Magnesium and depression: A systematic review

Nutritional Neuroscience

Volumn 16, Issue 5, 2013, Pages 191-206

  Derom, Marie Laure ^a   Sayón Orea, Carmen ^a   Martínez Ortega, José María ^b   Martínez González, Miguel A ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Depression; Magnesium; Major depression; Review

Indexed keywords

ANTIDEPRESSANT AGENT; CALCIUM; IMIPRAMINE; LITHIUM; LITHIUM CARBONATE; MAGNESIUM; MAGNESIUM CHLORIDE; MAGNESIUM GLYCINATE; MAGNESIUM OXIDE; MAGNESIUM SULFATE; MAGNESIUM TAURINATE; PLACEBO; POTASSIUM CHLORIDE; PSYCHOTROPIC AGENT; SPIRONOLACTONE; TRYPTOPHAN; UNCLASSIFIED DRUG;

BIPOLAR I DISORDER; BIPOLAR II DISORDER; CALCIUM BLOOD LEVEL; CASE STUDY; CEREBROSPINAL FLUID LEVEL; CLINICAL TRIAL (TOPIC); CROSS-SECTIONAL STUDY; DEPRESSION; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG EFFICACY; HUMAN; HYPOMAGNESEMIA; INTERVENTION STUDY; MAGNESIUM BLOOD LEVEL; MAGNESIUM METABOLISM; MAJOR DEPRESSION; NEUROPROTECTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVIEW; SYSTEMATIC REVIEW;

ANIMALS; CALCIUM; CROSS-SECTIONAL STUDIES; DEPRESSION; DIET; DIETARY SUPPLEMENTS; HUMANS; MAGNESIUM; NEUROPROTECTIVE AGENTS; PROSPECTIVE STUDIES;

EID: 84881520154     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830512Y.0000000044     Document Type: Review

References (87)

1. Andrade L, Caraveo-Anduaga JJ, Berglund P, Bijl R, Kessler RC, Demler O, et al. Cross-national comparisons of the prevalences and correlates of mental disorders. Bull World Health Organ 2000;78:413-26.
2. Aalto-Setala T, Marttunen M, Tuulio-Henriksson A, Poikolainen K, Lonnqvist J. One-month prevalence of depression and other DSM-IV disorders among young adults. Psychol Med 2001;31:791-801.
3. World Health Organization. The global burden of disease: 2004 update. Geneva: World Health Organization; 2008.
4. Sanders GT, Huijgen HJ, Sanders R. Magnesium in disease: a review with special emphasis on the serum ionized magnesium. Clin Chem Lab Med 1999;37:1011-33.
5. Touyz RM. Magnesium in clinical medicine. Front Biosci 2004; 9:1278-93.
6. King DE, Mainous AG, Geesey ME, Woolson RF. Dietary magnesium and C-reactive protein levels. J Am Coll Nutr 2005;24: 166-71.
7. Ford ES, Mokdad AH. Dietary magnesium intake in a national sample of US adults. J Nutr 2003;133:2879-82.
8. Dolega-Cieszkowski JH, Bobyn JP, Whiting SJ. Dietary intakes of Canadians in the 1990s using population-weighted data derived from the provincial nutrition surveys. Appl Physiol Nutr Metab 2006;31:753-58.
9. Song YQ, Sesso HD, Manson JE, Cook NR, Buring JE, Liu SM. Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year followup study. Am J Cardiol 2006;98:1616-21.
10. SongYQ, Manson JE, CookNR, Albert CM, Buring JE, Liu SM. Dietary magnesium intake and risk of cardiovascular disease among women. Am J Cardiol 2005;96:1135-41.
11. Song YQ, Manson JE, Buring JE, Liu SM. Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Diabetes Care 2004;27:59-65.
12. Jacka FN, Overland S, StewartR, TellGS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Austr NZ J Psychiatry 2009;43:45-52.
13. Murck H. Magnesium and affective disorders. Nutr Neurosci 2002;5:375-89.
14. Iseri L, Franch J. Magnesium: nature's physiologic calcium blocker. Am Heart J 1984;108:188-93.
15. Bresink I, Danysz W, Parsons CG, Mutschler E. Different binding affinities of NMDA receptor-channel blockers in various brain-regions-indication of NMDA receptor heterogeneity. Neuropharmacology 1995;34:533-40.
16. Gillessen T, Budd S, Lipton S. Excitatiory amino acid neurotoxicity. In: Alzheimer C (ed.) Molecular and cellular biology of neuroprotection in the CNS series: advances in experimental medicine and biology, Vol. 513. New York: Kluwer Academic/ Plenum Publishers; 2002. p. 3-40.
17. Sobolevskii AI, Khodorov BI. Blocker studies of the functional architecture of the NMDA receptor channel. Neurosci Behav Physiol 2002;32:157-71.
18. Durlach D, Bac P. Mechanisms of action on the nervous system in magnesium deficiency and dementia. In: Yasui M, Strong MJ, Ota K, Verity MA (eds.) Mineral and metal neurotoxicology. New York: CRC Press; 1997.
19. Poleszak E, Szewczyk B, Kedzierska E, Wlaz P, Pilc A, Nowak G. Antidepressant-and anxiolytic-like activity of magnesium in mice. Pharmacol Biochem Behav 2004;78:7-12.
20. Cardoso CC, Lobato KR, Binfare RW, Ferreira PK, Rosa AO, Santos AR, et al. Evidence for the involvement of the monoaminergic system in the antidepressant-like effect of magnesium. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:235-42.
21. Fromm L, Heath DL, Vink R, Nimmo AJ. Magnesium attenuates post-traumatic depression/anxiety following diffuse traumatic brain injury in rats. J Am Coll Nutr 2004;23:529S-33S.
22. Patten SB. International differences in major depression prevalence: What do they mean? J Clin Epidemiol 2003;56:711-16.
23. Eaton WW, Martins SS, Nestadt G, Bienvenu OJ, Clarke D, Alexandre P. The burden of mental disorders. Epidemiol Rev 2008;30:1-14.
24. Alonso J, Bruffaerts R, Gabilondo A, Haro JM, Kovess V, Vilagut G, et al. Depression. European Commission Task Force on major and chronic diseases of DG SANCO's Health Information Strand. Report 2007. Luxemburg 2008. p. 101-16.
25. Kessler RC, Angermeyer M, Anthony JC, de Graaf R, Demyttenaere K, Gasquet I, et al. Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative. World Psychiatry 2007;6:168-76.
26. Gabilondo A, Rojas-Farreras S, Vilagut G, Haro JM, Fernandez A, Pinto-Meza A, et al. Epidemiology of major depressive episode in a southern European country: results from the ESEMeD-Spain project. J Affect Disord 2010;120:76-85.
27. Nutt D. Anxiety and depression: individual entities or two sides of the same coin? Int J Psychiatry Clin Pract 2004;8:19-24.
28. Mykletun A, Bjerkeset O, Overland S, Prince M, Dewey M, Stewart R. Levels of anxiety and depression as predictors of mortality: the HUNT study. Br J Psychiatry 2009;195:118-25.
29. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Washington, DC: American Psychiatric Association; 2000.
30. Jacka F, Berk M. Food for thought. Acta Neuropsychiatry 2007; 19:321-23.
31. Sanchez-Villegas A, Doreste J, Schlatter J, Pla J, Bes-Rastrollo M, Martinez-Gonzalez MA. Association between folate, vitamin B-6 and vitamin B-12 intake and depression in the SUN cohort study. J Hum Nutr Diet 2009;22:122-33.
32. Tolmunen T, Hintikka J, Ruusunen A, Voutilainen S, Tanskanen A, Valkonen VP, et al. Dietary folate and the risk of depression in Finnish middle-aged men-a prospective follow-up study. Psychother Psychosom 2004;73:334-39.
33. Skarupski KA, Tangney C, Li H, Ouyang BC, Evans DA, Morris MC. Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. Am J Clin Nutr 2010;92:330-35.
34. Sanchez-Villegas A, Henriquez P, Figueiras A, Ortuno F, Lahortiga F, Martinez-Gonzalez MA. Long chain omega-3 fatty acids intake, fish consumption and mental disorders in the SUN cohort study. Eur J Nutr 2007;46:337-46.
35. Tanskanen A, Hibbeln JR, Tuomilehto J, Uutela A, Haukkala A, Viinamaki H, et al. Fish consumption and depressive symptoms in the general population in Finland. Psychiatr Serv 2001;52:529-31.
36. Saris NEL, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium-an update on physiological, clinical and analytical aspects. Clin Chim Acta 2000;294:1-26.
37. Shechter M. Does magnesium have a role in the treatment of patients with coronary artery disease? Am J Cardiovasc Drugs 2003;3:231-39.
38. Wolf FI, Trapani V. Cell (patho) physiology of magnesium. Clin Sci 2008;114:27-35.
39. Food and Nutrition Board IoM. Magnesium. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press; 1997. p. 190-249.
40. Galan P, Preziosi P, Durlach V, Valeix P, Ribas L, Bouzid D, et al. Dietary magnesium intake in a French adult population. Magnesium Res 1997;10:321-28.
41. Singewald N, Sinner C, Hetzenauer A, Sartori SB, Murck H. Magnesium-deficient diet alters depression-and anxiety-related behavior in mice-influence of desipramine and Hypericum perforatum extract. Neuropharmacology 2004;47:1189-97.
42. Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses 2006;67:362-70.
43. Enya M, Kanoh Y, Mune T, Ishizawa M, Sarui H, Yamamoto M, et al. Depressive state and paresthesia dramatically improved by intravenous MgSO4 in Gitelman's syndrome. Internal Med 2004;43:410-14.
44. Frazer A, Ramsey TA, Swann A, Bowden C, Brunswick D, Garver D, et al. Plasma and erythrocyte electrolytes in affective disorders. J Affect Disord 1983;5:103-13.
45. George MS, Rosenstein D, Rubinow DR, Kling MA, Post RM. CSF magnesium in affective disorder: lack of correlation with clinical course of treatment. Psychiatry Res 1994;51:139-46.
46. Joffe RT, Levitt AJ, Young LT. The thyroid, magnesium and calcium in major depression. Biol Psychiatry 1996;40:428-29.
47. Linder J, BrismarK, Beck-Friis J, Sääf J, WetterbergL. Ca andMg in affective disorders: difference between plasma and serum in relation to symptoms. Acta Psychiat Scand 1989;80:527-37.
48. Young LT, Robb JC, Levitt AJ, Cooke RG, Joffe RT. Serum Mg2+ and Ca2+/Mg2+ ratio in major depressive disorder. Neuropsychobiology 1996;34:26-8.
49. Banki CM, Vojnik M, Papp Z, Balla KZ, Arato M. Cerebrospinal-fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts. Biol Psychiatry 1985;20:163-71.
50. Kamei K, Tabata O, Muneoka K, Muraoka SI, Tomiyoshi R, Takigawa M. Electrolytes in erythrocytes of patients with depressive disorders. Psychiatry Clin Neurosci 1998;52:529-33.
51. Levine J, Stein D, Rapoport A, Kurtzman L. High serum and cerebrospinal fluid Ca/Mg ratio in recently hospitalized acutely depressed patients. Neuropsychobiology 1999;39:63-70.
52. Widmer J, Bovier P, Karege F, Raffin Y, Hilleret H, Gaillard JM, et al. Evolution of blood magnesium, sodium and potassium in depressed-patients followed for 3 months. Neuropsychobiology 1992;26:173-79.
53. Widmer J, Stella N, Raffin Y, Bovier P, Gaillard JM, Hilleret H, et al. Blood magnesium, potassium, sodium, calcium and cortisol in drug-free depressed patients. Magnesium Res 1993;6: 33-41.
54. Widmer J, Henrotte JG, Raffin Y, Bovier P, Hilleret H, Gaillard JM. Relationship between erythrocyte magnesium, plasma electrolytes and cortisol, and intensity of symptoms in major depressed patients. J Affect Disord 1995;34:201-9.
55. Widmer J, Henrotte JG, Raffin Y, Mouthon D, Chollet D, Stepanian R, et al. Relationship between blood magnesium and psychomotor retardation in drug-free patients with major depression. Eur Psychiatry 1998;13:90-7.
56. Imada Y, Yoshioka SI, Ueda T, Katayama S, Kuno Y, Kawahara R. Relationships between serum magnesium levels and clinical background factors in patients with mood disorders. Psychiatry Clin Neurosci 2002;56:509-14.
57. Zieba A, Kata R, Dudek D, Schlegel-Zawadzka M, Nowak G. Serum trace elements in animal models and human depression: Part III. Magnesium. Relationship with copper. Hum Psychopharm Clin 2000;15:631-5.
58. Derom ML, Martinez-Gonzalez MA, Sayon-Orea Mdel C, Bes-Rastrollo M, Beunza JJ, Sanchez-Villegas A. Magnesium intake is not related to depression risk in Spanish university graduates. J Nutr 2012;142:1053-9.
59. Kirov GK, Tsachev KN. Magnesium, schizophrenia and manicdepressive disease. Neuropsychobiology 1990;23:79-81.
60. Jung KI, Ock SM, Chung JH, Song CH. Associations of Serum Ca and Mg Levels with Mental Health in Adult Women Without Psychiatric Disorders. Biol Trace Elem Res 2010;133:153-61.
61. Barragan-Rodriguez L, Rodriguez-Moran M, Guerrero-Romero F. Depressive symptoms and hypomagnesemia in older diabetic subjects. Arch Med Res 2007;38:752-56.
62. Barragan-Rodriguez L, Rodriguez-Moran M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnesium Res 2008;21:218-23.
63. Hasey GM, Dalessandro E, Cooke RG, Warsh JJ. The interface between thyroid-activity, magnesium, and depression: a pilot study. Biol Psychiatry 1993;33:133-5.
64. Bhudia SK, Cosgrove DM, Naugle RI, Rajeswaran J, Lam BK, Walton E, et al. Magnesium as a neuroprotectant in cardiac surgery: a randomized clinical trial. J Thorac Cardiov Sur 2006;131:853-61.
65. Camardese G, De Risio L, Pizi G, Mattioli B, Buccelletti F, Serrani R, et al. Plasma magnesium levels and treatment outcome in depressed patients. Nutr Neurosci 2012; 15:78-84.
66. Walker AF, De Souza MC, Vickers MF, Abeyasekera S, Collins ML, Trinca LA. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. J Womens Health 1998;7:1157-65.
67. Frizel D, Coppen A, Marks V. Plasma magnesium and calcium in depression. Br J Psychiatry 1969;115:1375-77.
68. Enya M, Kanoh Y, Mune T, Ishizawa M, Sarui H, Yamamoto M, et al. Depressive state and paresthesia dramatically improved by intravenous MgSO4 in Gitelman's syndrome. Intern Med 2004;43:410-14.
69. Eby & Eby. Rapid recovery from major depression using magnesium treatment. Med Hypotheses 2006;67:362-70.
70. JimersonDC, Post RM, Carman JS, vanKammenDP, Wood JW, Goodwin FK, et al. CSF Calcium-clinical correlates in affectiveillness and schizophrenia. Biol Psychiatry 1979;14:37-51.
71. Ebel H, Gunther T. Magnesium metabolism-a review. J Clin Chem Clin Biol 1980;18:257-70.
72. Morris ME. Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms. Magnesium Res 1992;5:303-13.
73. Schain RJ. Cerebrospinal fluid and serum cation levels. Arch Neurol 1964;11:330-33.
74. Daini S, Tonioni F, Barra A, Lai C, Lacerenza R, Sgambato A, et al. Serum magnesium profile in heroin addicts: according to psychiatric comorbidity. Magnesium Res 2006;19:162-66.
75. Mark LP, Prost RW, Ulmer JL, Smith MM, Daniels DL, Strottman JM, et al. Pictorial review of glutamate excitotoxicity: Fundamental concepts for neuroimaging. Am J Neuroradiol 2001;22:1813-24.
76. Mann J, Truswwell AS. Essentials of human nutrition. New York: Oxford University Press; 2002.
77. Gullestad L, Dolva LO, Waage A, Falch D, Fagerthun H, Kjekshus J. Magnesium-deficiency diagnosed by an intravenous loading test. Scand J Clin Lab Inv 1992;52:245-53.
78. Golf SW, Riediger H, Matthes S, Kuhn D, Graef V, Temme H, et al. Homeostasis of magnesium in men after oral supplementation-results of a placebo controlled blind-study. Magnesium-Bulletin 1990;12:144-48.
79. Touitou Y, Touitou C, Bogdan A, Beck H, Reinberg A. Serum magnesium circadian-rhythm in human adults with respect to age, sex and mental status. Clin Chim Acta 1978;87:35-41.
80. Henrotte JG. Genetic regulation of blood and tissue magnesium content in mammals. Magnesium 1988;7:306-14.
81. Jabotinsky-Rubin K, Durst R, Levitin LA, Moscovich DG, Silver H, Lerner J, et al. Effects of haloperidol on human plasma magnesium. J Psychiatry Res 1993;27:155-59.
82. Nechifor M. Magnesium in major depression. Magnesium Res 2009;22:163S-166S.
83. Hewer W, Stark HW. Psychiatric disorders in elderly patients caused by disturbed calcium metabolism. Fortschritte Der Neurologie Psychiatrie 2010;78:161-67.
84. Tanaka M, Yamazaki S, Hayashino Y, Fukuhara S, Akiba T, Saito A, et al. Hypercalcaemia is associated with poor mental health in haemodialysis patients: results from Japan DOPPS. Nephrol Dial Transpl 2007;22:1658-64.
85. Jekel JF, Katz DL, Joann GE. Sample size, randomization, and probability theory. In: Jekel JF, Katz DL, Joann GE (eds.) Epidemiology, biostatics, and preventive medicine. 3d ed. Philadelphia: Saunders Elseviers; 2007. p. 197-212.
86. Ellenberg SS, Temple R. Placebo-controlled trials and activecontrol trials in the evaluation of new treatments-Part 2: Practical issues and specific cases. Ann Intern Med 2000;133: 464-70.
87. Reynolds T. The ethics of placebo-controlled trials. Ann Intern Med 2000;133:491-492.