Association of visit-to-visit variability in blood pressure with cognitive function in old age: Prospective cohort study

BMJ (Online)

Volumn 347, Issue 7919, 2013, Pages

  Sabayan, Behnam ^a   Wijsman, Liselotte W ^a,b   Foster Dingley, Jessica C ^a   Stott, David J ^c   Ford, Ian ^c   Buckley, Brendan M ^d   Sattar, Naveed ^e   Jukema, J Wouter ^a   Van Osch, Matthias J P ^a   Van Der Grond, Jeroen ^a   Van Buchem, Mark A ^a   Westendorp, Rudi G J ^a,b   De Craen, Anton J M ^a,b   Mooijaart, Simon P ^a,b,f  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Netherlands Consortium for Healthy Ageing   (Netherlands)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY COLLEGE CORK   (Ireland)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

^f Institute for Evidence Based Medicine in Old Age   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; PRAVASTATIN;

AGED; ARTICLE; ATTENTION; BLOOD PRESSURE VARIABILITY; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN SIZE; CARDIOVASCULAR DISEASE; COGNITION; COHORT ANALYSIS; DIASTOLIC BLOOD PRESSURE; FEMALE; HIPPOCAMPUS; HUMAN; IRELAND; MALE; MEMORY; MULTICENTER STUDY (TOPIC); NETHERLANDS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SPHYGMOMANOMETER; SYSTOLIC BLOOD PRESSURE; UNITED KINGDOM; WHITE MATTER LESION;

AGED; AGED, 80 AND OVER; AGING; BLOOD PRESSURE; BLOOD PRESSURE DETERMINATION; BRAIN INFARCTION; CARDIOVASCULAR DISEASES; COGNITION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MILD COGNITIVE IMPAIRMENT; PROSPECTIVE STUDIES; REGRESSION ANALYSIS;

EID: 84881470632     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.f4600     Document Type: Article

References (42)

1. Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlof B, et al. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010;375:895-905.
2. Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlof B, et al. Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke. Lancet Neurol 2010;9:469-80.
3. Gunstad J, Cohen RA, Tate DF, Paul RH, Poppas A, Hoth K, et al. Blood pressure variability and white matter hyperintensities in older adults with cardiovascular disease. Blood Press 2005;14:353-8. (Pubitemid 43135733)
4. Brickman AM, Reitz C, Luchsinger JA, Manly JJ, Schupf N, Muraskin J, et al. Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort. Arch Neurol 2010;67:564-9.
5. Havlik RJ, Foley DJ, Sayer B, Masaki K, White L, Launer LJ. Variability in midlife systolic blood pressure is related to late-life brain white matter lesions: the Honolulu-Asia Aging study. Stroke 2002;33:26-30. (Pubitemid 34052179)
6. Mancia G, Parati G. The role of blood pressure variability in end-organ damage. J Hypertens Suppl 2003;21:S17-23. (Pubitemid 37082785)
7. Diaz KM, Veerabhadrappa P, Kashem MA, Feairheller DL, Sturgeon KM, Williamson ST, et al. Relationship of visit-to-visit and ambulatory blood pressure variability to vascular function in African Americans. Hypertens Res 2012;35:55-61.
8. Diaz KM, Veerabhadrappa P, Kashem MA, Thakkar SR, Feairheller DL, Sturgeon KM, et al. Visit-to-visit and 24-h blood pressure variability: association with endothelial and smooth muscle function in African Americans. J Hum Hypertens 2013; published online 25 Apr.
9. Van Es AC, van der Grond J, de Craen AJ, Westendorp RG, Bollen EL, Blauw GJ, et al. Cerebral microbleeds and cognitive functioning in the PROSPER study. Neurology 2011;77:1446-52.
10. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010;9:689-701.
11. Kovari E, Gold G, Herrmann FR, Canuto A, Hof PR, Michel JP, et al. Cortical microinfarcts and demyelination significantly affect cognition in brain aging. Stroke 2004;35:410-4. (Pubitemid 38174421)
12. Wardlaw JM, Sandercock PA, Dennis MS, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke 2003;34:806-12.
13. Ten Dam VH, Box FM, de Craen AJ, van den Heuvel DM, Bollen EL, Murray HM, et al. Lack of effect of pravastatin on cerebral blood flow or parenchymal volume loss in elderly at risk for vascular disease. Stroke 2005;36:1633-6. (Pubitemid 41098753)
14. Ten Dam VH, van den Heuvel DM, van Buchem MA, Westendorp RG, Bollen EL, Ford I, et al. Effect of pravastatin on cerebral infarcts and white matter lesions. Neurology 2005;64:1807-9. (Pubitemid 40695828)
15. Trompet S, van Vliet P, de Craen AJ, Jolles J, Buckley BM, Murphy MB, et al. Pravastatin and cognitive function in the elderly. Results of the PROSPER study. J Neurol 2010;257:85-90.
16. Houx PJ, Shepherd J, Blauw GJ, Murphy MB, Ford I, Bollen EL, et al. Testing cognitive function in elderly populations: the PROSPER study. PROspective Study of Pravastatin in the Elderly at Risk. J Neurol Neurosurg Psychiatry 2002;73:385-9.
17. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, et al. Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 2004;23(Suppl 1):S208-19. (Pubitemid 39421720)
18. Widya RL, de Roos A, Trompet S, de Craen AJ, Westendorp RG, Smit JW, et al. Increased amygdalar and hippocampal volumes in elderly obese individuals with or at risk of cardiovascular disease. Am J Clin Nutr 2011;93:1190-5.
19. Altmann-Schneider I, Trompet S, de Craen AJ, van Es AC, Jukema JW, Stott DJ, et al. Cerebral microbleeds are predictive of mortality in the elderly. Stroke 2011;42:638-44.
20. Admiraal-Behloul F, van den Heuvel DM, Olofsen H, van Osch MJ, van der Grond J, van Buchem MA, et al. Fully automatic segmentation of white matter hyperintensities in MR images of the elderly. NeuroImage 2005;28:607-17. (Pubitemid 41541964)
21. Havekes LM, de Knijff P, Beisiegel U, Havinga J, Smit M, Klasen E. A rapid micromethod for apolipoprotein E phenotyping directly in serum. J Lipid Res 1987;28:455-63. (Pubitemid 17055558)
22. Olindo S, Cabre P, Deschamps R, Chatot-Henry C, Rene-Corail P, Fournerie P, et al. Acute stroke in the very elderly: epidemiological features, stroke subtypes, management, and outcome in Martinique, French West Indies. Stroke 2003;34:1593-7. (Pubitemid 36842607)
23. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360:1903-13. (Pubitemid 35472129)
24. Rothwell PM. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet 2010;375:938-48.
25. Eguchi K, Hoshide S, Schwartz JE, Shimada K, Kario K. Visit-to-visit and ambulatory blood pressure variability as predictors of incident cardiovascular events in patients with hypertension. Am J Hypertens 2012;25:962-8.
26. Dellasega C, Morris D. The MMSE to assess the cognitive state of elders. Mini-Mental State Examination. J Neurosci Nurs 1993;25:147-52.
27. Kim YS, Immink RV, Stok WJ, Karemaker JM, Secher NH, van Lieshout JJ. Dynamic cerebral autoregulatory capacity is affected early in Type 2 diabetes. Clin Sci (Lond) 2008;115:255-62.
28. Nagai M, Hoshide S, Ishikawa J, Shimada K, Kario K. Visit-to-visit blood pressure variations: new independent determinants for cognitive function in the elderly at high risk of cardiovascular disease. J Hypertens 2012;30:1556-63.
29. Packard CJ, Westendorp RG, Stott DJ, Caslake MJ, Murray HM, Shepherd J, et al. Association between apolipoprotein E4 and cognitive decline in elderly adults. J Am Geriatr Soc 2007;55:1777-85. (Pubitemid 350043781)
30. Sadigh-Eteghad S, Talebi M, Farhoudi M. Association of apolipoprotein E epsilon 4 allele with sporadic late onset Alzheimer's disease. A meta-analysis. Neurosciences (Riyadh) 2012;17:321-6.
31. Parati G, Lantelme P. Blood pressure variability, target organ damage and cardiovascular events. J Hypertens 2002;20:1725-9.
32. Kim KI, Lee JH, Chang HJ, Cho YS, Youn TJ, Chung WY, et al. Association between blood pressure variability and inflammatory marker in hypertensive patients. Circ J 2008;72:293-8.
33. Cecchi E, Giglioli C, Valente S, Lazzeri C, Gensini GF, Abbate R, et al. Role of hemodynamic shear stress in cardiovascular disease. Atherosclerosis 2011;214:249-56.
34. Barnes J, Bartlett JW, van de Pol LA, Loy CT, Scahill RI, Frost C, et al. A meta-analysis of hippocampal atrophy rates in Alzheimer's disease. Neurobiol Aging 2009;30:1711-23.
35. Goldstein IB, Bartzokis G, Guthrie D, Shapiro D. Ambulatory blood pressure and the brain: a 5-year follow-up. Neurology 2005;64:1846-52. (Pubitemid 40800696)
36. Goldstein IB, Bartzokis G, Guthrie D, Shapiro D. Ambulatory blood pressure and brain atrophy in the healthy elderly. Neurology 2002;59:713-9.
37. Gomez-Angelats E, de La Sierra A, Sierra C, Parati G, Mancia G, Coca A. Blood pressure variability and silent cerebral damage in essential hypertension. Am J Hypertens 2004;17:696-700. (Pubitemid 39091550)
38. Liu W, Liu R, Sun W, Peng Q, Zhang W, Xu E, et al. Different impacts of blood pressure variability on the progression of cerebral microbleeds and white matter lesions. Stroke 2012;43:2916-22.
39. Kario K, Motai K, Mitsuhashi T, Suzuki T, Nakagawa Y, Ikeda U, et al. Autonomic nervous system dysfunction in elderly hypertensive patients with abnormal diurnal blood pressure variation: relation to silent cerebrovascular disease. Hypertension 1997;30:1504-10. (Pubitemid 27528096)
40. Webb AJ, Fischer U, Mehta Z, Rothwell PM. Effects of antihypertensive- drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis. Lancet 2010;375:906-15.
41. Lopez-Arrieta JM, Birks J. Nimodipine for primary degenerative, mixed and vascular dementia. Cochrane Database Syst Rev 2002(3):CD000147.
42. Alagiakrishnan K, McCracken P, Feldman H. Treating vascular risk factors and maintaining vascular health: is this the way towards successful cognitive ageing and preventing cognitive decline? Postgrad Med J 2006;82:101-5. (Pubitemid 43266138)