Defects of mtDNA replication impaired mitochondrial biogenesis during Trypanosoma cruzi infection in human cardiomyocytes and chagasic patients: the role of Nrf1/2 and antioxidant response.

Journal of the American Heart Association

Volumn 1, Issue 6, 2012, Pages

  Wan, Xianxiu ^a   Gupta, Shivali ^b   Zago, Maria P ^b   Davidson, Mercy M ^b   Dousset, Pierre ^b   Amoroso, Alejandro ^b   Garg, Nisha Jain ^b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MITOCHONDRIAL DNA; NFE2L2 PROTEIN, HUMAN; NRF1 PROTEIN, HUMAN; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA COACTIVATOR-1; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CELL CULTURE; CHAGAS DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA REPLICATION; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; HEART MUSCLE CELL; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL DNA REPLICATION; MITOCHONDRIAL DYNAMICS; NRF2; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PGC-1Α; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TRYPANOSOMA CRUZI; ULTRASTRUCTURE; WESTERN BLOTTING;

CHAGAS DISEASE; MITOCHONDRIAL BIOGENESIS; MTDNA REPLICATION; NRF2; OXIDATIVE STRESS; PGC-1Α; TRYPANOSOMA CRUZI;

BLOTTING, WESTERN; CELLS, CULTURED; CHAGAS DISEASE; DNA REPLICATION; DNA, MITOCHONDRIAL; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, FLUORESCENCE; MITOCHONDRIAL DISEASES; MITOCHONDRIAL TURNOVER; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 2; NUCLEAR RESPIRATORY FACTOR 1; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRYPANOSOMA CRUZI;

EID: 84881239852     PISSN: None     EISSN: 20479980     Source Type: None    
DOI: 10.1161/JAHA.112.003855     Document Type: Article

References (0)