Pancreaticoduodenectomy in elderly adults: Is it justified in terms of mortality, long-term morbidity, and quality of life?

Journal of the American Geriatrics Society

Volumn 61, Issue 8, 2013, Pages 1351-1357

  Gerstenhaber, Fabian ^a,b   Grossman, Julie ^a   Lubezky, Nir ^a,b   Itzkowitz, Eran ^a,b   Nachmany, Ido ^a,b   Sever, Ronen ^a   Ben Haim, Menahem ^a,b   Nakache, Richard ^a,b   Klausner, Joseph M ^a,b   Lahat, Guy ^a,b  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

elderly; long term morbidity; mortality; pancreaticoduodenectomy; quality of life

Indexed keywords

ABDOMINAL ABSCESS; ACUTE HEART INFARCTION; AGED; ANASTOMOSIS LEAKAGE; ANEMIA; ARTICLE; CANCER SURVIVAL; CHOLECYSTECTOMY; CONTROLLED STUDY; DISEASE COURSE; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; FOLLOW UP; HEMORRHAGIC SHOCK; HOSPITAL READMISSION; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; JAUNDICE; KIDNEY FAILURE; LAPAROSCOPIC SURGERY; LONG TERM CARE; LUNG EMBOLISM; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTIPLE ORGAN FAILURE; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREAS FISTULA; PANCREAS RESECTION; PANCREATICODUODENECTOMY; PNEUMONIA; POSTOPERATIVE HEMORRHAGE; QUALITY OF LIFE; QUESTIONNAIRE; REHABILITATION CENTER; REOPERATION; RETROSPECTIVE STUDY; SEPSIS; SURGICAL MORTALITY; TREATMENT OUTCOME; TUMOR INVASION; WOUND INFECTION;

ELDERLY; LONG-TERM MORBIDITY; MORTALITY; PANCREATICODUODENECTOMY; QUALITY OF LIFE;

AGED; AGED, 80 AND OVER; CHEMORADIOTHERAPY, ADJUVANT; CHOLECYSTECTOMY, LAPAROSCOPIC; COMBINED MODALITY THERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTENSIVE CARE UNITS; ISRAEL; LENGTH OF STAY; MALE; PANCREATIC NEOPLASMS; PANCREATICODUODENECTOMY; PATIENT READMISSION; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; QUALITY OF LIFE; QUESTIONNAIRES; REHABILITATION CENTERS; UTILIZATION REVIEW;

EID: 84882238107     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.12360     Document Type: Article

References (29)

1. Kawai M, Yamaue H,. Analysis of clinical trials evaluating complications after pancreaticoduodenectomy: A new era of pancreatic surgery. Surg Today 2010; 40: 1011-1017.
2. Billings BJ, Christein JD, Harmsen WS, et al. Quality-of-life after total pancreatectomy: Is it really that bad on long-term follow-up? J Gastrointest Surg 2005; 9: 1059-1066; discussion 1066-1057.
3. Conlon KC, Klimstra DS, Brennan MF,. Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors. Ann Surg 1996; 223: 273-279.
4. Sohn TA, Yeo CJ, Cameron JL, et al. Resected adenocarcinoma of the pancreas-616 patients: Results, outcomes, and prognostic indicators. J Gastrointest Surg 2000; 4: 567-579.
5. Kotwall CA, Maxwell JG, Brinker CC, et al. National estimates of mortality rates for radical pancreaticoduodenectomy in 25,000 patients. Ann Surg Oncol 2002; 9: 847-854.
6. Diener MK, Knaebel HP, Heukaufer C, et al. A systematic review and meta-analysis of pylorus-preserving versus classical pancreaticoduodenectomy for surgical treatment of periampullary and pancreatic carcinoma. Ann Surg 2007; 245: 187-200.
7. Strasberg SM, Drebin JA, Soper NJ,. Evolution and current status of the Whipple procedure: An update for gastroenterologists. Gastroenterology 1997; 113: 983-994.
8. Yeo CJ, Cameron JL, Sohn TA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: Pathology, complications, and outcomes. Ann Surg 1997; 226: 248-257; discussion 257-260.
9. Makary MA, Winter JM, Cameron JL, et al. Pancreaticoduodenectomy in the very elderly. J Gastrointest Surg 2006; 10: 347-356.
10. Muss HB,. Cancer in the elderly: A societal perspective from the United States. Clin Oncol (R Coll Radiol) 2009; 21: 92-98.
11. Altekruse SF, Kosary CL, Krapcho M, et al. Seer Cancer Statistics Review, 1975-2007, National Cancer Institute [on-line]. Available at http://Seer.Cancer.Gov/Csr/1975-2007/ Accessed February 13, 2011.
12. Lahat G, Sever R, Lubezky N, et al. Pancreatic cancer: Surgery is a feasible therapeutic option for elderly patients. World J Surg Oncol 2011; 9: 10.
13. Brachet D, Lermite E, Vychnevskaia-Bressollette K, et al. Should pancreaticoduodenectomy be performed in the elderly? Hepatogastroenterology 2012; 59: 266-271.
14. Brozzetti S, Mazzoni G, Miccini M, et al. Surgical treatment of pancreatic head carcinoma in elderly patients. Arch Surg 2006; 141: 137-142.
15. Ballarin R, Spaggiari M, Di Benedetto F, et al. Do not deny pancreatic resection to elderly patients. J Gastrointest Surg 2009; 13: 341-348.
16. Scurtu R, Bachellier P, Oussoultzoglou E, et al. Outcome after pancreaticoduodenectomy for cancer in elderly patients. J Gastrointest Surg 2006; 10: 813-822.
17. Ito Y, Kenmochi T, Irino T, et al. The impact of surgical outcome after pancreaticoduodenectomy in elderly patients. World J Surg Oncol 2011; 9: 102.
18. Khan S, Sclabas G, Lombardo KR, et al. Pancreatoduodenectomy for ductal adenocarcinoma in the very elderly: Is it safe and justified? J Gastrointest Surg 2010; 14: 1826-1831.
19. Shore S, Vimalachandran D, Raraty MG, et al. Cancer in the elderly: Pancreatic cancer. Surg Oncol 2004; 13: 201-210.
20. Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993; 85: 365-376.
21. Fayers PM, Aaronson NK, Bjordal K, et al. The EORTC QLQ-C30 Scoring Manual, 3rd Ed. Brussels: European Organisation for Research and Treatment of Cancer, 2001.
22. Scott NW, Fayers PM, Aaronson NK, et al. EORTC QLQ-C30 Reference Values. Brussels: European Organisation for Research and Treatment of Cancer, 2008.
23. Osoba D, Rodrigues G, Myles J, et al. Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol 1998; 16: 139-144.
24. Fitzmaurice C, Seiler CM, Buchler MW, et al. Survival, mortality and quality of life after pylorus-preserving or classical Whipple operation. A systematic review with meta-analysis. Chirurg 2010; 81: 454-471.
25. Huang JJ, Yeo CJ, Sohn TA, et al. Quality of life and outcomes after pancreaticoduodenectomy. Ann Surg 2000; 231: 890-898.
26. Nguyen TC, Sohn TA, Cameron JL, et al. Standard vs. radical pancreaticoduodenectomy for periampullary adenocarcinoma: A prospective, randomized trial evaluating quality of life in pancreaticoduodenectomy survivors. J Gastrointest Surg 2003; 7: 1-9; discussion 9-11.
27. McLeod RS, Taylor BR, O'Connor BI, et al. Quality of life, nutritional status, and gastrointestinal hormone profile following the Whipple procedure. Am J Surg 1995; 169: 179-185.
28. Pignay-Demaria V, Lesperance F, Demaria RG, et al. Depression and anxiety and outcomes of coronary artery bypass surgery. Ann Thorac Surg 2003; 75: 314-321.
29. Lyness JM, Yu Q, Tang W, et al. Risks for depression onset in primary care elderly patients: Potential targets for preventive interventions. Am J Psychiatry 2009; 166: 1375-1383.