C-Glucosides with heteroaryl thiophene as novel sodium-dependent glucose cotransporter 2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5561-5572

  Koga, Yuichi ^a   Sakamaki, Shigeki ^a   Hongu, Mitsuya ^a   Kawanishi, Eiji ^a   Sakamoto, Toshiaki ^a   Yamamoto, Yasuo ^a   Kimata, Hirotaka ^a   Nakayama, Keiko ^a   Kuriyama, Chiaki ^a   Matsushita, Yasuaki ^a   Ueta, Kiichiro ^a   Tsuda Tsukimoto, Minoru ^a   Nomura, Sumihiro ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Canagliflozin; Glucoside; SGLT2 inhibitor; Thiophene; Type 2 diabetes

Indexed keywords

1 [BETA DEXTRO GLUCOPYRANOSYL] 4 METHYL 3 [5 [2 PYRIMIDYL] 2 THIENYLMETHYL]BENZENE; 1 [BETA DEXTRO GLUCOPYRANOSYL] 4 METHYL 3 [5 [3 PYRIDYL] 2 THIENYLMETHYL]BENZENE; 1 [BETA DEXTRO GLUCOPYRANOSYL] 4 METHYL 3 [5 [5 PYRIMIDYL] 2 THIENYLMETHYL]BENZENE; 1 [BETA DEXTRO GLUCOPYRANOSYL] 4 METHYL 3 [5 [5 THIAZOLYL] 2 THIENYLMETHYL]BENZENE; 4 CHLORO 1 [BETA DEXTRO GLUCOPYRANOSYL] 3 [5 [2 PYRAZOL 1 YL] 2 THIENYLMETHYL]BENZENE; 4 CHLORO 1 [BETA DEXTRO GLUCOPYRANOSYL] 3 [5 [3 PYRIDYL] 2 THIENYLMETHYL]BENZENE; 4 CHLORO 3 [5[6 FLUORO 3 PYRIDYL] 2 THIENYLMETHYL] 1 [BETA DEXTRO GLUCOPYRANOSYL]BENZENE; CANAGLIFLOZIN; GLUCOSIDE; PROTEIN INHIBITOR; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SODIUM DEPENDENT GLUCOSE COTRANSPORTER 2 INHIBITOR; TA 3404; THIOPHENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG SYNTHESIS; LIPID DIET; MALE; MAXIMUM PLASMA CONCENTRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

MUS;

CANAGLIFLOZIN; GLUCOSIDE; SGLT2 INHIBITOR; THIOPHENE; TYPE 2 DIABETES;

ANIMALS; BLOOD GLUCOSE; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; DIET, HIGH-FAT; GLUCOSIDES; HALF-LIFE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MICE; MONOSACCHARIDES; PROTEIN BINDING; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-GLUCOSE TRANSPORTER 1; SODIUM-GLUCOSE TRANSPORTER 2; THIOPHENES;

EID: 84881371173     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.05.048     Document Type: Article

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