STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population

International Journal of Immunopathology and Pharmacology

Volumn 26, Issue 2, 2013, Pages 473-478

  Yi, L ^a,b   Wang, J C ^c,d   Guo, X J ^a   Gu, Y H ^e   Tu, W Z ^f   Guo, G ^g   Yang, L ^h   Xiao, R ⁱ   Yu, L ^f   Mayes, M D ^a   Assassi, S ^a   Jin, L ^c   Zou, H J ^d,j   Zhou, Xiaodong ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b GANSU UNIVERSITY OF CHINESE MEDICINE   (China)

^c FUDAN UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

^e GANSU PROVINCIAL HOSPITAL   (China)

^f Shanghai Traditional Chinese Medical Integrated Hospital   (China)

^g Chengdu University of TCM ^*  (China)

^h CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

ⁱ CENTRAL SOUTH UNIVERSITY   (China)

^j FUDAN UNIVERSITY   (China)

more..

Author keywords

Chinese population; Genetics; Polymorphism; Scleroderma systemic sclerosis; Stat4

Indexed keywords

CENTROMERE ANTIBODY; STAT4 PROTEIN; DNA TOPOISOMERASE; ENZYME ANTIBODY; TOPOISOMERASE I ANTIBODY; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CHINESE; CONTROLLED STUDY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC SCLEROSIS; DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS; DISEASE ASSOCIATION; HAN CHINESE; HETEROZYGOTE; LIMITED CUTANEOUS SYSTEMIC SCLEROSIS; LUNG FIBROSIS;

EID: 84881231093     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201302600220     Document Type: Article

References (17)

1. Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 2007; 117:557-67. (Pubitemid 46348510)
2. Bunn CC, Black CM. Systemic sclerosis: an autoantibody mosaic. Clin Exp Immunol 1999; 117:207.
3. Steen VD. Autoantibodies in systemic sclerosis. Semin Arthritis Rheum 2005; 35:35-42. (Pubitemid 41111469)
4. Arnett FC, Howard RF, Tan F, et al. Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype. Arthritis Rheum 1996; 39:1362-70. (Pubitemid 26270096)
5. Steen V, Domsic RT, Lucas M, Fertig N, Medsger TA. A clinical and serologic comparison of African-American and Caucasian patients with systemic sclerosis. Arthritis Rheum 2012; doi 10.1002/art.34482. [Epub ahead of print]
6. Wang J, Assassi S, Guo G, et al. Clinical and serological features of systemic sclerosis in a Chinese cohort. Clin Rheumatol 2012; doi10.1007/s10067-012-2145-7 [Epub ahead of print]
7. Zhou X, Lee JE, Arnett FC, et al. HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans. Arthritis Rheum 2009; 60:3807-14.
8. McNeilage LJ, Youngchaiyud U, Whittingham S. Racial differences in antinuclear antibody patterns and clinical manifestations of scleroderma. Arthritis Rheum 1989; 32:54-60. (Pubitemid 19034924)
9. Radstake TR, Gorlova O, Rueda B, et al. Genomewide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet 2010; 42:426-9.
10. Thierfelder WE, van Deursen JM, Yamamoto K, et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996; 382:171-74. (Pubitemid 26242884)
11. Fukao T, Frucht DM, Yap G, Gadina M, O'Shea JJ, Koyasu S. Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J Immunol 2001; 166:4446-55. (Pubitemid 32233728)
12. Korman BD, Kastner DL, Gregersen PK, Remmers EF. STAT4: genetics, mechanisms, and implications for autoimmunity. Curr Allergy Asthma Rep 2008; 8:398-403.
13. Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980; 23:581-90.
14. LeRoy EC, Black C, Fleischmajer R, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15:202-205. (Pubitemid 18073738)
15. Rueda B, Broen J, Simeon C, et al. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype. Hum Mol Genet 2009; 18:2071-7.
16. Tsuchiya N, Kawasaki A, Hasegawa M, et al. Association of STAT4 polymorphism with systemic sclerosis in a Japanese population. Ann Rheum Dis 2009; 68:1375-76.
17. Avouac J, Fürnrohr BG, Tomcik M, et al. Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis. Arthritis Rheum 2011; 63:800-9.