Anti-dsDNA Antibody Isotypes in Systemic Lupus Erythematosus: IgA in Addition to IgG Anti-dsDNA Help to Identify Glomerulonephritis and Active Disease

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Villalta, Danilo ^a   Bizzaro, Nicola ^b   Bassi, Nicola ^c   Zen, Margherita ^c   Gatto, Mariele ^c   Ghirardello, Anna ^c   Iaccarino, Luca ^c   Punzi, Leonardo ^c   Doria, Andrea ^c  

^a S MARIA DEGLI ANGELI HOSPITAL   (Italy)

^b San Antonio Hospital   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; ANTIBODY DETECTION; ARTICLE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE DURATION; ELISA KIT; ENZYME LINKED IMMUNOSORBENT ASSAY; EUROPEAN CONSENSUS LUPUS ACTIVITY MEASURE SCORE; FEMALE; GLOMERULONEPHRITIS; HUMAN; INFECTION; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; MYOSITIS; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; PHENOTYPE; PROGNOSIS; PSORIATIC ARTHRITIS; RECEIVER OPERATING CHARACTERISTIC; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS;

ADULT; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; FEMALE; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; IMMUNOGLOBULIN M; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MALE; ROC CURVE; SEROEPIDEMIOLOGIC STUDIES; YOUNG ADULT;

EID: 84881503218     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071458     Document Type: Article

References (46)

1. Zen M, Bassi N, Nalotto L, Canova M, Bettio S, et al. (2012) Disease activity patterns in a monocentric cohort of SLE patients: a seven-year follow-up study. Clin Exp Rheumatol 30: 856-63.
2. Gatto M, Zen M, Ghirardello A, Bettio S, Bassi N, et al. (2012) Emerging and critical issues in the pathogenesis of lupus. Autoimmun Rev in press. doi:pii: S1568-9972(12)00213-3. 10.1016/j.autrev.2012.09.003.
3. Swaak AJK, Aarden LA, Statius van Eps LW, Feltkamp TEW, (1979) Anti-dsDNA and complement profiles as prognostic guides in systemic lupus erythematosus. Arthritis Rheum 22: 226-235.
4. McGrath Jr H, Biundo Jr JJ, (1985) A longitudinal study of high and low avidity antibodies to double-stranded DNA in systemic lupus erythematosus. Arthritis Rheum 28: 425-430.
5. Ter Borg EJ, Horst G, Hummel EJ, Limburg PG, Kallenberg CG, (1990) Measurement of increases in anti-double-stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus. Arthritis Rheum 33: 934-943.
6. Bootsma H, Spronk P, Derkesen R, de Boer G, Wolters-Dicke H, et al. (1995) Prevention of relapses in systemic lupus erythematosus. Lancet 345: 1595-1599.
7. Doria A, Zen M, Canova M, Bettio S, Bassi N, et al. (2010) SLE diagnosis and treatment: when early is early. Autoimmune Rev 10: 55-60.
8. Hamann D, Smeenk RJ (2007) Anti-dsDNA autoantibodies. In: Shoenfeld Y, Gershwin ME, Meroni PL (eds). Autoantibodies. 2nd Edition. Amsterdam: Elsevier Science BV. 159-167.
9. Hahn BH, (1998) Antibodies to DNA. N Engl J Med 338: 1359-1368.
10. Ohnishi K, Ebling FM, Mitchell B, Singh RR, Hahn BH, et al. (1994) Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics. Int Immunol 6: 817-830.
11. Ehrenstein MR, Katz DR, Griffiths MH, Papadaki L, Winkler TH, et al. (1995) Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. Kidney Int 48: 705-711.
12. Bootsma H, Spronk PE, Ter Borg EJ, Hummel EJ, De Boer G, et al. (1997) The predictive value of fluctuactions in IgM and IgG class anti-dsDNA antibodies for relapses in systemic lupus erythematosus. Ann Rheum Dis 56: 661-666.
13. Krippner H, Merle S, Jörgens K, Pirlet K, (1984) Antibodies to dsDNA and ssDNA in the immunoglobulin classes IgG and IgM: prognostic value in the course of SLE. Z Rheumatol 43: 265-271.
14. Witte T, Hartung K, Sachse C, Matthias T, Fricke M, et al. (1998) IgM anti-dsDNA antibodies in systemic lupus erythematosus: negative association with nephritis. Rheumatol Int 18: 85-91.
15. Förger F, Matthias T, Oppermann M, Becker H, Helmke K, (2004) Clinical significance of anti-dsDNA antibody isotypes: IgG/IgM ratio of anti-dsDNA antibodies as a prognosticmarker for lupus nephritis. Lupus 14: 36-44.
16. Shoenfeld Y, Toubi E, (2005) Protective autoantibodies. Role in homeostasis, clinical importance, and therapeutic potential. Arthritis Rheum 52: 2599-2606.
17. Witte T, (2008) IgM antibodies against dsDNA in SLE. Clin Rev Allerg Immunol 34: 345-347.
18. Doria A, Gatto M, (2012) Nephritogenic-antinephritogenic antibody network in lupus glomerulonephritis. Lupus 21: 1492-6.
19. Pisetsky DS, (2012) Antinuclear antibodies in rheumatic disease: a proposal for a functionbased classification. Scand J Immunol 76: 223-8.
20. Miltenburg AMM, Roos A, Slegtenhorst L, Daha MR, Breedveld FC, (1993) IgA antidsDNA antibodies in systemic lupus erythematosus: occurrence, incidence and association with clinical and laboratory variables of disease activity. J Rheumatol 20: 53-58.
21. Witte T, Hartung K, Matthias T, Sachse C, Fricke M, et al. (1998) Association of IgA antidsDNA antibodies with vasculitis and disease activity in systemic lupus erythematosus. Rheumatol Int 18: 63-69.
22. Atta AM, Pereira MM, Santiago M, Sousa-Atta MLB, (2009) Anti-dsDNA antibodies in Brazilian patients of mainly African descent with systemic lupus erythematosus: lack of association with lupus nephritis. Clin Rheumatol 28: 693-697.
23. Hochberg M, (1997) Updating the American College of Rheumatology revised criteria for classification of systemic lupus erythematosus. Arthritis Rheum 40: 1725-1734.
24. Vitali C, Bencivelli W, Isenberg DA, Smolen JS, Snaith ML, et al. (1992) Disease activity in systemic lupus erythematosus: report of the Consensus Study Group of the European Workshop for Rheumatology Research. II. Identification of the variables indicative of disease activity and their use in the development of an active score. Clin Exp Rheumatol 10: 541-547.
25. Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, et al. (2004) on behalf of the international society of nephrology and renal pathology society working group on the classification on lupus nephritis (2004) The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol 15: 241-250.
26. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, et al. (2002) European Study Group on Classification Criteria for Sjögren's Syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61: 554-8.
27. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, et al. (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62: 2569-81.
28. Bohan A, Peter JB, (1975) Polymyositis and dermatomyositis (first part). N Engl J Med 292: 344-7.
29. Bohan A, Peter JB, (1975) Polymyositis and dermatomyositis (second part). N Engl J Med 292: 403-7.
30. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee (1980) Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 23: 581-90.
31. Ghirardello A, Villalta D, Morozzi G, Afeltra A, Galeazzi M, et al. (2011) Diagnostic accuracy of currently available anti-double stranded DNA antibody assay. An Italian multicenter study. Clin Exp Rheumatol 29: 50-56.
32. Wallace DJ, Lin HC, Shen GQ, Peter JB, (1994) Antibodies to histone (H2A-H2B)-DNA complexes in the absence of antibodies to double-stranded DNA or to (H2A-H2B) complexes are more sensitive and specific for scleroderma-related disorders than for lupus. Arthritis Rheum 37: 1795-7.
33. Hasegawa M, Sato S, Kikuchi K, Takehara K, (1998) Antigen specificity of antihistone antibodies in systemic sclerosis. Ann Rheum Dis 57: 470-5.
34. Půtová I, Dostal C, Becvar R, (2007) Prevalence of antinucleosome antibodies by enzyme-linked immunosorbent assays in patients with systemic lupus erythematosus and other autoimmune systemic diseases. Ann N Y Acad Sci 1109: 275-86.
35. Villalta D, Bizzaro N, Corazza D, Tozzoli R, Tonutti E, (2002) Evaluation of a new automated enzyme fluoroimmunoassay using recombinant plasmid dsDNA for the detection of anti-dsDNA antibodies in SLE. J Clin Lab Anal 16: 227-32.
36. Palmer DK, O'Day K, Charbonneau H, Margolis RL, (1991) Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone. Proc Natl Acad Sci U S A 88: 3734-8.
37. Groottscholten C, van Bruggen MC, van der Pijl JW, de Jong EM, Ligtenberg G, et al. (2003) for the Dutch Working party on Systemic Lupus Erythematosus (2003) Deposition of nucleosomal antigens (histones and DNA) in the epidermal basement membrane in human lupus nephritis. Arthritis Rheum 48: 1355-1362.
38. Rekvig OP, Putterman C, Casu C, Gao HX, Ghirardello A, et al. (2012) Autoantibodies in lupus: culprits or passive bystanders? Autoimmun Rev 11: 596-603.
39. Ghirardello A, Doria A, Zampieri S, Tarricone E, Tozzoli R, et al. (2004) Antinucleosome antibodies in SLE: a two-year follow-up study of 101 patients. J Autoimmun 22: 235-240.
40. Smeenk RJT, Berden JHM, Swaak AJG (1996) Anti-dsDNA autoantibodies. In: Peter JB, Shoenfeld Y, editors. Autoantibodies. Elsevier Science: Amsterdam. 227-236.
41. Villalta D, Romelli PB, Savina C, Bizzaro N, Tozzoli R, et al. (2003) Anti-dsDNA antibody avidity determination by a simple reliable ELISA method for SLE diagnosis and monitoring. Lupus 12: 31-36.
42. Bassi N, Ghirardello A, Blank M, Zampieri S, Sarzi-Puttini P, et al. (2010) IgG antipentraxin 3 antibodies in systemic lupus erythematosus. Ann Rheum Dis 69: 1704-1710.
43. Boes M, Schmidt T, Linkemann K, Beaudette BC, Marshak-Rothstein A, et al. (2000) Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM. PNAS 97: 1184-1189.
44. Werwitzke S, Trick D, Kamino K, Matthias T, Kniesch K, et al. (2005) Inhibition of lupus disease by anti-double stranded DNA antibodies of the IgM isotype in the (NZB x NZW) F1 mouse. Arthritis Rheum 52: 3629-3638.
45. Daha NA, Banda NK, Roos A, Beurskens FJ, Bakker JM, et al. (2011) Complement activation by (auto-) antibodies. Mol Immunol 48: 1656-1665.
46. Sato N, Ohsawa I, Nagamachi S, Ishii M, Kusaba G, et al. (2011) Significance of glomerular activation of the alternative pathway and lectin pathway in lupus nephritis. Lupus 20: 1378-1386.