Cognitive improvement after HCV eradication: Extending the benefits

Hepatology

Volumn 58, Issue 2, 2013, Pages 480-482

  Bajaj, Jasmohan S ^a   Forton, Daniel M ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; PEGINTERFERON ALPHA; PEGINTERFERON ALPHA2B; RIBAVIRIN;

ANTIVIRAL THERAPY; COGNITION; COGNITIVE DEFECT; DEPRESSION; EDITORIAL; EXECUTIVE FUNCTION; GENETIC POLYMORPHISM; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LIVER CIRRHOSIS; LIVER FIBROSIS; PRIORITY JOURNAL; VIRAL CLEARANCE; WORKING MEMORY;

ANTIVIRAL AGENTS; COGNITION DISORDERS; FEMALE; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; RIBAVIRIN;

EID: 84881030450     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26481     Document Type: Editorial

References (14)

1. Forton DM, Allsop JM, Main J, Foster GR, Thomas HC, Taylor-Robinson SD. Evidence for a cerebral effect of the hepatitis C virus. Lancet 2001;358:38-39.
2. Senzolo M, Schiff S, D'Aloiso CM, Crivellin C, Cholongitas E, Burra P, et al. Neuropsychological alterations in hepatitis C infection: the role of inflammation. World J Gastroenterol 2011;17:3369-3374.
3. Schaefer M, Capuron L, Friebe A, Diez-Quevedo C, Robaeys G, Neri S, et al. Hepatitis C infection, antiviral treatment and mental health: a European expert consensus statement. J Hepatol 2012;57:1379-1390.
4. Fontana RJ, Bieliauskas LA, Back-Madruga C, Lindsay KL, Litman HJ, Lok AS, et al.; HALT-C Trial Group. Cognitive function does not worsen during long-term low-dose peginterferon therapy in patients with chronic hepatitis C. Am J Gastroenterol 2010;105:1551-1560.
5. Kraus MR, Schäfer A, Wissmann S, Reimer P, Scheurlen M. Neurocognitive changes in patients with hepatitis C receiving interferon alfa-2b and ribavirin. Clin Pharmacol Ther 2005;77:90-100.
6. Kraus MR, Schäfer A, Teuber G, Porst H, Paul K, Wollschläger S, et al. Improvement of neurocognitive function in responders to an antiviral therapy for chronic hepatitis C. Hepatology 2013;58:497-504.
7. Bajaj JS, Wade JB, Sanyal AJ. Spectrum of neuro-cognitive impairment in cirrhosis: implications for the assessment of hepatic encephalopathy Hepatology 2009;50:2014-2021.
8. Weissenborn K, Tryc AB, Heeren M, Worthmann H, Pflugrad H, Berding G, et al. Hepatitis C virus infection and the brain. Metab Brain Dis 2009;24:197-210.
9. Forton DM, Hamilton G, Allsop JM, Grover VP, Wesnes K, O'Sullivan C, et al. Cerebral immune activation in chronic hepatitis C infection: a magnetic resonance spectroscopy study. J Hepatol 2008;49:316-322.
10. Grover VP, Pavese N, Koh SB, Wylezinska M, Saxby BK, Gerhard A, et al. Cerebral microglial activation in patients with hepatitis C: in vivo evidence of neuroinflammation. Viral Hepat 2012;19:89-96.
11. Weissenborn K, Ennen JC, Bokemeyer M, Ahl B, Wurster U, Tillmann H, et al. Monoaminergic neurotransmission is altered in hepatitis C virus infected patients with chronic fatigue and cognitive impairment. Gut 2006;55:1624-1630.
12. Forton DM, Karayiannis P, Mahmud N, Taylor-Robinson SD, Thomas HC. Identification of unique hepatitis C virus quasispecies in the central nervous system and comparative analysis of internal translational efficiency of brain, liver, and serum variants. J Virol 2004;78:5170-5183.
13. Wilkinson J, Radkowski M, Laskus T. Hepatitis C virus neuroinvasion: identification of infected cells. J Virol 2009;83:1312-1319.
14. Fletcher NF, Wilson GK, Murray J, Hu K, Lewis A, Reynolds GM, et al. Hepatitis C virus infects the endothelial cells of the blood-brain barrier. Gastroenterology 2012;142:634-643.