Mitochondria toxin-induced acute cochlear cell death indicates cellular activity-correlated energy consumption

European Archives of Oto-Rhino-Laryngology

Volumn 270, Issue 9, 2013, Pages 2403-2415

  Zou, Jing ^a,b   Zhang, Ya ^b   Zhang, Weikai ^b,f   Poe, Dennis ^d,e   Zhai, Suoqiang ^c   Yang, Shiming ^c   Pyykkö, Ilmari ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

ATP; Auditory; Brainstem response; Dehydrogenase; DNA fragmentation; Hearing loss; Metabolism; Nuclear membrane; Programmed cell death; Respiratory chain; Succinate; Vertigo

Indexed keywords

3 NITROPROPIONIC ACID; PROPIDIUM IODIDE;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL DEATH; COCHLEA; COCHLEA FENESTRA; DNA STRAND; ENERGY CONSUMPTION; EPITHELIUM CELL; GUINEA PIG; HAIR CELL; HEARING IMPAIRMENT; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRIAL TOXICITY; NEUROFILAMENT; NONHUMAN; PERCEPTION DEAFNESS; PRIORITY JOURNAL; SPIRAL GANGLION; SPIRAL LIGAMENT; VESTIBULAR DISORDER;

ANIMALS; AUDITORY THRESHOLD; CELL DEATH; COCHLEA; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; EVOKED POTENTIALS, AUDITORY; GUINEA PIGS; HAIR CELLS, AUDITORY; HEARING LOSS, SENSORINEURAL; MITOCHONDRIA; NITRO COMPOUNDS; PROPIONATES; RATS; RATS, SPRAGUE-DAWLEY; SPIRAL GANGLION;

EID: 84881318060     PISSN: 09374477     EISSN: 14344726     Source Type: Journal    
DOI: 10.1007/s00405-012-2267-1     Document Type: Article

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