Evaluation of analgesic activity and toxicity of alkaloids in Myristica fragrans seeds in mice

Journal of Pain Research

Volumn 6, Issue , 2013, Pages 611-615

  Hayfaa, A Al Shammary ^a   Sahar, A A Malik Al Saadi ^b   Awatif, M Al Saeidy ^a  

^a UNIVERSITY OF THI QAR   (Iraq)

^b UNIVERSITY OF BASRAH   (Iraq)

Author keywords

Acetic acid; Analgesic; LD50; Mice; Nutmeg; Visceral pain

Indexed keywords

ACETIC ACID; ALCOHOL; ALKALOID; MYRISTICA FRAGRANS ALKALOID; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIZZINESS; FEMALE; GAIT DISORDER; LD 50; MALE; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; NUTMEG; SEED KERNEL; SEX DIFFERENCE; TOXICITY TESTING; TREATMENT RESPONSE; VISCERAL PAIN;

EID: 84881256364     PISSN: 11787090     EISSN: None     Source Type: Journal    
DOI: 10.2147/JPR.S45591     Document Type: Article

References (36)

1. Joseph J. The nutmeg: its botany, agronomy, production, composition, and uses. Journal of Plantation Crops. 1980;8(2):61-72.
2. Bamidele O, Akinnuga AM, Alagbonsi IA, Ojo OA, Olorunfemi JO, Akuyoma MA. Effects of ethanolic extract of Myristica fragrans Houtt. (nutmeg) on some heamatological indices in albino rats. International Journal of Medicine and Medical Sciences. 2011;3(6):215-218.
3. Nadkarni K. Myristica Fragrans. In: Indian Materia (3rd ed.), Bombay: Bombay Popular Prakashan; 1988.
4. Broadhurst CL, Polansky MM, Anderson RA. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem. 2000;48(3):849-852.
5. Adedire CO. Use of nutmeg Myristica fragrans (Houtt.) powder and oil for the control of cowpea storage bruchid, Callosobruchusmacul atusFabricius. ZeitschriftfürPflanzenkrankheiten und Pflanzenschutz. 2002;109(2):193-199.
6. Chaubey MK. Fumigant toxicity of essential oils from some common spices against pulse beetle Callosobruchuschinensis (Coleoptera: Bruchidae), JOleo Sci. 2008;57(3):171-179.
7. Jung WC, Jang YS, Hieu TT, Lee CK, Ahn YJ. Toxicity of Myristica fagrans seed compounds against Blattellagermanica (Dictyoptera: Blattellidae). J Med Entomol. 2007;44(3):524-529.
8. Park IK, Kim JN, Lee YS, Lee SG, Ahn YS, Shin SC. Toxicity of plant essential oils and their components against Lycoriellaingenua (Diptera: Sciaridae). J Econ Entomol. 2008;101(1):139-144.
9. Cho JY, Choi GJ, Son SW, et al. Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi. Pest Manag Sci. 2007;63(9):935-940.
10. Indu MN, Hatha AAM, Abirosh C, Harsha U, Vivekanandan G. Antimicrobial activity of some of the south-Indian spices against serotypes of Escherichia coli, Salmonella, Listeria Monocytogenes, and Aeromonas Hydrophila. Brazilian Journal of Microbiology. 2006;37(2): 153-158.
11. Narasimhan B, Dhake AS. Antibacterial principles from Myristicafragrans seeds. J Med Food. 2006;9(3):395-399.
12. Takikawa A, Abe K, Yamamoto M, et al. Antimicrobial activity of nutmeg against Escherichia coli O157. J BiosciBioeng. 2002;94(4):315-320.
13. Olaleye MT, Akinmoladun CA, Akindahunsi AA. Antioxidant properties of Myristica fragrans (Houtt) and its effect on selected organs of albino rats. African Journal of Biotechnology. 2006;5(15):1274-1278.
14. Adjene JO, Nwose EU. Histological effects of long term consumption of nutmeg on the medial geniculate body of adult Wistar rats. N Am J Med Sci. 2010;2(3):134-137.
15. Adjene JO. Histological effects of chronic consumption of nutmeg on the superior colliculus of adult Wistar rats. International Journal of Biomedical and Health Sciences. 2010;6(1):51-55.
16. Eweka A,Eweka A. Histological effects of oral administration of nutmeg on the kidneys of adult Wistar rats. N Am J Med Sci. 2010;2(4): 189-192.
17. Gleason FK, Cholett R,Plant Biochemistry. Sudbury, Mass: Jones & Bartlett Learning LLC; 2012:1-22.
18. Grycová L, Dostál J, Marek R. Quaternary protoberberine alkaloids. Phytochemistry. 2007;68(2):150-175.
19. Robert MF, Wink M, editors. Introduction. In: Robert MF, Wink M, editors. Alkaloids: Biochemistry, and Medical Application Language of Science. Springer 1998:1-6.
20. Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans - antidiarrhoeal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24(10):675-680.
21. Sonavane G, Sarveiya V, Kasture V, Kasture SB. Behavioural actions of Myristica fragrans seeds. Indian Journal of Pharmacology. 2001;33(6): 417-424.
22. Harborne JB. Phytochemical Methods. 2nd ed. New York: Chapman and Hall; 1984.
23. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16(2):109-110.
24. Sharma AK, Agarwal V, Kumar R, Balasubramaniam A, Mishra A, Gupta R. Pharmacological studies on seeds of Alangiumsalvifolium Linn. Acta Pol Pharm. 2011;68(6):897-904.
25. Pascoe D. Toxicology. Edward Arnold Limited. London; 1983:1-60.
26. Loomis TA, Hayes AW. Loomis's Essentials of Toxicology. 4th ed. California: Academic Press; 1996.
27. Tajuddin A, Ahmad S, Latif A, Qasmi IA, Amin KM. An experimental study of sexual function improving effect of Myristica fragrans Houtt. (Nutmeg). BMC Complementary and Alternative Medicine. 2005;5:16.
28. Ghosh AK, Banerje M, Mandal TK, Mishra A, Bhowmik MK. A study on analgesic efficacy and adverse effects of aloe vera in Wistarrats. Pharmacology Online. 2011;1:1098-1108.
29. Prabhu V, Nalini G, Chidambaranathan N, Sudarshan S. Evaluation of anti inflammatory and analgesic activity of Tridaxprocumbens Linn against formalin, acetic acid and CFA induced pain models. International Journal of Pharmacy and Pharmaceutical Sciences. 2011;3(2):126-130.
30. Collier HO, Dinneen LC, Johnson CA, Schneider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J PharmacolChemother. 1968;32(2):295-310.
31. Ribeiro RA, Vale ML, Thomazzi SM, et al. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur J Pharmacol. 2000;387(1): 111-118.
32. Vane J. The evolution of non-steroidal anti-inflammatory drugs and their mechanisms of action. Drugs. 1987;33(Suppl 1):18-27.
33. Sarkar A. Herbal Toxicology. New Delhi: Discovery Publishing House Private Limited; 2009.
34. Mukherjee A, Chaliha M, Das S. Study of analgesic activity of ethanol extracts of Phlogacanthusthyrsiflorus on experimental animal models. Bangladesh Journal of Pharmacology. 2009;4(2):147-149.
35. Jamaluddin ATM, Qais N, Ali MA, Howlader MA, Shams-Ud-Doha KM, Sarker AA. Analgesic activity of extracts of whole plants of Amaranthusspinosus Linn. International Journal of Drug Development and Research. 2011;3(4):189-193.
36. Zulfiker AHM, Rahman MM, Hossain MK, Hamid K, Mazumder MEH, Rana MS. In vivo analgesic activity of ethanolic extract of two medicinal plants - Scopariadulcis L and Ficusracemosa Linn. Biology and Medicine. 2010;2(2):42-48.