Elevated CSF cytokines in the jarisch-herxheimer reaction of general paresis

JAMA Neurology

Volumn 70, Issue 8, 2013, Pages 1060-1064

  Davis, Larry E ^a   Oyer, Ryan ^b   Beckham, J David ^b   Tyler, Kenneth L ^b  

^a NEW MEXICO VA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETIRACETAM; GADOLINIUM; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 8; PENICILLIN G;

ADULT; ALCOHOLISM; ANXIETY; ARTICLE; ATAXIA; BRAIN ATROPHY; BRAIN INFARCTION; CASE REPORT; CONFABULATION; CONTROLLED STUDY; DELUSION; DEMENTIA; DRUG FEVER; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXECUTIVE FUNCTION; HALLUCINATION; HERXHEIMER REACTION; HUMAN; HYPERREFLEXIA; HYPERTENSION; MALE; MENTAL DETERIORATION; MILD COGNITIVE IMPAIRMENT; NEUTROPHILIA; PARESIS; PLEOCYTOSIS; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PUPIL REFLEX; SEIZURE; TACHYCARDIA; TREATMENT OUTCOME; URINE INCONTINENCE;

EID: 84882319318     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2013.2120     Document Type: Article

References (30)

1. Jarisch A. Therapeutische versuche bei syphilis. Wien MedWochenschr. 1895;45:721-724.
2. Herxheimer K, Krause D. Ueber eine bei syphilitischen vorkommende quecksbilberreaktion. Dtsch MedWochenschr. 1902;28:895-897.
3. Warrell DA, Perine PL, Bryceson AD, Parry EH, Pope HM. Physiologic changes during the Jarisch-Herxheimer reaction in early syphilis: a comparison with louse-borne relapsing fever. Am J Med. 1971;51(2):176-185.
4. Vaughan C, Cronin CC,Walsh EK, WheltonM. The Jarisch-Herxheimer reaction in leptospirosis. Postgrad Med J. 1994;70(820):118-121.
5. Dwindelle JH, Rein CR, Sternberg SH, Sheldon AJ. Preliminary report on the evaluation of penicillin in the treatment of yaws. Am J Trop Med Hyg. 1946;26:311-318.
6. Maloy AL, Black RD, Segurola RJ Jr. Lyme disease complicated by the Jarisch-Herxheimer reaction. J Emerg Med. 1998;16(3):437-438.
7. Heyman A, Sheldon WH, Evans LD. Pathogenesis of the Jarisch-Herxheimer reaction: a review of clinical and experimental observations. Br J Vener Dis. 1952;28(2):50-60.
8. Miller WM, Gorini F, Botelho G, et al. Jarisch-Herxheimer reaction among syphilis patients in Rio de Janeiro, Brazil. Int J STD AIDS. 2010;21(12):806-809.
9. Young EJ,Weingarten NM, Baughn RE, Duncan WC. Studies on the pathogenesis of the Jarisch-Herxheimer reaction: development of an animal model and evidence against a role for classical endotoxin. J Infect Dis. 1982;146(5): 606-615.
10. Farmer TW. Jarisch-Herxheimer reaction in early syphilis treated with crystalline penicillin G. J AmMed Assoc. 1948;138(7):480-485.
11. Li J,Wang LN, Zheng HY. Jarisch-Herxheimer reaction among syphilis patients in China [published onlineMay 21, 2012]. J Eur Acad Dermatol Venereol. doi:10.1111/j.1468- 3083.2012.04544.x.
12. Aronson IK, Soltani K. The enigma of the pathogenesis of the Jarisch-Herxheimer reaction. Br J Vener Dis. 1976;52(5):313-315.
13. Kobayashi J, Nakagawa Y, Tobisawa S, Isozaki E, Koide R. Deterioration of MRI findings related to Jarisch-Herxheimer reaction in a patient with neurosyphilis. J Neurol. 2011;258(4):699-701.
14. Cooper PJ, Fekade D, Remick DG, Grint P, Wherry J, Griffin GE. Recombinant human interleukin-10 fails to alter proinflammatory cytokine production or physiologic changes associated with the Jarisch-Herxheimer reaction. J Infect Dis. 2000;181(1):203-209.
15. Negussie Y, Remick DG, DeForge LE, Kunkel SL, Eynon A, Griffin GE. Detection of plasma tumor necrosis factor, interleukins 6, and 8 during the Jarisch-Herxheimer Reaction of relapsing fever. J Exp Med. 1992;175(5):1207- 1212.
16. Griffin GE. Cytokines involved in human septic shock: the model of the Jarisch-Herxheimer reaction. J Antimicrob Chemother. 1998;41(suppl A):25-29.
17. Kaplanski G, Granel B, Vaz T, Durand JM. Jarisch-Herxheimer reaction complicating the treatment of chronic Q fever endocarditis: elevated TNFalpha and IL-6 serum levels. J Infect. 1998;37(1): 83-84.
18. Fekade D, Knox K, Hussein K, et al. Prevention of Jarisch-Herxheimer reactions by treatment with antibodies against tumor necrosis factor alpha. N Engl J Med. 1996;335(5):311-315.
19. Tantalo LC, Lukehart SA, Marra CM. Treponema pallidum strain-specific differences in neuroinvasion and clinical phenotype in a rabbit model. J Infect Dis. 2005;191(1):75-80.
20. BaggioliniM. Chemokines and leukocyte traffic. Nature. 1998;392(6676):565-568.
21. Luster AD. Chemokines: chemotactic cytokines that mediate inflammation. N Engl J Med. 1998;338(7):436-445.
22. Ehrlich LC, Hu S, ShengWS, et al. Cytokine regulation of human microglial cell IL-8 production. J Immunol. 1998;160(4):1944-1948.
23. Horuk R, Martin AW,Wang Z, et al. Expression of chemokine receptors by subsets of neurons in the central nervous system. J Immunol. 1997;158(6):2882-2890.
24. Puma C, DanikM, Quirion R, Ramon F, Williams S. The chemokine interleukin-8 acutely reduces Ca(2+) currents in identified cholinergic septal neurons expressing CXCR1 and CXCR2 receptor mRNAs. J Neurochem. 2001;78(5):960-971.
25. Burkhart CS, Siegemund M, Steiner LA. Cerebral perfusion in sepsis. Crit Care. 2010;14(2): 215.
26. Reinsfelt B, Ricksten SE, Zetterberg H, Blennow K, Freden-Lindqvist J,Westerlind A. Cerebrospinal fluid markers of brain injury, inflammation, and blood-brain barrier dysfunction in cardiac surgery. Ann Thorac Surg. 2012;94(2):549-555.
27. Henningsson AJ, Tjernberg I, Malmvall BE, Forsberg P, Ernerudh J. Indications of Th1 and Th17 responses in cerebrospinal fluid from patients with Lyme neuroborreliosis: a large retrospective study. J Neuroinflammation. 2011;8:36.
28. Marra CM, Tantalo LC, Sahi SK, Maxwell CL, Lukehart SA. CXCL13 as a cerebrospinal fluidmarker for neurosyphilis in HIV-infected patients with syphilis. Sex Transm Dis. 2010;37(5):283-287.
29. Schmidt C, Plate A, Angele B, et al. A prospective study on the role of CXCL13 in Lyme neuroborreliosis. Neurology. 2011;76(12):1051-1058.
30. Nagafuchi M, Nagafuchi Y, Sato R, et al. Adult meningism and viral meningitis, 1997-2004: clinical data and cerebrospinal fluid cytokines. Intern Med. 2006;45(21):1209-1212.