NCI-H295R, a Human Adrenal Cortex-Derived Cell Line, Expresses Purinergic Receptors Linked to Ca2+-Mobilization/Influx and Cortisol Secretion

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Nishi, Haruhisa ^a   Arai, Hirokazu ^a   Momiyama, Toshihiko ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANGIOTENSIN II; CALCIUM ION; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; CELL PROTEIN; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR A2A; G PROTEIN COUPLED RECEPTOR A2B; GLUCOCORTICOID; HYDROCORTISONE; MESSENGER RNA; NUCLEOTIDASE; PURINERGIC P2X5 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; PURINERGIC P2Y14 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; PURINERGIC RECEPTOR; STROMAL INTERACTION MOLECULE 1; THAPSIGARGIN; TRANSIENT RECEPTOR C CHANNEL; UNCLASSIFIED DRUG;

ADRENAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL LEVEL; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROCORTISONE RELEASE; MOLECULAR DYNAMICS; NUCLEOTIDE METABOLISM; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEROIDOGENESIS;

ADENOSINE TRIPHOSPHATE; ADRENAL CORTEX; ANGIOTENSIN II; BUCLADESINE; CALCIUM; CALCIUM SIGNALING; CELL LINE; GENE EXPRESSION; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; PURINERGIC AGONISTS; RECEPTORS, PURINERGIC; RECEPTORS, PURINERGIC P2Y1; RNA INTERFERENCE; RNA, MESSENGER;

EID: 84881332658     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071022     Document Type: Article

References (47)

1. Burnstock G, (2006) Pathophysiology and Therapeutic Potential of Purinergic Signaling. Pharmacol Rev 58: 58-86.
2. Burnstock G, (2007) Purine and pyrimidine receptors. Cell Mol Life Sci 64: 1471-1483.
3. Burnstock G, Verkhratsky A, (2010) Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death. Cell Death Dis 1: e9.
4. Chen Y, Huang S, Wang S, (2008) Adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling pathway. Int J Biochem Cell B 40: 2815-2825.
5. Matsuoka H, Yamada K, Atarashi K, Takagi M, Sugimoto T, (1990) Role of adenosine A1 and A2 receptors in the regulation of aldosterone production in rat adrenal glands. Experienta 46: 726-728.
6. Ukena D, Daly J, Kirk K, Jacobson K, (1986) Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochromocytoma cells, platelets and fat cells. Life Sci 38: 797-807.
7. Kawamura M, Matsui T, Niitsu A, Kondo T, Ohno Y, et al. (1991) Extracellular ATP stimulates steroidogenesis in bovine adrenocortical fasciculata cells via P2 purinoceptors. Jpn J Pharmacol 56: 543-545.
8. Hoey D, Nicol M, Williams B, Walker S, (1994) Primary cultures of bovine inner zone adrenocortical cells secrete cortisol in response to adenosine 5′-triphosphate, adenosine 5′-diphosphate, and uridine 5′-triphosphate via a nucleotide receptor that may be coupled to two signal generation systems. Endocrinology 135: 1553-1560.
9. Nishi H, Kato F, Masaki E, Kawamura M, (2002) ADP-sensitive purinoceptors induce steroidogenesis via adenylyl cyclase activation in bovine adrenocortical fasciculata cells. Brit J Pharmacol 137: 177-184.
10. Kawamura M, Niitsu A, Nishi H, Masaki E, (2001) Extracellular ATP potentiates steroidogenic effect of adrenocorticotropic hormone in bovine adrenocortical fasciculata cells. Jpn J Pharmacol 85: 376-381.
11. Gazdar AF, Oie HK, Shackleton CH, Chen TR, Triche TJ, et al. (1990) Establishment and Characterization of a Human Adrenocortical Carcinoma Cell Line That Expresses Multiple Pathways of Steroid Biosynthesis. Cancer Res 50: 5488-5496.
12. Rainey WE, Bird IM, Mason JI, (1994) The NCI-H295 cell line: a pluripotent model for human adrenocortical studies. Mol Cell Endocrinol 100: 45-50.
13. Bird I, Mason J, WE R, (1995) Hormonal regulation of angiotensin II type 1 receptor expression and AT1-R mRNA levels in human adrenocortical cells. Endocr Res 21: 169-182.
14. Suda N, Shibata H, Kurihara I, Ikeda Y, Kobayashi S, et al. (2011) Coactivation of SF-1-Mediated Transcription of Steroidogenic Enzymes by Ubc9 and PIAS1. Endocrinology 152: 2266-2277.
15. Tkachenko IV, Jääskeläinen T, Jääskeläinen J, Palvimo JJ, Voutilainen R, (2011) Interleukins 1α and 1β as regulators of steroidogenesis in human NCI-H295R adrenocortical cells. Steroids 76: 1103-1115.
16. Xing Y, Cohen A, Rothblat G, Sankaranarayanan S, Weibel G, et al. (2011) Aldosterone production in human adrenocortical cells Is stimulated by high-density lipoprotein 2 (HDL2) through increased expression of aldosterone synthase (CYP11B2). Endocrinology 152: 751-763.
17. Belloni AS, Malendowicz Lk, Rucinski M, Guidolin D, Nussdorfer GG, (2007) Galanin stimulates cortisol secretion from human adrenocortical cells through the activation of galanin receptor subtype 1 coupled to the adenylate cyclase-dependent signaling cascade. Int J Mol Med 20: 859-864.
18. Condon J, Gosden C, Gardener D, Nickson P, Hewison M, et al. (1988) Expression of Type 2 11beta-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life. J Clin Endocr Metab 83: 4490-4497.
19. Gallo-Payet N, Grazzini E, Côté M, Chouinard L, Chorvátová A, et al. (1996) Role of Ca2+ in the action of adrenocorticotropin in cultured human adrenal glomerulosa cells. J Clin Invest 98: 460-466.
20. Nishi H, (1999) Two different P2Y receptors linked to steroidogenesis in bovine adrenocortical cells. Jpn J Pharmacol 81: 194-199.
21. Pastan I, Macchia V, (1967) Mechanism of thyroid-stimulating hormone action. Studies with dibutyl 3′,5′-adenosine monophosphate and lecithinase C. J Biol Chem 242: 5757-5761.
22. Nishi H, Hori S, Niitsu A, Kawamura M, (2004) Adenosine 5′-(gamma-thio) triphosphate (ATPgammaS) stimulates both P2Y receptors linked to inositol phosphates production and cAMP accumulation in bovine adrenocortical fasciculata cells. Life Sci 74: 1181-1190.
23. Guibert C, Marthan R, Savineau J, (1996) Angiotensin II-induced Ca(2+)-oscillations in vascular myocytes from the rat pulmonary artery. Am J Physiol Lung Cell Mol Physiol 270: L637-L642.
24. Matute C, Pulakat L, Río C, Valcárcel C, Miledi R, (1994) Properties of angiotensin II receptors in glial cells from the adult corpus callosum. Proc Natl Acad Sci USA 91: 3774-3778.
25. Kawamura M, Terasaka O, Ebisawa T, Kondo I, Masaki E, et al. (2003) Integrity of actin-network is involved in uridine 5′-triphosphate evoked store-operated Ca2+ entry in bovine adrenocortical fasciculata cells. J Pharmacol Sci 91: 23-33.
26. Lewis R, Cahalan M, (1995) Potassium and calcium channels in lymphocytes. Annu Rev Immunol 13: 623-653.
27. Gill D, Waldron R, Rys-Sikora K, Ufret-Vincenty C, Graber M, et al. (1996) Calcium pools, calcium entry, and cell growth. Bioscience Rep 16: 139-157.
28. Burnstock G, (2007) Physiology and Pathophysiology of Purinergic Neurotransmission. Physiol Rev 87: 659-797.
29. Kimura T, (1981) ACTH stimulation on cholesterol side chain cleavage activity of adrenocortical mitochondria. Transfer of the stimulus from plasma membrane to mitochondria. Mol Cell Biochem 36: 105-122.
30. Zimmermann H, (2000) Extracellular metabolism of ATP and other nucleotides. N-S Arch Pharmakol 362: 299-309.
31. Doyle MP, Linden J, Duling BR, (1994) Nucleoside-induced arteriolar constriction: a mast cell-dependent response. Am J Physiology 226: H2042-2050.
32. Bo X, Jiang L-H, Wilson HL, Kim M, Burnstock G, et al. (2003) Pharmacological and Biophysical Properties of the Human P2X5 Receptor. Mol Pharmacol 63: 1407-1416.
33. Zhou X, Galligan JJ, (1996) P2X purinoceptors in cultured myenteric neurons of guinea-pig small intestine. The Journal of Physiology 496: 719-729.
34. Slavinski EA, Jull JW, Auersperg N, (1976) Steroidogenic pathways and trophic response to adrenocorticotrophin of cultured adrenocortical cells in different states of differentiation. J Endocrinol 69: 385-394.
35. Calderwood S, Stevenson M, Hahn G, (1988) Effects of heat on cell calcium and inositol lipid metabolism. Radiat Res 113: 414-425.
36. James G, Butt AM, (2002) P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system. Eur J Pharmacol 447: 247-260.
37. Bird IM, Mathis JM, Mason JI, Rainey WE, (1995) Ca2+-regulated expression of steroid hydroxylases in H295R human adrenocortical cells. Endocrinology 136: 5677-5684.
38. Spät A, (1988) Stimulus-secretion coupling in angiotensin-stimulated adrenal glomerulosa cells. J Steroid Biochem 29: 443-453.
39. Enyeart JA, Liu H, Enyeart JJ, (2010) cAMP Analogs and Their Metabolites Enhance TREK-1 mRNA and K+ Current Expression in Adrenocortical Cells. Mol Pharmacol 77: 469-482.
40. Liu H, Enyeart JA, Enyeart JJ, (2008) ACTH inhibits bTREK-1 K+ channels through multiple cAMP-dependent signaling pathways. J Gen Physiol 132: 279-294.
41. Liu H, Enyeart JA, Enyeart JJ, (2007) Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis. Am J Physiol Cell Physiol 293: C682-695.
42. Clerc RG, Stauffer A, Weibel F, Hainaut E, Perez A, et al. (2010) Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels. J Hypertens 28: 1676-1686.
43. Imagawa K, Okayama S, Takaoka M, Kawata H, Naya N, et al. (2006) Inhibitory effect of efonidipine on aldosterone synthesis and secretion in human adrenocarcinoma (H295R) cells. J Cardiovasc Pharmacol 47: 133-138.
44. Akizuki O, Inayoshi A, Kitayama T, Yao K, Shirakura S, et al. (2008) Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R. Eur J Pharmacol 584: 424-434.
45. Qin H, Kent P, Isales C, Parker P, Wilson M, et al. (2009) The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells. J Endocrinol 202: 77-86.
46. Aritomi S, Wagatsuma H, Numata T, Uriu Y, Nogi Y, et al. (2011) Expression of N-type calcium channels in human adrenocortical cells and their contribution to corticosteroid synthesis. Hypertens Res 34: 193-201.
47. Niitsu A, (1992) Calcium is essential for ATP-induced steroidogenesis in bovine adrenocortical fasciculata cells. Jpn J Pharmacol 60: 269-274.