Adipocytes regulate the bone marrow microenvironment in a mouse model of obesity

Molecular Medicine Reports

Volumn 8, Issue 3, 2013, Pages 823-828

  Xu, Fei ^a   Du, Yu ^a   Hang, Shilong ^a   Chen, Anmin ^a   Guo, Fengjin ^a   Xu, Tao ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Adipocyte; Obesity; Osteoblasts osteoclast; Osteoprotegerin receptor activator of nuclear factor B ligand receptor activator of nuclear factor B system

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; CATHEPSIN K; MESSENGER RNA; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE MARROW; BONE METABOLISM; COCULTURE; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; OBESITY; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PROTEIN ANALYSIS; RNA ANALYSIS; TIBIA;

ACID PHOSPHATASE; ADIPOCYTES; ALKALINE PHOSPHATASE; ANIMALS; BONE DENSITY; BONE MARROW CELLS; CATHEPSIN K; CELLS, CULTURED; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; OSTEOCALCIN; OSTEOGENESIS; OSTEOPROTEGERIN; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B;

EID: 84881133062     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1572     Document Type: Article

References (22)

1. Bahia L, Coutinho ES, Barufaldi LA, et al: The costs of overweight and obesity-related diseases in the Brazilian public health system: cross-sectional study. BMC Public Health 12: 440, 2012.
2. Mathus-Vliegen EM: Obesity and the elderly. J Clin Gastroenterol 46: 533-544, 2012.
3. Cao JJ: Effects of obesity on bone metabolism. J Orthop Surg Res 6: 30, 2011.
4. Halade GV, Rahman MM, Williams PJ and Fernandes G: High fat diet-induced animal model of age-associated obesity and osteoporosis. J Nutr Biochem 21: 1162-1169, 2010.
5. Bredella MA, Torriani M, Ghomi RH, et al: Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women. Obesity (Silver Spring) 19: 49-53, 2011.
6. Dimitri P, Bishop N, Walsh JS and Eastell R: Obesity is a risk factor for fracture in children but is protective against fracture in adults: a paradox. Bone 50: 457-466, 2012.
7. Prieto-Alhambra D, Premaor MO, Fina Aviles F, et al: The association between fracture and obesity is site-dependent: a population-based study in postmenopausal women. J Bone Miner Res 27: 294-300, 2012.
8. Kawai M, de Paula FJ and Rosen CJ: New insights into osteoporosis: the bone-fat connection. J Intern Med 272: 317-329, 2012.
9. Aguila MB, Pinheiro Ada R, Parente LB and Mandarim-de-Lacerda CA: Dietary effect of different high-fat diet on rat liver stereology. Liver Int 23: 363-370, 2003.
10. Compston JE, Watts NB, Chapurlat R, et al: Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med 124: 1043-1050, 2011.
11. Shapses SA and Sukumar D: Bone metabolism in obesity and weight loss. Annu Rev Nutr 32: 287-309, 2012.
12. Thomas T and Burguera B: Is leptin the link between fat and bone mass? J Bone Miner Res 17: 1563-1169, 2002.
13. Verzeletti GN, Gaio EJ, Linhares DS and Rösing CK: Effect of obesity on alveolar bone loss in experimental periodontitis in Wistar rats. J Appl Oral Sci 20: 218-221, 2012.
14. Dytfeld J, Ignaszak-Szczepaniak M, Gowin E, et al: Influence of lean and fat mass on bone mineral density (BMD) in postmenopausal women with osteoporosis. Arch Gerontol Geriatr 53: e237-e242, 2011.
15. Chen JR, Lazarenko OP, Wu X, et al: Obesity reduces bone density associated with activation of PPARγ and suppression of Wnt/β-catenin in rapidly growing male rats. PLoS One 5: e13704, 2010.
16. Halade GV, El Jamali A, Williams PJ, et al: Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice. Exp Gerontol 46: 43-52, 2011.
17. Savopoulos C, Dokos C, Kaiafa G and Hatzitolios A: Adipogenesis and osteoblastogenesis: trans-differentiation in the pathophysiology of bone disorders. Hippokratia 15: 18-21, 2011.
18. Hirotani H, Tuohy NA, Woo JT, et al: The calcineurin/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cells. J Biol Chem 279: 13984-13992, 2004.
19. Oshima K, Nampei A, Matsuda M, et al: Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 331: 520-526, 2005.
20. Goto H, Osaki M, Fukushima T, et al: Human bone marrow adipocytes support dexamethasone-induced osteoclast differentiation and function through RANKL expression. Biomed Res 32: 37-44, 2011.
21. Fujita Y, Watanabe K and Maki K: Serum leptin levels negatively correlate with trabecular bone mineral density in high-fat diet-induced obesity mice. J Musculoskelet Neuronal Interact 12: 84-94, 2012.
22. Tyrovola JB, Spyropoulos MN, Makou M and Perrea D: Root resorption and the OPG/RANKL/RANK system: a mini review. J Oral Sci 50: 367-376, 2008.