-
1
-
-
33748686575
-
Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use
-
doi:10.1124/pr.58.3.5
-
Bender, A. T., and Beavo, J. A. (2006). Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol. Rev. 58, 488-520. doi: 10.1124/pr.58.3.5
-
(2006)
Pharmacol. Rev.
, vol.58
, pp. 488-520
-
-
Bender, A.T.1
Beavo, J.A.2
-
2
-
-
54049086905
-
PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model
-
doi: 10.1016/j.brainres.2008.06.122
-
Black, K. L., Yin, D., Ong, J. M., Hu, J., Konda, B. M., Wang, X., et al. (2008). PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model. Brain Res. 1230, 290-302. doi: 10.1016/j.brainres.2008.06.122
-
(2008)
Brain Res
, vol.1230
, pp. 290-302
-
-
Black, K.L.1
Yin, D.2
Ong, J.M.3
Hu, J.4
Konda, B.M.5
Wang, X.6
-
3
-
-
84874595442
-
Incidence rate of prostate cancer in men treated for erectile dysfunction with phosphodiesterase type 5 inhibitors: retrospective analysis
-
doi:10.1038/aja.2012.162
-
Chavez, A. H., Scott Coffield, K., Hasan Rajab, M., and Jo, C. (2013). Incidence rate of prostate cancer in men treated for erectile dysfunction with phosphodiesterase type 5 inhibitors: retrospective analysis. Asian J. Androl. 15, 246-248. doi: 10.1038/aja.2012.162
-
(2013)
Asian J. Androl
, vol.15
, pp. 246-248
-
-
Chavez, A.H.1
Scott Coffield, K.2
Hasan Rajab, M.3
Jo, C.4
-
4
-
-
84864313244
-
PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter
-
doi:10.1111/j.1349-7006.2012.02328.x
-
Chen, J. J., Sun, Y. L., Tiwari, A. K., Xiao, Z. J., Sodani, K., Yang, D. H., et al. (2012). PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter. Cancer Sci. 103, 1531-1537. doi: 10.1111/j.1349-7006.2012.02328.x
-
(2012)
Cancer Sci
, vol.103
, pp. 1531-1537
-
-
Chen, J.J.1
Sun, Y.L.2
Tiwari, A.K.3
Xiao, Z.J.4
Sodani, K.5
Yang, D.H.6
-
5
-
-
0035823559
-
Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4 Resistance to 6-mercaptopurine and 6-thioguanine
-
doi:10.1074/jbc.M104833200
-
Chen, Z. S., Lee, K., and Kruh, G. D. (2001). Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. J. Biol. Chem. 276, 33747-33754. doi: 10.1074/jbc.M104833200
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33747-33754
-
-
Chen, Z.S.1
Lee, K.2
Kruh, G.D.3
-
6
-
-
78149278340
-
Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction
-
doi:10.1073/pnas.1006965107
-
Das, A., Durrant, D., Mitchell, C., Mayton, E., Hoke, N. N., Salloum, F. N., et al. (2010). Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction. Proc. Natl. Acad. Sci. U.S.A. 107, 18202-18207. doi: 10.1073/pnas.1006965107
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 18202-18207
-
-
Das, A.1
Durrant, D.2
Mitchell, C.3
Mayton, E.4
Hoke, N.N.5
Salloum, F.N.6
-
7
-
-
57649155045
-
Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta
-
doi:10.1074/jbc.M801547200
-
Das, A., Xi, L., and Kukreja, R. C. (2008). Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta. J. Biol. Chem. 283, 29572-29585. doi: 10.1074/jbc.M801547200
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 29572-29585
-
-
Das, A.1
Xi, L.2
Kukreja, R.C.3
-
8
-
-
78649329704
-
Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells
-
doi:10.1007/s10549-010-0765-7
-
Di, X., Gennings, C., Bear, H. D., Graham, L. J., Sheth, C. M., White, K. L., et al. (2010). Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells. Breast Cancer Res. Treat. 124, 349-360. doi: 10.1007/s10549-010-0765-7
-
(2010)
Breast Cancer Res. Treat.
, vol.124
, pp. 349-360
-
-
Di, X.1
Gennings, C.2
Bear, H.D.3
Graham, L.J.4
Sheth, C.M.5
White, K.L.6
-
9
-
-
79955726360
-
The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter
-
doi:10.1371/journal.pone.0019329
-
Ding, P. R., Tiwari, A. K., Ohnuma, S., Lee, J. W., An, X., Dai, C. L., et al. (2011). The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter. PLoS ONE 6:e19329. doi: 10.1371/journal.pone.0019329
-
(2011)
PLoS ONE
, vol.6
-
-
Ding, P.R.1
Tiwari, A.K.2
Ohnuma, S.3
Lee, J.W.4
An, X.5
Dai, C.L.6
-
10
-
-
33745869420
-
An anti-tumor role for cGMP-dependent protein kinase
-
doi:10.1016/j.canlet.2005.08.035
-
Hou, Y., Gupta, N., Schoenlein, P., Wong, E., Martindale, R., Ganapathy, V., et al. (2006). An anti-tumor role for cGMP-dependent protein kinase. Cancer Lett. 240, 60-68. doi: 10.1016/j.canlet.2005.08.035
-
(2006)
Cancer Lett
, vol.240
, pp. 60-68
-
-
Hou, Y.1
Gupta, N.2
Schoenlein, P.3
Wong, E.4
Martindale, R.5
Ganapathy, V.6
-
11
-
-
0034730755
-
The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides
-
doi:10.1074/jbc.M005463200
-
Jedlitschky, G., Burchell, B., and Keppler, D. (2000). The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J. Biol. Chem. 275, 30069-30074. doi: 10.1074/jbc.M005463200
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 30069-30074
-
-
Jedlitschky, G.1
Burchell, B.2
Keppler, D.3
-
12
-
-
0036830654
-
Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation
-
doi:10.1016/S0006-2952(02)01345-X
-
Li, H., Liu, L., David, M. L., Whitehead, C. M., Chen, M., Fetter, J. R., et al. (2002). Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation. Biochem. Pharmacol. 64, 1325-1336. doi: 10.1016/S0006-2952(02)01345-X
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 1325-1336
-
-
Li, H.1
Liu, L.2
David, M.L.3
Whitehead, C.M.4
Chen, M.5
Fetter, J.R.6
-
13
-
-
0035872448
-
Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis
-
Piazza, G. A., Thompson, W. J., Pamukcu, R., Alila, H. W., Whitehead, C. M., Liu, L., et al. (2001). Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. Cancer Res. 61, 3961-3968.
-
(2001)
Cancer Res
, vol.61
, pp. 3961-3968
-
-
Piazza, G.A.1
Thompson, W.J.2
Pamukcu, R.3
Alila, H.W.4
Whitehead, C.M.5
Liu, L.6
-
14
-
-
0142026063
-
Phase I and II study of exisulind in combination with capecitabine in patients with metastatic breast cancer
-
doi:10.1200/JCO.2003.02.114
-
Pusztai, L., Zhen, J. H., Arun, B., Rivera, E., Whitehead, C., Thompson, W. J., et al. (2003). Phase I and II study of exisulind in combination with capecitabine in patients with metastatic breast cancer. J. Clin. Oncol. 21, 3454-3461. doi: 10.1200/JCO.2003.02.114
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 3454-3461
-
-
Pusztai, L.1
Zhen, J.H.2
Arun, B.3
Rivera, E.4
Whitehead, C.5
Thompson, W.J.6
-
15
-
-
35848941746
-
PDE5 inhibitors beyond erectile dysfunction
-
doi:10.1038/sj.ijir.3901577
-
Sandner, P., Hutter, J., Tinel, H., Ziegelbauer, K., and Bischoff, E. (2007). PDE5 inhibitors beyond erectile dysfunction. Int. J. Impot. Res. 19, 533-543. doi: 10.1038/sj.ijir.3901577
-
(2007)
Int. J. Impot. Res.
, vol.19
, pp. 533-543
-
-
Sandner, P.1
Hutter, J.2
Tinel, H.3
Ziegelbauer, K.4
Bischoff, E.5
-
16
-
-
0037222292
-
Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells
-
doi:10.1038/sj.ijir.3901577
-
Sarfati, M., Mateo, V., Baudet, S., Rubio, M., Fernandez, C., Davi, F., et al. (2003). Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells. Blood 101, 265-269. doi: 10.1182/blood-2002-01-0075
-
(2003)
Blood
, vol.101
-
-
Sarfati, M.1
Mateo, V.2
Baudet, S.3
Rubio, M.4
Fernandez, C.5
Davi, F.6
-
17
-
-
33751531874
-
-
doi:10.1038/sj.ijir.3901577
-
Serafini, P., Meckel, K., Kelso, M., Noonan, K., Califano, J., Koch, W., et al. (2006). Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J. Exp. Med. 203, 2691-2702. doi: 10.1084/jem.20061104
-
(2006)
, vol.203
-
-
Serafini, P.1
Meckel, K.2
Kelso, M.3
Noonan, K.4
Califano, J.5
Koch, W.6
-
18
-
-
79954569834
-
-
doi:10.1158/0008-5472.CAN-10-3820
-
Shi, Z., Tiwari, A. K., Shukla, S., Robey, R. W., Singh, S., Kim, I. W., et al. (2011). Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance. Cancer Res. 71, 3029-3041. doi: 10.1158/0008-5472.CAN-10-3820
-
(2011)
, vol.71
, pp. 3029-3041
-
-
Shi, Z.1
Tiwari, A.K.2
Shukla, S.3
Robey, R.W.4
Singh, S.5
Kim, I.W.6
-
19
-
-
0038625015
-
Cyclic guanosine monophosphate phosphodiesterase activity in human gingival carcinoma
-
doi:10.1034/j.1600-0714.2003.00083.x
-
Spoto, G., Fioroni, M., Rubini, C., Contento, A., Di Nicola, M., Forcella, S., et al. (2003). Cyclic guanosine monophosphate phosphodiesterase activity in human gingival carcinoma. J. Oral Pathol. Med. 32, 189-194. doi: 10.1034/j.1600-0714.2003.00083.x
-
(2003)
J. Oral Pathol. Med.
, vol.32
, pp. 189-194
-
-
Spoto, G.1
Fioroni, M.2
Rubini, C.3
Contento, A.4
Di Nicola, M.5
Forcella, S.6
-
20
-
-
0034234978
-
Exisulind induction of apoptosis involves guanosine 3', 5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin
-
Thompson, W. J., Piazza, G. A., Li, H., Liu, L., Fetter, J., Zhu, B., et al. (2000). Exisulind induction of apoptosis involves guanosine 3', 5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res. 60, 3338-3342.
-
(2000)
Cancer Res
, vol.60
, pp. 3338-3342
-
-
Thompson, W.J.1
Piazza, G.A.2
Li, H.3
Liu, L.4
Fetter, J.5
Zhu, B.6
-
21
-
-
80051525438
-
Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/beta-catenin-mediated transcription in human breast tumor cells
-
doi:10.1158/1940-6207.CAPR-11-0095
-
Tinsley, H. N., Gary, B. D., Keeton, A. B., Lu, W., Li, Y., and Piazza, G. A. (2011). Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/beta-catenin-mediated transcription in human breast tumor cells. Cancer Prev. Res. (Phila.) 4, 1275-1284. doi: 10.1158/1940-6207.CAPR-11-0095
-
(2011)
Cancer Prev. Res. (Phila. ).
, vol.4
, pp. 1275-1284
-
-
Tinsley, H.N.1
Gary, B.D.2
Keeton, A.B.3
Lu, W.4
Li, Y.5
Piazza, G.A.6
-
22
-
-
84880081204
-
Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models
-
doi: 10.1158/1535-7163.MCT-13-0100.[Epub ahead of print]
-
Tiwari, A. K., Zhang, R., and Gallo, J. M. (2013). Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models. Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-13-0100. [Epub ahead of print].
-
(2013)
Mol. Cancer Ther
-
-
Tiwari, A.K.1
Zhang, R.2
Gallo, J.M.3
-
23
-
-
0142158595
-
Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival
-
'Whitehead, C. M., Earle, K. A., Fetter, J., Xu, S., Hartman, T., Chan, D. C., et al. (2003). Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival. Mol. Cancer Ther. 2, 479-488.
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 479-488
-
-
Whitehead, C.M.1
Earle, K.A.2
Fetter, J.3
Xu, S.4
Hartman, T.5
Chan, D.C.6
-
24
-
-
33847644982
-
The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels
-
doi:10.2174/156802607779941198
-
Zhu, B., and Strada, S. J. (2007). The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels. Curr. Top. Med. Chem. 7, 437-454. doi: 10.2174/156802607779941198
-
(2007)
Curr. Top. Med. Chem
, vol.7
, pp. 437-454
-
-
Zhu, B.1
Strada, S.J.2
|