Synthesis and in vitro cytostatic activity of 1,2- and 1,3- diacylglycerophosphates of clofarabine

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5414-5419

  Tsybulskaya, Ilona ^a   Kulak, Tamara ^a   Baranovsky, Alexander ^a   Golubeva, Marina ^a   Kuzmitsky, Boleslav ^a   Kalinichenko, Elena ^a  

^a INSTITUTE OF BIOORGANIC CHEMISTRY   (Belarus)

Author keywords

Antitumor activity; Clofarabine; Phosphoramidite approach 1,2 , 1,3 Diacylglycerophospholipids; Prodrugs

Indexed keywords

[2 CHLORO 9 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL)ADENINE] 5' (1,2 DI O MYRISTOYL SN GLYCER 3 YL)PHOSPHATE; [2 CHLORO 9 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL)ADENINE] 5' (1,2 DI O PALMITOYL SN GLYCER 3 YL)PHOSPHATE; [2 CHLORO 9 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL)ADENINE] 5' (1,3 DI O MYRISTOYLGLYCER 2 YL)PHOSPHATE; [2 CHLORO 9 (2 DEOXY 2 FLUORO BETA DEXTRO ARABINOFURANOSYL)ADENINE] 5' (1,3 DI O PALMITOYLGLYCER 2 YL)PHOSPHATE; ANTINEOPLASTIC AGENT; CLOFARABINE; PHOSPHATIDIC ACID; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOSTASIS; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY;

1,2-, 1,3-DIACYLGLYCEROPHOSPHOLIPIDS; ANTITUMOR ACTIVITY; CLOFARABINE; PHOSPHORAMIDITE APPROACH; PRODRUGS;

ADENINE NUCLEOTIDES; ARABINONUCLEOSIDES; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOSTATIC AGENTS; GLYCEROPHOSPHATES; HELA CELLS; HL-60 CELLS; HUMANS; MCF-7 CELLS;

EID: 84881371896     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.019     Document Type: Article

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