Tenofovir-related Fanconi's syndrome and osteomalacia in a teenager with HIV

BMJ Case Reports

Volumn , Issue , 2013, Pages

  Lucey, Julie M ^a   Hsu, Peter ^a   Ziegler, John B ^a  

^a SYDNEY CHILDREN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR PLUS LAMIVUDINE; ALKALINE PHOSPHATASE; ANTIRETROVIRUS AGENT; BICARBONATE; CALCITRIOL; CALCIUM; COLECALCIFEROL; CREATININE; DIDANOSINE PLUS LAMIVUDINE PLUS ZIDOVUDINE; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; LOPINAVIR PLUS RITONAVIR; MULTIDRUG RESISTANCE PROTEIN 4; PARATHYROID HORMONE; PHOSPHATE; POTASSIUM; TENOFOVIR DISOPROXIL; UNCLASSIFIED DRUG; VITAMIN; ADENINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PHOSPHONIC ACID DERIVATIVE;

ADOLESCENT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BACKACHE; BONE DENSITY; BONE PAIN; CASE REPORT; CD4 LYMPHOCYTE COUNT; CLINICAL FEATURE; CREATININE BLOOD LEVEL; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DISEASE DURATION; DRUG BLOOD LEVEL; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DUAL ENERGY X RAY ABSORPTIOMETRY; ELECTROLYTE INTAKE; FANCONI RENOTUBULAR SYNDROME; FOLLOW UP; FOOT FRACTURE; FOOT PAIN; FOOT RADIOGRAPHY; GLUCOSURIA; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; HYPERLIPIDEMIA; HYPOPHOSPHATEMIA; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE DISORDER; MALE; MEDICAL HISTORY; METABOLIC ACIDOSIS; METATARSAL BONE; OSTEOLYSIS; OSTEOMALACIA; OSTEOPENIA; PARATHYROID HORMONE BLOOD LEVEL; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROTEINURIA; STRESS FRACTURE; TREATMENT OUTCOME; VIRUS LOAD; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; ANALOGS AND DERIVATIVES; CHEMICALLY INDUCED; COMPLICATION; HIV INFECTIONS;

ADENINE; ADOLESCENT; ANTI-HIV AGENTS; FANCONI SYNDROME; HIV INFECTIONS; HUMANS; MALE; ORGANOPHOSPHONATES; OSTEOMALACIA;

EID: 84882369956     PISSN: None     EISSN: 1757790X     Source Type: Journal    
DOI: 10.1136/bcr-2013-008674     Document Type: Article

References (20)

1. Verhelst D, Monge M, Meynard JL, et al. Fanconi syndrome and renal failure induced by tenofovir: a first case report. Am J Kidney Dis 2002;40:1331-3. (Pubitemid 35403147)
2. Hussain S, Khayat A, Tolaymat A, et al. Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir. Pediatr Nephrol 2006;21:1034-6. (Pubitemid 43885106)
3. Gafni RI, Hazra R, Reynolds JC, et al. Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy: impact on bone mineral density in HIV-infected children. Pediatrics 2006;118:e711-18. (Pubitemid 46089998)
4. Laprise C, Baril J, Dufresne S, et al. Association between tenofovir exposure and reduced kidney function in a cohort of HIV-positive patients: results from 10 Years of follow-up. Clin Infect Dis 2013;56:567-75.
5. Viani RM, Dankner WM, Muelenaer PA, et al. Resolution of HIV-associated nephrotic syndrome with highly active antiretroviral therapy delivered by gastrostomy tube. Pediatrics 1999;104:1394-6.
6. Zimmermann AE, Pizzoferrato T, Bedford J, et al. Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions. Clin Infect Dis 2006;42:283-90. (Pubitemid 43054205)
7. International Society for Clinical Densitometry Official Positions. http://www.iscd.org. Updated 2007. (accessed Jul. 2012).
8. Holick M, Binkley N, Bischoff-Ferrari H, et al. Clinical practice guideline: evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011;96:1911-30.
9. http:www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf (accessed on 14 Feb. 2013, p. 41).
10. Onyeador N, Patel D, Lyall H, et al. Renal tubular dysfunction associated with tenofovir based HAART in perinatally acquired HIV: the need for paediatric formulations and pharmacokinetic studies (Abstracts of the 14th Annual Conference of the British HIV Association). HIV Med 2008;9(Suppl 1):26.
11. Wever K, van Agtmael M, Carr A. Incomplete reversibility of tenofovir-related renal toxicity in HIV-infected men. J AIDS 2010;55:78-81.
12. Williams J, Chadwick DR. Tenofovir-induced renal tubular dysfunction presenting with hypocalcaemia. J Infect 2006;52:107-8.
13. Judd A, Boyd KL, Stöhr W, et al. Effect of tenofovir disoproxil fumarate on risk of renal abnormality in HIV-1-infected children on antiretroviral therapy: a nested case-control study. AIDS 2010;24:525-34.
14. Purdy JB, Gafni RI, Reynolds JC, et al. Decreased bone mineral density with off-label use of Tenofovir in HIV-infected children and adolescents. J Paediatr 2008;152:582-4. (Pubitemid 351381047)
15. Wanner DP, Tyndall A, Walker U. Tenofovir-induced osteomalacia. Clin Exp Rheumatol 2009;27:1001-3.
16. Rodriguez M, Daniels B, Gunawardene S, et al. High frequency of vitamin D deficiency in ambulatory HIV positive patients. Aids Res Hum Retro 2009;25:9-14.
17. Wools-Kaloustian KK, Gupta SK Will there be an epidemic of HIV-related chronic kidney disease in sub-Saharan Africa? Too soon to tell. Kidney Int 2008;74:845-7.
18. Mulenga LB, Kruse G, Lakhi S, et al. Baseline renal insufficiency and risk of death among HIV-infected adults on antiretroviral therapy in Lusaka, Zambia. AIDS 2008;22:1821-7.
19. WHO. Antiretroviral therapy for HIV infection in adults and adolescents: recommedations for a public health approach. http://www.who.int/hiv/pub/ guidelines/artadultguidelines.pdf (accessed 5 Apr. 2013). 2010.
20. Department of Health and Human Services. Guidelines for the use of antiretroviral Agents in pediatric HIV infection. DHSS. 2012. http://aidsinfo.nih.gov/guidelines/html/2/pediatric-arv-guidelines/0 (accessed 5 Feb. 2013).