Thrombolytic therapy for the treatment of prosthetic heart valve thrombosis in pregnancy with low-dose, slow infusion of tissue-type plasminogen activator

Circulation

Volumn 128, Issue 5, 2013, Pages 532-540

  Özkan, Mehmet ^a   Çakal, Beytullah ^a   Karakoyun, Süleyman ^a   Gürsoy, Ozan Mustafa ^a   Çevik, Cihan ^b   Kalçik, Macit ^a   Oǧuz, Ali Emrah ^a   Gündüz, Sabahattin ^a   Astarcioglu, Mehmet Ali ^a   Aykan, Ahmet Çaǧri ^a   Bayram, Zübeyde ^a   Biteker, Murat ^a   Kaynak, Evren ^c   Kahveci, Gökhan ^a   Duran, Nilüfer Ekşi ^a   Yildiz, Mustafa ^a  

^a Kosuyolu Kartal Heart Training and Research Hospital   (Turkey)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

echocardiography, transesophageal; heart valves; mechanical thrombolysis; pregnancy; thrombosis

Indexed keywords

LOW MOLECULAR WEIGHT HEPARIN; STREPTOKINASE; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE; WARFARIN;

ADULT; ARTICLE; ASYMPTOMATIC DISEASE; BLEEDING; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CLINICAL ARTICLE; DRUG EFFICACY; DRUG SAFETY; DYSPNEA; FEMALE; FETUS MORTALITY; FETUS OUTCOME; FIBRINOLYTIC THERAPY; GESTATIONAL AGE; HEART ATRIUM FIBRILLATION; HEART PALPITATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; LOW DRUG DOSE; MECHANICAL THROMBECTOMY; OUTCOME ASSESSMENT; PARTIAL THROMBOPLASTIN TIME; PATIENT SAFETY; PLACENTA DISORDER; PREGNANCY; PREGNANT WOMAN; PRIORITY JOURNAL; PROSTHETIC VALVE THROMBOSIS; SECOND TRIMESTER PREGNANCY; THROMBOEMBOLISM; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; TRANSIENT ISCHEMIC ATTACK;

ECHOCARDIOGRAPHY, TRANSESOPHAGEAL; HEART VALVES; MECHANICAL THROMBOLYSIS; PREGNANCY; THROMBOSIS;

ADULT; FEMALE; HEART DISEASES; HEART VALVE PROSTHESIS; HUMANS; INFUSIONS, INTRAVENOUS; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PROSPECTIVE STUDIES; THROMBOLYTIC THERAPY; THROMBOSIS; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84881108424     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.001145     Document Type: Article

References (48)

1. Elkayam U, Singh H, Irani A, Akhter MW. Anticoagulation in pregnant women with prosthetic heart valves. J Cardiovasc Pharmacol Ther. 2004;9:107-115.
2. Chan WS, Anand S, Ginsberg JS. Anticoagulation of pregnant women with mechanical heart valves: A systematic review of the literature. Arch Intern Med. 2000;160:191-196.
3. McLintock C, McCowan LM, North RA. Maternal complications and pregnancy outcome in women with mechanical prosthetic heart valves treated with enoxaparin. BJOG. 2009;116:1585-1592.
4. Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Barón-Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Iung B, Lancellotti P, Pierard L, Price S, Schäfers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M. Guidelines on the management of valvular heart disease (version 2012): The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology and the European Association for Cardio-Thoracic Surgery. Eur Heart J. 2012;33:2451-2496.
5. Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: A report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2008;52:e1-e142.
6. Weiss BM, von Segesser LK, Alon E, Seifert B, Turina MI. Outcome of cardiovascular surgery and pregnancy: A systematic review of the period 1984-1996. Am J Obstet Gynecol. 1998;179(pt 1):1643-1653.
7. Ozkan M, Gunduz S, Biteker M, Astarcioglu MA, Cevik C, Kaynak E, Yildiz M, Oǧuz E, Aykan AÇ, Ertürk E, Karavelioǧlu Y, Gökdeniz T, Kaya H, Gürsoy OM, Çakal B, Karakoyun S, Duran N, Özdemir N. Comparison of different TRansesophageal echocardiography guided thrOmbolytic regimens for prosthetIc vAlve thrombosis: TROIA Trial. JACC Imaging. 2013;6:206-216.
8. Leeander I, Nilsson M, Astedt B. Depression of plasminogen activator activity during pregnancy by the placental inhibitor PAI 2. Fibrinolysis. 1988;2:165-167.
9. Moisson P, Cornier E, Rozensztajn L, Catinat J. Thrombosis of a mitral valve prosthesis in a pregnant woman: Treatment with streptokinase [in French]. Coeur Med Interne. 1979;18:425-432.
10. Witchitz S, Veyrat C, Moisson P, Scheinman N, Rozenstajn L. Fibrinolytic treatment of thrombus on prosthetic heart valves. Br Heart J. 1980;44:545-554.
11. Jimenez M, Vergnes C, Brottier L, Dequeker JL, Billes MA, Lorient Roudaut MF, Choussat A, Boisseau MR. Recurrent thrombosis of an aortic valve prosthesis in a pregnant woman: Treatment with urokinase [in French]. J Mal Vasc. 1988;13:46-49.
12. Tissot H, Vergnes C, Rougier P, Bricaud H, Dallay D. Fibrinolytic treatment with urokinase and streptokinase for recurrent thrombosis in two valve prostheses for the aortic and mitral valves during pregnancy [in French]. J Gynecol Obstet Biol Reprod (Paris). 1991;20:1093-1096.
13. Souto JC, Zuazu-Jausoro I, Mateo J, Borrás X, Fontcuberta J. Shortterm treatment of thrombosis of heart valve prostheses with high doses of streptokinase: Presentation of 5 cases [in Spanish]. Med Clin (Barc). 1991;96:261-264.
14. Ramamurthy S, Talwar KK, Saxena A, Juneja R, Takkar D. Prosthetic mitral valve thrombosis in pregnancy successfully treated with streptokinase. Am Heart J. 1994;127:446-448.
15. Azzano O, French P, Robin J, Quinson P, de La Bourdonnaye T, Champsaur G, Mellier G, Normand J, Bozio A. Thrombolytic therapy with rtPA for thrombosis of tricuspid valve prosthesis during pregnancy [in French]. Arch Mal Coeur Vaiss. 1995;88:267-270.
16. Di Roio C, Perrot D, Védrinne JM, Méllier G, Robin J, Motin J. Thrombolytic therapy with rtPA of recurrent thrombosis in tricuspid valve prosthesis during pregnancy [in French]. Ann Fr Anesth Reanim. 1996;15:666-668.
17. Rinaldi JP, Yassine M, Aboujaoudé F, Belhakem H, Alsagheer S, Ben Ahmed F, Lemarié P, Boursier M, Khalifé K. Successful thrombolysis on an aortic valve prosthesis by plasminogen tissue activator during pregnancy [in French]. Arch Mal Coeur Vaiss. 1999;92:427-430.
18. Fleyfel M, Bourzoufi K, Huin G, Subtil D, Puech F. Recombinant tissue type plasminogen activator treatment of thrombosed mitral valve prosthesis during pregnancy. Can J Anaesth. 1997;44:735-738.
19. Sánchez A, Cortadellas J, Figueras J, González T, Soler Soler J. Fibrinolytic treatment for patients with prosthesis thrombosis and high surgical risk [in Spanish]. Rev Esp Cardiol. 2001;54:1452-1455.
20. Anbarasan C, Kumar VS, Latchumanadhas K, Mullasari AS. Successful thrombolysis of prosthetic mitral valve thrombosis in early pregnancy. J Heart Valve Dis. 2001;10:393-395.
21. Nanas JN, Kontoyannis SA, Mitsibounas DN, Stamatelopoulos SF. Thrombolytic treatment for thrombosis of a mitral valve prosthesis during pregnancy. Intensive Care Med. 2001;27:1668-1669.
22. Abbadi H. Successful thrombolysis of mitral valve prosthesis by streptokinase during pregnancy. East Mediterr Health J. 2001;7:283-286.
23. Behrendt P, Schwartzkopff B, Perings S, Gerhardt A, Zotz RB, Strauer BE. Successful thrombolysis of St. Jude medical aortic prosthesis with tissue-type plasminogen activator in a pregnant woman: A case report. Cardiol Rev. 2002;10:349-353.
24. Nassar AH, Abdallah ME, Moukarbel GV, Usta IM, Gharzuddine WS. Sequential use of thrombolytic agents for thrombosed mitral valve prosthesis during pregnancy. J Perinat Med. 2003;31:257-260.
25. Sahnoun-Trabelsi I, Jimenez M, Choussat A, Roudaut R. Prosthetic valve thrombosis in pregnancy: A single-center study of 12 cases [in French]. Arch Mal Coeur Vaiss. 2004;97:305-310.
26. Varadarajan P, Isaeff D, Pai RG. Prosthetic valve thrombosis presenting as an acute embolic myocardial infarction in a pregnant patient: Issues on anticoagulation regimens and thrombolytic therapy. Echocardiography. 2006;23:774-779.
27. Sandset PM, Arnesen H, Jakobsen AF, Wergeland H. Anticoagulant treatment in a hypercoagulable woman with mechanical prosthetic mitral valve: Failure of high dose low molecular weight heparin (LMWH) treatment. Second International Symposium. on Women's Health Issues in Thrombosis and Hemostasis. 2007;119(suppl 1):S97-S118.
28. Choi C, Midwall S, Chaille P, Conti CR. Treatment of mechanical valve thrombosis during pregnancy. Clin Cardiol. 2007;30:271-276.
29. Wei A, Alison J, Goldstein J, Tippett C, Coughlan PB. Prosthetic pulmonary valve thrombosis in pregnancy successfully treated with thrombolysis. Intern Med J. 2008;38:142-143.
30. Maegdefessel L, Issa H, Scheler C, Thäle V, Schlitt A, Hartelt U, Grabitz R, Buerke M. 27-Year old pregnant woman with syncope and dyspnea after aortic alloplastic heart valve replacement 15 years ago [in German]. Internist (Berl). 2008;49:868-872.
31. Slaoui M, Cherradi R, Ounzar M, Massou S, Srairi JE. Thrombosis valvular prosthesis of Starr treated successfully by tenecteplase during pregnancy [in French]. Ann Fr Anesth Reanim. 2010;29:500-501.
32. Kaya EB, Kocabaş U, Aksoy H, Aytemir K, Tokgözoǧlu L. Successful fibrinolytic treatment in a pregnant woman with acute mitral prosthetic valve thrombosis. Clin Cardiol. 2010;33:E101-E103.
33. Ozer O, Davutoglu V, Soydinc HE, Cebesoy FB, Sari I, Akcay M. Fibrinolytic therapy of prosthetic mitral valve thrombosis during pregnancy: Three case reports and review of the literature. Clin Appl Thromb Hemost. 2010;16:406-413.
34. Srinivas BC, Moorthy N, Kuldeep A, Jeevan H, Chandrasekaran D, Manjunath CN. Thrombolytic therapy in prosthetic valve thrombosis during early pregnancy. Indian Heart J. 2012;64:74-76.
35. Leonhardt G, Gaul C, Nietsch HH, Buerke M, Schleussner E. Thrombolytic therapy in pregnancy. J Thromb Thrombolysis. 2006;21:271-276.
36. Ozkan M, Kaymaz C, Kirma C, Sönmez K, Ozdemir N, Balkanay M, Yakut C, Deligönül U. Intravenous thrombolytic treatment of mechanical prosthetic valve thrombosis: A study using serial transesophageal echocardiography. J Am Coll Cardiol. 2000;35:1881-1889.
37. Alpert JS. The thrombosed prosthetic valve: Current recommendations based on evidence from the literature. J Am Coll Cardiol. 2003;41:659-660.
38. Ozkan M, Biteker M, Duran NE, Yildiz M. Images in cardiovascular medicine: Huge prosthetic mitral valve thrombosis in a pregnant woman. Circulation. 2009;120:e151-e152.
39. Tong AT, Roudaut R, Ozkan M, Sagie A, Shahid MS, Pontes Júnior SC, Carreras F, Girard SE, Arnaout S, Stainback RF, Thadhani R, Zoghbi WA; Prosthetic Valve Thrombolysis - Role of Transesophageal Echocardiography (PRO-TEE) Registry Investigators. Transesophageal echocardiography improves risk assessment of thrombolysis of prosthetic valve thrombosis: Results of the international PRO-TEE registry. J Am Coll Cardiol. 2004;43:77-84.
40. Cáceres-Lóriga FM, Pérez-López H, Morlans-Hernández K, Facundo-Sánchez H, Santos-Gracia J, Valiente-Mustelier J, Rodiles-Aldana F, Marrero-Mirayaga MA, Betancourt BY, López-Saura P. Thrombolysis as first choice therapy in prosthetic heart valve thrombosis: A study of 68 patients. J Thromb Thrombolysis. 2006;21:185-190.
41. Karthikeyan G, Math RS, Mathew N, Shankar B, Kalaivani M, Singh S, Bahl VK, Hirsh J, Eikelboom JW. Accelerated infusion of streptokinase for the treatment of left-sided prosthetic valve thrombosis: A randomized controlled trial. Circulation. 2009;120:1108-1114.
42. Roudaut R, Lafitte S, Roudaut MF, Courtault C, Perron JM, Jaïs C, Pillois X, Coste P, DeMaria A. Fibrinolysis of mechanical prosthetic valve thrombosis: A single-center study of 127 cases. J Am Coll Cardiol. 2003;41:653-658.
43. Keuleers S, Herijgers P, Herregods MC, Budts W, Dubois C, Meuris B, Verhamme P, Flameng W, Van de Werf F, Adriaenssens T. Comparison of thrombolysis versus surgery as a first line therapy for prosthetic heart valve thrombosis. Am J Cardiol. 2011;107:275-279.
44. Torbicki A, Perrier A, Konstantinides S, Agnelli G, Galiè N, Pruszczyk P, Bengel F, Brady AJ, Ferreira D, Janssens U, Klepetko W, Mayer E, Remy-Jardin M, Bassand JP; ESC Committee for Practice Guidelines (CPG). Guidelines on the diagnosis and management of acute pulmonary embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J. 2008;29:2276-2315.
45. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, Larrue V, Bluhmki E, Davis S, Donnan G, Schneider D, Diez-Tejedor E, Trouillas P. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II): Second European-Australasian Acute Stroke Study Investigators. Lancet. 1998;352:1245-1251.
46. Menon V, Harrington RA, Hochman JS, Cannon CP, Goodman SD, Wilcox RG, Schünemann HJ, Ohman EM. Thrombolysis and adjunctive therapy in acute myocardial infarction: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(suppl):549S-575S.
47. Ahearn GS, Hadjiliadis D, Govert JA, Tapson VF. Massive pulmonary embolism during pregnancy successfully treated with recombinant tissue plasminogen activator: A case report and review of treatment options. Arch Intern Med. 2002;162:1221-1227.
48. Sezer K, Kamel N, Unlu C, Celik HK. Impact of first trimester and postpartum period thyroid autoantibodies on abortus incidence in Turkish pregnant women. Gynecol Endocrinol. 2009;25:387-391.