Successful stem cell transplant with antibody-based conditioning for XIAP deficiency with refractory hemophagocytic lymphohistiocytosis

Blood

Volumn 121, Issue 24, 2013, Pages 4966-4968

  Worth, Austen J J ^a   Nikolajeva, Olga ^a   Chiesa, Robert ^a   Rao, Kanchan ^a   Veys, Paul ^a   Amrolia, Persis J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ANTIBODY; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DEXAMETHASONE; ETOPOSIDE; FLUDARABINE; METHYLPREDNISOLONE; MONOCLONAL ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; X LINKED INHIBITOR OF APOPTOSIS; ANTINEOPLASTIC AGENT;

BLOOD CLOTTING DISORDER; BONE MARROW SUPPRESSION; CANDIDIASIS; CARDIOVASCULAR DISEASE; CASE REPORT; CHILD; ENGRAFTMENT SYNDROME; FEVER; GRAFT VERSUS HOST REACTION; HEMOPHAGOCYTIC SYNDROME; HEPATOSPLENOMEGALY; HERPETIC STOMATITIS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LETTER; MALE; MULTIPLE ORGAN FAILURE; NEUROTOXICITY; PARAINFLUENZA VIRUS 2; PARAINFLUENZA VIRUS INFECTION; POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RASH; SEPSIS; SINGLE DRUG DOSE; STEM CELL TRANSPLANTATION; X LINKED INHIBITOR OF APOPTOSIS DEFICIENCY; ALLOTRANSPLANTATION; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; REVIEW; UNRELATED DONORS; X CHROMOSOME LINKED DISORDER;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; CHILD, PRESCHOOL; GENETIC DISEASES, X-LINKED; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; LYMPHOPROLIFERATIVE DISORDERS; MALE; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; UNRELATED DONORS;

EID: 84881379235     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-01-478735     Document Type: Letter

References (5)

1. Marsh RA, Rao K, Satwani P, et al. Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes. Blood. 2013;121(6):877-883.
2. Jost PJ, Grabow S, Gray D, et al. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature. 2009;460(7258):1035-1039.
3. Schattenberg JM, Schuchmann M. Shortcut to death. Hepatology. 2009;50(6):2040-2043.
4. Straathof KC, Rao K, Eyrich M, et al. Haemopoietic stem-cell transplantation with antibody-based minimal-intensity conditioning: a phase 1/2 study. Lancet. 2009;374(9693):912-920.
5. Pachlopnik Schmid J, Côte M, Ménager MM, et al. Inherited defects in lymphocyte cytotoxic activity. Immunol Rev. 2010;235(1):10-23.