The incidence of severe hypoglycaemia in pregnant women with type 1 diabetes mellitus can be reduced with unchanged HbA1c levels and pregnancy outcomes in a routine care setting

Diabetes Research and Clinical Practice

Volumn 101, Issue 2, 2013, Pages 123-130

  Ringholm, Lene ^a   Secher, A L ^a,b   Pedersen Bjergaard, U ^b,c   Thorsteinsson, B ^b,c   Andersen, H U ^d   Damm, P ^a,b   Mathiesen, E R ^a,b  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c HILLERØD HOSPITAL   (Denmark)

^d STENO DIABETES CENTER   (Denmark)

Author keywords

Continuous glucose monitoring; Education; Insulin analogue; Insulin dose; Insulin pump therapy; Pregnancy; Severe hypoglycaemia; Type 1 diabetes mellitus

Indexed keywords

GLUCAGON; GLUCOSE; HEMOGLOBIN A1C; INSULIN; INSULIN DERIVATIVE;

ADULT; ARTICLE; BEDTIME DOSAGE; BLOOD GLUCOSE MONITORING; CAREGIVER; COHORT ANALYSIS; CONTROLLED STUDY; CONVULSION; DISEASE SEVERITY; DRUG DOSE REDUCTION; FEMALE; GESTATIONAL AGE; HEALTH EDUCATION; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN PUMP; MAJOR CLINICAL STUDY; MORBIDITY; PATIENT CARE; PREDICTIVE VALUE; PREGNANCY OUTCOME; PREGNANT WOMAN; PROSPECTIVE STUDY; STRUCTURED INTERVIEW; UNCONSCIOUSNESS;

EID: 84881228745     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2013.06.002     Document Type: Article

References (35)

1. Rosenn B.M., Miodovnik M., Holcberg G., Khoury J.C., Siddiqi T.A. Hypoglycemia: the price of intensive insulin therapy for pregnant women with insulin-dependent diabetes mellitus. Obstet Gynecol 1995, 85:417-422.
2. Evers I.M., ter Braak E.W., de Valk H.W., van Der S.B., Janssen N., Visser G.H. Risk indicators predictive for severe hypoglycemia during the first trimester of type 1 diabetic pregnancy. Diabetes Care 2002, 25:554-559.
3. Kimmerle R., Heinemann L., Delecki A., Berger M. Severe hypoglycemia incidence and predisposing factors in 85 pregnancies of type I diabetic women. Diabetes Care 1992, 15:1034-1037.
4. Nielsen L.R., Pedersen-Bjergaard U., Thorsteinsson B., Johansen M., Damm P., Mathiesen E.R. Hypoglycemia in pregnant women with type 1 diabetes: predictors and role of metabolic control. Diabetes Care 2008, 31:9-14.
5. Robertson H., Pearson D.W., Gold A.E. Severe hypoglycaemia during pregnancy in women with Type 1 diabetes is common and planning pregnancy does not decrease the risk. Diabet Med 2006, 26:824-826.
6. Donnelly L.A., Morris A.D., Frier B.M., Ellis J.D., Donnan P.T., Durrant R., et al. Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study. Diabet Med 2005, 22:749-755.
7. Kristensen P.L., Hansen L.S., Jespersen M.J., Pedersen-Bjergaard U., Beck-Nielsen H., Christiansen J.S., et al. Insulin analogues and severe hypoglycaemia in type 1 diabetes. Diabetes Res Clin Pract 2012, 96:17-23.
8. Leckie A.M., Graham M.K., Grant J.B., Ritchie P.J., Frier B.M. Frequency, severity, and morbidity of hypoglycemia occurring in the workplace in people with insulin-treated diabetes. Diabetes Care 2005, 28:1333-1338.
9. MacLeod K.M., Hepburn D.A., Frier B.M. Frequency and morbidity of severe hypoglycaemia in insulin-treated diabetic patients. Diabet Med 1993, 10:238-245.
10. Pedersen-Bjergaard U., Pramming S., Heller S.R., Wallace T.M., Rasmussen A.K., Jørgensen H.V., et al. Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection. Diabetes Metab Res Rev 2004, 20:479-486.
11. ter Braak E.W., Appelman A.M., van de L.M., Stolk R.P., van Haeften T.W., Erkelens D.W. Clinical characteristics of type 1 diabetic patients with and without severe hypoglycemia. Diabetes Care 2000, 23:1467-1471.
12. Secher A.L., Ringholm L., Andersen H.U., Damm P., Mathiesen E.R. The effect of real-time continuous glucose monitoring in pregnant women with diabetes: a randomized controlled trial. Diabetes Care 2013, (Epub ahead of print).
13. American Diabetes Association Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia. Diabetes Care 2005, 28:1245-1249.
14. Pedersen-Bjergaard U., Agerholm-Larsen B., Pramming S., Hougaard P., Thorsteinsson B. Prediction of severe hypoglycaemia by angiotensin-converting enzyme activity and genotype in type 1 diabetes. Diabetologia 2003, 46:89-96.
15. Pedersen-Bjergaard U., Pramming S., Thorsteinsson B. Recall of severe hypoglycaemia and self-estimated state of awareness in type 1 diabetes. Diabetes Metab Res Rev 2003, 19:232-240.
16. Nielsen L.R., Ekbom P., Damm P., Glümer C., Frandsen M.M., Jensen D.M., et al. HbA1c levels are significantly lower in early and late pregnancy. Diabetes Care 2004, 27:1200-1201.
17. Ringholm L., Pedersen-Bjergaard U., Thorsteinsson B., Damm P., Mathiesen E.R. Hypoglycaemia during pregnancy in women with Type 1 diabetes. Diabet Med 2012, 29:558-566.
18. Nielsen L.R., Damm P., Mathiesen E.R. Improved pregnancy outcome in type 1 diabetic women with microalbuminuria or diabetic nephropathy: effect of intensified antihypertensive therapy. Diabetes Care 2009, 32:38-44.
19. Marsal K., Persson P.H., Larsen T., Lilja H., Selbing A., Sultan B. Intrauterine growth curves based on ultrasonically estimated foetal weights. Acta Paediatr 1996, 85:843-848.
20. Pramming S., Thorsteinsson B., Bendtson I., Binder C. Symptomatic hypoglycaemia in 411 type 1 diabetic patients. Diabet Med 1991, 8:217-222.
21. Diabetes and Driving in Europe. A Report of the Second European Working Group on Diabetes and Driving, an advisory board to the Driving Licence Committee of the European Union, 2011; http://ec.europa.eu/transport/road_safety/behavior/doc/diabetes_and_driving_in_europe_final_1_en.pdf.
22. Bode B.W., Steed R.D., Davidson P.C. Reduction in severe hypoglycemia with long-term continuous subcutaneous insulin infusion in type I diabetes. Diabetes Care 1996, 19:324-327.
23. Worm D., Nielsen L.R., Mathiesen E.R., Norgaard K. Continuous glucose monitoring system with an alarm: a tool to reduce hypoglycemic episodes in pregnancy with diabetes. Diabetes Care 2006, 29:2759-2760.
24. Siebenhofer A., Plank J., Berghold A., Jeitler K., Horvath K., Narath M., et al. Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus. Cochrane Database Syst Rev 2006, CD003287.
25. Singh S.R., Ahmad F., Lal A., Yu C., Bai Z., Bennett H. Efficacy and safety of insulin analogues for the management of diabetes mellitus: a meta-analysis. CMAJ 2009, 180:385-397.
26. Monami M., Marchionni N., Mannucci E. Long-acting insulin analogues vs. NPH human insulin in type 1 diabetes. A meta-analysis. Diabetes Obes Metab 2009, 11:372-378.
27. Garcia-Dominguez M., Herranz L., Hillman N., Martin-Vaquero P., Vanez M., Moya-Chimenti E., et al. Use of insulin lispro during pregnancy in women with pregestational diabetes mellitus. Med Clin (Barc.) 2011, 137:581-586.
28. Heller S., Damm P., Mersebach H., Skjøth T.V., Kaaja R., Hod M., et al. Hypoglycemia in type 1 diabetic pregnancy: role of preconception insulin aspart treatment in a randomized study. Diabetes Care 2010, 33:473-477.
29. Mathiesen E.R., Kinsley B., Amiel S.A., Heller S., McCance D., Duran S., et al. Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy: a randomized trial of insulin aspart versus human insulin in 322 pregnant women. Diabetes Care 2007, 30:771-776.
30. Gallen I.W., Jaap A., Roland J.M., Chirayath H.H. Survey of glargine use in 115 pregnant women with Type 1 diabetes. Diabet Med 2008, 25:165-169.
31. Imbergamo M.P., Amato M.C., Sciortino G., Gambina M., Accidenti M., Criscimanna A., et al. Use of glargine in pregnant women with type 1 diabetes mellitus: a case-control study. Clin Ther 2008, 30:1476-1484.
32. Lapolla A., Di Cianni G., Bruttomesso D., Dalfra M.G., Fresa R., Mello G., et al. Use of insulin detemir in pregnancy: a report on 10 Type 1 diabetic women. Diabet Med 2009, 26:1181-1182.
33. Mathiesen E.R., Hod M., Ivanisevic M., Duran Garcia S., Brøndsted L., Jovanovic, et al. Maternal efficacy and safety outcomes in a randomized, controlled trial comparing insulin detemir with NPH insulin in 310 pregnant women with type 1 diabetes. Diabetes Care 2012, 35:2012-2017.
34. Poyhonen-Alho M., Ronnemaa T., Saltevo J., Ekblad U., Kaaja R.J. Use of insulin glargine during pregnancy. Acta Obstet Gynecol Scand 2007, 86:1171-1174.
35. Secher A.L., Madsen A.B., Ringholm L., Barfred C., Stage E., Andersen H.U., et al. Patient satisfaction and barriers to initiating real-time continuous glucose monitoring in early pregnancy in women with diabetes. Diabet Med 2012, 29:272-277.