Downregulation of Securin by the variant RNF213 R4810K(rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients

Biochemical and Biophysical Research Communications

Volumn 438, Issue 1, 2013, Pages 13-19

  Hitomi, Toshiaki ^a   Habu, Toshiyuki ^a   Kobayashi, Hatasu ^a   Okuda, Hiroko ^a   Harada, Kouji H ^a   Osafune, Kenji ^b   Taura, Daisuke ^a   Sone, Masakatsu ^a   Asaka, Isao ^b   Ameku, Tomonaga ^b   Watanabe, Akira ^b   Kasahara, Tomoko ^b   Sudo, Tomomi ^b   Shiota, Fumihiko ^b   Hashikata, Hirokuni ^a   Takagi, Yasushi ^a   Morito, Daisuke ^c   Miyamoto, Susumu ^a   Nakao, Kazuwa ^a   Koizumi, Akio ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c KYOTO SANGYO UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Endothelium; IPS cells; Moyamoya disease; RNF213; Securin

Indexed keywords

PROTEIN; RNF213 PROTEIN; SECURIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALLELE; ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; FIBROBLAST; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GROWTH CURVE; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOYAMOYA DISEASE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; RNA INTERFERENCE; SKIN FIBROBLAST; UMBILICAL VEIN ENDOTHELIAL CELL; WILD TYPE;

ANGIOGENESIS; ENDOTHELIUM; IPS CELLS; MOYAMOYA DISEASE; RNF213; SECURIN;

CELLS, CULTURED; CHILD; DOWN-REGULATION; ENDOTHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; MOYAMOYA DISEASE; MUTATION; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; PLURIPOTENT STEM CELLS; UBIQUITIN-PROTEIN LIGASES;

EID: 84881551395     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.07.004     Document Type: Article

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