Effect of seminal plasma application to the vaginal vault in in vitro fertilization or intracytoplasmic sperm injection treatment cycles - A double-blind, placebo-controlled, randomized study

Journal of Assisted Reproduction and Genetics

Volumn 30, Issue 7, 2013, Pages 907-911

  Friedler, S ^a,b   Ben Ami, I ^a   Gidoni, Y ^a   Strassburger, D ^a   Kasterstein, E ^a   Maslansky, B ^a   Komarovsy, D ^a   Bern, O ^a   Ron El, R ^a   Raziel, A ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b BARZILAI MEDICAL CENTER   (Israel)

Author keywords

Implantation; Intercourse; IVF; Pregnancy rate; Seminal plasma

Indexed keywords

PLACEBO;

ADULT; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; NIDATION; OOCYTE RETRIEVAL; OVARY FOLLICLE CELL; PREGNANCY RATE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEMINAL PLASMA; SPONTANEOUS ABORTION; VAGINA;

ADULT; DOUBLE-BLIND METHOD; EMBRYO IMPLANTATION; EMBRYO TRANSFER; FEMALE; HUMANS; INFERTILITY; MALE; OOCYTE RETRIEVAL; PLACEBOS; PREGNANCY; PREGNANCY RATE; PROSPECTIVE STUDIES; SEMEN; SPERM INJECTIONS, INTRACYTOPLASMIC; VAGINA;

EID: 84881125076     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-013-0033-y     Document Type: Article

References (20)

1. Tremellen KP, Seamark RF, Robertson SA. Seminal transforming growth factor beta1 stimulates granulocyte-macrophage colony-stimulating factor production and inflammatory cell recruitment in the murine uterus. Biol Reprod. 1998;58:1217-25.
2. Robertson SA, Mau VJ, Tremellen KP, Seamark RF. Role of high molecular weight seminal vesicle proteins in eliciting the uterine inflammatory response to semen in mice. J Reprod Fertil. 1996;107:265-77.
3. O'Leary S, Jasper MJ, Warnes GM, Armstrong DT, Robertson SA. Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig. Reproduction. 2004;128:237-47.
4. Gutsche S, von Wolff M, Strowitzki T, Thaler CJ. Seminal plasma induces mRNA expression of IL-1beta, IL-6 and LIF in endometrial epithelial cells vitro. Mol Hum Reprod. 2003;9:785-91.
5. Von Wolff M, Nowak O, Pinheiro RM, Strowitzki T. Seminal plasma - immunmodulatory potential in men with normal and abnormal sperm count. Eur J Obstet Gynecol Reprod Biol. 2007;124:73-8.
6. Pinheiro RM, Capp E, Strowitzki T, von Wolff M. The effect of selected genes involved in implantation. Hum Reprod. 2007;122 Suppl 1:P-493.
7. Robertson SA. Seminal plasma and male factor signaling in the female reproductive tract. Cell Tissue Res. 2005;322:43-52.
8. Bellinge BS, Copeland CM, Thomas TD, Mazzucchelli RE, O'Neil G, Cohen MJ. The influence of patient insemination on the implantation rate in an in vitro fertilization and embryo transfer program. Fertil Steril. 1986;46:252-6.
9. Coulam CB, Stern JJ. Effect of seminal plasma on implantation rates. Early Pregnancy. 1995;1:33-6.
10. Tremellen KP, Valbuena D, Landeras J, Ballesteros A, Martinez J, Mendoza S, et al. The effect of intercourse on pregnancy rates during assisted human reproduction. Hum Reprod. 2000;15:2653-8.
11. Von Wolff M, Sabine Rosner S, Thone C, Pinheiro RM, Jauckus J, Bruckner T, et al. Intravaginal and intracervical application of seminal plasma in in vitro fertilization or intracytoplasmic sperm injection treatment cycles - a double-blind, placebo-controlled, randomized pilot study. Fertil Steril. 2009;91:167-7.
12. Fishel S, Webster J, Jackson P, Faratian B. Evaluation of high vaginal insemination at oocyte recovery in patients undergoing in vitro fertilization. Fertil Steril. 1989;51(1):135-8.
13. Friedler S, Gilboa S, Schachter M, Raziel A, Strassburger D, Ron-El R. Luteal phase characteristics following GnRH antagonist or agonist treatment - a comparative study. Reprod Biomed Online. 2001;12:27-32.
14. Robertson SA, Guerin LR, Moldenhauer LM, Hayball JD. Activating T regulatory cells for tolerance in early pregnancy - the contribution of seminal fluid. J Reprod Immunol. 2009;83(1-2):109-16.
15. Sharkey DJ, Tremellen KP, Jasper MJ, Gemzell-Danielsson K, Robertson SA. Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus. J Immunol. 2012;188(5):2445-54. doi: 10.4049/jimmunol.1102736. Epub 2012 Jan 23.
16. Doyle U, Sampson N, Zenzmaier C, Schwärzler P, Berger P. Seminal plasma enhances and accelerates progesterone-induced decidualisation of human endometrial stromal cells. Reprod Fertil Dev. 2012;24(3):517-22.
17. Sharkey DJ, Macpherson AM, Tremellen KP, Robertson SA. Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells. Mol Hum Reprod. 2007;13(7):491-501.
18. Leyendecker G, Kunz G, Wildt L, Beil D, Deininger H. Uterine hyperperistalsis and dysperistalsis as dysfunctions of the mechanism of rapid sperm transport in patients with endometriosis and infertility. Hum Reprod. 1996;11:1542-51.
19. Kunz G, Beil D, Deiniger H, Leyendecker G. The uterine peristaltic pump. Normal and impeded sperm transport within the female genital tract. Adv Exp Med Biol. 1997;424:267-77.
20. Horcajades JA, Riesewijk A, Polman J, Van Os R, Pellicer A, Mosselmann S, et al. Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles. Mol Hum Reprod. 2005;11:195-205.