The impact of clinical factors, riluzole and therapeutic interventions on ALS survival: A population based study in Modena, Italy

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Volumn 14, Issue 5-6, 2013, Pages 338-345

  Georgoulopoulou, Eleni ^a   Fini, Nicola ^a   Vinceti, Marco ^a   Monelli, Marco ^b   Vacondio, Paolo ^c   Bianconi, Giorgia ^b   Sola, Patrizia ^a   Nichelli, Paolo ^a   Mandrioli, Jessica ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c Health District ^*  (Italy)

Author keywords

Prognostic factors; Riluzole; Survival; Therapeutic intervention

Indexed keywords

RILUZOLE;

ADULT; AGE; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CORRELATION ANALYSIS; ENTERIC FEEDING; FEMALE; GENDER; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; NONINVASIVE VENTILATION; OVERALL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL; SURVIVAL RATE; SURVIVAL TIME; TRACHEOSTOMY;

AGE FACTORS; AGED; AMYOTROPHIC LATERAL SCLEROSIS; COHORT STUDIES; ENTERAL NUTRITION; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HUMANS; ITALY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NONINVASIVE VENTILATION; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RILUZOLE; SEX FACTORS; TRACHEOSTOMY; TREATMENT OUTCOME;

EID: 84881337118     PISSN: 21678421     EISSN: 21679223     Source Type: Journal    
DOI: 10.3109/21678421.2013.763281     Document Type: Article

References (26)

1. Beghi E, 1. Chiò A, Couratier P, Esteban J, Hardiman O, Logroscino G, et al. The epidemiology and treatment of ALS: Focus on the heterogeneity of the disease and critical appraisal of therapeutic trials. Amyotroph Lateral Scler. 2011 ; 12: 1-10
2. Chiò A, Logroscino G, Hardiman O, Swingler R, Mitchell D, Beghi E, et al. Prognostic factors in ALS: A critical review. Amyotroph Lateral Scler. 2009 ; 10: 310-23
3. Radunovic A, Annane D, Jewitt K, Mustfa N. M echanical ventilation for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev 2009; 4: CD004427
4. Miller R G, Mitchell J D, Moore D H. R iluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev 2012; 3: CD001447
5. Ng L, Khan F, Mathers S. M ultidisciplinary care for adults with amyotrophic lateral sclerosis or motor neuron disease. Cochrane Database Syst Rev 2009; 4: CD007425
6. Katzberg H D, Benatar M. E nteral tube feeding for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev 2011; 1: CD004030
7. Bourke SC, Tomlinson M, Williams T L, Bullock R E, Shaw PJ, Gibson GJ. Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: A randomized controlled trial. Lancet Neurol. 2006 ; 5: 140-7
8. Georgoulopoulou E, Vinceti M, Bonvicini F, Sola P, Goldoni CA, de Girolamo G, et al. Changing incidence and subtypes of ALS in Modena, Italy: A 10-years prospective study. Amyotroph Lateral Scler. 2011 ; 12: 451-7
9. Logroscino G, Traynor BJ, Hardiman O, Chio A, Couratier P, Mitchell JD, et al. Descriptive epidemiology of amyotrophic lateral sclerosis: New evidence and unsolved issues. J Neurol Neurosurg Psychiatry. 2008 ; 79: 6-11
10. Chiò A, Calvo A, Moglia C, Mazzini L, Mora G ; PARALS study group. Phenotypic heterogeneity of amyotrophic lateral sclerosis: A population based study. J Neurol Neurosurg Psychiatry. 2011 ; 82: 740-6
11. Atsuta N, Watanabe H, Ito M, Tanaka F, Tamakoshi A, Nakano I, et al. Age at onset infl uences on wide-ranged clinical features of sporadic amyotrophic lateral sclerosis. J Neurol Sci. 2008 ; 276: 163-9
12. Bensimon G, Lacomblez L, Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med. 1994 ; 330: 585-91
13. Rowland LP. R iluzole for the treatment of amyotrophic lateral sclerosis: Too soon to tell? N Engl J Med. 1994 ; 330: 636-7
14. Mitchell JD, O'B rien MR, Joshi M. A udit of outcomes in motor neuron disease (MND) patients treated with riluzole. Amyotroph Lateral Scler Other Motor Neuron Disord. 2006 ; 7: 67-71
15. Traynor B J, Alexander M, Corr B, Frost E, Mahon L, Hardiman O. Riluzole and prognosis in ALS: Fi ndings of the Irish ALS register over a fi ve-year study period (1995-2000). Amyotroph Lateral Scler Other Motor Neuron Disord. 2001 ; 2(Suppl 2): 43-4
16. Brooks BR, Belden DS, Roelke K, Parnell J, Peper S, Houdek A, et al. Survival in non-riluzole treated amyotrophic lateral sclerosis (ALS) - motor neuron disease (MND) patients with disease onset before and since 1996 is identical: A clinic-based epidemiological study. Amyotroph Lateral Scler Other Motor Neuron Disord. 2001 ; 2: 60-1
17. Turner MR, Bakker M, Sham P, Shaw CE, Leigh PN, Al-Chalabi A. The Kings'Database 1999-2000: An analysis of the effect on survival of interventions in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2001; 2(Suppl 2): 43
18. Zoccolella S, Beghi E, Palagano G, Fraddosio A, Guerra V, Samarelli V, et al. Riluzole and amyotrophic lateral sclerosis survival: A population based study in southern Italy. Eur J Neurol. 2007 ; 14: 262-8
19. EFNS Task Force on Diagnosis and Management of Amyotrophic Lateral Sclerosis: Andersen PM, Abrahams S, Borasio GD, de Carvalho M, Chio A, van Damme P, et al. EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS): Revised report of an EFNS task force. Eur J Neurol. 2012 ; 19: 360-75
20. Traynor BJ, Alexander M, Corr B, Frost E, Hardiman O. Effect of a multidisciplinary amyotrophic lateral sclerosis(ALS) clinic on ALS survival: A population based study, 1996-2000. J Neurol Neurosurg Psychiatry. 2003 ; 74: 1258-61
21. Chio A, Bottacchi E, Buffa C, Mutani R, Mora G ; P ARALS. Positive effects of tertiary centres for amyotrophic lateral sclerosis on outcome and use of hospital facilities. J Neurol Neurosurg Psychiatry. 2006 ; 77: 948-50
22. Zoccolella S, Beghi E, Palagano G, Fraddosio A, Guerra V, Lepore V, et al. ALS multidisciplinary clinic and survival: Results from a population based study in southern Italy. J Neurol. 2007 ; 254: 1107-12
23. Chi ò A, Calvo A, Ghiglione P, Mazzini L, Mutani R, Mora G ; PARALS. Tracheostomy in amyotrophic lateral sclerosis: A 10-year population based study in Italy. J Neurol Neurosurg Psychiatry. 2010 ; 81: 1141-3
24. Bensimon G, Lacomblez L, Delumeau J C, Bejuit R, Truffi net P, Meininger V ; Riluzole/ALS Study Group II. A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis. J Neurol. 2002 ; 249: 609-15
25. Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Lancet. 1996 ; 347: 1425-31
26. Chiò A, Canosa A, Gallo S, Cammarosano S, Moglia C, Fuda G, et al. ALS clinical trials: Do enrolled patients accurately represent the ALS population? Neurology. 2011 ; 77: 1432-7