Increased Reticulocytosis during Infancy Is Associated with Increased Hospitalizations in Sickle Cell Anemia Patients during the First Three Years of Life

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Meier, Emily Riehm ^a,b,c   Byrnes, Colleen ^a   Lee, Y Terry ^a   Wright, Elizabeth C ^a   Schechter, Alan N ^a   Luban, Naomi L C ^b,c   Miller, Jeffery L ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN;

AREA UNDER THE CURVE; ARTICLE; CHILD; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; HEMOGLOBIN BLOOD LEVEL; HIGH RISK PATIENT; HOSPITALIZATION; HUMAN; INFANCY; INFANT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; NEWBORN SCREENING; PATIENT IDENTIFICATION; PREDICTIVE VALUE; PRESCHOOL CHILD; RECEIVER OPERATING CHARACTERISTIC; RETICULOCYTE COUNT; RETICULOCYTOSIS; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SICKLE CELL ANEMIA;

ANEMIA, SICKLE CELL; CHILD, PRESCHOOL; HEMOGLOBINS; HOSPITALIZATION; HUMANS; INFANT; LEUKOCYTE COUNT; LOGISTIC MODELS; PROPORTIONAL HAZARDS MODELS; RETICULOCYTES; RETICULOCYTOSIS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 84881363412     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070794     Document Type: Article

References (28)

1. Serjeant GR, Serjeant BE (2001) Sickle Cell Disease 3rd ed. Oxford, England: Oxford University Press. 792 p.
2. Pearson HA, Spencer RP, Cornelius EA, (1969) Functional asplenia in sickle-cell anemia. N Engl J Med 281: 923-926.
3. Gaston MH, Verter JI, Woods G, Pegelow C, Kelleher J, et al. (1986) Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial. N Engl J Med 314: 1593-1599.
4. Battersby AJ, Knox-Macaulay HH, Carrol ED, (2010) Susceptibility to invasive bacterial infections in children with sickle cell disease. Pediatr Blood Cancer 55: 401-406.
5. Adams R, McKie VC, Hsu L, Files B, Vichinsky E, et al. (1998) Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med 339: 5-11.
6. Walters MC, Patience M, Leisenring W, Eckman JR, Scott JP, et al. (1996) Bone marrow transplantation for sickle cell disease. N Engl J Med 335: 369-376.
7. Platt OS, (2008) Hydroxyurea for the treatment of sickle cell anemia. N Engl J Med 358: 1362-1369.
8. Josephson CD, Su LL, Hillyer KL, Hillyer CD, (2007) Transfusion in the patient with sickle cell disease: a critical review of the literature and transfusion guidelines. Transfus Med Rev 21: 118-33.
9. Weatherall DJ, Clegg JB, (2001) Inherited hemoglobin disorders: an increasing global health problem. Bull World Health Organ 79: 704-712.
10. McGann PT, Ferris MG, Macosso P, de Oliveira V, Ramamurthy U, et al. (2012) A prospective pilot newborn screening and treatment program for sickle cell anemia in the Republic of Angola. Blood 120: Abstract #480.
11. Sebastiani P, Solovieff N, Hartley SW, Milton JN, Riva A, et al. (2010) Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. Am J Hematol 85: 29-35.
12. Gaston M, Rosse WF, (1982) The cooperative study of sickle cell disease: review of study design and objectives. Am J Pediatr Hematol Oncol 4: 197-201.
13. Bray GL, Muenz L, Makris N, Lessin LS, (1994) Assessing clinical severity in children with sickle cell disease. Preliminary results from a cooperative study. Am J Pediatr Hematol Oncol 16: 50-54.
14. Gill FM, Sleeper LA, Weiner SJ, Brown AK, Bellevue R, et al. (1995) Clinical events in the first decade in a cohort of infants with sickle cell disease. Cooperative Study of Sickle Cell Disease. Blood 86: 776-783.
15. Miller ST, Sleeper LA, Pegelow CH, Enos LE, Wang WC, et al. (2000) Prediction of adverse outcomes in children with sickle cell disease. N Engl J Med 342: 83-89.
16. Quinn CT, Lee NJ, Shull EP, Ahmad N, Rogers ZR, et al. (2008) Prediction of adverse outcomes in children with sickle cell disease: a study of the Dallas Newborn Cohort. Blood 111: 544-548.
17. Wang WC, Ware RE, Miller ST, Iyer RC, Casella JF, et al. (2011) Hydroxycarbamide in very young children with sickle-cell anaemia: a mulicentre, randomised controlled trial (BABY HUG). Lancet 377: 1663-72.
18. Emond AM, Collis R, Darvill D, Higgs DR, Maude GH, et al. (1985) Acute splenic sequestration in homozygous sickle cell disease: natural history and management. J Pediatr 107: 201-6.
19. Brugnara C (2003) Reference Values in Infancy and Childhood. In: Nathan DG, Ginsburg D, Orkin SH, Look AT, editors. Hematology of Infancy and Childhood, 6th ed. Philadelphia: W.B. Saunders. 1835-1864.
20. Hanley JA, McNeil BJ, (1982) The meaning and use of the area under a Receiver Operator Characteristic (ROC) curve. Radiology 143: 29-36.
21. O'Brien RT, Pearson HA, (1971) Physiologic anemia of the newborn infant. J Pediatr 79: 132-138.
22. Oneal PA, Gantt NM, Schartz JD, Bhanu NV, Lee YT, et al. (2006) Fetal hemoglobin silencing in humans. Blood 108: 2081-86.
23. Serjeant GR, Grandison Y, Lowrie Y, Mason K, Phillips J, et al. (1981) The development of haematological changes in homozygous sickle cell disease: a cohort study from birth to 6 years. Br J Haematol 48: 533-543.
24. Silva CM, Giovani P, Viana MB, (2011) High reticulocyte count is an independent risk factor for cerebrovascular disease in children with sickle cell anemia. Pediatr Blood Cancer 56: 116-121.
25. Quinn CT, Rogers ZR, McCavit TL, Buchanan GR, (2010) Improved survival of children and adolescents with sickle cell disease. Blood 115: 3447-3452.
26. Meier ER, Byrnes C, Weissman M, Noel P, Luban NL, et al. (2011) Expression patterns of fetal hemoglobin in sickle cell erythrocytes are both patient- and treatment-specific during childhood. Pediatr Blood Cancer 56: 103-109.
27. Noguchi CT, Rodgers GP, Serjeant G, Schechter AN, (1988) Levels of fetal hemoglobin necessary for treatment of sickle cell disease. N Engl J Med 318: 96-99.
28. Browne PV, Hebbel RP, (1996) CD36-positive stress reticulocytosis in sickle cell anemia. J Lab Clin Med 127: 340-347.