Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain

Journal of Clinical Investigation

Volumn 123, Issue 8, 2013, Pages 3373-3377

  Navaratna, Deepti ^a   Fan, Xiang ^a   Leung, Wendy ^a   Lok, Josephine ^a   Guo, Shuzhen ^a   Xing, Changhong ^a   Wang, Xiaoying ^a   Lo, Eng H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; GELATINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; UPREGULATION;

ANIMALS; BRAIN; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; ENZYME INDUCTION; HUMANS; MATRIX METALLOPROTEINASE 9; MICROVESSELS; PRIMARY CELL CULTURE; PROTEOLYSIS; RATS; RECEPTOR, TRKB; UP-REGULATION;

EID: 84881262919     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI65767     Document Type: Article

References (15)

1. Brands AM, Biessels GJ, de Haan EH, Kappelle LJ, Kessels RP. The effects of type 1 diabetes on cognitive performance: A meta-analysis. Diabetes Care. 2005;28(3):726-735.
2. Stewart R, Liolitsa D. Type 2 diabetes mellitus, cognitive impairment and dementia. Diabet Med. 1999;16(2):93-112.
3. Allen KV, Frier BM, Strachan MW. The relationship between type 2 diabetes and cognitive dysfunction: Longitudinal studies and their methodological limitations. Eur J Pharmacol. 2004;490(1-3):169-175.
4. Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM. Diabetes mellitus and the risk of dementia: the Rotterdam Study. Neurology. 1999; 53(9):1937-1942.
5. Qiu C, Kivipelto M, Aguero-Torres H, Winblad B, Fratiglioni L. Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex. J Neurol Neurosurg Psychiatry. 2004;75(6):828-833.
6. Xu WL, Qiu CX, Wahlin A, Winblad B, Fratiglioni L. Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Neurology. 2004;63(7):1181-1186.
7. Peila R, Rodriguez BL, Launer LJ, Honolulu-Asia Aging Study. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu- Asia Aging Study. Diabetes. 2002;51(4):1256-1262.
8. Kissela BM, et al. Epidemiology of ischemic stroke in patients with diabetes: The greater Cincinnati/ Northern Kentucky Stroke Study. Diabetes Care. 2005;28(2):355-359.
9. Schneider AT, et al. Ischemic stroke subtypes: A population-based study of incidence rates among blacks and whites. Stroke. 2004;35(7):1552-1556.
10. Wolf PA, D'Agostino RB, Belanger AJ, Kannel WB. Probability of stroke: A risk profile from the Framingham Study. Stroke. 1991;22(3):312-318.
11. Guo S, et al. Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci U S A. 2008;105(21):7582-7587.
12. Dugas JC, Mandemakers W, Rogers M, Ibrahim A, Daneman R, Barres BA. A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinal motor neurons. J Neurosci. 2008;28(33):8294-8305.
13. Michaluk P, et al. Beta-dystroglycan as a target for MMP-9, in response to enhanced neuronal activity. J Biol Chem. 2007;282(22):16036-16041.
14. Bracken BK, Turrigiano GG. Experience-dependent regulation of TrkB isoforms in rodent visual cortex. Dev Neurobiol. 2009;69(5):267-278.
15. Hwang JJ, Park MH, Choi SY, Koh JY. Activation of the trk signaling pathway by extracellular zinc. role of metalloproteinases. J Biol Chem. 2005; 280(12):11995-12001.