Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients

Atherosclerosis

Volumn 230, Issue 1, 2013, Pages 48-51

  Hirayama, Satoshi ^a   Nakagawa, Saori ^b   Soda, Satoshi ^c   Kamimura, Yumiko ^b   Nishioka, Emiko ^a   Ueno, Tsuyoshi ^a   Fukushima, Yoshifumi ^a   Higuchi, Ken ichi ^d   Inoue, Masanori ^e   Seino, Utako ^f   Ohmura, Hirotoshi ^a   Yamato, Susumu ^b   Miida, Takashi ^a  

^a JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^c NIIGATA CITY GENERAL HOSPITAL   (Japan)

^d Johoku Clinic   (Japan)

^e Inoue Medical Clinic   (Japan)

^f Niigata Prefectural Radiation Monitoring Center   (Japan)

Author keywords

Cholesterol precursors; Ezetimibe; Gas chromatography mass spectrometry (GC MS); NPC1L1; Oxysterols; Plant sterols

Indexed keywords

EZETIMIBE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL;

ADULT; AGED; ARTICLE; BILE ACID SYNTHESIS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; JAPANESE; MALE; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL;

CHOLESTEROL PRECURSORS; EZETIMIBE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY (GC-MS); NPC1L1; OXYSTEROLS; PLANT STEROLS;

ABSORPTION; AGED; ANTHROPOMETRY; ANTICHOLESTEREMIC AGENTS; AZETIDINES; BILE ACIDS AND SALTS; BODY MASS INDEX; CASE-CONTROL STUDIES; CHOLESTEROL; DIET; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROXYCHOLESTEROLS; HYPERCHOLESTEROLEMIA; INTESTINE, SMALL; JAPAN; LIFE STYLE; MALE; MIDDLE AGED; OXYGEN; PHYTOSTEROLS; STEROLS; TRIGLYCERIDES;

EID: 84881649124     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.06.016     Document Type: Article

References (15)

1. Nagasaka H., Miida T., Hirano K., Ota A., Yorifuji T., Takatani T., et al. Reduced apolipoprotein E-rich high-density lipoprotein level at birth is restored to the normal range in patients with familial hypercholesterolemia in the first year of life. JClin Endocrinol Metab 2008, 93:779-783.
2. Kallio M.J., Salmenpera L., Siimes M.A., Perheentupa J., Gylling H., Miettinen T.A. Apoprotein E phenotype determines serum cholesterol in infants during both high-cholesterol breast feeding and low-cholesterol formula feeding. JLipid Res 1997, 38:759-764.
3. Miida T., Hirayama S., Nakamura Y. Cholesterol-independent effects of statins and new therapeutic targets: ischemic stroke and dementia. JAtheroscler Thromb 2004, 11:253-264.
4. Kanayama T., Arito M., So K., Hachimura S., Inoue J., Sato R. Interaction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities. JBiol Chem 2007, 282:10290-10298.
5. Thongtang N., Lin J., Schaefer E.J., Lowe R.S., Tomassini J.E., Shah A.K., et al. Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients. Atherosclerosis 2012, 225:388-396.
6. Ahmida H.S., Bertucci P., Franzò L., Massoud R., Cortese C., Lala A., et al. Simultaneous determination of plasmatic phytosterols and cholesterol precursors using gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM). JChromatogr B 2006, 842:43-47.
7. Yamazaki R., Nakagawa S., Tanabe A., Ikeuchi T., Miida T., Yamato S. Determination of 24S-hydroxycholesterol in human cerebrospinal fluid by gas chromatography/mass spectrometry. Bunseki Kagaku 2008, 57:707-713.
8. Miettinen T.A., Gylling H., Lindbohm N., Miettinen T.E., Rajaratnam R.A., Relas H. Finnish treat-to-target study investigators. Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. JLab Clin Med 2003, 141:131-137.
9. Strandberg T.E., Tilvis R.S., Pitkala K.H., Miettinen T.A. Cholesterol and glucose metabolism and recurrent cardiovascular events among the elderly: a prospective study. JAm Coll Cardiol 2006, 48:708-714.
10. Buchwald H., Varco R.L., Matts J.P., Long J.M., Fitch L.L., Campbell G.S., et al. Effect of partial ileal bypass surgery on mortality and morbidity from coronary heartdisease in patients with hypercholesterolemia. Report of the program on the surgical control of the hyperlipidemias (POSCH). NEngl J Med 1990, 323:946-955.
11. Nagasaka H., Okano Y., Kimura A., Mizuochi T., Yoshino M., Sanayama Y., et al. Oxysterol changes along with cholesterol and vitamin D changes in adult phenylketonuric patients diagnosed by newborn mass-screening. Clin Chim Acta 2013, 416:54-59.
12. Brown A.J., Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999, 142:1-28.
13. Sundseth S.S., Waxman D.J. Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation invivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback. JBiol Chem 1990, 265:15090-15095.
14. Del Puppo M., Galli Kienle M., Crosignani A., Petroni M.L., Amati B., Zuin M., et al. Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. JLipid Res 2001, 42:437-441.
15. Dzeletovic S., Breuer O., Lund E., Diczfalusy U. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal Biochem 1995, 225:73-80.