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Volumn 28, Issue 7, 2013, Pages 501-509

The efficacy of additional bevacizumab to cytotoxic chemotherapy regimens for the treatment of colorectal cancer: An updated meta-analysis for randomized trials

Author keywords

bevacizumab; colorectal cancer; cytotoxic chemotherapy regimens; meta analysis

Indexed keywords

BEVACIZUMAB; CAPECITABINE; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; LEVAMISOLE; OXALIPLATIN;

EID: 84881414803     PISSN: 10849785     EISSN: 15578852     Source Type: Journal    
DOI: 10.1089/cbr.2012.1458     Document Type: Review
Times cited : (15)

References (44)
  • 1
    • 11844273837 scopus 로고    scopus 로고
    • Colorectal cancer
    • Weitz J, Koch M, Debus J, et al. Colorectal cancer. Lancet 2005;365:153
    • (2005) Lancet , vol.365 , pp. 153
    • Weitz, J.1    Koch, M.2    Debus, J.3
  • 2
    • 84863115967 scopus 로고    scopus 로고
    • Effectiveness of bevacizumab with first-line combination chemotherapy for Medicare patients with stage IV colorectal cancer
    • Meyerhardt JA, Li L, Sanoff HK, et al. Effectiveness of bevacizumab with first-line combination chemotherapy for Medicare patients with stage IV colorectal cancer. J Clin Oncol 2012;30:608
    • (2012) J Clin Oncol , vol.30 , pp. 608
    • Meyerhardt, J.A.1    Li, L.2    Sanoff, H.K.3
  • 3
    • 49049105525 scopus 로고    scopus 로고
    • Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the tree study
    • Hochster HS, Hart LL, Ramanathan RK, et al. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE Study. J Clin Oncol 2008;26:3523
    • (2008) J Clin Oncol , vol.26 , pp. 3523
    • Hochster, H.S.1    Hart, L.L.2    Ramanathan, R.K.3
  • 4
    • 4644252335 scopus 로고    scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: An updated meta-analysis
    • Thirion P, Michiels S, Pignon JP, et al. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: An updated meta-analysis. J Clin Oncol 2004;22:3766
    • (2004) J Clin Oncol , vol.22 , pp. 3766
    • Thirion, P.1    Michiels, S.2    Pignon, J.P.3
  • 5
    • 0028351657 scopus 로고
    • Chemotherapy for colorectal cancer
    • Moertel CG. Chemotherapy for colorectal cancer. N Engl J Med 1994;330:1136
    • (1994) N Engl J Med , vol.330 , pp. 1136
    • Moertel, C.G.1
  • 6
    • 0035503151 scopus 로고    scopus 로고
    • Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study
    • Van Cutsem E, Twelves C, Cassidy J, et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study. J Clin Oncol 2001;19:4097
    • (2001) J Clin Oncol , vol.19 , pp. 4097
    • Van Cutsem, E.1    Twelves, C.2    Cassidy, J.3
  • 7
    • 11144354462 scopus 로고    scopus 로고
    • Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: Integrated efficacy data and novel analyses from two large, randomised, phase III trials
    • Van Cutsem E, Hoff PM, Harper P, et al. Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: Integrated efficacy data and novel analyses from two large, randomised, phase III trials. Br J Cancer 2004;90:1190
    • (2004) Br J Cancer , vol.90 , pp. 1190
    • Van Cutsem, E.1    Hoff, P.M.2    Harper, P.3
  • 8
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
    • Hoff PM, Ansari R, Batist G, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study. J Clin Oncol 2001;19:2282
    • (2001) J Clin Oncol , vol.19 , pp. 2282
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3
  • 9
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • Kabbinavar FF, Hambleton J, Mass RD, et al. Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 2005;23:3706
    • (2005) J Clin Oncol , vol.23 , pp. 3706
    • Kabbinavar, F.F.1    Hambleton, J.2    Mass, R.D.3
  • 10
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335
    • (2004) N Engl J Med , vol.350 , pp. 2335
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 11
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tissue in vivo I. Vascular reactions of mice to wounds and to normal and neoplastic transplants
    • Algire GH, Chalkley HW, Legallais FY, et al. Vascular reactions of normal and malignant tissue in vivo, I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst 1945;6:73
    • (1945) J Natl Cancer Inst , Issue.6 , pp. 73
    • Algire, G.H.1    Chalkley, H.W.2    Legallais, F.Y.3
  • 12
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy. Nat Med 2001;7:987
    • (2001) Nat Med , vol.7 , pp. 987
    • Jain, R.K.1
  • 13
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett CG, Boucher Y, di Tomaso E, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004;10:145
    • (2004) Nat Med , vol.10 , pp. 145
    • Willett, C.G.1    Boucher, Y.2    Di Tomaso, E.3
  • 14
    • 0035253586 scopus 로고    scopus 로고
    • Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: Pharmacologic and long-term safety data
    • Margolin K, Gordon MS, Holmgren E, et al. Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: Pharmacologic and long-term safety data. J Clin Oncol 2001;19:851
    • (2001) J Clin Oncol , vol.19 , pp. 851
    • Margolin, K.1    Gordon, M.S.2    Holmgren, E.3
  • 15
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (folfox4) for previously treated metastatic colorectal cancer: Results from the eastern cooperative oncology group study e3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007;25:1539
    • (2007) J Clin Oncol , vol.25 , pp. 1539
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 16
    • 35648956134 scopus 로고    scopus 로고
    • Performance of the trim and fill method in the presence of publication bias and between- study heterogeneity
    • Peters JL, Sutton AJ, Jones DR, et al. Performance of the trim and fill method in the presence of publication bias and between- study heterogeneity. Stat Med 2007;26:4544
    • (2007) Stat Med , vol.26 , pp. 4544
    • Peters, J.L.1    Sutton, A.J.2    Jones, D.R.3
  • 17
    • 0033619529 scopus 로고    scopus 로고
    • Explaining heterogeneity in metaanalysis: A comparison of methods
    • Thompson SG, Sharp SJ. Explaining heterogeneity in metaanalysis: A comparison of methods. Stat Med 1999;18:2693
    • (1999) Stat Med , vol.18 , pp. 2693
    • Thompson, S.G.1    Sharp, S.J.2
  • 18
    • 0037098203 scopus 로고    scopus 로고
    • Statistical methods for assessing the influence of study characteristics on treatment effects in meta-epidemiological research
    • Sterne JA, Juni P, Schulz KF, et al. Statistical methods for assessing the influence of study characteristics on treatment effects in meta-epidemiological research. Stat Med 2002; 21:1513
    • (2002) Stat Med , vol.21 , pp. 1513
    • Sterne, J.A.1    Juni, P.2    Schulz, K.F.3
  • 19
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 1998;17:2815
    • (1998) Stat Med , vol.17 , pp. 2815
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 20
    • 0037202566 scopus 로고    scopus 로고
    • Aggregate data meta-analysis with time-to-event outcomes
    • Williamson PR, Smith CT, Hutton JL, et al. Aggregate data meta-analysis with time-to-event outcomes. Stat Med 2002; 21:3337
    • (2002) Stat Med , vol.21 , pp. 3337
    • Williamson, P.R.1    Smith, C.T.2    Hutton, J.L.3
  • 21
    • 34547450763 scopus 로고    scopus 로고
    • Practical methods for incorporating summary time-to-event data into meta-analysis
    • Tierney JF, Stewart LA, Ghersi D, et al. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 2007;8:16
    • (2007) Trials , vol.8 , pp. 16
    • Tierney, J.F.1    Stewart, L.A.2    Ghersi, D.3
  • 22
    • 0037208589 scopus 로고    scopus 로고
    • Phase ii, randomized trial comparing bevacizumab plus fluorouracil (fu)/leucovorin (lv) with fu/lv alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003;21:60
    • (2003) J Clin Oncol , vol.21 , pp. 60
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 23
    • 3042529038 scopus 로고    scopus 로고
    • Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma
    • Blackwell K, Hurwitz H, Lieberman G, et al. Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma. Cancer 2004;101:77
    • (2004) Cancer , vol.101 , pp. 77
    • Blackwell, K.1    Hurwitz, H.2    Lieberman, G.3
  • 24
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in firstline metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar FF, Schulz J, McCleod M, et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in firstline metastatic colorectal cancer: Results of a randomized phase II trial. J Clin Oncol 2005;23:3697
    • (2005) J Clin Oncol , vol.23 , pp. 3697
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 25
    • 8644249844 scopus 로고    scopus 로고
    • Bevacizumab in combination with irinotecan plus fluorouracil plus leucovorin chemotherapy prolongs survival but increases adverse events in people with metastatic colorectal cancer
    • Choti MA. Bevacizumab in combination with irinotecan plus fluorouracil plus leucovorin chemotherapy prolongs survival but increases adverse events in people with metastatic colorectal cancer. Cancer Treat Rev 2004;30:715
    • (2004) Cancer Treat Rev , vol.30 , pp. 715
    • Choti, M.A.1
  • 26
    • 21244450758 scopus 로고    scopus 로고
    • Association of k-ras, braf, and p53 status with the treatment effect of bevacizumab
    • Ince WL, Jubb AM, Holden SN, et al. Association of k-ras, braf, and p53 status with the treatment effect of bevacizumab. J Natl Cancer Inst 2005;97:981
    • (2005) J Natl Cancer Inst , vol.97 , pp. 981
    • Ince, W.L.1    Jubb, A.M.2    Holden, S.N.3
  • 27
    • 61449202998 scopus 로고    scopus 로고
    • The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
    • Hurwitz HI, Yi J, Ince W, et al. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist 2009;14:22
    • (2009) Oncologist , vol.14 , pp. 22
    • Hurwitz, H.I.1    Yi, J.2    Ince, W.3
  • 28
    • 77956083776 scopus 로고    scopus 로고
    • Treatment of colorectal cancer with and without bevacizumab: A phase III study
    • Stathopoulos GP, Batziou C, Trafalis D, et al. Treatment of colorectal cancer with and without bevacizumab: A phase III study. Oncology 2010;78:376
    • (2010) Oncology , vol.78 , pp. 376
    • Stathopoulos, G.P.1    Batziou, C.2    Trafalis, D.3
  • 29
    • 80054779014 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer: A randomized phase III ARTIST trial
    • Guan ZZ, Xu JM, Luo RC, et al. Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer: A randomized phase III ARTIST trial. Chin J Cancer 2011;30:682
    • (2011) Chin J Cancer , vol.30 , pp. 682
    • Guan, Z.Z.1    Xu, J.M.2    Luo, R.C.3
  • 30
    • 34147190880 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab plus FOLFOX4 as secondline treatment of colorectal cancer
    • Cohen MH, Gootenberg J, Keegan P, et al. FDA drug approval summary: Bevacizumab plus FOLFOX4 as secondline treatment of colorectal cancer. Oncologist 2007;12:356
    • (2007) Oncologist , vol.12 , pp. 356
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3
  • 31
    • 66149147757 scopus 로고    scopus 로고
    • Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer
    • Allegra CJ, Yothers G, OConnell MJ, et al. Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer. J Clin Oncol 2009;27:3385
    • (2009) J Clin Oncol , vol.27 , pp. 3385
    • Allegra, C.J.1    Yothers, G.2    Oconnell, M.J.3
  • 32
    • 79551521053 scopus 로고    scopus 로고
    • Phase iii trial assessing bevacizumab in stages ii and iii carcinoma of the colon: Results of nsabp protocol c-08
    • Allegra CJ, Yothers G, OConnell MJ, et al. Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08. J Clin Oncol 2011;29:11
    • (2011) J Clin Oncol , vol.29 , pp. 11
    • Allegra, C.J.1    Yothers, G.2    Oconnell, M.J.3
  • 33
    • 77955497309 scopus 로고    scopus 로고
    • Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: Results of the australasian gastrointestinal trials group randomized phase iii max study
    • Tebbutt NC, Wilson K, Gebski VJ, et al. Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: Results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study. J Clin Oncol 2010;28:3191
    • (2010) J Clin Oncol , vol.28 , pp. 3191
    • Tebbutt, N.C.1    Wilson, K.2    Gebski, V.J.3
  • 34
    • 79960149283 scopus 로고    scopus 로고
    • Impact of KRAS and BRAF gene mutation status on outcomes from the phase III AGITG MAX trial of capecitabine alone or in combination with bevacizumab and mitomycin in advanced colorectal cancer
    • Price TJ, Hardingham JE, Lee CK, et al. Impact of KRAS and BRAF gene mutation status on outcomes from the phase III AGITG MAX trial of capecitabine alone or in combination with bevacizumab and mitomycin in advanced colorectal cancer. J Clin Oncol 2011;29:2675
    • (2011) J Clin Oncol , vol.29 , pp. 2675
    • Price, T.J.1    Hardingham, J.E.2    Lee, C.K.3
  • 35
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as firstline therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as firstline therapy in metastatic colorectal cancer: A randomized phase III study. J Clin Oncol 2008;26:2013
    • (2008) J Clin Oncol , vol.26 , pp. 2013
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3
  • 36
    • 0034729931 scopus 로고    scopus 로고
    • Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: A meta-analysis
    • Buyse M, Thirion P, Carlson RW, et al. Relation between tumour response to first-line chemotherapy and survival in advanced colorectal cancer: A meta-analysis. Lancet 2000;356:373
    • (2000) Lancet , vol.356 , pp. 373
    • Buyse, M.1    Thirion, P.2    Carlson, R.W.3
  • 37
    • 77954008527 scopus 로고    scopus 로고
    • Bevacizumab combined with chemotherapy for patients with advanced colorectal cancer: A systematic review
    • Welch S, Spithoff K, Rumble RB, et al. Bevacizumab combined with chemotherapy for patients with advanced colorectal cancer: A systematic review. Ann Oncol 2010;21:1152
    • (2010) Ann Oncol , vol.21 , pp. 1152
    • Welch, S.1    Spithoff, K.2    Rumble, R.B.3
  • 38
    • 78651371513 scopus 로고    scopus 로고
    • Optimizing the efficacy of first-line chemotherapy plus bevacizumab in metastatic colorectal cancer: Analysis of multiple methods
    • Li S, Chi P. Optimizing the efficacy of first-line chemotherapy plus bevacizumab in metastatic colorectal cancer: Analysis of multiple methods. BioDrugs 2011;25:43
    • (2011) BioDrugs , vol.25 , pp. 43
    • Li, S.1    Chi, P.2
  • 39
    • 67349286163 scopus 로고    scopus 로고
    • A meta-analysis of randomized controlled trials comparing chemotherapy plus bevacizumab with chemotherapy alone in metastatic colorectal cancer
    • Cao Y, Tan A, Gao F, et al. A meta-analysis of randomized controlled trials comparing chemotherapy plus bevacizumab with chemotherapy alone in metastatic colorectal cancer. Int J Colorectal Dis 2009;24:677
    • (2009) Int J Colorectal Dis , vol.24 , pp. 677
    • Cao, Y.1    Tan, A.2    Gao, F.3
  • 40
    • 0029964873 scopus 로고    scopus 로고
    • Characterisation and clinical management of CPT-11 (irinotecan)-induced adverse events: The European perspective
    • Bleiberg H, Cvitkovic E. Characterisation and clinical management of CPT-11 (irinotecan)-induced adverse events: The European perspective. Eur J Cancer 1996;32A Suppl 3:S18
    • (1996) Eur J Cancer , vol.32 A , Issue.SUPPL. 3
    • Bleiberg, H.1    Cvitkovic, E.2
  • 41
    • 0029919195 scopus 로고    scopus 로고
    • CPT-11 in the treatment of colorectal cancer: Clinical efficacy and safety profile
    • Rougier P, Bugat R. CPT-11 in the treatment of colorectal cancer: Clinical efficacy and safety profile. Semin Oncol 1996;23(1 Suppl 3):34
    • (1996) Semin Oncol , vol.23 , Issue.1 SUPPL. 3 , pp. 34
    • Rougier, P.1    Bugat, R.2
  • 42
    • 0031014627 scopus 로고    scopus 로고
    • Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy
    • Rougier P, Bugat R, Douillard JY, et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol 1997;15:251
    • (1997) J Clin Oncol , vol.15 , pp. 251
    • Rougier, P.1    Bugat, R.2    Douillard, J.Y.3
  • 43
    • 0033558004 scopus 로고    scopus 로고
    • A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma
    • Rothenberg ML, Cox JV, DeVore RF, et al. A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma. Cancer 1999;85:786
    • (1999) Cancer , vol.85 , pp. 786
    • Rothenberg, M.L.1    Cox, J.V.2    Devore, R.F.3
  • 44
    • 33748669385 scopus 로고    scopus 로고
    • Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/ leucovorin administered bimonthly in elderly patients with colorectal cancer
    • Goldberg RM, Tabah-Fisch I, Bleiberg H, et al. Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/ leucovorin administered bimonthly in elderly patients with colorectal cancer. J Clin Oncol 2006;24:4085.
    • (2006) J Clin Oncol , vol.24 , pp. 4085
    • Goldberg, R.M.1    Tabah-Fisch, I.2    Bleiberg, H.3


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