Serum metabolic signatures of four types of human arthritis

Journal of Proteome Research

Volumn 12, Issue 8, 2013, Pages 3769-3779

  Jiang, Miao ^a   Chen, Tianlu ^b   Feng, Hui ^c   Zhang, Yinan ^b   Li, Li ^a   Zhao, Aihua ^b   Niu, Xuyan ^a   Liang, Fei ^a   Wang, Minzhi ^a   Zhan, Junping ^a   Lu, Cheng ^a   He, Xiaojuan ^a   Xiao, Lianbo ^c   Jia, Wei ^b,d   Lu, Aiping ^a,e  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^c Guanghua Hospital of Integrative Medicine   (China)

^d UNIVERSITY OF HAWAII   (United States)

^e HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

ankylosing spondylitis; gouty arthritis; metabonomics; osteoarthritis; rheumatoid arthritis

Indexed keywords

ALANINE; ARABINITOL; ASPARTIC ACID; BIOLOGICAL MARKER; CARNITINE; CITRIC ACID; CITRULLINE; CREATINE; CYSTEINE; DIHYDROXYFUMARIC ACID; GLYCERALDEHYDE; HISTAMINE; HOMOSERINE; LACTIC ACID; LYSINE; MALIC ACID; PYROGLUTAMIC ACID; SARCOSINE; SUCCINIC ACID; SUCROSE; TAURINE; THREONINE; TRYPTOPHAN; TYROSINE; URIC ACID; VALINE;

ADULT; ANKYLOSING SPONDYLITIS; ARTICLE; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GAS CHROMATOGRAPHY; GOUT; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLITE; OSTEOARTHRITIS; PHENOTYPE; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RHEUMATOID ARTHRITIS; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84881159364     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr400415a     Document Type: Article

References (57)

1. Gabriel, S. E.; Michaud, K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases Arthritis Res. Ther. 2009, 11 (3) 229
2. Blanco, F. J.; Ruiz-Romero, C. Osteoarthritis: Metabolomic characterization of metabolic phenotypes in OA Nat. Rev. Rheumatol. 2012, 8 (3) 130-2
3. Arnett, F. C.; Edworthy, S. M.; Bloch, D. A.; McShane, D. J.; Fries, J. F.; Cooper, N. S.; Healey, L. A.; Kaplan, S. R.; Liang, M. H.; Luthra, H. S. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis Arthritis Rheum. 1988, 31 (3) 315-24
4. Ciurtin, C.; Cojocaru, V. M.; Miron, I. M.; Preda, F.; Milicescu, M.; Bojinca, M.; Costan, O.; Nicolescu, A.; Deleanu, C.; Kovacs, E.; Stoica, V. Correlation between different components of synovial fluid and pathogenesis of rheumatic diseases Rom. J. Intern. Med. 2006, 44 (2) 171-81
5. Jiang, W. Y. Therapeutic wisdom in traditional Chinese medicine: A perspective from modern science Discovery Med. 2005, 5 (29) 455-61
6. Jiang, W. Y. Therapeutic wisdom in traditional Chinese medicine: a perspective from modern science Trends Pharmacol. Sci. 2005, 26 (11) 558-63
7. Anagnostopoulos, I.; Zinzaras, E.; Alexiou, I.; Papathanasiou, A. A.; Davas, E.; Koutroumpas, A.; Barouta, G.; Sakkas, L. I. The prevalence of rheumatic diseases in central Greece: a population survey BMC Musculoskeletal Disord. 2010, 11, 98
8. Helmick, C. G.; Felson, D. T.; Lawrence, R. C.; Gabriel, S.; Hirsch, R.; Kwoh, C. K.; Liang, M. H.; Kremers, H. M.; Mayes, M. D.; Merkel, P. A.; Pillemer, S. R.; Reveille, J. D.; Stone, J. H. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I Arthritis Rheum. 2008, 58 (1) 15-25
9. Lawrence, R. C.; Felson, D. T.; Helmick, C. G.; Arnold, L. M.; Choi, H.; Deyo, R. A.; Gabriel, S.; Hirsch, R.; Hochberg, M. C.; Hunder, G. G.; Jordan, J. M.; Katz, J. N.; Kremers, H. M.; Wolfe, F. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II Arthritis Rheum. 2008, 58 (1) 26-35
10. Agency for Healthcare Research and Quality National and regional statistics in the national inpatient sample (http://www.hcup-us.ahrq.gov/ reports/statbriefs/sb34.jsp).
11. Schirmer, M.; Dejaco, C.; Duftner, C. Advances in the evaluation and classification of chronic inflammatory rheumatic diseases Discovery Med. 2012, 13 (71) 299-304
12. Visser, H. Early diagnosis of rheumatoid arthritis: Best practice and research Clin. Rheumatol. 2005, 19 (1) 55-72
13. Harrison, B. J.; Symmons, D. P.; Barrett, E. M.; Silman, A. J. The performance of the 1987 ARA classification criteria for rheumatoid arthritis in a population based cohort of patients with early inflammatory polyarthritis. American Rheumatism Association J. Rheumatol. 1998, 25 (12) 2324-30
14. van der Heijde, D.; Sieper, J.; Maksymowych, W. P.; Dougados, M.; Burgos-Vargas, R.; Landewe, R.; Rudwaleit, M.; Braun, J. 2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis Ann. Rheum. Dis. 2011, 70 (6) 905-8
15. Annemans, L.; Spaepen, E.; Gaskin, M.; Bonnemaire, M.; Malier, V.; Gilbert, T.; Nuki, G. Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005 Ann. Rheum. Dis. 2008, 67 (7) 960-6
16. Wang, Z.; Chen, Z.; Yang, S.; Wang, Y.; Yu, L.; Zhang, B.; Rao, Z.; Gao, J.; Tu, S. (1)H NMR-based metabolomic analysis for identifying serum biomarkers to evaluate methotrexate treatment in patients with early rheumatoid arthritis Exp. Ther. Med. 2012, 4 (1) 165-71
17. van Wietmarschen, H. A.; Dai, W.; van der Kooij, A. J.; Reijmers, T. H.; Schroen, Y.; Wang, M.; Xu, Z.; Wang, X.; Kong, H.; Xu, G.; Hankemeier, T.; Meulman, J. J.; van der Greef, J. Characterization of rheumatoid arthritis subtypes using symptom profiles, clinical chemistry and metabolomics measurements PLoS ONE 2012, 7 (9) e44331
18. Attur, M.; Dave, M.; Abramson, S. B.; Amin, A. Activation of diverse eicosanoid pathways in osteoarthritic cartilage: a lipidomic and genomic analysis Bull. Hosp. Jt. Dis. 2012, 70 (2) 99-108
19. Suzuki, N. Mass spectrometry-based quantitative analysis and biomarker discovery J. Pharm. Soc. Jpn. 2011, 131 (9) 1305-9
20. Fernie, A. R.; Trethewey, R. N.; Krotzky, A. J.; Willmitzer, L. Metabolite profiling: from diagnostics to systems biology Nat. Rev.: Mol. Cell Biol. 2004, 5 (9) 763-9
21. Trygg, J.; Holmes, E.; Lundstedt, T. Chemometrics in metabonomics J. Proteome Res. 2007, 6 (2) 469-79
22. Madsen, R.; Lundstedt, T.; Trygg, J. Chemometrics in metabolomics - a review in human disease diagnosis Anal. Chim. Acta 2010, 659 (1-2) 23-33
23. Gu, Y.; Lu, C.; Zha, Q.; Kong, H.; Lu, X.; Lu, A.; Xu, G. Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry Mol. Biosyst. 2012, 8 (5) 1535-43
24. Madsen, R. K.; Lundstedt, T.; Gabrielsson, J.; Sennbro, C. J.; Alenius, G. M.; Moritz, T.; Rantapaa-Dahlqvist, S.; Trygg, J. Diagnostic properties of metabolic perturbations in rheumatoid arthritis Arthritis Res. Ther. 2011, 13 (1) R19
25. Lauridsen, M. B.; Bliddal, H.; Christensen, R.; Danneskiold-Samsoe, B.; Bennett, R.; Keun, H.; Lindon, J. C.; Nicholson, J. K.; Dorff, M. H.; Jaroszewski, J. W.; Hansen, S. H.; Cornett, C. 1H NMR spectroscopy-based interventional metabolic phenotyping: a cohort study of rheumatoid arthritis patients J. Proteome Res. 2010, 9 (9) 4545-53
26. Naughton, D. P.; Haywood, R.; Blake, D. R.; Edmonds, S.; Hawkes, G. E.; Grootveld, M. A comparative evaluation of the metabolic profiles of normal and inflammatory knee-joint synovial fluids by high resolution proton NMR spectroscopy FEBS Lett. 1993, 332 (3) 221-5
27. Naughton, D.; Whelan, M.; Smith, E. C.; Williams, R.; Blake, D. R.; Grootveld, M. An investigation of the abnormal metabolic status of synovial fluid from patients with rheumatoid arthritis by high field proton nuclear magnetic resonance spectroscopy FEBS Lett. 1993, 317 (1-2) 135-8
28. Duffy, J. M.; Grimshaw, J.; Guthrie, D. J.; McNally, G. M.; Mollan, R. A.; Spedding, P. L.; Trocha-Grimshaw, J.; Walker, B.; Walsh, E. 1H-nuclear magnetic resonance studies of human synovial fluid in arthritic disease states as an aid to confirming metabolic activity in the synovial cavity Clin. Sci. 1993, 85 (3) 343-51
29. Fischer, R.; Trudgian, D. C.; Wright, C.; Thomas, G.; Bradbury, L. A.; Brown, M. A.; Bowness, P.; Kessler, B. M. Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis Mol. Cell. Proteomics 2012, 11 (2) M111 013904
30. Patra, D.; Sandell, L. J. Evolving biomarkers in osteoarthritis J. Knee Surg. 2011, 24 (4) 241-9
31. Lu, C.; Zha, Q.; Chang, A.; He, Y.; Lu, A. Pattern differentiation in Traditional Chinese Medicine can help define specific indications for biomedical therapy in the treatment of rheumatoid arthritis J. Altern. Complementary Med. 2009, 15 (9) 1021-5
32. Liu, Y.; Sun, X.; Di, D.; Quan, J.; Zhang, J.; Yang, X. A metabolic profiling analysis of symptomatic gout in human serum and urine using high performance liquid chromatography-diode array detector technique Clin. Chim. Acta 2011, 412 (23-24) 2132-40
33. Chandra, P. E.; Sokolove, J.; Hipp, B. G.; Lindstrom, T. M.; Elder, J. T.; Reveille, J. D.; Eberl, H.; Klause, U.; Robinson, W. H. Novel multiplex technology for diagnostic characterization of rheumatoid arthritis Arthritis Res. Ther. 2011, 13 (3) R102
34. Tam, L. S.; Gu, J.; Yu, D. Pathogenesis of ankylosing spondylitis Nat. Rev. Rheumatol. 2010, 6 (7) 399-405
35. Hugle, T.; Kovacs, H.; Heijnen, I. A.; Daikeler, T.; Baisch, U.; Hicks, J. M.; Valderrabano, V. Synovial fluid metabolomics in different forms of arthritis assessed by nuclear magnetic resonance spectroscopy Clin. Exp. Rheumatol. 2012, 30 (2) 240-5
36. van Wietmarschen, H.; Yuan, K.; Lu, C.; Gao, P.; Wang, J.; Xiao, C.; Yan, X.; Wang, M.; Schroen, J.; Lu, A.; Xu, G.; van der Greef, J. Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients J. Clin. Rheumatol. 2009, 15 (7) 330-7
37. Bao, Y.; Zhao, T.; Wang, X.; Qiu, Y.; Su, M.; Jia, W. Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers J. Proteome Res. 2009, 8 (4) 1623-30
38. Qiu, Y.; Cai, G.; Su, M.; Chen, T.; Zheng, X.; Xu, Y.; Ni, Y.; Zhao, A.; Xu, L. X.; Cai, S.; Jia, W. Serum metabolite profiling of human colorectal cancer using GC-TOF MS and UPLC-QTOF MS J. Proteome Res. 2009, 8 (10) 4844-50
39. Jonsson, P.; Johansson, A. I.; Gullberg, J.; Trygg, J.; A, J.; Grung, B.; Marklund, S.; Sjostrom, M.; Antti, H.; Moritz, T. High-throughput data analysis for detecting and identifying differences between samples in GC/MS-based metabolomic analyses Anal. Chem. 2005, 77 (17) 5635-42
40. Chen, T.; Xie, G.; Wang, X.; Fan, J.; Qiu, Y.; Zheng, X.; Qi, X.; Cao, Y.; Su, M.; Xu, L. X.; Yen, Y.; Liu, P.; Jia, W. Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma Mol. Cell. Proteomics 2011, 10 (7) M110 004945
41. Hitchon, C. A.; El-Gabalawy, H. S.; Bezabeh, T. Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation Rheumatol. Int. 2009, 29 (10) 1205-11
42. Meshitsuka, S.; Yamazaki, E.; Inoue, M.; Hagino, H.; Teshima, R.; Yamamoto, K. Nuclear magnetic resonance studies of synovial fluids from patients with rheumatoid arthritis and osteoarthritis Clin. Chim. Acta 1999, 281 (1-2) 163-7
43. Lopez, H. L. Nutritional interventions to prevent and treat osteoarthritis. Part II: focus on micronutrients and supportive nutraceuticals PM R 2012, 4 (5 Suppl) S155-68
44. Lopez, H. L. Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients PM R 2012, 4 (5 Suppl) S145-54
45. Fink, M. P. Ethyl pyruvate: a novel anti-inflammatory agent J. Intern. Med. 2007, 261 (4) 349-62
46. Taylor, P. C.; Sivakumar, B. Hypoxia and angiogenesis in rheumatoid arthritis Curr. Opin. Rheumatol. 2005, 17 (3) 293-8
47. He, H.; Ren, X.; Wang, X.; Shi, X.; Ding, Z.; Gao, P.; Xu, G. Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts J. Pharm. Biomed. Anal. 2012, 59, 130-7
48. Giera, M.; Ioan-Facsinay, A.; Toes, R.; Gao, F.; Dalli, J.; Deelder, A. M.; Serhan, C. N.; Mayboroda, O. A. Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS Biochim. Biophys. Acta 2012, 1821 (11) 1415-24
49. Ouyang, X.; Dai, Y.; Wen, J. L.; Wang, L. X. (1)H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus Lupus 2011, 20 (13) 1411-20
50. van der Greef, J.; van Wietmarschen, H.; Schroen, J.; Wang, M.; Hankemeier, T.; Xu, G. Systems biology-based diagnostic principles as pillars of the bridge between Chinese and Western medicine Planta Med. 2010, 76 (17) 2036-47
51. Wu, T.; Xie, C.; Han, J.; Ye, Y.; Weiel, J.; Li, Q.; Blanco, I.; Ahn, C.; Olsen, N.; Putterman, C.; Saxena, R.; Mohan, C. Metabolic disturbances associated with systemic lupus erythematosus PLoS ONE 2012, 7 (6) e37210
52. Churchill, G. A. Fundamentals of experimental design for cDNA microarrays Nat. Genet. 2002, 32 (Suppl) 490-5
53. Yang, Y. H.; Dudoit, S.; Luu, P.; Lin, D. M.; Peng, V.; Ngai, J.; Speed, T. P. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation Nucleic Acids Res. 2002, 30 (4) e15
54. Akdis, C. A.; Blaser, K. Histamine in the immune regulation of allergic inflammation J. Allergy Clin. Immunol. 2003, 112 (1) 15-22
55. Tetlow, L. C.; Woolley, D. E. Histamine stimulates the proliferation of human articular chondrocytes in vitro and is expressed by chondrocytes in osteoarthritic cartilage Ann. Rheum. Dis. 2003, 62 (10) 991-4
56. Gao, P.; Lu, C.; Zhang, F.; Sang, P.; Yang, D.; Li, X.; Kong, H.; Yin, P.; Tian, J.; Lu, X.; Lu, A.; Xu, G. Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis Analyst 2008, 133 (9) 1214-20
57. Liu, Y.; Sun, X.; Di, D.; Quan, J.; Zhang, J.; Yang, X. A metabolic profiling analysis of symptomatic gout in human serum and urine using high performance liquid chromatography-diode array detector technique Clin. Chim. Acta 2011, 412 (23-24) 2132-40