Utility of 14 novel biomarkers in patients with acute chest pain and undetectable levels of conventional cardiac troponin

International Journal of Cardiology

Volumn 167, Issue 4, 2013, Pages 1164-1169

  Meune, Christophe ^a,b   Balmelli, Cathrin ^a   Twerenbold, Raphael ^a   Reiter, Miriam ^a   Reichlin, Tobias ^a   Ziller, Ronny ^a   Drexler, Beatrice ^a   Stelzig, Claudia ^a   Freese, Michael ^a   Wolf, Claudia ^a   Haaf, Philip ^a   Osswald, Stefan ^a   Mueller, Christian ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Cardiac troponin; Chest pain; Growth differentiation factor 15; Midregional pro adrenomedullin; Prognosis

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ATRIAL NATRIURETIC FACTOR; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; COPEPTIN; ENDOTHELIN 1; GROWTH DIFFERENTIATION FACTOR 15; MYELOID RELATED PROTEIN 4; MYELOID RELATED PROTEIN 8; MYELOPEROXIDASE; MYOGLOBIN; PREGNANCY ASSOCIATED PLASMA PROTEIN A; PROADRENOMEDULLIN; TROPONIN T; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; BLOOD ANALYSIS EQUIPMENT; FEMALE; FOLLOW UP; HEART MUSCLE REVASCULARIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NONCARDIAC CHEST PAIN; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; THORAX PAIN; UNSTABLE ANGINA PECTORIS;

CARDIAC TROPONIN; CHEST PAIN; GROWTH DIFFERENTIATION FACTOR 15; MIDREGIONAL PRO-ADRENOMEDULLIN; PROGNOSIS;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CHEST PAIN; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TROPONIN T;

EID: 84881474669     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2012.03.117     Document Type: Article

References (41)

1. E.W. Nawar, R.W. Niska, and J. Xu National Hospital Ambulatory Medical Care Survey: 2005 emergency department summary Adv Data 2007 1 32
2. K. Thygesen, J. Mair, and H. Katus Recommendations for the use of cardiac troponin measurement in acute cardiac care Eur Heart J 31 2010 2197 2204
3. J.L. Anderson, C.D. Adams, and E.M. Antman ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine Circulation 116 2007 e148 e304
4. W. Hochholzer, D.A. Morrow, and R.P. Giugliano Novel biomarkers in cardiovascular disease: update 2010 Am Heart J 160 2010 583 594
5. T. Reichlin, W. Hochholzer, and S. Bassetti Early diagnosis of myocardial infarction with sensitive cardiac troponin assays N Engl J Med 361 2009 858 867
6. M. Reiter, R. Twerenbold, and T. Reichlin Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays Eur Heart J 32 2011 1379 1389
7. O. Schulz, K. Kirpal, and J. Stein Importance of low concentrations of cardiac troponins Clin Chem 52 2006 1614 1615
8. K.M. Eggers, A.S. Jaffe, L. Lind, P. Venge, and B. Lindahl Value of cardiac troponin I cutoff concentrations below the 99th percentile for clinical decision-making Clin Chem 55 2009 85 92
9. J. Sanchis, V. Bodi, and A. Llacer Risk stratification of patients with acute chest pain and normal troponin concentrations Heart 91 2005 1013 1018
10. F.S. Apple, A.H. Wu, and J. Mair Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome Clin Chem 51 2005 810 824
11. L.M. Biasucci CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: clinical use of inflammatory markers in patients with cardiovascular diseases: a background paper Circulation 110 2004 e560 e567
12. T. Reichlin, A. Irfan, and R. Twerenbold Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction Circulation 124 2011 136 145
13. C. Meune, B. Drexler, and P. Haaf he GRACE score's performance in predicting in-hospital and 1-year outcome in the era of high-sensitivity cardiac troponin assays and B-type natriuretic peptide Heart 97 2011 1479 1483
14. T. Mueller, A. Gegenhuber, W. Poelz, and M. Haltmayer Preliminary evaluation of the AxSYM B-type natriuretic peptide (BNP) assay and comparison with the ADVIA Centaur BNP assay Clin Chem 50 2004 1104 1106
15. N.G. Morgenthaler, J. Struck, C. Alonso, and A. Bergmann Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin Clin Chem 52 2006 112 119
16. M. Potocki, T. Breidthardt, and A. Mueller Copeptin and risk stratification in patients with acute dyspnea Crit Care 14 2010 R213
17. T. Reichlin, T. Socrates, and P. Egli Use of myeloperoxidase for risk stratification in acute heart failure Clin Chem 56 2010 944 951
18. N.G. Morgenthaler, J. Struck, B. Thomas, and A. Bergmann Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma Clin Chem 50 2004 234 236
19. N.G. Morgenthaler, J. Struck, C. Alonso, and A. Bergmann Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay Clin Chem 51 2005 1823 1829
20. J. Papassotiriou, N.G. Morgenthaler, J. Struck, C. Alonso, and A. Bergmann Immunoluminometric assay for measurement of the C-terminal endothelin-1 precursor fragment in human plasma Clin Chem 52 2006 1144 1151
21. D.A. Morrow, Y. Wang, and K. Croce Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial Am Heart J 155 2008 49 55
22. T. Kempf, R. Horn-Wichmann, and G. Brabant Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assay Clin Chem 53 2007 284 291
23. C.E. Metz Receiver operating characteristic analysis: a tool for the quantitative evaluation of observer performance and imaging systems J Am Coll Radiol 3 2006 413 422
24. K.C. Wollert, T. Kempf, and T. Peter Prognostic value of growth-differentiation factor-15 in patients with non-ST-elevation acute coronary syndrome Circulation 115 2007 962 971
25. E.M. Antman, M.J. Tanasijevic, and B. Thompson Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes N Engl J Med 335 1996 1342 1349
26. C.W. Hamm, B.U. Goldmann, C. Heeschen, G. Kreymann, J. Berger, and T. Meinertz Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I N Engl J Med 337 1997 1648 1653
27. World Health Organisation. European Detailed Mortality Database (DMDB). www. euro.who.int/hfadb. Updated January 2012.
28. C.A. Daly, B. De Stavola, and J.L. Sendon Predicting prognosis in stable angina-results from the Euro heart survey of stable angina: prospective observational study BMJ 332 2006 262 267
29. F. Beygui, J. Silvain, and A. Pena Usefulness of biomarker strategy to improve GRACE score's prediction performance in patients with non-ST-segment elevation acute coronary syndrome and low event rates Am J Cardiol 106 2010 650 658
30. P. Damman, M.A. Beijk, and W.J. Kuijt Multiple biomarkers at admission significantly improve the prediction of mortality in patients undergoing primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction J Am Coll Cardiol 57 2010 29 36
31. S.W. Goodacre, M. Bradburn, E. Cross, P. Collinson, A. Gray, and A.S. Hall The Randomised Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department Heart 97 2011 190 196
32. J.L. Januzzi Jr., F. Bamberg, and H. Lee High-sensitivity troponin T concentrations in acute chest pain patients evaluated with cardiac computed tomography Circulation 121 2010 1227 1234
33. T. Omland, J.A. de Lemos, and M.S. Sabatine A sensitive cardiac troponin T assay in stable coronary artery disease N Engl J Med 361 2009 2538 2547
34. G. Ndrepepa, S. Braun, and J. Mehilli Prognostic value of sensitive troponin T in patients with stable and unstable angina and undetectable conventional troponin Am Heart J 161 2011 68 75
35. S.Q. Khan, R.J. O'Brien, and J. Struck Prognostic value of midregional pro-adrenomedullin in patients with acute myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) study J Am Coll Cardiol 49 2007 1525 1532
36. A. Maisel, C. Mueller, and R. Nowak Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial J Am Coll Cardiol 55 2010 2062 2076
37. K.M. Eggers, T. Kempf, T. Allhoff, B. Lindahl, L. Wallentin, and K.C. Wollert Growth-differentiation factor-15 for early risk stratification in patients with acute chest pain Eur Heart J 29 2008 2327 2335
38. K.A. Volz, D.C. McGillicuddy, G.L. Horowitz, and L.D. Sanchez Creatine kinase-MB does not add additional benefit to a negative troponin in the evaluation of chest pain Am J Emerg Med 30 2012 188 190
39. T. Jernberg, M. Stridsberg, P. Venge, and B. Lindahl N-terminal pro brain natriuretic peptide on admission for early risk stratification of patients with chest pain and no ST-segment elevation J Am Coll Cardiol 40 2002 437 445
40. M.S. Sabatine, D.A. Morrow, and J.A. de Lemos Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia J Am Coll Cardiol 44 2004 1988 1995
41. K. Bibbins-Domingo, M. Ansari, N.B. Schiller, B. Massie, and M.A. Whooley B-type natriuretic peptide and ischemia in patients with stable coronary disease: data from the Heart and Soul study Circulation 108 2003 2987 2992