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Volumn 15, Issue 4, 2013, Pages

Progestin effects on cell proliferation pathways in the postmenopausal mammary gland

Author keywords

Breast cancer; Denosumab; Estrogen; Gene expression; Postmenopausal hormone therapy; Progestin; RANKL; Tibolone

Indexed keywords

AMPHIREGULIN; CONJUGATED ESTROGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GESTAGEN; HYPOCALCIN; MEDROXYPROGESTERONE ACETATE; MESSENGER RNA; MONOCLONAL ANTIBODY KI 67; OSTEOCLAST DIFFERENTIATION FACTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SOMATOMEDIN BINDING PROTEIN 1; STAT5 PROTEIN; STAT5A PROTEIN; THROMBOSPONDIN; TIBOLONE; TRANSFORMING GROWTH FACTOR BETA; BIOLOGICAL MARKER; ESTROGEN; ESTROGEN RECEPTOR; PREGNANE DERIVATIVE; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

EID: 84881447455     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3456     Document Type: Article
Times cited : (34)

References (53)
  • 1
    • 0346599193 scopus 로고    scopus 로고
    • National use of postmenopausal hormone therapy: annual trends and response to recent evidence
    • 10.1001/jama.291.1.47, 14709575
    • Hersh AL, Stefanick ML, Stafford RS. National use of postmenopausal hormone therapy: annual trends and response to recent evidence. JAMA 2004, 291:47-53. 10.1001/jama.291.1.47, 14709575.
    • (2004) JAMA , vol.291 , pp. 47-53
    • Hersh, A.L.1    Stefanick, M.L.2    Stafford, R.S.3
  • 3
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
    • 10.1001/jama.288.3.321, 12117397, Writing Group for the Women's Health Initiative Investigators
    • Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J. Writing Group for the Women's Health Initiative Investigators Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002, 288:321-333. 10.1001/jama.288.3.321, 12117397, Writing Group for the Women's Health Initiative Investigators.
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3    LaCroix, A.Z.4    Kooperberg, C.5    Stefanick, M.L.6    Jackson, R.D.7    Beresford, S.A.8    Howard, B.V.9    Johnson, K.C.10    Kotchen, J.M.11    Ockene, J.12
  • 8
    • 0034673201 scopus 로고    scopus 로고
    • Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin
    • 10.1093/jnci/92.4.328, 10675382
    • Ross RK, Paganini-Hill A, Wan PC, Pike MC. Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin. J Natl Cancer Inst 2000, 92:328-332. 10.1093/jnci/92.4.328, 10675382.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 328-332
    • Ross, R.K.1    Paganini-Hill, A.2    Wan, P.C.3    Pike, M.C.4
  • 11
    • 33751062430 scopus 로고    scopus 로고
    • Tibolone for the treatment of moderate to severe vasomotor symptoms and genital atrophy in postmenopausal women: a multicenter, randomized, double-blind, placebo-controlled study
    • 10.1097/01.gme.0000247016.41007.c9, 17006377
    • Swanson SG, Drosman S, Helmond FA, Stathopoulos VM. Tibolone for the treatment of moderate to severe vasomotor symptoms and genital atrophy in postmenopausal women: a multicenter, randomized, double-blind, placebo-controlled study. Menopause 2006, 13:917-925. 10.1097/01.gme.0000247016.41007.c9, 17006377.
    • (2006) Menopause , vol.13 , pp. 917-925
    • Swanson, S.G.1    Drosman, S.2    Helmond, F.A.3    Stathopoulos, V.M.4
  • 13
    • 0027216228 scopus 로고
    • Human endometrial 3 beta-hydroxysteroid dehydrogenase/isomerase can locally reduce intrinsic estrogenic/progestagenic activity ratios of a steroidal drug (Org OD 14)
    • 10.1016/0960-0760(93)90003-F, 8499344
    • Tang B, Markiewicz L, Kloosterboer HJ, Gurpide E. Human endometrial 3 beta-hydroxysteroid dehydrogenase/isomerase can locally reduce intrinsic estrogenic/progestagenic activity ratios of a steroidal drug (Org OD 14). J Steroid Biochem Mol Biol 1993, 45:345-351. 10.1016/0960-0760(93)90003-F, 8499344.
    • (1993) J Steroid Biochem Mol Biol , vol.45 , pp. 345-351
    • Tang, B.1    Markiewicz, L.2    Kloosterboer, H.J.3    Gurpide, E.4
  • 16
    • 0346996801 scopus 로고    scopus 로고
    • Progesterone involvement in breast development and tumorigenesis-as revealed by progesterone receptor " knockout" and " knockin" mouse models
    • 10.1016/S0039-128X(03)00133-8, 14667968
    • Ismail PM, Amato P, Soyal SM, DeMayo FJ, Conneely OM, O'Malley BW, Lydon JP. Progesterone involvement in breast development and tumorigenesis-as revealed by progesterone receptor " knockout" and " knockin" mouse models. Steroids 2003, 68:779-787. 10.1016/S0039-128X(03)00133-8, 14667968.
    • (2003) Steroids , vol.68 , pp. 779-787
    • Ismail, P.M.1    Amato, P.2    Soyal, S.M.3    DeMayo, F.J.4    Conneely, O.M.5    O'Malley, B.W.6    Lydon, J.P.7
  • 17
    • 9544220659 scopus 로고    scopus 로고
    • Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition
    • 10.1093/hmg/ddh301, 15385441
    • Pavlicek A, Noskov VN, Kouprina N, Barrett JC, Jurka J, Larionov V. Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition. Hum Mol Genet 2004, 13:2737-2751. 10.1093/hmg/ddh301, 15385441.
    • (2004) Hum Mol Genet , vol.13 , pp. 2737-2751
    • Pavlicek, A.1    Noskov, V.N.2    Kouprina, N.3    Barrett, J.C.4    Jurka, J.5    Larionov, V.6
  • 18
    • 84992645525 scopus 로고    scopus 로고
    • The mammary glands of macaques
    • 3070964, 21475638
    • Cline JM, Wood CE. The mammary glands of macaques. Toxicol Pathol 2008, 36:134s-141s. 3070964, 21475638.
    • (2008) Toxicol Pathol , vol.36
    • Cline, J.M.1    Wood, C.E.2
  • 20
    • 0030067711 scopus 로고    scopus 로고
    • Effects of hormone replacement therapy on the mammary gland of surgically postmenopausal cynomolgus macaques
    • 10.1016/S0002-9378(96)70379-4, 8572040
    • Cline JM, Soderqvist G, von Schoultz E, Skoog L, von Schoultz B. Effects of hormone replacement therapy on the mammary gland of surgically postmenopausal cynomolgus macaques. Am J Obstet Gynecol 1996, 174:93-100. 10.1016/S0002-9378(96)70379-4, 8572040.
    • (1996) Am J Obstet Gynecol , vol.174 , pp. 93-100
    • Cline, J.M.1    Soderqvist, G.2    von Schoultz, E.3    Skoog, L.4    von Schoultz, B.5
  • 21
    • 0036834499 scopus 로고    scopus 로고
    • Effects of tibolone and hormone replacement therapy on the breast of cynomolgus monkeys
    • 10.1097/00042192-200211000-00007, 12439101
    • Cline JM, Register TC, Clarkson TB. Effects of tibolone and hormone replacement therapy on the breast of cynomolgus monkeys. Menopause 2002, 9:422-429. 10.1097/00042192-200211000-00007, 12439101.
    • (2002) Menopause , vol.9 , pp. 422-429
    • Cline, J.M.1    Register, T.C.2    Clarkson, T.B.3
  • 22
    • 0035181597 scopus 로고    scopus 로고
    • A comparison of tibolone and conjugated equine estrogens effects on coronary artery atherosclerosis and bone density of postmenopausal monkeys
    • 10.1210/jc.86.11.5396, 11701713
    • Clarkson TB, Anthony MS, Wagner JD. A comparison of tibolone and conjugated equine estrogens effects on coronary artery atherosclerosis and bone density of postmenopausal monkeys. J Clin Endocrinol Metab 2001, 86:5396-5404. 10.1210/jc.86.11.5396, 11701713.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5396-5404
    • Clarkson, T.B.1    Anthony, M.S.2    Wagner, J.D.3
  • 23
    • 0037433040 scopus 로고    scopus 로고
    • Identifying differentially expressed genes using false discovery rate controlling procedures
    • 10.1093/bioinformatics/btf877, 12584122
    • Reiner A, Yekutieli D, Benjamini Y. Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 2003, 19:368-375. 10.1093/bioinformatics/btf877, 12584122.
    • (2003) Bioinformatics , vol.19 , pp. 368-375
    • Reiner, A.1    Yekutieli, D.2    Benjamini, Y.3
  • 24
    • 76049101223 scopus 로고    scopus 로고
    • Endometrial profile of tamoxifen and low-dose estradiol combination therapy
    • 10.1158/1078-0432.CCR-09-1541, 2818660, 20103679
    • Wood CE, Kaplan JR, Fontenot MB, Williams JK, Cline JM. Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Clin Cancer Res 2010, 16:946-956. 10.1158/1078-0432.CCR-09-1541, 2818660, 20103679.
    • (2010) Clin Cancer Res , vol.16 , pp. 946-956
    • Wood, C.E.1    Kaplan, J.R.2    Fontenot, M.B.3    Williams, J.K.4    Cline, J.M.5
  • 25
    • 57849107986 scopus 로고    scopus 로고
    • Effects of tibolone and conventional HRT on the expression of estrogen and progesterone receptors in the breast
    • 10.1016/j.maturitas.2008.09.018, 18980817
    • Ma L, Hofling M, Masironi B, von Schoultz B, Cline JM, Sahlin L. Effects of tibolone and conventional HRT on the expression of estrogen and progesterone receptors in the breast. Maturitas 2008, 61:345-349. 10.1016/j.maturitas.2008.09.018, 18980817.
    • (2008) Maturitas , vol.61 , pp. 345-349
    • Ma, L.1    Hofling, M.2    Masironi, B.3    von Schoultz, B.4    Cline, J.M.5    Sahlin, L.6
  • 26
    • 77954530773 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 5a mediates mammary ductal branching and proliferation in the nulliparous mouse
    • 10.1210/en.2009-1282, 2875824, 20392833
    • Santos SJ, Haslam SZ, Conrad SE. Signal transducer and activator of transcription 5a mediates mammary ductal branching and proliferation in the nulliparous mouse. Endocrinology 2010, 151:2876-2885. 10.1210/en.2009-1282, 2875824, 20392833.
    • (2010) Endocrinology , vol.151 , pp. 2876-2885
    • Santos, S.J.1    Haslam, S.Z.2    Conrad, S.E.3
  • 27
    • 34848827653 scopus 로고    scopus 로고
    • EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases
    • 10.1074/jbc.M705064200, 17636266
    • Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J Biol Chem 2007, 282:26656-26664. 10.1074/jbc.M705064200, 17636266.
    • (2007) J Biol Chem , vol.282 , pp. 26656-26664
    • Zhu, J.1    Jia, X.2    Xiao, G.3    Kang, Y.4    Partridge, N.C.5    Qin, L.6
  • 31
    • 33846911452 scopus 로고    scopus 로고
    • RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini
    • 10.1128/MCB.01298-06, 1800710, 17145767
    • Gonzalez-Suarez E, Branstetter D, Armstrong A, Dinh H, Blumberg H, Dougall WC. RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini. Mol Cell Biol 2007, 27:1442-1454. 10.1128/MCB.01298-06, 1800710, 17145767.
    • (2007) Mol Cell Biol , vol.27 , pp. 1442-1454
    • Gonzalez-Suarez, E.1    Branstetter, D.2    Armstrong, A.3    Dinh, H.4    Blumberg, H.5    Dougall, W.C.6
  • 33
    • 0033305673 scopus 로고    scopus 로고
    • Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast
    • 10.1210/jc.84.12.4559, 10599719
    • Hofseth LJ, Raafat AM, Osuch JR, Pathak DR, Slomski CA, Haslam SZ. Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast. J Clin Endocrinol Metab 1999, 84:4559-4565. 10.1210/jc.84.12.4559, 10599719.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 4559-4565
    • Hofseth, L.J.1    Raafat, A.M.2    Osuch, J.R.3    Pathak, D.R.4    Slomski, C.A.5    Haslam, S.Z.6
  • 34
    • 0035969246 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium
    • 10.1083/jcb.200107065, 2198867, 11706048
    • Miyoshi K, Shillingford JM, Smith GH, Grimm SL, Wagner KU, Oka T, Rosen JM, Robinson GW, Hennighausen L. Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol 2001, 155:531-542. 10.1083/jcb.200107065, 2198867, 11706048.
    • (2001) J Cell Biol , vol.155 , pp. 531-542
    • Miyoshi, K.1    Shillingford, J.M.2    Smith, G.H.3    Grimm, S.L.4    Wagner, K.U.5    Oka, T.6    Rosen, J.M.7    Robinson, G.W.8    Hennighausen, L.9
  • 35
    • 69849084075 scopus 로고    scopus 로고
    • Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis
    • 10.1186/bcr1368, 1413974, 16524451
    • Sternlicht MD. Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis. Breast Cancer Res 2006, 8:201. 10.1186/bcr1368, 1413974, 16524451.
    • (2006) Breast Cancer Res , vol.8 , pp. 201
    • Sternlicht, M.D.1
  • 36
    • 37549032769 scopus 로고    scopus 로고
    • Estrogen and progesterone are critical regulators of Stat5a expression in the mouse mammary gland
    • 2194608, 17884938
    • Santos SJ, Haslam SZ, Conrad SE. Estrogen and progesterone are critical regulators of Stat5a expression in the mouse mammary gland. Endocrinology 2008, 149:329-338. 2194608, 17884938.
    • (2008) Endocrinology , vol.149 , pp. 329-338
    • Santos, S.J.1    Haslam, S.Z.2    Conrad, S.E.3
  • 37
    • 78650208471 scopus 로고    scopus 로고
    • Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers
    • 10.1007/s12672-010-0048-0, 3000471, 21258428
    • Kariagina A, Xie J, Leipprandt JR, Haslam SZ. Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers. Horm Cancer 2010, 1:229-244. 10.1007/s12672-010-0048-0, 3000471, 21258428.
    • (2010) Horm Cancer , vol.1 , pp. 229-244
    • Kariagina, A.1    Xie, J.2    Leipprandt, J.R.3    Haslam, S.Z.4
  • 38
    • 69249229479 scopus 로고    scopus 로고
    • Osteoimmunology: crosstalk between the immune and bone systems
    • 10.1007/s10875-009-9316-6, 19585227
    • Nakashima T, Takayanagi H. Osteoimmunology: crosstalk between the immune and bone systems. J Clin Immunol 2009, 29:555-567. 10.1007/s10875-009-9316-6, 19585227.
    • (2009) J Clin Immunol , vol.29 , pp. 555-567
    • Nakashima, T.1    Takayanagi, H.2
  • 42
    • 62749173582 scopus 로고    scopus 로고
    • Strain-specific differences in the mechanisms of progesterone regulation of murine mammary gland development
    • 2654739, 18988671
    • Aupperlee MD, Drolet AA, Durairaj S, Wang W, Schwartz RC, Haslam SZ. Strain-specific differences in the mechanisms of progesterone regulation of murine mammary gland development. Endocrinology 2009, 150:1485-1494. 2654739, 18988671.
    • (2009) Endocrinology , vol.150 , pp. 1485-1494
    • Aupperlee, M.D.1    Drolet, A.A.2    Durairaj, S.3    Wang, W.4    Schwartz, R.C.5    Haslam, S.Z.6
  • 43
    • 77649259667 scopus 로고    scopus 로고
    • Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
    • 10.1073/pnas.0915148107, 2840294, 20133621
    • Beleut M, Rajaram RD, Caikovski M, Ayyanan A, Germano D, Choi Y, Schneider P, Brisken C. Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci USA 2010, 107:2989-2994. 10.1073/pnas.0915148107, 2840294, 20133621.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2989-2994
    • Beleut, M.1    Rajaram, R.D.2    Caikovski, M.3    Ayyanan, A.4    Germano, D.5    Choi, Y.6    Schneider, P.7    Brisken, C.8
  • 46
    • 0031597895 scopus 로고    scopus 로고
    • Role of hormones in mammary cancer initiation and progression
    • 10.1023/A:1018770218022, 10819504
    • Russo IH, Russo J. Role of hormones in mammary cancer initiation and progression. J Mammary Gland Biol Neoplasia 1998, 3:49-61. 10.1023/A:1018770218022, 10819504.
    • (1998) J Mammary Gland Biol Neoplasia , vol.3 , pp. 49-61
    • Russo, I.H.1    Russo, J.2
  • 47
    • 0023867603 scopus 로고
    • Proliferative and secretory activity in human breast during natural and artificial menstrual cycles
    • 1880536, 3337211
    • Going JJ, Anderson TJ, Battersby S, MacIntyre CC. Proliferative and secretory activity in human breast during natural and artificial menstrual cycles. Am J Pathol 1988, 130:193-204. 1880536, 3337211.
    • (1988) Am J Pathol , vol.130 , pp. 193-204
    • Going, J.J.1    Anderson, T.J.2    Battersby, S.3    MacIntyre, C.C.4
  • 48
    • 51649125766 scopus 로고    scopus 로고
    • Progestins in hormone replacement therapies reactivate cancer stem cells in women with preexisting breast cancers: a hypothesis
    • 10.1210/jc.2008-0938, 2567860, 18647813
    • Horwitz KB, Sartorius CA. Progestins in hormone replacement therapies reactivate cancer stem cells in women with preexisting breast cancers: a hypothesis. J Clin Endocrinol Metab 2008, 93:3295-3298. 10.1210/jc.2008-0938, 2567860, 18647813.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3295-3298
    • Horwitz, K.B.1    Sartorius, C.A.2
  • 50
    • 84884354925 scopus 로고    scopus 로고
    • Identification of hormone-responsive genes as biomarkers for menstrual cycle phases and menopausal status [abstract]
    • Wang J, Lee O, Heinz R, Ivancic D, Shcholtens D, Chatterton RT, Khan SA. Identification of hormone-responsive genes as biomarkers for menstrual cycle phases and menopausal status [abstract]. Cancer 2011, 71.
    • (2011) Cancer , vol.71
    • Wang, J.1    Lee, O.2    Heinz, R.3    Ivancic, D.4    Shcholtens, D.5    Chatterton, R.T.6    Khan, S.A.7
  • 51
    • 0242495765 scopus 로고    scopus 로고
    • Receptor activator of NF-kappaB ligand induction via Jak2 and Stat5a in mammary epithelial cells
    • 10.1074/jbc.M308545200, 12952963
    • Srivastava S, Matsuda M, Hou Z, Bailey JP, Kitazawa R, Herbst MP, Horseman ND. Receptor activator of NF-kappaB ligand induction via Jak2 and Stat5a in mammary epithelial cells. J Biol Chem 2003, 278:46171-46178. 10.1074/jbc.M308545200, 12952963.
    • (2003) J Biol Chem , vol.278 , pp. 46171-46178
    • Srivastava, S.1    Matsuda, M.2    Hou, Z.3    Bailey, J.P.4    Kitazawa, R.5    Herbst, M.P.6    Horseman, N.D.7
  • 53
    • 0035162210 scopus 로고    scopus 로고
    • Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects
    • 10.1006/dbio.2000.9961, 11133161
    • Gallego MI, Binart N, Robinson GW, Okagaki R, Coschigano KT, Perry J, Kopchick JJ, Oka T, Kelly PA, Hennighausen L. Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol 2001, 229:163-175. 10.1006/dbio.2000.9961, 11133161.
    • (2001) Dev Biol , vol.229 , pp. 163-175
    • Gallego, M.I.1    Binart, N.2    Robinson, G.W.3    Okagaki, R.4    Coschigano, K.T.5    Perry, J.6    Kopchick, J.J.7    Oka, T.8    Kelly, P.A.9    Hennighausen, L.10


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