Antioxidant and anti-inflammatory effects of quercetin in functional and morphological alterations in streptozotocin-induced diabetic rats

Research in Veterinary Science

Volumn 95, Issue 2, 2013, Pages 389-397

  Maciel, R M ^a   Costa, M M ^a   Martins, D B ^b   Franca R T ^a   Schmatz, R ^a   Graca D L ^a   Duarte, M M M F ^c   Danesi, C C ^a   Mazzanti, C M ^a   Schetinger, M R C ^a   Paim, F C ^a   Palma, H E ^a   Abdala, F H ^a   Stefanello, N ^a   Zimpel, C K ^a   Felin, D V ^a   Lopes, S T A ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b UNIVERSIDADE DE CRUZ ALTA   (Brazil)

^c UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

Author keywords

Diabetes mellitus; Hepatic enzymes; Oxidative stress; Proteins electrophoresis

Indexed keywords

ALCOHOL; CATALASE; GLUCOSE; QUERCETIN; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; ELECTROPHORESIS; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER; MALE; MORPHOLOGY; NONHUMAN; OXIDATIVE STRESS; PANCREAS; PROTEIN DETERMINATION; RAT; STREPTOZOCIN DIABETES;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

DIABETES MELLITUS; HEPATIC ENZYMES; OXIDATIVE STRESS; PROTEINS ELECTROPHORESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CATALASE; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIPID PEROXIDATION; MALE; QUERCETIN; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 84881546047     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2013.04.028     Document Type: Article

References (49)

1. Alexiewicz J.M., Kumar D., Smogorzewski M., Klin M., Massry S.G. Polymorphonuclear leukocytes in non-insulin dependent diabetes mellitus: abnormalities in metabolism and function. Annals Internal Medicine 1995, 123:919-924.
2. Baral R., Rand J.S., Catt M., Farrow H.A. Prevalence of feline diabetes mellitus in feline private practice. Journal of Veterinary Internal Medicine 2003, 17:433.
3. Catchpole B., Ristic J.M., Fleeman L.M., Davison L.J. Canine diabetes mellitus: can old dogs teach us new tricks?. Diabetologia 2005, 48:1948-1956.
4. Center S.A. Distúrbios hidroeletrolíticos e ácido-básicos na doença hepática. Anormalidades de fluidos eletrólitos e equilíbrio ácido-básico na clínica de pequenos animais 2007, 421-460. Roca, São Paulo, Brazil. third ed. S.P. DiBartola (Ed.).
5. Coskun O., Kanter M., Korkmaz A., Oter S. Quercetin a flavonoid antioxidant, prevents and protes streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacological Research 2005, 51:117-123.
6. Cullen J.M. Fígado, sistema biliar e pâncreas exócrino. Bases da patologia em veterinária 2009, 393-461. Elsevier Editora Ltda, Rio de Janeiro, Brazil. fourth ed. M.D. McGavin, J.F. Zachary (Eds.).
7. Dallaqua B., Damasceno D.C. Evidence of the antioxidant effect of medicinal plants used in the treatment of Diabetes mellitus in animals: an update. Revista Brasileira PI Medicina 2011, 13:367-373.
8. Das S., Vasisht S., Snehalata K., Das N., Srivastava L.M. Correlation between total antioxidant status and peroxidation in hypercholesterolemia. Current Science 2000, 78:486-487.
9. Davison L.J., Herrtage M.E., Catchpole B. Study of 253 dogs in the United Kingdom with diabetes mellitus. The Veterinary Record 2005, 156:467-471.
10. De Groot H. Reactive oxygen species in tissue injury. Hepatogastroentrology 1994, 41:328-332.
11. Engelich G., Wright D.G., Hartshorn K.L. Acquired disorders of phagocyte function complicating medical and surgical illnesses. Clinical Infectious Diseases 2001, 33:2040-2048.
12. Erlund I. Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutrition Research 2004, 24:851-874.
13. Fridovich I. Oxygen toxicity: a radical explanation. Journal of Experimental Biology 1998, 201:1203-1209.
14. Gaspar J., Laires A., Monteiro M., Laureano O., Ramos E., Rueff J. Quercetin and the mutagenicity of wines. Mutagenesis 1993, 8:51-55.
15. Haag-Weber M., Horl W. Dysfunction of polymorphonuclear leukocytes in uremia. Seminars in Nephrology 1996, 16:192-201.
16. Hoenig M. Comparative aspects of diabetes mellitus in dogs and cats. Molecular and Cellular Endocrinology 2002, 197:221-229.
17. Jensen J., Lai Y.C. Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance. Archives of Physiology and Biochemistry 2009, 115:13-21.
18. Jin X., Zeng L., He S., Chen Y., Tian B., Mai G., Yang G., Wei L., Zhang Y., Li H., Wang L., Qiao C., Cheng J., Lu Y. Comparison of single high-dose streptozotocin with partial pancreatectomy combined with low-dose streptozotocin for diabetes induction in rhesus monkeys. Experimental Biology and Medicine 2010, 235:877-885.
19. Levine R.L., Garland D., Oliver C.N., Amici A., Climent I., Lenz A.G., Ahn B.W., Shaltiel S., Stadtman E.R. Determination of carbonyl content in oxidatively modified proteins. Methods in Enzymology 1990, 186:464-478.
20. Maritim A.C., Sanders R.A., Watkins J.B. Diabetes, oxidative stress, and antioxidants: a review. Journal of Biochemical and Molecular Toxicology 2003, 17:24-38.
21. Misra H.P., Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and simple assay for superoxide dismutase. The Journal of Biology Chemistry 1972, 247:3170-3175.
22. Montilla P.L., Vargas J.F., Túnez I.F., Carmem M., Munoz de Agueda M., Cabrera E.S. Oxidative stress in diabetic rats induced by streptozotocin: protective effect of melatonin. Journal of Pineal Research 1998, 25:94-100.
23. Myers R.K., McGavin M.D. Respostas celulares e teciduais à lesão. Bases da patologia em veterinária 2009, 3-62. Elsevier Editora Ltda, Rio de Janeiro, Brazil. fourth ed. M.D. McGavin, J.F. Zachary (Eds.).
24. Naoum P.C. Eletroforese técnicas e diagnósticos 1999, Santos Livraria Editora, São Paulo, Brazil, 154p. second ed.
25. 2 solutions in the UV). Analytical Biochemistry 1972, 49:474-478.
26. Nelson R.W. Diabetes melito canina. Manual de endocrinologia canina e felina 2009, 137-156. Editora Roca, São Paulo, Brazil. third ed. C.T. Moonney, M.E. Peterson (Eds.).
27. Obrosova I.G., Drel V.R., Pacher P., Stevens M.J., Yorek M.A. Oxidative-nitrosative stress and poly (ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited. Diabetes 2005, 54:3435-3441.
28. Pomposelli J.J., Baxter J.K., Barbineau T., Pomfret E.A., Driscoll D.F., Forse R.A., Bistrian B.R. Early postoperative glucose control predicts nosocomial infection rate in diabetic patients. Journal of Parenteral and Enteral Nutrition 1998, 22:77-81.
29. Powers A.C. Diabetes melito. Harrison Medicina Interna 2009, 2275-2304. McGraw-Hill Interamericana do Brasil LTDA, São Paulo, Brazil. seventeenth ed. E. Braunwald, D.L. Kaspor, A.S. Fauci, S.L. Hauser, D.L. Longo, J.L. Jameson (Eds.).
30. Ramachandran B., Ravi K., Narayanan V., Kandaswamy M., Subramanian S. Effect of macrocyclic binuclear oxovanadium complex on tissue defense system in streptozotocin-induced diabetic rats. Clinical Chimica Acta 2004, 345:141-150.
31. Rand J.S., Fleeman L.M., Farrow H.A., Appleton D.J., Lederer R. Canine and feline diabetes mellitus: nature ornurture?. The Journal of Nutrition 2004, 134:2072S-2080S.
32. Ravel R. Laboratório Clínico - aplicações clínicas dos dados laboratoriais 1997, Guanabara Koogan, Rio de Janeiro, Brazil, pp. 272-290. sixth ed.
33. Renard C.B., Kramer F., Johansson F., Lamharzi N., Tannock L.R., von Herrath M.G., Chait A., Bornfeldt K.E. Diabetes and diabetes-associated lipid abnormalities have distintinct effects on initiation and progression of atherosclerotic lesions. The Journal Clinical Investigation 2004, 114:659-668.
34. Rivera L., Moron R., Sanchez M., Zarzuelo A., Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity 2008, 16:2081-2087.
35. Robertson R.P., Harmon J.S. Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic islet beta cell. Free Radical Biology & Medicine 2006, 41:177-184.
36. Saxena A., Vikram N. Role of selected Indian plants in the management of type 2 diabetes: a review. Journal of Alternative and Complementary Medicine 2004, 10:369-378.
37. Schrand A.M., Rahman M.F., Hussain S.M., Schlager J.J., Smith D.A., Syed A.F. Metal-based nanoparticles and theirs toxicity assessment. Nanomedicine Nanobiotechnology 2010, 2:544-568.
38. Shulman G.L. Cellular mechanisms of insulin resisteance. The Journal of Clinical Investigation 2000, 106:171-176.
39. Sies H. Strategies of antioxidant defense. European Journal Biochemistry 1993, 215:213-219.
40. Stanley M.P.P., Menon V.P. Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytotherapy Research 2001, 15:213-218.
41. Stewart L.K., Wang Z., Ribnicky D., Soileau J.L., Cefalu W.T., Gettys T.W. Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice during the development of diet-induced obesity. Diabetologia 2009, 52:514-523.
42. Suba V., Murugesan T., Arnachalam G., Mandal S.C., Saha B.P. Anti-diabetic potential of Barleria lupulina extract in rats. Phytomedicine 2004, 11:202-205.
43. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiology Research 2001, 50:537-546.
44. Szymanowicz A., Cartier B., Couaillac J.P., Covaillac J.P., Gibaud C., Pouling G., Rivière H., Le Carrer D. Proposition de commentaires interprétatifs prêts à l'emploi pour l"électrophorèse des protéines sériques. Annales de Biologie Clinique 2006, 64:367-380.
45. Unger R.H., Foster D.W. Diabetes mellitus. Williams' Textbook of Endocrinology 1998, 973-1059. WB Saunders, Philadelphia. ninth ed. J.D. Wilson (Ed.).
46. Vanholder R., Ringoir S., Dhondt A., Hakim R.M. Phagocytosis in uremic and hemodialysis patients: prospective and cross-sectional study. Kidney International 1991, 39:320-327.
47. Wohaieb S.A., Godin D.V. Alterations in free radical tissue-defense mechanisms in streptozotocin-induced in rats. Diabetes 1987, 36:1014-1018.
48. Yan H., Harding J.J. Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase. Biochemical Journal 1997, 328:599-605.
49. Youl E., Bardy G., Magous R., Cros G., Sejalon F., Virsolon F., Richard S., Quignard J.F., Gross R., Petit P., Bataille D., Oiry C. Quercetin potentiates insulin secretion and protects INS-1 pancreatic β-cells against oxidative damage via the ERK1/2 pathway. British Journal of Pharmacology 2010, 161:799-814.