Can matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF) enhance antimicrobial stewardship efforts in the acute care setting?

Infection Control and Hospital Epidemiology

Volumn 34, Issue 9, 2013, Pages 990-995

  Tamma, Pranita D ^a   Tan, Kennard ^b   Nussenblatt, Veronique R ^a   Turnbull, Alison E ^c   Carroll, Karen C ^a   Cosgrove, Sara E ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b ROYAL JUBILEE HOSPITAL   (Canada)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; VANCOMYCIN;

ANTIBIOTIC THERAPY; ARTICLE; CLINICAL DECISION MAKING; ENTEROCOCCUS FAECALIS; HEALTHCARE ASSOCIATED INFECTION; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; OBSERVATIONAL STUDY; PATIENT CARE; PHYSICIAN;

ANTI-BACTERIAL AGENTS; BACTEREMIA; BACTERIAL INFECTIONS; DRUG UTILIZATION REVIEW; HUMANS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 84881155229     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/671731     Document Type: Article

References (8)

1. Tan KE, Ellis BC, Lee R, Stamper PD, Zhang SX, Carroll KC. Prospective evaluation of a matrix-assisted laser desorption ionization-time of flight mass spectrometry system in a hospital clinical microbiology laboratory for identification of bacteria and yeasts: a bench-by-bench study for assessing the impact on time to identification and cost-effectiveness. J Clin Microbiol 2012;50: 3301-3308.
2. Wieser A, Schneider L, Jung J, Schubert S. MALDI-TOF MS in microbiological diagnostics-identification of microorganisms and beyond (mini review). Appl Microbiol Biotechnol 2012;93:965-974.
3. Garnacho-Montero J, Ortiz-Leyba C, Herrera-Melero I, et al. Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: a matched cohort study. J Antimicrob Chemother 2008;61:436-441.
4. Kang CI, Kim SH, Park WB, et al. Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother 2005;49:760-766.
5. Clerc O, Prod'Hom G, Vogne C, Bizzini A, Calandra T, Greub G. Impact of matrix-assisted laser desorption ionization time-offlight mass spectrometry (MALDI-TOF) on the clinical management of patients with gram-negative bacteremia: a prospective observational study. Clin Infect Dis 2013;56:1101-1107.
6. Vlek AL, Bonten MJ, Boel CH. Direct matrix-assisted laser de-sorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia. PLoS One 2012;7:e32589.
7. Hodiamont CJ, Gouliouris T, Rozemeijer W, Veldkamp KE, Wever P, Visser C. Direct identification of micro-organisms in positive blood cultures using MALDI-TOF MS: consequences for advice on antibiotic therapy. Poster presented at: European Congress of Clinical Microbiology and Infectious Diseases 2012; April 3, 2012; London; Poster 2322.
8. Tamma PD, Cosgrove SE. Antimicrobial stewardship. Infect Dis Clin North Am 2011;25:245-260.