Grade of pulmonary right-to-left shunt on contrast echocardiography and cerebral complications: A striking association

Chest

Volumn 144, Issue 2, 2013, Pages 542-548

  Velthuis, Sebastiaan ^a   Buscarini, Elisabetta ^b   Van Gent, Marco W F ^a   Gazzaniga, Pietro ^b   Manfredi, Guido ^b   Danesino, Cesare ^c   Schonewille, Wouter J ^a   Westermann, Cornelis J J ^a   Snijder, Repke J ^a   Mager, Johannes J ^a   Post, Martijn C ^a  

^a ST ANTONIUS HOSPITAL   (Netherlands)

^b MAGGIORE HOSPITAL   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN ABSCESS; BRAIN ISCHEMIA; CONTRAST ECHOCARDIOGRAPHY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE CLASSIFICATION; FEMALE; HEART LEFT VENTRICLE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; MICROBUBBLE; NEUROIMAGING; NEUROLOGIST; PREDICTION; PREVALENCE; PRIORITY JOURNAL; PULMONARY ARTERIOVENOUS FISTULA; PULMONARY RIGHT TO LEFT SHUNT; RENDU OSLER WEBER DISEASE; TRANSIENT ISCHEMIC ATTACK; TRANSTHORACIC ECHOCARDIOGRAPHY;

EID: 84881508436     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.12-1599     Document Type: Article

References (26)

1. Begbie ME, Wallace GM, Shovlin CL. Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): a view from the 21st century. Postgrad Med J. 2003; 79 (927): 18-24.
2. Gossage JR, Kanj G. Pulmonary arteriovenous malformations. A state of the art review. Am J Respir Crit Care Med. 1998; 158 (2): 643-661.
3. Shovlin CL, Letarte M. Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms. Thorax. 1999; 54 (8): 714-729.
4. Mager JJ, Overtoom TT, Blauw H, Lammers JW, Westermann CJ. Embolotherapy of pulmonary arteriovenous malformations: long-term results in 112 patients. J Vasc Interv Radiol. 2004; 15 (5): 451-456.
5. Shovlin CL, Guttmacher AE, Buscarini E, et al. Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). Am J Med Genet. 2000; 91 (1): 66-67.
6. Berg JN, Gallione CJ, Stenzel TT, et al. The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2. Am J Hum Genet. 1997; 61 (1): 60-67.
7. McAllister KA, Grogg KM, Johnson DW, et al. Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet. 1994; 8 (4): 345-351.
8. Gallione CJ, Repetto GM, Legius E, et al. A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). Lancet. 2004; 363 (9412): 852-859.
9. Bayrak-Toydemir P, McDonald J, Akarsu N, et al. A fourth locus for hereditary hemorrhagic telangiectasia maps to chromosome 7. Am J Med Genet A. 2006; 140 (20): 2155-2162.
10. Cole SG, Begbie ME, Wallace GM, Shovlin CL. A new locus for hereditary haemorrhagic telangiectasia (HHT3) maps to chromosome 5. J Med Genet. 2005; 42 (7): 577-582.
11. Faughnan ME, Palda VA, Garcia-Tsao G, et al; HHT Foundation International-Guidelines Working Group. International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia. J Med Genet. 2011; 48 (2): 73-87.
12. Gazzaniga P, Buscarini E, Leandro G, et al. Contrast echocardiography for pulmonary arteriovenous malformations screening: does any bubble matter? Eur J Echocardiogr. 2009; 10 (4): 513-518.
13. van Gent MW, Post MC, Snijder RJ, Westermann CJ, Plokker HW, Mager JJ. Real prevalence of pulmonary right-to-left shunt according to genotype in patients with hereditary hemorrhagic telangiectasia: a transthoracic contrast echocardiography study. Chest. 2010; 138 (4): 833-839.
14. van Gent MW, Post MC, Snijder RJ, et al. Grading of pulmonary right-to-left shunt with transthoracic contrast echocardiography: does it predict the indication for embolotherapy? Chest. 2009; 135 (5): 1288-1292.
15. Zukotynski K, Chan RP, Chow CM, Cohen JH, Faughnan ME. Contrast echocardiography grading predicts pulmonary arteriovenous malformations on CT. Chest. 2007; 132 (1): 18-23.
16. Gossage JR. Role of contrast echocardiography in screening for pulmonary arteriovenous malformation in patients with hereditary hemorrhagic telangiectasia. Chest. 2010; 138(4): 769-771.
17. Letteboer TG, Zewald RA, Kamping EJ, et al. Hereditary hemorrhagic telangiectasia: ENG and ALK-1 mutations in Dutch patients. Hum Genet. 2005; 116 (1-2): 8-16.
18. van Gent MW, Post MC, Luermans JG, et al. Screening for pulmonary arteriovenous malformations using transthoracic contrast echocardiography: a prospective study. Eur Respir J. 2009; 33 (1): 85-91.
19. Kjeldsen AD, Oxhøj H, Andersen PE, Green A, Vase P. Prevalence of pulmonary arteriovenous malformations (PAVMs) and occurrence of neurological symptoms in patients with hereditary haemorrhagic telangiectasia (HHT). J Intern Med. 2000; 248 (3): 255-262.
20. Maher CO, Piepgras DG, Brown RDJ Jr, Friedman JA, Pollock BE. Cerebrovascular manifestations in 321 cases of hereditary hemorrhagic telangiectasia. Stroke. 2001; 32 (4): 877-882.
21. Moussouttas M, Fayad P, Rosenblatt M, et al. Pulmonary arteriovenous malformations: cerebral ischemia and neurologic manifestations. Neurology. 2000; 55 (7): 959-964.
22. Shovlin CL, Jackson JE, Bamford KB, et al. Primary determinants of ischaemic stroke/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia. Thorax. 2008; 63 (3): 259-266.
23. Cottin V, Chinet T, Lavolé A, et al; Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P). Pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia: a series of 126 patients. Medicine (Baltimore). 2007; 86 (1): 1-17.
24. Anzola GP, Morandi E, Casilli F, Onorato E. Different degrees of right-to-left shunting predict migraine and stroke: data from 420 patients. Neurology. 2006; 66 (5): 765-767.
25. Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: systematic review and metaanalysis of observational studies. BMJ. 2005; 330 (7482): 63.
26. Rigatelli G, Dell'Avvocata F, Cardaioli P, et al. Permanent right-to-left shunt is the key factor in managing patent foramen ovale. J Am Coll Cardiol. 2011; 58 (21): 2257-2261.