Stem cell-based therapy for prevention of delayed fracture union: A randomized and prospective preliminary study

Molecular Therapy

Volumn 21, Issue 8, 2013, Pages 1631-1638

  Liebergall, Meir ^a   Schroeder, Josh ^a   Mosheiff, Rami ^a   Gazit, Zulma ^a   Yoram, Zilberman ^a   Rasooly, Linda ^a   Daskal, Anat ^a   Khoury, Amal ^a   Weil, Yoram ^a   Beyth, Shaul ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BLOOD ANALYSIS; BONE MARROW BIOPSY; BONE MINERALIZATION; CLINICAL ARTICLE; COMPOSITE GRAFT; CONTROLLED STUDY; DISTAL TIBIA FRACTURE; FEMALE; FLUOROSCOPY; FRACTURE HEALING; FRACTURE NONUNION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRAMEDULLARY NAIL; INTRAMEDULLARY NAILING; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MINIMALLY INVASIVE PROCEDURE; OPEN STUDY; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PATIENT SAFETY; PLATE FIXATION; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; THERAPY EFFECT; THROMBOCYTE RICH PLASMA;

ADOLESCENT; ADULT; CELL- AND TISSUE-BASED THERAPY; FEMALE; FRACTURES, UNUNITED; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; QUALITY OF LIFE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84881312927     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.109     Document Type: Article

References (30)

1. Megas, P and Panagiotis, M (2005). Classification of non-union. Injury 36 Suppl 4: S30-S37.
2. Clancey, GJ and Hansen, ST Jr (1978). Open fractures of the tibia: A review of one hundred and two cases. J Bone Joint Surg Am 60: 118-122.
3. Zelle, BA, Bhandari, M, Espiritu, M, Koval, KJ and Zlowodzki, M; Evidence-Based Orthopaedic Trauma Working Group (2006). Treatment of distal tibia fractures without articular involvement: A systematic review of 1125 fractures. J Orthop Trauma 20: 76-79.
4. Phieffer, LS and Goulet, JA (2006). Delayed unions of the tibia. J Bone Joint Surg Am 88: 206-216.
5. Goulet, JA, Senunas, LE, DeSilva, GL and Greenfield, ML (1997). Autogenous iliac crest bone graft. Complications and functional assessment. Clin Orthop Relat Res 76-81.
6. Younger, EM and Chapman, MW (1989). Morbidity at bone graft donor sites. J Orthop Trauma 3: 192-195.
7. Sen, MK and Miclau, T (2007). Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions? Injury 38 Suppl 1: S75-S80.
8. Pittenger, MF, Mackay, AM, Beck, SC, Jaiswal, RK, Douglas, R, Mosca, JD et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147.
9. Kuo, TK, Ho, JH and Lee, OK (2009). Mesenchymal stem cell therapy for nonmusculoskeletal diseases: Emerging applications. Cell Transplant 18: 1013-1028.
10. Mauney, JR, Volloch, V and Kaplan, DL (2005). Role of adult mesenchymal stem cells in bone tissue engineering applications: Current status and future prospects. Tissue Eng 11: 787-802.
11. Aslan, H, Zilberman, Y, Kandel, L, Liebergall, M, Oskouian, RJ, Gazit, D et al. (2006). Osteogenic differentiation of noncultured immunoisolated bone marrow-derived CD105+ cells. Stem Cells 24: 1728-1737.
12. Oestern, HJ, Tscherne, H (1984). Pathophysiology and classification of soft tissue injuries associated with fractures. Springer Verlag: Berlin.
13. Einhorn, TA (1995). Enhancement of fracture-healing. J Bone Joint Surg Am 77: 940-956.
14. McKibbin, B (1978). The biology of fracture healing in long bones. J Bone Joint Surg Br 60-B: 150-162.
15. Müller, ME, Nazarian, S, Koch, P, Schatzker, J (1990). The Comprehensive Classification of Fractures of Long Bones, 1st edn. Springer-Verlag: Berlin and New York.
16. Guo, JJ, Tang, N, Yang, HL and Tang, TS (2010). A prospective, randomised trial comparing closed intramedullary nailing with percutaneous plating in the treatment of distal metaphyseal fractures of the tibia. J Bone Joint Surg Br 92: 984-988.
17. Im, GI and Tae, SK (2005). Distal metaphyseal fractures of tibia: A prospective randomized trial of closed reduction and intramedullary nail versus open reduction and plate and screws fixation. J Trauma 59: 1219-23; discussion 1223.
18. Heckman, JD and Sarasohn-Kahn, J (1997). The economics of treating tibia fractures. The cost of delayed unions. Bull Hosp Jt Dis 56: 63-72.
19. Bone, LB, Kassman, S, Stegemann, P and France, J (1994). Prospective study of union rate of open tibial fractures treated with locked, unreamed intramedullary nails. J Orthop Trauma 8: 45-49.
20. Banwart, JC, Asher, MA and Hassanein, RS (1995). Iliac crest bone graft harvest donor site morbidity. A statistical evaluation. Spine 20: 1055-1060.
21. Carreon, LY, Glassman, SD, Anekstein, Y and Puno, RM (2005). Platelet gel (AGF) fails to increase fusion rates in instrumented posterolateral fusions. Spine 30: E243-6; discussion E247.
22. Bruder, SP, Kraus, KH, Goldberg, VM and Kadiyala, S (1998). The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am 80: 985-996.
23. Chatterjea A, Meijer G, van Blitterswijk C, de Boer J (2010). Clinical application of human mesenchymal stromal cells for bone tissue engineering. Stem Cells Int 215: 1-12.
24. Marcacci, M, Kon, E, Moukhachev, V, Lavroukov, A, Kutepov, S, Quarto, R et al. (2007). Stem cells associated with macroporous bioceramics for long bone repair: 6-to 7-year outcome of a pilot clinical study. Tissue Eng 13: 947-955.
25. Redfern, DJ, Syed, SU and Davies, SJ (2004). Fractures of the distal tibia: Minimally invasive plate osteosynthesis. Injury 35: 615-620.
26. Marsh, JL, Slongo, TF, Agel, J, Broderick, JS, Creevey, W, DeCoster, TA et al. (2007). Fracture and dislocation classification compendium - 2007: Orthopaedic Trauma Association classification, database and outcomes committee. J Orthop Trauma 21 (10 Suppl): S1-133.
27. Gustilo, RB and Anderson, JT (1976). Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: Retrospective and prospective analyses. J Bone Joint Surg Am 58: 453-458.
28. Whelan, DB, Bhandari, M, McKee, MD, Guyatt, GH, Kreder, HJ, Stephen, D et al. (2002). Interobserver and intraobserver variation in the assessment of the healing of tibial fractures after intramedullary fixation. J Bone Joint Surg Br 84: 15-18.
29. Starr, AJ (2008). Fracture repair: Successful advances, persistent problems, and the psychological burden of trauma. J Bone Joint Surg Am 90 Suppl 1: 132-137.
30. Ware, JE, Kosinski, M, Keller SD (1995). SF-12: How to Score the SF-12 Physical and Mental Health Summary Scales. The Health Institute, New England Medical Center: Boston, M.A.