A directional tuning map of Drosophila elementary motion detectors

Nature

Volumn 500, Issue 7461, 2013, Pages 212-216

  Maisak, Matthew S ^a   Haag, Juergen ^a   Ammer, Georg ^a   Serbe, Etienne ^a   Meier, Matthias ^a   Leonhardt, Aljoscha ^a   Schilling, Tabea ^a   Bahl, Armin ^a   Rubin, Gerald M ^b   Nern, Aljoscha ^b   Dickson, Barry J ^c   Reiff, Dierk F ^a,d   Hopp, Elisabeth ^a   Borst, Alexander ^a  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b Janelia Farm Research Campus ^*  (United States)

^c RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; DATA PROCESSING; EYE; FLY; FUNCTIONAL ROLE; MOVEMENT; NEUROLOGY; PHYSIOLOGICAL RESPONSE; PHYSIOLOGY; VISION;

ARTICLE; BRAIN NERVE CELL; CELL SUBPOPULATION; CONTROLLED STUDY; DENDRITE; DROSOPHILA; FLUORESCENCE MICROSCOPY; IMAGE PROCESSING; NONHUMAN; OPTIC LOBE; PHOTORECEPTOR; PRIORITY JOURNAL; VISUAL STIMULATION; WALKING;

ANIMALS; BEHAVIOR, ANIMAL; DROSOPHILA; INTERNEURONS; LOCOMOTION; MOTION PERCEPTION; NEURONS; SIGNAL TRANSDUCTION; VISUAL PATHWAYS;

EID: 84881440433     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12320     Document Type: Article

References (34)

1. Bausenwein, B., Dittrich, A. P. M. & Fischbach, K. F. The optic lobe of Drosophila melanogaster II. Sorting of retinotopic pathways in the medulla. Cell Tissue Res. 267, 17-28 (1992).
2. Akerboom, J. et al. Optimization of a GCaMP calcium indicator for neural activity imaging. J. Neurosci. 32, 13819-13840 (2012).
3. Cajal, S. R.& Sanchez, D. Contribucion al conocimiento de los centros nerviosos de los insectos (Imprenta de Hijos de Nicholas Moja, 1915).
4. Strausfeld, N. J. Atlas of an Insect Brain (Springer, 1976).
5. Fischbach, K. F. & Dittrich, A. P. M. The optic lobe of Drosophila melanogaster. I. A Golgi analysis of wild-type structure. Cell Tissue Res. 258, 441-475 (1989).
6. Reichardt, W. Autocorrelation, a principle for the evaluation of sensory information by the central nervous system. In Sensory Communication (ed. Rosenblith, W. A.) 303-317 (MIT Press and John Wiley & Sons, 1961).
7. Borst, A., Haag, J. & Reiff, D. F. Fly motion vision. Annu. Rev. Neurosci. 33, 49-70 (2010).
8. Buchner, E., Buchner. S. & Buelthoff, I. Deoxyglucose mapping of nervous activity induced in Drosophila brain by visualmovement. 1. Wildtype. J. Comp. Physiol. 155, 471-483 (1984).
9. Strausfeld, N. J. & Lee, J. K. Neuronal basis for parallel visual processing in the fly. Vis. Neurosci. 7, 13-33 (1991).
10. Schnell, B., Raghu, V. S., Nern, A. & Borst, A. Columnar cells necessary for motion responses of wide-field visual interneurons in Drosophila. J. Comp. Physiol. A 198, 389-395 (2012).
11. Douglass, J. K. & Strausfeld, N. J. Visual motion-detection circuits in flies: Parallel direction- and non-direction-sensitive pathways between the medulla and lobula plate. J. Neurosci. 16, 4551-4562 (1996).
12. Franceschini, N., Riehle, A.& Le Nestour, A. Directionally selectivemotion detection by insect neurons. In Facets of Vision (ed. Stavenga, H.) 360-390 (Springer, 1989).
13. Joesch, M., Schnell, B., Raghu, S. V., Reiff, D. F. & Borst, A. ON and OFF pathways in Drosophila motion vision. Nature 468, 300-304 (2010).
14. Pfeiffer, B. D. et al. Tools for neuroanatomy and neurogenetics in Drosophila. Proc. Natl Acad. Sci. USA 105, 9715-9720 (2008).
15. Denk, W., Strickler, J. H. & Webb, W. W. Two-photon laser scanning fluorescence microscopy. Science 248, 73-76 (1990).
16. Oyster, C. W.&Barlow, H. B. Direction-selective units in rabbit retina: distributionof preferred directions. Science 155, 841-842 (1967).
17. Sweeney, S. T., Broadie, K., Keane, J., Niemann, H. & O'Kane, C. J. Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects. Neuron 14, 341-351 (1995).
18. Seelig, J. D. et al. Two-photon calcium imaging from head-fixed Drosophila during optomotor walking behavior. Nature Methods 7, 535-540 (2010).
19. Clark, D. A., Bursztyn, L., Horowitz, M. A., Schnitzer, M. J. & Clandinin, T. R. Defining the computational structure of the motion detector in Drosophila. Neuron 70, 1165-1177 (2011).
20. Egelhaaf, M. & Borst, A. Calcium accumulation in visual interneurons of the fly: Stimulus dependence and relationship to membrane potential. J. Neurophysiol. 73, 2540-2552 (1995).
21. Joesch, M., Plett, J., Borst, A. & Reiff, D. F. Response properties of motion-sensitive visual interneurons in the lobula plate of Drosophila melanogaster. Curr. Biol. 18, 368-374 (2008).
22. Schnell, B. et al. Processing of horizontal optic flow in three visual interneurons of the Drosophila brain. J. Neurophysiol. 103, 1646-1657 (2010).
23. Borst, A. & Egelhaaf, M. Direction selectivity of fly motion-sensitive neurons is computed in a two-stage process. Proc.Natl Acad. Sci.USA87, 9363-9367(1990).
24. Single, S., Haag, J. & Borst, A. Dendritic computation of direction selectivity and gain control in visual interneurons. J. Neurosci. 17, 6023-6030 (1997).
25. Eichner, H., Joesch, M., Schnell, B., Reiff, D. F.& Borst, A. Internal structure of the fly elementary motion detector. Neuron 70, 1155-1164 (2011).
26. Joesch, M., Weber, F., Eichner, H. & Borst, A. Functional specialization of parallel motion detection circuits in the fly. J. Neurosci. 33, 902-905 (2013).
27. Egelhaaf, M. & Borst, A. Are there separate ON and OFF channels in fly motion vision? Vis. Neurosci. 8, 151-164 (1992).
28. Takemura, S. Y., Lu, Z. & Meinertzhagen, I. A. Synaptic circuits of the Drosophila optic lobe: the input terminals to the medulla. J. Comp. Neurol. 509, 493-513 (2008).
29. Euler, T., Detwiler, P. B. & Denk, W. Directionally selective calcium signals in dendrites of starburst amacrine cells. Nature 418, 845-852 (2002).
30. Pologruto, T. A., Sabatini, B. L. & Svoboda, K. ScanImage: Flexible software for operating laser scanning microscopes. Biomed. Eng. Online 2, 13 (2003).
31. Jenett, A. et al.A Gal4-driver line resource for Drosophila neurobiology. Cell Rep. 2, 991-1001 (2012).
32. Reiff, D. F., Plett, J., Mank, M., Griesbeck, O. & Borst, A. Visualizing retinotopic halfwave rectified input to the motion detection circuitry of Drosophila. Nature Neurosci. 13, 973-978 (2010).
33. Euler, T. et al. Eyecup scope-optical recording of light stimulus-evoked fluorescence signals in the retina. Pfluger Arch. 457, 1393-1414 (2009).
34. Reiser, M. B. & Dickinson, M. H. A modular display system for insect behavioral neuroscience. J. Neurosci. Methods 167, 127-139 (2008).