Low Birthweight (LBW) and Neonatal Hyperbilirubinemia (NNH) in an Indian Cohort: Association of Homocysteine, Its Metabolic Pathway Genes and Micronutrients as Risk Factors

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Sukla, Krishna Kishore ^a   Tiwari, Pankaj Kumar ^a   Kumar, Ashok ^a   Raman, Rajiva ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYANOCOBALAMIN; CYTOSINE; FOLIC ACID; GUANINE; HOMOCYSTEINE; THYMINE; TRACE ELEMENT;

ALLELE; ARTICLE; BLOOD GROUP ABO INCOMPATIBILITY; CBS GENE; CYANOCOBALAMIN DEFICIENCY; CYANOCOBALAMIN GENE; DIETARY INTAKE; DISEASE PREDISPOSITION; FEMALE; FETUS DISTRESS; FOLATE GENE; FOLATE METABOLISM; FOLIC ACID DEFICIENCY; GENE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HCY GENE; HETEROZYGOTE; HOMOCYSTEINE GENE; HOMOCYSTINURIA; HOMOZYGOTE; HUMAN; INCIDENCE; INDIAN; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; MATERNAL NUTRITION; MTHFR GENE; NEONATAL HYPERBILIRUBINEMIA; NEWBORN; NEWBORN JAUNDICE; PREMATURITY; PREVALENCE; PROTEIN BLOOD LEVEL; RISK FACTOR; SEPSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SLC19A1 GENE; TCN2 GENE;

COHORT STUDIES; FEMALE; FOLIC ACID; GENOTYPE; HOMOCYSTEINE; HUMANS; HYPERBILIRUBINEMIA, NEONATAL; INCIDENCE; INDIA; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; MALE; MICRONUTRIENTS; PREGNANCY; RISK FACTORS; VITAMIN B 12;

EID: 84881148215     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071587     Document Type: Article

References (29)

1. World Bank report on malnourishment 2011: http://data.worldbank.org/indicator/SP.DYN.IMRT.IN. Accessed 2012 November 12.
2. James KS, (2011) India's demographic change: opportunities and challenges. Science 333: 576-580. doi:10.1126/science.1207969. PubMed: 21798938.
3. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, et al. (2010) Global, regional, and national causes of child mortality in 2008. Lancet 375: 1969-1987. doi:10.1016/S0140-6736(10)60549-1. PubMed: 20466419.
4. Yajnik CS, Deshpande SS, Panchanadikar AV, Naik SS, Deshpande JA, et al. (2005) Maternal total homocysteine concentration and neonatal size in India. Asia Pac J Clin Nutr 14: 179-181. PubMed: 15927937.
5. Jain V, Paul VK, (2012) Guest editorial: Fetal growth restriction and its consequences. Rev Endocr Metab Disord 13: 83-84. doi:10.1007/s11154-012-9218-4. PubMed: 22532056.
6. Paul VK, Sachdev HS, Mavalankar D, Ramachandran P, Sankar MJ, et al. (2011) Reproductive health, and child health and nutrition in India: meeting the challenge. Lancet 377: 332-349. doi:10.1016/S0140-6736(10)61492-4. PubMed: 21227494.
7. Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, et al. (2004) Facts and recommendations about total homocysteine determinations: An Expert Opinion. Clin Chem 50: 3-32. doi:10.1373/clinchem.2003.021634. PubMed: 14709635.
8. Black MM, (2008) Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull 29: S126-S131. PubMed: 18709887.
9. Murphy MM, Fernandez-Ballart JD, (2011) Homocysteine in pregnancy. Adv Clin Chem 53: 105-137. doi:10.1016/B978-0-12-385855-9.00005-9. PubMed: 21404916.
10. Yakub M, Moti N, Parveen S, Chaudhry B, Azam I, (2012) Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population. PLOS ONE 7: e33222. doi:10.1371/journal.pone.0033222. PubMed: 22470444.
11. Kumar J, Garg G, Sundaramoorthy E, Prasad PV, Karthikeyan G, et al. (2009) Vitamin B12 deficiency is associated with coronary artery disease in an Indian population. Clin Chem Lab Med 47: 334-338. PubMed: 19676146.
12. Godbole K, Gayathri P, Ghule S, Sasirekha BV, Kanitkar-Damle A, et al. (2011) Maternal one-carbon metabolism, MTHFR and TCN2 genotypes and neural tube defects in India. Birth Defects Res A Clin Mol Teratol 91: 848-856. doi:10.1002/bdra.20841. PubMed: 21770021.
13. Sukla KK, Raman R, (2012) Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population. Eur J Clin Nutr 66: 111-118. doi:10.1038/ejcn.2011.152. PubMed: 21878957.
14. American Academy of Pediatrics, Clinical Practice Manual, Subcommittee on Hyperbilirubinemia (2004) Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 114: 297-316.
15. Miller JW, Ramos MI, Garrod MG, Flynn MA, Green R, (2002) Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults. Blood 100: 718-720. doi:10.1182/blood-2002-01-0209. PubMed: 12091374.
16. Couto FD, Moreira LM, Dos Santos DB, Reis MG, Gonçalves MS, (2007) Folate, vitamin B12 and total homocysteine levels in neonates from Brazil. Eup J Clin Nutr 61: 382-386. doi:10.1038/sj.ejcn.1602528. PubMed: 16988650.
17. Guerra-Shinohara EM, Paiva AA, Rondo PH, Yamasaki K, Terzi CA, et al. (2002) Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B12. Br J Obstet Gynaecol 109: 784-791. doi:10.1111/j.1471-0528.2002.01307.x. PubMed: 12135215.
18. Hay G, Clausen T, Whitelaw A, Trygg K, Johnston C, et al. (2010) Maternal Folate and Cobalamin status predicts vitamin status in newborns and 6-month old Infants. J Nutr 140: 557-564. doi:10.3945/jn.109.117424. PubMed: 20071650.
19. Ba Y, Yu H, Liu F, Geng X, Zhu C, et al. (2011) Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood. Eur J Clin Nutr 65: 480-485. doi:10.1038/ejcn.2010.294. PubMed: 21245875.
20. Karademir F, Suleymanoglu S, Ersen A, Aydinoz S, Gultepe M, et al. (2007) Vitamin B12, folate, homocysteine and urinary methylmalonic acid levels in infants. J Int Med Res 35: 384-388. doi:10.1177/147323000703500313. PubMed: 17593867.
21. Koc A, Kocyigit A, Soran M, Demir N, Sevinc E, et al. (2006) High frequency of maternal vitamin B12 deficiency as an important cause of infantile vitamin B12 deficiency in Sanliurfa province of Turkey. Eur J Nutr 45: 291-297. doi:10.1007/s00394-006-0598-7. PubMed: 16601915.
22. Minet JC, Bissé E, Aebischer CP, Beil A, Wieland H, et al. (2007) Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates. Am J Clin Nutr 72: 751-757. PubMed: 10966894.
23. Wallace JM, Bonham MP, Strain J, Duffy EM, Robson PJ, et al. (2008) Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles child development study. Am J Clin Nutr 87: 391-397. PubMed: 18258630.
24. Taneja S, Bhandari N, Strand TA, Sommerfelt H, Refsum H, et al. (2007) Cobalamin and folate status in infants and young children in a low-to-middle income community in India. Am J Clin Nutr 86: 1302-1309. PubMed: 17991639.
25. Relton CL, Pearce MS, Parker L, (2005) The influence of erythrocyte folate and serum vitamin B12 status on birth weight. Br J Nutr 93: 593-599. doi:10.1079/BJN20041395. PubMed: 15975157.
26. Fredriksen A, Meyer K, Ueland PM, Vollset SE, Grotmol T, et al. (2007) Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat 28: 856-865. doi:10.1002/humu.20522. PubMed: 17436311.
27. Pavlíková M, Sokolová J, Janosíková B, Melenovská P, Krupková L, et al. (2012) Rare allelic variants determine folate status in an unsupplemented European population. J Nutr 142: 1403-1409. doi:10.3945/jn.112.160549. PubMed: 22695967.
28. Khanduri U, Sharma A, (2007) Megaloblastic anaemia: prevalence and causative factors. Natl Med J India 20: 172-175. PubMed: 18085121.
29. Kawade N, Onishi S, (1981) The prenatal and postnatal development of UDP lucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver. Biochem J 196: 257-260. PubMed: 6796071.