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Volumn 19, Issue 15, 2013, Pages 4040-4045

Molecular pathways: ROS1 fusion proteins in cancer

Author keywords

[No Author keywords available]

Indexed keywords

AP 26113; AT 13387; CD74 ANTIGEN; CRIZOTINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEFITINIB; HEAT SHOCK PROTEIN 90 INHIBITOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE A; PROTEIN TYROSINE PHOSPHATASE SHP 2; ROS1 FUSION PROTEIN; SODIUM PHOSPHATE COTRANSPORTER 2B; SYNDECAN 4; UNCLASSIFIED DRUG; ONCOPROTEIN; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; ROS1 PROTEIN, HUMAN;

EID: 84881245421     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-2851     Document Type: Article
Times cited : (302)

References (47)
  • 1
    • 0022766181 scopus 로고
    • Human c-ros-1 gene homologous to the v-ros sequence of ur2 sarcoma virus encodes for a transmembrane receptorlike molecule
    • Matsushime H, Wang LH, Shibuya M. Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule. Mol Cell Biol 1986;6: 3000-4.
    • (1986) Mol Cell Biol , vol.6 , pp. 3000-3004
    • Matsushime, H.1    Wang, L.H.2    Shibuya, M.3
  • 3
    • 0034693799 scopus 로고    scopus 로고
    • The protein tyrosine kinase family of the human genome
    • Robinson DR, Wu YM, Lin SF. The protein tyrosine kinase family of the human genome. Oncogene 2000;19:5548-57.
    • (2000) Oncogene , vol.19 , pp. 5548-5557
    • Robinson, D.R.1    Wu, Y.M.2    Lin, S.F.3
  • 4
    • 58049170380 scopus 로고    scopus 로고
    • The multifaceted roles of the receptor tyrosine kinase ros in development and cancer
    • Acquaviva J,WongR, Charest A. The multifaceted roles of the receptor tyrosine kinase ROS in development and cancer. Biochim Biophys Acta 2009;1795:37-52.
    • (2009) Biochim Biophys Acta , vol.1795 , pp. 37-52
    • Acquaviva, J.1    Wong, R.2    Charest, A.3
  • 5
    • 84865089246 scopus 로고    scopus 로고
    • Analysis of receptor tyrosine kinase ros1-positive tumors in non-small cell lung cancer: Identification of a fig-ros1 fusion
    • Rimkunas VM, Crosby KE, Li D, Hu Y, Kelly ME, Gu TL, et al. Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion. Clin Cancer Res 2012;18: 4449-57.
    • (2012) Clin Cancer Res , vol.18 , pp. 4449-4457
    • Rimkunas, V.M.1    Crosby, K.E.2    Li, D.3    Hu, Y.4    Kelly, M.E.5    Gu, T.L.6
  • 6
    • 80052055991 scopus 로고    scopus 로고
    • Ros receptor tyrosine kinase: A new potential target for anticancer drugs
    • El-Deeb IM, Yoo KH, Lee SH. ROS receptor tyrosine kinase: a new potential target for anticancer drugs. Med Res Rev 2010;31:794-818.
    • (2010) Med Res Rev , vol.31 , pp. 794-818
    • El-Deeb, I.M.1    Yoo, K.H.2    Lee, S.H.3
  • 7
    • 0029892926 scopus 로고    scopus 로고
    • The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis
    • Sonnenberg-Riethmacher E, Walter B, Riethmacher D, Godecke S, Birchmeier C. The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. Genes Dev 1996;10:1184-93.
    • (1996) Genes Dev , vol.10 , pp. 1184-1193
    • Sonnenberg-Riethmacher, E.1    Walter, B.2    Riethmacher, D.3    Godecke, S.4    Birchmeier, C.5
  • 8
    • 0029864883 scopus 로고    scopus 로고
    • Two chimeric receptors of epidermal growth factor receptor and c-ros that differ in their transmembrane domains have opposite effects on cell growth
    • Xiong Q, Chan JL, Zong CS, Wang LH. Two chimeric receptors of epidermal growth factor receptor and c-Ros that differ in their transmembrane domains have opposite effects on cell growth. Mol Cell Biol 1996;16:1509-18.
    • (1996) Mol Cell Biol , vol.16 , pp. 1509-1518
    • Xiong, Q.1    Chan, J.L.2    Zong, C.S.3    Wang, L.H.4
  • 9
    • 0032561353 scopus 로고    scopus 로고
    • Stat3 plays an important role in oncogenic ros-And insulin-like growth factor i receptor-induced anchorage-independent growth
    • Zong CS, Zeng L, Jiang Y, Sadowski HB, Wang LH. Stat3 plays an important role in oncogenic Ros-And insulin-like growth factor I receptor-induced anchorage-independent growth. J Biol Chem 1998;273:28065-72.
    • (1998) J Biol Chem , vol.273 , pp. 28065-28072
    • Zong, C.S.1    Zeng, L.2    Jiang, Y.3    Sadowski, H.B.4    Wang, L.H.5
  • 10
    • 0034461581 scopus 로고    scopus 로고
    • Vav3 mediates receptor protein tyrosine kinase signaling, regulates gtpase activity, modulates cell morphology, and induces cell transformation
    • Zeng L, Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M, et al. Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. Mol Cell Biol 2000;20:9212-24.
    • (2000) Mol Cell Biol , vol.20 , pp. 9212-9224
    • Zeng, L.1    Sachdev, P.2    Yan, L.3    Chan, J.L.4    Trenkle, T.5    McClelland, M.6
  • 12
    • 0037192825 scopus 로고    scopus 로고
    • The role of phosphatidylinositol 3-kinase, rho family gtpases, and stat3 in ros-induced cell transformation
    • Nguyen KT, Zong CS, Uttamsingh S, Sachdev P, Bhanot M, Le MT, et al. The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation. J Biol Chem 2002; 277:11107-15.
    • (2002) J Biol Chem , vol.277 , pp. 11107-11115
    • Nguyen, K.T.1    Zong, C.S.2    Uttamsingh, S.3    Sachdev, P.4    Bhanot M Le, M.T.5
  • 13
    • 0023477402 scopus 로고
    • Expression and rearrangement of the ros1 gene in human glioblastoma cells
    • Birchmeier C, Sharma S, Wigler M. Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proc Natl Acad Sci U S A 1987;84:9270-4.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 9270-9274
    • Birchmeier, C.1    Sharma, S.2    Wigler, M.3
  • 14
    • 0037402509 scopus 로고    scopus 로고
    • Fusion of fig to the receptor tyrosine kinase ros in a glioblastoma with an interstitial del (6)(q21q21)
    • Charest A, Lane K, McMahon K, Park J, Preisinger E, Conroy H, et al. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer 2003;37:58-71.
    • (2003) Genes Chromosomes Cancer , vol.37 , pp. 58-71
    • Charest, A.1    Lane, K.2    McMahon, K.3    Park, J.4    Preisinger, E.5    Conroy, H.6
  • 15
    • 79251579592 scopus 로고    scopus 로고
    • Survey of tyrosine kinase signaling reveals ros kinase fusions in human cholangiocarcinoma
    • GuTL, Deng X, Huang F, Tucker M, Crosby K, Rimkunas V, et al. Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS ONE 2011;6:e15640.
    • (2011) PLoS ONE , vol.6
    • Gu, T.L.1    Deng, X.2    Huang, F.3    Tucker, M.4    Crosby, K.5    Rimkunas, V.6
  • 16
    • 82755170504 scopus 로고    scopus 로고
    • Chromosome 3 anomalies investigated by genome wide snp analysis of benign, low malignant potential and low grade ovarian serous tumours
    • Birch AH, Arcand SL, Oros KK, Rahimi K, Watters AK, Provencher D, et al. Chromosome 3 anomalies investigated by genome wide SNP analysis of benign, low malignant potential and low grade ovarian serous tumours. PLoS ONE 2011;6:e28250.
    • (2011) PLoS ONE , vol.6
    • Birch, A.H.1    Arcand, S.L.2    Oros, K.K.3    Rahimi, K.4    Watters, A.K.5    Provencher, D.6
  • 17
    • 84871181092 scopus 로고    scopus 로고
    • Identification of kif5b-ret and gopc-ros1 fusions in lung adenocarcinomas through a comprehensive mrna-based screen for tyrosine kinase fusions
    • Suehara Y, Arcila M, Wang L, Hasanovic A, Ang D, Ito T, et al. Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions. Clin Cancer Res 2012;18:6599-608.
    • (2012) Clin Cancer Res , vol.18 , pp. 6599-6608
    • Suehara, Y.1    Arcila, M.2    Wang, L.3    Hasanovic, A.4    Ang, D.5    Ito, T.6
  • 18
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 2007;131:1190-203.
    • (2007) Cell , vol.131 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3    Possemato, A.4    Yu, J.5    Haack, H.6
  • 20
    • 84866434919 scopus 로고    scopus 로고
    • Genomic landscape of non-small cell lung cancer in smokers and never-smokers
    • Govindan R, Ding L, Griffith M, Subramanian J, Dees ND, Kanchi KL, et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 2012;150:1121-34.
    • (2012) Cell , vol.150 , pp. 1121-1134
    • Govindan, R.1    Ding, L.2    Griffith, M.3    Subramanian, J.4    Dees, N.D.5    Kanchi, K.L.6
  • 21
    • 84868309107 scopus 로고    scopus 로고
    • The transcriptional landscape and mutational profile of lung adenocarcinoma
    • Seo JS, Ju YS, Lee WC, Shin JY, Lee JK, Bleazard T, et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res 2012;22:2109-19.
    • (2012) Genome Res , vol.22 , pp. 2109-2119
    • Seo, J.S.1    Ju, Y.S.2    Lee, W.C.3    Shin, J.Y.4    Lee, J.K.5    Bleazard, T.6
  • 22
    • 84876666653 scopus 로고    scopus 로고
    • Identification of ros1 rearrangement in gastric adenocarcinoma
    • Lee J, Lee SE, Kang SY, Do IG, Lee S, Ha SY, et al. Identification of ROS1 rearrangement in gastric adenocarcinoma. Cancer 2013;119: 1627-35.
    • (2013) Cancer , vol.119 , pp. 1627-1635
    • Lee, J.1    Lee, S.E.2    Kang, S.Y.3    Do, I.G.4    Lee, S.5    Ha, S.Y.6
  • 23
    • 84886260922 scopus 로고    scopus 로고
    • Alkandrosgene rearrangements detected in colorectal cancer (crc) by fluorescence in situ hybridization (fish)
    • abstr 3545).
    • Weickhardt AJ, Nguyen TT, Paskulin DD, Le AT, Aisner D, Schulte N, et al. ALKandROSgene rearrangements detected in colorectal cancer (CRC) by fluorescence in situ hybridization (FISH). J Clin Oncol 31, 2013 (suppl; abstr 3545).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Weickhardt, A.J.1    Nguyen, T.T.2    Paskulin, D.D.3    Le, A.T.4    Aisner, D.5    Schulte, N.6
  • 24
    • 84881222854 scopus 로고    scopus 로고
    • Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions
    • abstr 10513).
    • Lovly CM, Lipson D, Otto G, Brennan T, Sankar S, Stephens PJ, et al. Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions. J Clin Oncol 31, 2013 (suppl; abstr 10513).
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Lovly, C.M.1    Lipson, D.2    Otto, G.3    Brennan, T.4    Sankar, S.5    Stephens, P.J.6
  • 25
    • 84876882782 scopus 로고    scopus 로고
    • Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types
    • Giacomini CP, Sun S, Varma S, Shain AH, Giacomini MM, Balagtas J, et al. Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PLoS Genet 2013;9:e1003464.
    • (2013) PLoS Genet , vol.9
    • Giacomini, C.P.1    Sun, S.2    Varma, S.3    Shain, A.H.4    Giacomini, M.M.5    Balagtas, J.6
  • 26
    • 0037417996 scopus 로고    scopus 로고
    • Oncogenic targeting of an activated tyrosine kinase to the golgi apparatus in a glioblastoma
    • Charest A, Kheifets V, Park J, Lane K, McMahon K, Nutt CL, et al. Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma. Proc Natl Acad Sci U S A 2003;100: 916-21.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 916-921
    • Charest, A.1    Kheifets, V.2    Park, J.3    Lane, K.4    McMahon, K.5    Nutt, C.L.6
  • 27
    • 84864835466 scopus 로고    scopus 로고
    • The oncogenic lung cancer fusion kinase cd74-ros activates a novel invasiveness pathway through e-syt1 phosphorylation
    • Jun HJ, Johnson H, Bronson RT, de Feraudy S, White F, Charest A. The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation. Cancer Res 2012;72:3764-74.
    • (2012) Cancer Res , vol.72 , pp. 3764-3774
    • Jun, H.J.1    Johnson, H.2    Bronson, R.T.3    De Feraudy, S.4    White, F.5    Charest, A.6
  • 29
    • 33747887175 scopus 로고    scopus 로고
    • Ros fusion tyrosine kinase activates a sh2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice
    • Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, et al. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/ phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res 2006;66:7473-81.
    • (2006) Cancer Res , vol.66 , pp. 7473-7481
    • Charest, A.1    Wilker, E.W.2    McLaughlin, M.E.3    Lane, K.4    Gowda, R.5    Coven, S.6
  • 31
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    • McDermott U, Iafrate AJ, Gray NS, Shioda T, Classon M, Maheswaran S, et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res 2008;68:3389-95.
    • (2008) Cancer Res , vol.68 , pp. 3389-3395
    • McDermott, U.1    Iafrate, A.J.2    Gray, N.S.3    Shioda, T.4    Classon, M.5    Maheswaran, S.6
  • 33
    • 84862846839 scopus 로고    scopus 로고
    • Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ros1-translocated lung cancer
    • Yasuda H, de Figueiredo-Pontes LL, Kobayashi S, Costa DB. Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer. J Thorac Oncol 2012;7:1086-90.
    • (2012) J Thorac Oncol , vol.7 , pp. 1086-1090
    • Yasuda, H.1    De Figueiredo-Pontes, L.L.2    Kobayashi, S.3    Costa, D.B.4
  • 34
    • 79960250811 scopus 로고    scopus 로고
    • Insights into alk-driven cancers revealed through development of novel alk tyrosine kinase inhibitors
    • Lovly CM, Heuckmann JM, de Stanchina E, Chen H, Thomas RK, Liang C, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. Cancer Res 2011;71: 4920-31.
    • (2011) Cancer Res , vol.71 , pp. 4920-4931
    • Lovly, C.M.1    Heuckmann, J.M.2    De Stanchina, E.3    Chen, H.4    Thomas, R.K.5    Liang, C.6
  • 35
    • 84860352732 scopus 로고    scopus 로고
    • Treating alk-positive lung cancer-early successes and future challenges
    • Camidge DR, Doebele RC. Treating ALK-positive lung cancer-early successes and future challenges. Nat Rev Clin Oncol 2012;9: 268-77.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 268-277
    • Camidge, D.R.1    Doebele, R.C.2
  • 36
    • 0031031464 scopus 로고    scopus 로고
    • Effect of dimerization on signal transduction and biological function of oncogenic ros, insulin, and insulin-like growth factor i receptors
    • Chan JL, Lai M, Wang LH. Effect of dimerization on signal transduction and biological function of oncogenic Ros, insulin, and insulin-like growth factor I receptors. J Biol Chem 1997;272: 146-53.
    • (1997) J Biol Chem , vol.272 , pp. 146-153
    • Chan, J.L.1    Lai, M.2    Wang, L.H.3
  • 37
    • 84871784888 scopus 로고    scopus 로고
    • Ros1 receptor tyrosine kinase, a druggable target, is frequently overexpressed in non-small cell lung carcinomas via genetic and epigenetic mechanisms
    • Lee HJ, Seol HS, Kim JY, Chun SM, Suh YA, Park YS, et al. ROS1 receptor tyrosine kinase, a druggable target, is frequently overexpressed in non-small cell lung carcinomas via genetic and epigenetic mechanisms. Ann Surg Oncol 2013;20:200-8.
    • (2013) Ann Surg Oncol , vol.20 , pp. 200-208
    • Lee, H.J.1    Seol, H.S.2    Kim, J.Y.3    Chun, S.M.4    Suh, Y.A.5    Park, Y.S.6
  • 38
    • 82355161909 scopus 로고    scopus 로고
    • Spectrum of oncogenic driver mutations in lung adenocarcinomas from east asian never smokers
    • Li C, Fang R, Sun Y, Han X, Li F, Gao B, et al. Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers. PLoS ONE 2011;6:e28204.
    • (2011) PLoS ONE , vol.6
    • Li, C.1    Fang, R.2    Sun, Y.3    Han, X.4    Li, F.5    Gao, B.6
  • 40
    • 79954606778 scopus 로고    scopus 로고
    • Targeting anaplastic lymphoma kinase in lung cancer
    • Shaw AT, Solomon B. Targeting anaplastic lymphoma kinase in lung cancer. Clin Cancer Res 2011;17:2081-6.
    • (2011) Clin Cancer Res , vol.17 , pp. 2081-2086
    • Shaw, A.T.1    Solomon, B.2
  • 41
    • 84875224942 scopus 로고    scopus 로고
    • Ros1-rearranged lung cancer: A clinicopathologic and molecular study of 15 surgical cases
    • Yoshida A, Kohno T, Tsuta K, Wakai S, Arai Y, Shimada Y, et al. ROS1-rearranged lung cancer: a clinicopathologic and molecular study of 15 surgical cases. Am J Surg Pathol 2013;37:554-62.
    • (2013) Am J Surg Pathol , vol.37 , pp. 554-562
    • Yoshida, A.1    Kohno, T.2    Tsuta, K.3    Wakai, S.4    Arai, Y.5    Shimada, Y.6
  • 42
    • 84878348202 scopus 로고    scopus 로고
    • Clinical activity of crizotinib in patients with advanced non-small cell lung cancer (nsclc) harboring ros1 gene rearrangment
    • Ou SH, Camidge DR, Engelman J, Clark J, Tye L, Wilner K, et al. Clinical activity of crizotinib in patients with advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangment. Ann Oncol 2012;23(Suppl 9):ix389.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Ou, S.H.1    Camidge, D.R.2    Engelman, J.3    Clark, J.4    Tye, L.5    Wilner, K.6
  • 43
    • 77958478674 scopus 로고    scopus 로고
    • Rational, biologically based treatment of egfrmutant non-small-cell lung cancer
    • Pao W, Chmielecki J. Rational, biologically based treatment of EGFRmutant non-small-cell lung cancer. Nat Rev Cancer 2010;10:760-74.
    • (2010) Nat Rev Cancer , vol.10 , pp. 760-774
    • Pao, W.1    Chmielecki, J.2
  • 44
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with alk-positive nonsmall-cell lung cancer: Updated results from a phase 1 study
    • Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB, et al. Activity and safety of crizotinib in patients with ALK-positive nonsmall-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 2012;13:1011-9.
    • (2012) Lancet Oncol , vol.13 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3    Iafrate, A.J.4    Varella-Garcia, M.5    Fox, S.B.6
  • 45
    • 84881255505 scopus 로고    scopus 로고
    • The dual alk/egfr inhibitor ap26113 also potently inhibits activated and gatekeeper mutant forms of ros1
    • abstract 164
    • Anjum R, Vodala S, Zhang S, Moran L, Keats J, Squillace R, et al. The dual ALK/EGFR inhibitor AP26113 also potently inhibits activated and gatekeeper mutant forms of ROS1. EORTC Annual Meeting 2012: abstract 164.
    • (2012) EORTC Annual Meeting
    • Anjum, R.1    Vodala, S.2    Zhang, S.3    Moran, L.4    Keats, J.5    Squillace, R.6
  • 46
    • 84877679409 scopus 로고    scopus 로고
    • Targeted inhibition of the molecular chaperone hsp90 overcomes alk inhibitor resistance in non-small cell lung cancer
    • Sang J, Acquaviva J, Friedland JC, Smith DL, Sequeira M, Zhang C, et al. Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer. Cancer Discov 2013;3:430-43.
    • (2013) Cancer Discov , vol.3 , pp. 430-443
    • Sang, J.1    Acquaviva, J.2    Friedland, J.C.3    Smith, D.L.4    Sequeira, M.5    Zhang, C.6
  • 47
    • 73349096261 scopus 로고    scopus 로고
    • Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Hammerman PS, Janne PA, Johnson BE. Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 2009;15:7502-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 7502-7509
    • Hammerman, P.S.1    Janne, P.A.2    Johnson, B.E.3


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