

EID: 84882381547     PISSN: 03911977     EISSN: 18271634     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H et al. Fat tissue, aging, and cellular senescence. Aging Cell 2010;9:667-84.
2. Wozniak SE, Gee LL, Wachtel MS, and Frezza EE. Adipose tissue: the new endocrine organ? a review article. Digest Dis Sci 2009;54:1847-56.
3. Cancello R, Clement K. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. International J Obstet Gynaecol 2006;113:1141-7.
4. Lafontan M and Berlan M. Do regional differences in adipocyte biology provide new pathophysiological insights? Trends Pharmacol Sci 2003;24:276-83.
5. Huffman DM, Barzilai N. Role of visceral adipose tissue in aging. Biochem Biophys Acta 2009;1790:1117-23.
6. Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J et al. Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity. Am J Physiol 2007;292:E1041-E1051.
7. Lutz W, Sanderson W, Scherbov S. The coming acceleration of global population ageing. Nature 2008;451:716-9.
8. Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 2009;15:1082-7.
9. Zhang L, Ebenezer PJ, Dasuri K, Fernandez-Kim SO, Francis J, Mariappan N et al. Aging is associated with hypoxia and oxidative stress in adipose tissue: Implications for adipose function. Am J Physiol Endocrinol Metab 2011 May 17.
10. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-95.
11. Tschritter O, Fritsche A, Thamer C, Haap M, Shirkavand F, Rah S et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 2003;52:239-43
12. Hivert MF, Sullivan LM, Fox CS, Nathan D., D'Agostino RB, Wilson P et al. Associations of Adiponectin, Resistin, and Tumor Necrosis Factor-alpha with Insulin Resistance. J Clin Endocrinol Metab 2008;93:3165-72.
13. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001;86:1930-5.
14. Spranger J, Mohlig M, Wegewitz M, Ristow M, Pfeiffer AF, Schill T et al. Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome. Clin Endocrinol 2004;61:738-46.
15. Gulcelik NE, Aral Y, Setter R, Demir Y, Culha C, Adiponectin is an independent determinant of insulin resistance in women with polycystic ovary syndrome. Gynecol Endocrinol 2006;22:511-5.
16. von Zglinicki T, Burkle A, Kirkwood TB. Stress, DNA damage and ageing: an integrative approach. Experiment Gerontol 2001;36:1049-62.
17. Kushner EJ, Van Guilder GP, Maceneaney OJ, Cech JN, Stauffer BL, De Souza CA. Aging and endothelial progenitor cell telomere length in healthy men. Clin Chem and Labor Med 2009;47:47-50.
18. Al-Attas OS, Al-Daghri NM, Alokail MS, Alfadda A, Bamakhramah A, Sabico S et al. Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: the influence of circulating adiponectin. Eur J Endocrinol 2010;163:601-7.
19. Arai Y, Nakazawa S, Kojima T, Takayama M, Ebihara Y, Shimuzu K et al. High adiponectin concentration and its role for longevity in female centerinans. Geriatr Gerontol Int 2006;6:32-9.
20. Bik W, Baranowska-Bik A, Wolinska-Witort E, Martynska L, Chmielowska M, Szybinska A et al. The relationship between adiponectin levels and metabolic status in cenetrinan, early elderly, young obese women. Neuro Endocrinol Lett 2006;27:493-500.
21. Atzmon G, Pollin T, Crandall J, Taner K, Schecter CB, Scherer PE et al. Adiponectin levels and genotype: a potential regulator of life span in humans. J Gerontol A Biol Sci Med Sci 2008;63 A: 447-53.
22. Khabour OF, Mesmar FS, Alatoum MA, Gharaibeh MY, Alzoubi KH. Associations of polymorphisms in adiponectin and leptin genes with men's longevity. Aging Male 2010;13:188-93.
23. Poehls J, Wassel C, Haris TB, Havel PJ, Swarbrick MM, Cummings SR et al. Association of Adiponectin and Mortality in Older Adults: Health ABC Study. Diabetologia 2009;52:591-95.
24. Kizer JR, Arnold AM, Strotmeyer ES, Ives DG, Cushman M, Ding J et al. Change in circulating adiponectin in advanced old age: Determinants and impact on physical function and mortality. The cardiovascular health study all stars study. J Gerontol A Biol Sci Med Sci 2010;65 A: 1208-14.
25. Gulcelik NE, Usman A, Gurlek A. Role of adipocytokines in predicting the development of diabetes and its late complications. Endocr 2009;36:397-403.
26. Rizza S, Gigli F, Galli A, Micchelini B, Lauro D, Lauro R et al. Adiponectin isoforms in elderly patients with or without coronary artery disease. J Am Geriatr Soc 2010;58:702-6.
27. Teoh H, Strauss MH, Szmitko PE, Verma S. Adiponectin and myocardial infarction: a paradox or a paradigm? Eur Heart J 2006;27:2266-8.
28. Ouchi N, Walsh K. A novel role for adiponectin in the regulation of inflammation. Arterioscler Thromb Vasc Biol 2008;28:1219-21.
29. Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS et al. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest 2007;117:375-86.
30. Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000;62:413-37.
31. Ku IA, Farzaneh-Far R, Vittinghoff E, Zhang MH, Na B, Whooley MA. Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: The Heart and Soul Study. Atherosclerosis 2010 [Epub ahead of print].
32. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the Mouse obese gene and its human homologue. Nature 1994;372:425-32.
33. Yang R, Barouch LA. Leptin signaling and obesity: cardiovascular consequences. Ore Res 2007;101:545-59.
34. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998;394:897-901.
35. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ et al. Leptin regulates proinflammatory immune responses. FASEB J 1998;12:57-65.
36. Hubbard RE, O'Mahony MS, Calver BL, Woodhouse KW. Nutrition, inflammation, and leptin levels in aging and frailty. J Am Geriatr Soc 2008;56:279-84.
37. Sánchez-Rodríguez M, García-Sánchez A, Retana-Ugalde R, Mendoza-Núñez VM. Serum leptin levels and blood pressure in the overweight elderly. Arch Med Res 2000;31:425-8.
38. Mann DR, Johnson AO, Gimpel T, Castracane VD. Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans. J Clin End Metab 2003;88:3339-45.
39. Ostlund RE Jr, Yang JW, Klein S, Gingerich R. Relationship between plasma leptin concentration and body fat, gender, diet, age and metabolic covariates. J Clin Endocrinol Metab 1996;81:3909-13.
40. Moller N, O'Brien P, Nair KS. Disruption of the relationship between fat content and leptin levels with aging in humans. J Clin Endocrinol Metab 1998;83:931-4.
41. Arai Y, Takayama M, Abe Y, Hirose N. Adipokines and aging. J Atheroscler Thromb 2011;18:545-50.
42. Arai Y, Takayama M, Gondo Y, Inagaki H, Yamamura K, Nakazawa S et al. Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival beyond 100 years of age. J Gerontol A Biol Sci Med Sci 2008;63:1209-18.
43. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F et al. European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39:412-23.
44. Cruz-Jentoft AJ, Landi F, Topinkova E, Michel JP. Understanding sarcopenia as a geriatric syndrome. Curr Opin Clin Nutr Metab Care 2010;13:1-7.
45. Rolland Y, Czerwinski S, Abellan Van Kan G, Morley JE, Cesari M, Onder G et al. Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging 2008;12:433-50.
46. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al. Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56:M 146-56.
47. Bauer JM, Sieber CC. Sarcopenia and frailty: a clinician's controversial point of view. Exp Gerontol 2008;43:674-8.
48. Sinclair A, Viljoen A. The metabolic syndrome in older persons. Clin Geriatr Med 2010;26:261-74.
49. Barzilay JI, Blaum C, Moore T, Xue QL, Hirsch CH, Walston JD et al. Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study. Arch Intern Med 2007;167:635-41.
50. Cesari M, Penninx BW, Pahor M, Lauretani F, Corsi AM, Rhys Williams G et al. Inflammatory markers and physical performance in older persons: The InCHIANTI study. J Gerontol A Biol Sci Med Sci 2004;59:242-8.
51. Hamrick MW, Herberg S, Arounleut P, He HZ, Shiver A, Qi RQ et al. The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice. Biochem Biophys Res Commun 2010;400:379-83.
52. Waters DL, Quails CR, Dorin RI, Veldhuis JD, Baumgartner RN. Altered growth hormone, Cortisol, and leptin secretion in healthy elderly persons with sarcopenia and mixed body composition phenotypes. J Gerontol A Biol Sci Med Sci 2008;63:536-41.
53. Zoico E, Rossi A, Di Francesco V, Sepe A, Olioso D, Pizzini F et al. Adipose tissue infiltration in skeletal muscle of healthy elderly men: relationships with body composition, insulin resistance, and inflammation at the systemic and tissue level. J Gerontol A Biol Sci Med Sci 2010;65:295-9.
54. Cankurtaran M, Halil M, Yavuz BB, Dagli N, Oyan B, Ariogul S. Prevalence and correlates of metabolic syndrome (MS) in older adults. Arch Gerontol Geriatr 2006;42:35-45.
55. Halil M, Cankurtaran M, Ulger Z, Balam Yavuz B, Altun B, Turgan C et al. Awareness and control of hypertension among the elderly in a university hospital. Clin Exp Hypertens 2006;28:683-93.
56. Sattar N, Wannamethee G, Sarwar N, Chernova J, Lawlor DA, Kelly A et al. Leptin and coronary heart disease: prospective study and systematic review. J Am Coll Cardiol 2009;53:167-75.
57. Lieb W, Sullivan LM, Harris TB, Roubenoff R, Benjamin EJ, Levy D et al. Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals. Diabetes Care 2009;32 612-6.
58. Dede DS, Yavuz B, Yavuz BB, Cankurtaran M, Halil M, Ulger Z et al. Assessment of endothelial function in Alzheimer's disease: is Alzheimer's disease a vascular disease? J Am Geriatr Soc 2007;55:1613-7.
59. Carlsson CM. Type 2 diabetes mellitus, dyslipidemia, and Alzheimer's disease. J Alzheimers Dis 2010;20:711-22.
60. Akter K, Lanza EA, Martin SA, Myronyuk N, Rua M, Raffa RB. Diabetes mellitus and Alzheimer's disease: shared pathology and treatment? Br J Clin Pharmacol 2011;71:365-76.
61. Balistreri CR, Caruso C, Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm 2010;2010:802078.
62. Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB et al. Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA 2009;302:2565-72.
63. Greco SJ, Sarkar S, Johnston JM, Zhu X, Su B, Casadesus G et al. Leptin reduces Alzheimer's diseaserelated tau phosphorylation in neuronal cells. Biochem Biophys Res Commun 2008;376:536-41.
64. Harvey J, Solovyova N, Irving A. Leptin and its role in hippocampal synaptic plasticity. Prog Lipid Res 2006;45:369-78.
65. Harvey J, Shanley LJ, O'Malley D, Irving AJ. Leptin: a potential cognitive enhancer? Biochemical Society Transactions 2005;33:1029-32.
66. Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK et al. Leptin: a novel therapeutic strategy for Alzheimer's disease. J Alzheimers Dis 2009;16:731-40.
67. Narita K, Kosaka H, Okazawa H, Murata T, Wada Y. Relationship between plasma leptin level and brain structure in elderly: a voxel-based morphometric study. Biol Psychiatry 2009;65:992-4.
68. Pannacciulli N, Le D S N T, Chen K, Reiman EM, Krakoff J. Relationships between plasma leptin concentrations and human brain structures voxelbased morphometric study. Neuroscience Letters 2007;412:248-53.