Dysfunctional uveoscleral pathway in a rat model of congenital glaucoma

Journal of Physiology and Pharmacology

Volumn 64, Issue 3, 2013, Pages

  Gatzioufas, Zisis ^a,b   Hafezi, F ^a   Kopsidas, K ^b   Thanos, S ^b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Ciliary body; Congenital glaucoma; Intraocular pressure; Optic nerve; Uveoscleral pathway

Indexed keywords

DEXTRAN; EOSIN; HEMATOXYLIN; RHODAMINE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR EYE CHAMBER ANGLE; ARTICLE; CHOROID; CILIARY BODY; CONGENITAL GLAUCOMA; CONTROLLED STUDY; DISEASE SEVERITY; DYSFUNCTIONAL UVEOSCLERAL PATHWAY; ELECTRON MICROSCOPY; FLUORESCENCE MICROSCOPY; FROZEN SECTION; HISTOPATHOLOGY; INTRAOCULAR PRESSURE; IRIS; NONHUMAN; PATHOGENESIS; QUANTITATIVE ANALYSIS; RAT; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; SUPRACHOROIDAL SPACE; TRABECULAR MESHWORK; VISUAL DISORDER;

EID: 84881566504     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Bill A. Conventional and uveoscleral drainage of aqueous humor in the cynomolgus monkey (Macaca irus) at normal and high intraocular pressures. Exp Eye Res 1966; 5: 45-54.
2. McMaster PR, Macri FJ. Secondary aqueous humor outflow pathways in the rabbit, cat and monkey. Arch Ophthalmol 1968; 79: 297-303.
3. Krohn J, Bertelsen T. Corrosion casts of the suprachoroidal space and uveoscleral drainage routes in the pig eye. Acta Ophthalmol Scand 1997; 75: 28-31.
4. Lindsey JD, Weinreb RN. Identification of the mouse uveoscleral outflow pathway using fluorescent dextran. Invest Ophthalmol Vis Sci 2002; 43: 2201-2205.
5. Nilsson SF. The uveoscleral outflow routes. Eye (Lond) 1997; 11: 149-154.
6. Thanos S, Naskar R. Correlation between retinal ganglion cell death and chronically developing inherited glaucoma in a new rat mutant. Exp Eye Res 2004; 79: 119-129.
7. Naskar R, Thanos S. Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure. Mol Vis 2006; 12: 1199-1210.
8. Lasseck J, Schroer U, Koenig S, Thanos S. Regeneration of retinal ganglion cell axons in organ culture is increased in rats with hereditary buphthalmos. Exp Eye Res 2007; 85: 90-104.
9. Gatzioufas Z, Charalambous P, Seitz B, et al. Cholinergic inhibition by botulinum toxin in a rat model of congenital glaucoma raises intraocular pressure. Br J Ophthalmol 2008; 92: 826-831.
10. Van der Zypen E. Experimental morphological study on structure and function of the filtration angle of the rat eye. Ophthalmologica 1977; 174: 285-298.
11. Pederson JE. Uveoscleral outflow. In: The Glaucomas, Ritch R, Shields MB, Krupin T, (eds). St. Louis, Mosby, 1996: pp. 337-343.
12. Lindsey JD, Hofer A, Wright KN, Weinreb RN. Partitioning of the aqueous outflow in rat eyes. Invest Ophthalmol Vis Sci 2009; 50: 5754-5758.
13. Camelo S, Shanley A, Voon AS, McMenamin PG. The distribution of antigen in lymphoid tissues following its injection into the anterior chamber of the rat eye. J Immunol 2004; 172: 5388-5395.
14. Schroder U, Arfors KE, Tangen O. Stability of fluorescein labelled dextrans in vivo and in vitro. Microvasc Res 1976; 11: 33-39.
15. Toris CB, Gregerson DS, Pederson JE. Uveoscleral outflow using different-sized fluorescent tracers in normal and inflamed eyes. Exp Eye Res 1987; 45: 525-532.
16. Tawara A, Inomata H. Developmental immaturity of the trabecular meshwork in congenital glaucoma. Am J Ophthalmol 1981; 92: 508-525.
17. Ueno A, Tawara A, Kubota T, Ohnishi Y, Inomata H, Solomon AS. Histopathological changes in iridocorneal angle of inherited glaucoma in rabbits. Graefe's Arch Clin Exp Ophthalmol 1999; 237: 654-660.
18. Blasiak A, Blasiak T, Lewandowski MH. Electrophysiology and pharmacology of the optic input to the rat intergeniculate leaflet in vitro. J Physiol Pharmacol 2009; 60: 171-180.
19. Jernajczyk W, Sobanska A, Czerwosz L, Szatkowska E. The influence of age and gender on the latency of eye movement in healthy humans. J Physiol Pharmacol 2005; 56(Suppl. 4): 93-97.