High concentrations of drug in target tissues following local controlled release are utilized for both drug distribution and biologic effect: An example with epicardial inotropic drug delivery

Journal of Controlled Release

Volumn 171, Issue 2, 2013, Pages 201-207

  Maslov, Mikhail Y ^a   Edelman, Elazer R ^b   Wei, Abraham E ^a   Pezone, Matthew J ^a   Lovich, Mark A ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

CAMP; Contractility; Epicardial drug delivery; Heart rate; Inotrope; Systemic vascular resistance

Indexed keywords

BLOOD PRESSURE; DRUG PRODUCTS; HISTOLOGY; TISSUE;

BIOLOGICAL RESPONSE; CAMP; CONCENTRATION GRADIENTS; CONTRACTILITY; HEART RATES; INOTROPE; RECEPTOR INTERACTION; TISSUE CONCENTRATIONS;

CONTROLLED DRUG DELIVERY;

ADRENALIN; CYCLIC AMP;

ADRENALIN BLOOD LEVEL; ADRENALIN RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; EPICARDIUM; HEART MUSCLE CONTRACTILITY; HEART RATE; HEART VENTRICLE CONTRACTILITY; INFUSION; INFUSION RATE; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SECOND MESSENGER; SUSTAINED DRUG RELEASE; SYSTEMIC VASCULAR RESISTANCE; TACHYCARDIA; TARGET ORGAN; UPREGULATION;

CAMP; CONTRACTILITY; EC; EPICARDIAL; EPICARDIAL DRUG DELIVERY; HEART RATE; HR; INOTROPE; INTRAVENOUS; IV; LEFT VENTRICULAR ANTERIOR WALL; LEFT VENTRICULAR INFERIOR WALL; LVAW; LVIW; MAX DP/DT; MAXIMUM RATE OF CHANGE OF PRESSURE; SVR; SYSTEMIC VASCULAR RESISTANCE;

ALGINATES; ANIMALS; CALCIUM; CARDIOTONIC AGENTS; CYCLIC AMP; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; EPINEPHRINE; GLUCURONIC ACID; HEART VENTRICLES; HEXURONIC ACIDS; HYDROGELS; INFUSIONS, INTRAVENOUS; MALE; MYOCARDIAL CONTRACTION; PERICARDIUM; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84881522885     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.06.038     Document Type: Article

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