Dabrafenib (Tafinlar) and Trametinib (Mekinist) for metastatic melanoma

Medical Letter on Drugs and Therapeutics

Volumn 55, Issue 1422, 2013, Pages 62-63

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; DABRAFENIB; DACARBAZINE; IPILIMUMAB; MEKINIST; MITOGEN ACTIVATED PROTEIN KINASE 1; PACLITAXEL; TAFINLAR; TRAMETINIB; UNCLASSIFIED DRUG; VEMURAFENIB;

ALOPECIA; ARTHRALGIA; CARDIOMYOPATHY; CELL PROLIFERATION; DIARRHEA; DISEASE COURSE; DRUG WITHDRAWAL; FEVER; HAND FOOT SYNDROME; HEADACHE; HUMAN; HYPERKERATOSIS; INTERSTITIAL LUNG DISEASE; IRITIS; LETTER; LYMPHEDEMA; METASTATIC MELANOMA; PAPILLOMA; PROGRESSION FREE SURVIVAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RASH; RECOMMENDED DRUG DOSE; RETINA VEIN OCCLUSION; SKIN CARCINOMA; UVEITIS;

ANTINEOPLASTIC AGENTS; HUMANS; IMIDAZOLES; MELANOMA; OXIMES; PYRIDONES; PYRIMIDINONES;

EID: 84881037448     PISSN: 0025732X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (8)

1. Vemurafenib (Zelboraf) for metastatic melanoma. Med Lett Drugs Ther 2011; 53:77.
2. Ipilimumab (Yervoy) for metastatic melanoma. Med Lett Drugs Ther 2011; 53:51.
3. KT Flaherty et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012; 367:1694.
4. A Hauschild et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012; 380:358.
5. KB Kim et al. Phase II study of the MEK1/MEK2 inhibitor trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor. J Clin Oncol 2013; 31:482.
6. KT Flaherty et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 2012; 367:107.
7. Inhibitors and inducers of CYP enzymes and P-glycoprotein. Med Lett Drugs Ther 2013; 55:e44.
8. Wholesale acquisition cost. Source: $ource® Monthly (Selected from FDB MedKnowledge™) July 5, 2013. Reprinted with permission by FDB, Inc. All rights reserved. ©2013. www.fdbhealth.com/policies/drug-pricing-policy. Actual retail prices may be higher.