Synthesis and antioxidant activity of a novel series of pyrazolotriazine, coumarin, oxoazinone, and pyrazinopyrimidine derivatives

Archiv der Pharmazie

Volumn 346, Issue 8, 2013, Pages 626-634

  Gouda, Moustafa A ^a,b  

^a Mansoura University   (Egypt)

^b TAIBAH UNIVERSITY   (Saudi Arabia)

Author keywords

ABTS antioxidant assay; Bleomycin dependent DNA damage; Coumarin; Oxopropanenitrile; Pyrazolotriazone; Pyrimidine

Indexed keywords

2 (2 (3 (1H INDOL 3 YL) 1H PYRAZOL 5 YL)HYDRAZONO) 3 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 3 OXOPROPANENITRILE; 2 (2 (4 CHLOROPHENYL)HYDRAZONO) 3 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 3 OXOPROPANENITRILE; 2 (2 (4 METHOXYPHENYL)HYDRAZONO) 3 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 3 OXOPROPANENITRILE; 2 (2 (4 TOLYL)HYDRAZONO) 3 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 3 OXOPROPANENITRILE; 3 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 2 (2 (4,6 DIMETHYL 2H PYRAZOLO[3,4 B]PYRIDIN 3 Y)HYDRAZANO) 3 OXOPROPANENITRILE; 3 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 3 OXO 2 [2 [4 ((1,5DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H PYRAZOL 4 YL) DIAZENYL) 5 METHYL 1H PYRAZOL 3 YL]HYDRAZONO] PROPANENITRILE; 3 OXO 2H CHROMENE 3 CARBONITRILE; 3 OXO 3H BENZO[F] CHROMENE 3 CARBONITRILE; 3 OXO 3H NAPHTHO[2,1 B[1,4]]OXAZINE 3 CARBONITRILE; 3,4,8,9,9A PENTAZA 5,7 DIMETHYL 1 OXO 9,9A DIHYDRO 1H FLUORENE 2 CARBONITRILE; 4,6 DIHYDRO 7 (1H INDOL 3 YL) 4 OXOPYRAZOLO[5,1 C][1,2,4]TRIAZINE 3 CARBONITRILE; 4,7 DIOXO 2 THIOXO 1,2,3,4,7,8 HEXAHYDROPTERIDINE 6 CARBONITRILE; 5 METHOXY 8 METHYL 2,6 DIOXO 6,9 DIHYDRO 2H PYRANO [2,3 G]CHROMENE 3 CARBONITRILE; 8 ((2,3 DIMETHYL 5 OXO 1 PHENYL 2,5 DIHYDRO 1H PYRAZOL 4 YL)DIAZENYL) 7 METHYL 4 OXO 4,6 DIHYDROPYRAZOLO[5,1 C] [1,2,4]TRIAZINE 3 CARBONITIRLE; ASCORBIC ACID; BLEOMYCIN; CARBON NITROGEN MONOCYCLE; COUMARIN; FREE RADICAL; OXOAZINONE; PRAZINOPYRIMIDINE DERIVATIVE; PYRAZOLOTRIAZINE; PYRIDO[2,3:3,4] 4 OXO 4,6DIHYDROPYRAZOLO[5,1 C][1,2,4]TRIAZINE 3 CARBONITRILE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DNA DAMAGE; DRUG SYNTHESIS; HEATING; HYDROLYSIS; IN VITRO STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ABTS ANTIOXIDANT ASSAY; BLEOMYCIN-DEPENDENT DNA DAMAGE; COUMARIN; OXOPROPANENITRILE; PYRAZOLOTRIAZONE; PYRIMIDINE;

ANTIOXIDANTS; ASCORBIC ACID; BENZOTHIAZOLES; BLEOMYCIN; COUMARINS; DNA DAMAGE; DRUG DESIGN; MOLECULAR STRUCTURE; PTERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS; TRIAZINES;

EID: 84881370504     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201300128     Document Type: Article

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