메뉴 건너뛰기




Volumn 4 JUN, Issue , 2013, Pages

Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CAPECITABINE; CYTOTOXIC AGENT; DOCETAXEL; DOXORUBICIN; PACLITAXEL; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; PROSTATE SPECIFIC ANTIGEN; SILDENAFIL; SULINDAC; TADALAFIL; VARDENAFIL; VINBLASTINE;

EID: 84881646555     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2013.00082     Document Type: Note
Times cited : (17)

References (24)
  • 1
    • 33748686575 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use
    • doi:10.1124/pr.58.3.5
    • Bender, A. T., and Beavo, J. A. (2006). Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol. Rev. 58, 488-520. doi: 10.1124/pr.58.3.5
    • (2006) Pharmacol. Rev. , vol.58 , pp. 488-520
    • Bender, A.T.1    Beavo, J.A.2
  • 2
    • 54049086905 scopus 로고    scopus 로고
    • PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model
    • doi: 10.1016/j.brainres.2008.06.122
    • Black, K. L., Yin, D., Ong, J. M., Hu, J., Konda, B. M., Wang, X., et al. (2008). PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model. Brain Res. 1230, 290-302. doi: 10.1016/j.brainres.2008.06.122
    • (2008) Brain Res , vol.1230 , pp. 290-302
    • Black, K.L.1    Yin, D.2    Ong, J.M.3    Hu, J.4    Konda, B.M.5    Wang, X.6
  • 3
    • 84874595442 scopus 로고    scopus 로고
    • Incidence rate of prostate cancer in men treated for erectile dysfunction with phosphodiesterase type 5 inhibitors: retrospective analysis
    • doi:10.1038/aja.2012.162
    • Chavez, A. H., Scott Coffield, K., Hasan Rajab, M., and Jo, C. (2013). Incidence rate of prostate cancer in men treated for erectile dysfunction with phosphodiesterase type 5 inhibitors: retrospective analysis. Asian J. Androl. 15, 246-248. doi: 10.1038/aja.2012.162
    • (2013) Asian J. Androl , vol.15 , pp. 246-248
    • Chavez, A.H.1    Scott Coffield, K.2    Hasan Rajab, M.3    Jo, C.4
  • 4
    • 84864313244 scopus 로고    scopus 로고
    • PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter
    • doi:10.1111/j.1349-7006.2012.02328.x
    • Chen, J. J., Sun, Y. L., Tiwari, A. K., Xiao, Z. J., Sodani, K., Yang, D. H., et al. (2012). PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter. Cancer Sci. 103, 1531-1537. doi: 10.1111/j.1349-7006.2012.02328.x
    • (2012) Cancer Sci , vol.103 , pp. 1531-1537
    • Chen, J.J.1    Sun, Y.L.2    Tiwari, A.K.3    Xiao, Z.J.4    Sodani, K.5    Yang, D.H.6
  • 5
    • 0035823559 scopus 로고    scopus 로고
    • Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4 Resistance to 6-mercaptopurine and 6-thioguanine
    • doi:10.1074/jbc.M104833200
    • Chen, Z. S., Lee, K., and Kruh, G. D. (2001). Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. J. Biol. Chem. 276, 33747-33754. doi: 10.1074/jbc.M104833200
    • (2001) J. Biol. Chem. , vol.276 , pp. 33747-33754
    • Chen, Z.S.1    Lee, K.2    Kruh, G.D.3
  • 6
    • 78149278340 scopus 로고    scopus 로고
    • Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction
    • doi:10.1073/pnas.1006965107
    • Das, A., Durrant, D., Mitchell, C., Mayton, E., Hoke, N. N., Salloum, F. N., et al. (2010). Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction. Proc. Natl. Acad. Sci. U.S.A. 107, 18202-18207. doi: 10.1073/pnas.1006965107
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 18202-18207
    • Das, A.1    Durrant, D.2    Mitchell, C.3    Mayton, E.4    Hoke, N.N.5    Salloum, F.N.6
  • 7
    • 57649155045 scopus 로고    scopus 로고
    • Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta
    • doi:10.1074/jbc.M801547200
    • Das, A., Xi, L., and Kukreja, R. C. (2008). Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta. J. Biol. Chem. 283, 29572-29585. doi: 10.1074/jbc.M801547200
    • (2008) J. Biol. Chem. , vol.283 , pp. 29572-29585
    • Das, A.1    Xi, L.2    Kukreja, R.C.3
  • 8
    • 78649329704 scopus 로고    scopus 로고
    • Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells
    • doi:10.1007/s10549-010-0765-7
    • Di, X., Gennings, C., Bear, H. D., Graham, L. J., Sheth, C. M., White, K. L., et al. (2010). Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells. Breast Cancer Res. Treat. 124, 349-360. doi: 10.1007/s10549-010-0765-7
    • (2010) Breast Cancer Res. Treat. , vol.124 , pp. 349-360
    • Di, X.1    Gennings, C.2    Bear, H.D.3    Graham, L.J.4    Sheth, C.M.5    White, K.L.6
  • 9
    • 79955726360 scopus 로고    scopus 로고
    • The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter
    • doi:10.1371/journal.pone.0019329
    • Ding, P. R., Tiwari, A. K., Ohnuma, S., Lee, J. W., An, X., Dai, C. L., et al. (2011). The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter. PLoS ONE 6:e19329. doi: 10.1371/journal.pone.0019329
    • (2011) PLoS ONE , vol.6
    • Ding, P.R.1    Tiwari, A.K.2    Ohnuma, S.3    Lee, J.W.4    An, X.5    Dai, C.L.6
  • 10
    • 33745869420 scopus 로고    scopus 로고
    • An anti-tumor role for cGMP-dependent protein kinase
    • doi:10.1016/j.canlet.2005.08.035
    • Hou, Y., Gupta, N., Schoenlein, P., Wong, E., Martindale, R., Ganapathy, V., et al. (2006). An anti-tumor role for cGMP-dependent protein kinase. Cancer Lett. 240, 60-68. doi: 10.1016/j.canlet.2005.08.035
    • (2006) Cancer Lett , vol.240 , pp. 60-68
    • Hou, Y.1    Gupta, N.2    Schoenlein, P.3    Wong, E.4    Martindale, R.5    Ganapathy, V.6
  • 11
    • 0034730755 scopus 로고    scopus 로고
    • The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides
    • doi:10.1074/jbc.M005463200
    • Jedlitschky, G., Burchell, B., and Keppler, D. (2000). The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J. Biol. Chem. 275, 30069-30074. doi: 10.1074/jbc.M005463200
    • (2000) J. Biol. Chem. , vol.275 , pp. 30069-30074
    • Jedlitschky, G.1    Burchell, B.2    Keppler, D.3
  • 12
    • 0036830654 scopus 로고    scopus 로고
    • Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation
    • doi:10.1016/S0006-2952(02)01345-X
    • Li, H., Liu, L., David, M. L., Whitehead, C. M., Chen, M., Fetter, J. R., et al. (2002). Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation. Biochem. Pharmacol. 64, 1325-1336. doi: 10.1016/S0006-2952(02)01345-X
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1325-1336
    • Li, H.1    Liu, L.2    David, M.L.3    Whitehead, C.M.4    Chen, M.5    Fetter, J.R.6
  • 13
    • 0035872448 scopus 로고    scopus 로고
    • Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis
    • Piazza, G. A., Thompson, W. J., Pamukcu, R., Alila, H. W., Whitehead, C. M., Liu, L., et al. (2001). Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. Cancer Res. 61, 3961-3968.
    • (2001) Cancer Res , vol.61 , pp. 3961-3968
    • Piazza, G.A.1    Thompson, W.J.2    Pamukcu, R.3    Alila, H.W.4    Whitehead, C.M.5    Liu, L.6
  • 14
    • 0142026063 scopus 로고    scopus 로고
    • Phase I and II study of exisulind in combination with capecitabine in patients with metastatic breast cancer
    • doi:10.1200/JCO.2003.02.114
    • Pusztai, L., Zhen, J. H., Arun, B., Rivera, E., Whitehead, C., Thompson, W. J., et al. (2003). Phase I and II study of exisulind in combination with capecitabine in patients with metastatic breast cancer. J. Clin. Oncol. 21, 3454-3461. doi: 10.1200/JCO.2003.02.114
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3454-3461
    • Pusztai, L.1    Zhen, J.H.2    Arun, B.3    Rivera, E.4    Whitehead, C.5    Thompson, W.J.6
  • 15
  • 16
    • 0037222292 scopus 로고    scopus 로고
    • Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells
    • doi:10.1038/sj.ijir.3901577
    • Sarfati, M., Mateo, V., Baudet, S., Rubio, M., Fernandez, C., Davi, F., et al. (2003). Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells. Blood 101, 265-269. doi: 10.1182/blood-2002-01-0075
    • (2003) Blood , vol.101
    • Sarfati, M.1    Mateo, V.2    Baudet, S.3    Rubio, M.4    Fernandez, C.5    Davi, F.6
  • 17
    • 33751531874 scopus 로고    scopus 로고
    • doi:10.1038/sj.ijir.3901577
    • Serafini, P., Meckel, K., Kelso, M., Noonan, K., Califano, J., Koch, W., et al. (2006). Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J. Exp. Med. 203, 2691-2702. doi: 10.1084/jem.20061104
    • (2006) , vol.203
    • Serafini, P.1    Meckel, K.2    Kelso, M.3    Noonan, K.4    Califano, J.5    Koch, W.6
  • 18
    • 79954569834 scopus 로고    scopus 로고
    • doi:10.1158/0008-5472.CAN-10-3820
    • Shi, Z., Tiwari, A. K., Shukla, S., Robey, R. W., Singh, S., Kim, I. W., et al. (2011). Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance. Cancer Res. 71, 3029-3041. doi: 10.1158/0008-5472.CAN-10-3820
    • (2011) , vol.71 , pp. 3029-3041
    • Shi, Z.1    Tiwari, A.K.2    Shukla, S.3    Robey, R.W.4    Singh, S.5    Kim, I.W.6
  • 19
    • 0038625015 scopus 로고    scopus 로고
    • Cyclic guanosine monophosphate phosphodiesterase activity in human gingival carcinoma
    • doi:10.1034/j.1600-0714.2003.00083.x
    • Spoto, G., Fioroni, M., Rubini, C., Contento, A., Di Nicola, M., Forcella, S., et al. (2003). Cyclic guanosine monophosphate phosphodiesterase activity in human gingival carcinoma. J. Oral Pathol. Med. 32, 189-194. doi: 10.1034/j.1600-0714.2003.00083.x
    • (2003) J. Oral Pathol. Med. , vol.32 , pp. 189-194
    • Spoto, G.1    Fioroni, M.2    Rubini, C.3    Contento, A.4    Di Nicola, M.5    Forcella, S.6
  • 20
    • 0034234978 scopus 로고    scopus 로고
    • Exisulind induction of apoptosis involves guanosine 3', 5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin
    • Thompson, W. J., Piazza, G. A., Li, H., Liu, L., Fetter, J., Zhu, B., et al. (2000). Exisulind induction of apoptosis involves guanosine 3', 5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res. 60, 3338-3342.
    • (2000) Cancer Res , vol.60 , pp. 3338-3342
    • Thompson, W.J.1    Piazza, G.A.2    Li, H.3    Liu, L.4    Fetter, J.5    Zhu, B.6
  • 21
    • 80051525438 scopus 로고    scopus 로고
    • Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/beta-catenin-mediated transcription in human breast tumor cells
    • doi:10.1158/1940-6207.CAPR-11-0095
    • Tinsley, H. N., Gary, B. D., Keeton, A. B., Lu, W., Li, Y., and Piazza, G. A. (2011). Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/beta-catenin-mediated transcription in human breast tumor cells. Cancer Prev. Res. (Phila.) 4, 1275-1284. doi: 10.1158/1940-6207.CAPR-11-0095
    • (2011) Cancer Prev. Res. (Phila. ). , vol.4 , pp. 1275-1284
    • Tinsley, H.N.1    Gary, B.D.2    Keeton, A.B.3    Lu, W.4    Li, Y.5    Piazza, G.A.6
  • 22
    • 84880081204 scopus 로고    scopus 로고
    • Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models
    • doi: 10.1158/1535-7163.MCT-13-0100.[Epub ahead of print]
    • Tiwari, A. K., Zhang, R., and Gallo, J. M. (2013). Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models. Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-13-0100. [Epub ahead of print].
    • (2013) Mol. Cancer Ther
    • Tiwari, A.K.1    Zhang, R.2    Gallo, J.M.3
  • 23
    • 0142158595 scopus 로고    scopus 로고
    • Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival
    • 'Whitehead, C. M., Earle, K. A., Fetter, J., Xu, S., Hartman, T., Chan, D. C., et al. (2003). Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival. Mol. Cancer Ther. 2, 479-488.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 479-488
    • Whitehead, C.M.1    Earle, K.A.2    Fetter, J.3    Xu, S.4    Hartman, T.5    Chan, D.C.6
  • 24
    • 33847644982 scopus 로고    scopus 로고
    • The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels
    • doi:10.2174/156802607779941198
    • Zhu, B., and Strada, S. J. (2007). The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels. Curr. Top. Med. Chem. 7, 437-454. doi: 10.2174/156802607779941198
    • (2007) Curr. Top. Med. Chem , vol.7 , pp. 437-454
    • Zhu, B.1    Strada, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.