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Volumn 106-107, Issue , 2013, Pages 17-32

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

Author keywords

Mitochondrial dysfunction; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; CALCIUM; DJ 1 PROTEIN; LEUCINE RICH REPEAT KINASE 2; MANEB; MITOCHONDRIAL DNA; PARAQUAT; PARKIN; PINK1 PROTEIN; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; UNCLASSIFIED DRUG;

EID: 84881027032     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2013.04.004     Document Type: Review
Times cited : (596)

References (263)
  • 2
    • 78349309594 scopus 로고    scopus 로고
    • Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects
    • Amo T., Sato S., Saiki S., Wolf A.M., Toyomizu M., Gautier C.A., Shen J., Ohta S., Hattori N. Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiology of Disease 2011, 41:111-118.
    • (2011) Neurobiology of Disease , vol.41 , pp. 111-118
    • Amo, T.1    Sato, S.2    Saiki, S.3    Wolf, A.M.4    Toyomizu, M.5    Gautier, C.A.6    Shen, J.7    Ohta, S.8    Hattori, N.9
  • 3
    • 33846115045 scopus 로고    scopus 로고
    • Anonymous A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease
    • Anonymous A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology 2007, 68:20-28.
    • (2007) Neurology , vol.68 , pp. 20-28
  • 4
    • 77957351763 scopus 로고    scopus 로고
    • Variations of the CAG trinucleotide repeat in DNA polymerase gamma (POLG1) is associated with Parkinson's disease in Sweden
    • Anvret A., Westerlund M., Sydow O., Willows T., Lind C., Galter D., Belin A.C. Variations of the CAG trinucleotide repeat in DNA polymerase gamma (POLG1) is associated with Parkinson's disease in Sweden. Neuroscience Letters 2010, 485:117-120.
    • (2010) Neuroscience Letters , vol.485 , pp. 117-120
    • Anvret, A.1    Westerlund, M.2    Sydow, O.3    Willows, T.4    Lind, C.5    Galter, D.6    Belin, A.C.7
  • 6
    • 7444270637 scopus 로고    scopus 로고
    • Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells
    • Barlow B.K., Lee D.W., Cory-Slechta D.A., Opanashuk L.A. Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells. Neurotoxicology 2005, 26:63-75.
    • (2005) Neurotoxicology , vol.26 , pp. 63-75
    • Barlow, B.K.1    Lee, D.W.2    Cory-Slechta, D.A.3    Opanashuk, L.A.4
  • 7
    • 0038051345 scopus 로고    scopus 로고
    • Mitochondria, oxidative damage, and inflammation in Parkinson's disease
    • Beal M.F. Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Annals of the New York Academy of Sciences 2003, 991:120-131.
    • (2003) Annals of the New York Academy of Sciences , vol.991 , pp. 120-131
    • Beal, M.F.1
  • 8
    • 64649093555 scopus 로고    scopus 로고
    • Mitochondrial fusion and division: regulation and role in cell viability
    • Benard G., Karbowski M. Mitochondrial fusion and division: regulation and role in cell viability. Seminars in Cell & Developmental Biology 2009, 20:365-374.
    • (2009) Seminars in Cell & Developmental Biology , vol.20 , pp. 365-374
    • Benard, G.1    Karbowski, M.2
  • 12
    • 84863104152 scopus 로고    scopus 로고
    • Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice
    • Bian M., Liu J., Hong X., Yu M., Huang Y., Sheng Z., Fei J., Huang F. Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. PloS One 2012, 7:e39953.
    • (2012) PloS One , vol.7
    • Bian, M.1    Liu, J.2    Hong, X.3    Yu, M.4    Huang, Y.5    Sheng, Z.6    Fei, J.7    Huang, F.8
  • 13
    • 68949125734 scopus 로고    scopus 로고
    • Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease
    • Biskup S., West A.B. Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease. Biochimica et Biophysica Acta 2009, 1792:625-633.
    • (2009) Biochimica et Biophysica Acta , vol.1792 , pp. 625-633
    • Biskup, S.1    West, A.B.2
  • 20
    • 79953685935 scopus 로고    scopus 로고
    • Alterations in the mitochondrial proteome of neuroblastoma cells in response to complex 1 inhibition
    • Burte F., De Girolamo L.A., Hargreaves A.J., Billett E.E. Alterations in the mitochondrial proteome of neuroblastoma cells in response to complex 1 inhibition. Journal of Proteome Research 2011, 10:1974-1986.
    • (2011) Journal of Proteome Research , vol.10 , pp. 1974-1986
    • Burte, F.1    De Girolamo, L.A.2    Hargreaves, A.J.3    Billett, E.E.4
  • 23
    • 84860223145 scopus 로고    scopus 로고
    • Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease
    • Cardoso S.M., Esteves A.R., Arduino D.M. Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease. Neuro-Degenerative Diseases 2012, 10:38-40.
    • (2012) Neuro-Degenerative Diseases , vol.10 , pp. 38-40
    • Cardoso, S.M.1    Esteves, A.R.2    Arduino, D.M.3
  • 27
    • 77951096150 scopus 로고    scopus 로고
    • Mitochondrial dynamics - fusion, fission, movement, and mitophagy - in neurodegenerative diseases
    • Chen H., Chan D.C. Mitochondrial dynamics - fusion, fission, movement, and mitophagy - in neurodegenerative diseases. Human Molecular Genetics 2009, 18:R169-R176.
    • (2009) Human Molecular Genetics , vol.18
    • Chen, H.1    Chan, D.C.2
  • 31
  • 33
    • 33745589773 scopus 로고    scopus 로고
    • Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    • Clark I.E., Dodson M.W., Jiang C., Cao J.H., Huh J.R., Seol J.H., Yoo S.J., Hay B.A., Guo M. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006, 441:1162-1166.
    • (2006) Nature , vol.441 , pp. 1162-1166
    • Clark, I.E.1    Dodson, M.W.2    Jiang, C.3    Cao, J.H.4    Huh, J.R.5    Seol, J.H.6    Yoo, S.J.7    Hay, B.A.8    Guo, M.9
  • 34
    • 38349105900 scopus 로고    scopus 로고
    • Complex I is the major site of mitochondrial superoxide production by paraquat
    • Cocheme H.M., Murphy M.P. Complex I is the major site of mitochondrial superoxide production by paraquat. The Journal of Biological Chemistry 2008, 283:1786-1798.
    • (2008) The Journal of Biological Chemistry , vol.283 , pp. 1786-1798
    • Cocheme, H.M.1    Murphy, M.P.2
  • 35
    • 44749085250 scopus 로고    scopus 로고
    • Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification
    • Cole N.B., Dieuliis D., Leo P., Mitchell D.C., Nussbaum R.L. Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification. Experimental Cell Research 2008, 314:2076-2089.
    • (2008) Experimental Cell Research , vol.314 , pp. 2076-2089
    • Cole, N.B.1    Dieuliis, D.2    Leo, P.3    Mitchell, D.C.4    Nussbaum, R.L.5
  • 36
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
    • Conway K.A., Harper J.D., Lansbury P.T. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nature Medicine 1998, 4:1318-1320.
    • (1998) Nature Medicine , vol.4 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 37
    • 0034681163 scopus 로고    scopus 로고
    • Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy
    • Conway K.A., Lee S.J., Rochet J.C., Ding T.T., Williamson R.E., Lansbury P.T. Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:571-576.
    • (2000) Proceedings of the National Academy of Sciences of the United States of America , vol.97 , pp. 571-576
    • Conway, K.A.1    Lee, S.J.2    Rochet, J.C.3    Ding, T.T.4    Williamson, R.E.5    Lansbury, P.T.6
  • 38
    • 37649004547 scopus 로고    scopus 로고
    • Cell systems and the toxic mechanism(s) of alpha-synuclein
    • Cookson M.R., van der Brug M. Cell systems and the toxic mechanism(s) of alpha-synuclein. Experimental Neurology 2008, 209:5-11.
    • (2008) Experimental Neurology , vol.209 , pp. 5-11
    • Cookson, M.R.1    van der Brug, M.2
  • 39
    • 63649095770 scopus 로고    scopus 로고
    • Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California
    • Costello S., Cockburn M., Bronstein J., Zhang X., Ritz B. Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California. American Journal of Epidemiology 2009, 169:919-926.
    • (2009) American Journal of Epidemiology , vol.169 , pp. 919-926
    • Costello, S.1    Cockburn, M.2    Bronstein, J.3    Zhang, X.4    Ritz, B.5
  • 40
    • 34147177574 scopus 로고    scopus 로고
    • Clinical research: testing a novel strategy against Parkinson's disease
    • Couzin J. Clinical research: testing a novel strategy against Parkinson's disease. Science 2007, 315:1778.
    • (2007) Science , vol.315 , pp. 1778
    • Couzin, J.1
  • 42
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: mechanisms and models
    • Dauer W., Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003, 39:889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 44
    • 33750354046 scopus 로고    scopus 로고
    • Parkin and defective ubiquitination in Parkinson's disease
    • Dawson T.M. Parkin and defective ubiquitination in Parkinson's disease. Journal of Neural Transmission 2006, 70(Suppl.):209-213.
    • (2006) Journal of Neural Transmission , vol.70 , Issue.SUPPL. , pp. 209-213
    • Dawson, T.M.1
  • 46
    • 0029964357 scopus 로고    scopus 로고
    • MPP(+)-induced neurotoxicity in mouse is age-dependent: evidenced by the selective inhibition of complexes of electron transport
    • Desai V.G., Feuers R.J., Hart R.W., Ali S.F. MPP(+)-induced neurotoxicity in mouse is age-dependent: evidenced by the selective inhibition of complexes of electron transport. Brain Research 1996, 715:1-8.
    • (1996) Brain Research , vol.715 , pp. 1-8
    • Desai, V.G.1    Feuers, R.J.2    Hart, R.W.3    Ali, S.F.4
  • 47
    • 44049099669 scopus 로고    scopus 로고
    • Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
    • Devi L., Raghavendran V., Prabhu B.M., Avadhani N.G., Anandatheerthavarada H.K. Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. The Journal of Biological Chemistry 2008, 283:9089-9100.
    • (2008) The Journal of Biological Chemistry , vol.283 , pp. 9089-9100
    • Devi, L.1    Raghavendran, V.2    Prabhu, B.M.3    Avadhani, N.G.4    Anandatheerthavarada, H.K.5
  • 48
    • 80053173420 scopus 로고    scopus 로고
    • Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease
    • Diedrich M., Kitada T., Nebrich G., Koppelstaetter A., Shen J., Zabel C., Klose J., Mao L. Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease. Proteome Science 2011, 9:59.
    • (2011) Proteome Science , vol.9 , pp. 59
    • Diedrich, M.1    Kitada, T.2    Nebrich, G.3    Koppelstaetter, A.4    Shen, J.5    Zabel, C.6    Klose, J.7    Mao, L.8
  • 49
    • 33747191688 scopus 로고    scopus 로고
    • Acute neurotoxic effects of mancozeb and maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction
    • Domico L.M., Zeevalk G.D., Bernard L.P., Cooper K.R. Acute neurotoxic effects of mancozeb and maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction. Neurotoxicology 2006, 27:816-825.
    • (2006) Neurotoxicology , vol.27 , pp. 816-825
    • Domico, L.M.1    Zeevalk, G.D.2    Bernard, L.P.3    Cooper, K.R.4
  • 50
    • 20444450523 scopus 로고    scopus 로고
    • Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains
    • Doss-Pepe E.W., Chen L., Madura K. Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains. The Journal of Biological Chemistry 2005, 280:16619-16624.
    • (2005) The Journal of Biological Chemistry , vol.280 , pp. 16619-16624
    • Doss-Pepe, E.W.1    Chen, L.2    Madura, K.3
  • 53
    • 84867693278 scopus 로고    scopus 로고
    • Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1
    • Elm J.J. Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1. Movement Disorders:Official Journal of the Movement Disorder Society 2012, 27:1513-1521.
    • (2012) Movement Disorders:Official Journal of the Movement Disorder Society , vol.27 , pp. 1513-1521
    • Elm, J.J.1
  • 60
    • 0027343340 scopus 로고
    • Similarities and differences between MPTP-induced parkinsonsim and Parkinson's disease. Neuropathologic considerations
    • Forno L.S., DeLanney L.E., Irwin I., Langston J.W. Similarities and differences between MPTP-induced parkinsonsim and Parkinson's disease. Neuropathologic considerations. Advances in Neurology 1993, 60:600-608.
    • (1993) Advances in Neurology , vol.60 , pp. 600-608
    • Forno, L.S.1    DeLanney, L.E.2    Irwin, I.3    Langston, J.W.4
  • 63
    • 65549124540 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease
    • Gandhi P.N., Chen S.G., Wilson-Delfosse A.L. Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease. Journal of Neuroscience Research 2009, 87:1283-1295.
    • (2009) Journal of Neuroscience Research , vol.87 , pp. 1283-1295
    • Gandhi, P.N.1    Chen, S.G.2    Wilson-Delfosse, A.L.3
  • 66
    • 79956088518 scopus 로고    scopus 로고
    • Characterization of reduced and oxidized dopamine and 3,4-dihydrophenylacetic acid, on brain mitochondrial electron transport chain activities
    • Gautam A.H., Zeevalk G.D. Characterization of reduced and oxidized dopamine and 3,4-dihydrophenylacetic acid, on brain mitochondrial electron transport chain activities. Biochimica et Biophysica Acta 2011, 1807:819-828.
    • (2011) Biochimica et Biophysica Acta , vol.1807 , pp. 819-828
    • Gautam, A.H.1    Zeevalk, G.D.2
  • 68
    • 84863624459 scopus 로고    scopus 로고
    • Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening
    • Giaime E., Yamaguchi H., Gautier C.A., Kitada T., Shen J. Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. PloS One 2012, 7:e40501.
    • (2012) PloS One , vol.7
    • Giaime, E.1    Yamaguchi, H.2    Gautier, C.A.3    Kitada, T.4    Shen, J.5
  • 73
    • 0020514306 scopus 로고
    • Intracellular and extracellular electrophysiology of nigral dopaminergic neurons - 2 Action potential generating mechanisms and morphological correlates
    • Grace A.A., Bunney B.S. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons - 2 Action potential generating mechanisms and morphological correlates. Neuroscience 1983, 10:317-331.
    • (1983) Neuroscience , vol.10 , pp. 317-331
    • Grace, A.A.1    Bunney, B.S.2
  • 77
    • 0029050583 scopus 로고
    • Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease
    • Haas R.H., Nasirian F., Nakano K., Ward D., Pay M., Hill R., Shults C.W. Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease. Annals of Neurology 1995, 37:714-722.
    • (1995) Annals of Neurology , vol.37 , pp. 714-722
    • Haas, R.H.1    Nasirian, F.2    Nakano, K.3    Ward, D.4    Pay, M.5    Hill, R.6    Shults, C.W.7
  • 78
    • 18144406539 scopus 로고    scopus 로고
    • Oxidative stress and inflammation in Parkinson's disease: is there a causal link?
    • Hald A., Lotharius J. Oxidative stress and inflammation in Parkinson's disease: is there a causal link?. Experimental Neurology 2005, 193:279-290.
    • (2005) Experimental Neurology , vol.193 , pp. 279-290
    • Hald, A.1    Lotharius, J.2
  • 79
    • 33745280651 scopus 로고    scopus 로고
    • Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity
    • Hampe C., Ardila-Osorio H., Fournier M., Brice A., Corti O. Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity. Human Molecular Genetics 2006, 15:2059-2075.
    • (2006) Human Molecular Genetics , vol.15 , pp. 2059-2075
    • Hampe, C.1    Ardila-Osorio, H.2    Fournier, M.3    Brice, A.4    Corti, O.5
  • 80
    • 0027535984 scopus 로고
    • Stable parkinsonian syndrome and uneven loss of striatal dopamine fibres following chronic MPTP administration in baboons
    • Hantraye P., Varastet M., Peschanski M., Riche D., Cesaro P., Willer J.C., Maziere M. Stable parkinsonian syndrome and uneven loss of striatal dopamine fibres following chronic MPTP administration in baboons. Neuroscience 1993, 53:169-178.
    • (1993) Neuroscience , vol.53 , pp. 169-178
    • Hantraye, P.1    Varastet, M.2    Peschanski, M.3    Riche, D.4    Cesaro, P.5    Willer, J.C.6    Maziere, M.7
  • 86
    • 0024997609 scopus 로고
    • 1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles
    • Hasegawa E., Takeshige K., Oishi T., Murai Y., Minakami S. 1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles. Biochemical and Biophysical Research Communications 1990, 170:1049-1055.
    • (1990) Biochemical and Biophysical Research Communications , vol.170 , pp. 1049-1055
    • Hasegawa, E.1    Takeshige, K.2    Oishi, T.3    Murai, Y.4    Minakami, S.5
  • 87
    • 0025942723 scopus 로고
    • Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease
    • Hattori N., Tanaka M., Ozawa T., Mizuno Y. Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease. Annals of Neurology 1991, 30:563-571.
    • (1991) Annals of Neurology , vol.30 , pp. 563-571
    • Hattori, N.1    Tanaka, M.2    Ozawa, T.3    Mizuno, Y.4
  • 88
    • 0021280826 scopus 로고
    • Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice
    • Heikkila R.E., Hess A., Duvoisin R.C. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science 1984, 224:1451-1453.
    • (1984) Science , vol.224 , pp. 1451-1453
    • Heikkila, R.E.1    Hess, A.2    Duvoisin, R.C.3
  • 93
    • 56349103980 scopus 로고    scopus 로고
    • The molecular mechanism of mitochondrial fusion
    • Hoppins S., Nunnari J. The molecular mechanism of mitochondrial fusion. Biochimica et Biophysica Acta 2009, 1793:20-26.
    • (2009) Biochimica et Biophysica Acta , vol.1793 , pp. 20-26
    • Hoppins, S.1    Nunnari, J.2
  • 94
    • 84863230106 scopus 로고    scopus 로고
    • Interaction between α-Synuclein and tau genotypes and the progression of parkinson's disease
    • Huang Y., Rowe D.B., Halliday G.M. Interaction between α-Synuclein and tau genotypes and the progression of parkinson's disease. Journal of Parkinson's Disease 2011, 1:271-276.
    • (2011) Journal of Parkinson's Disease , vol.1 , pp. 271-276
    • Huang, Y.1    Rowe, D.B.2    Halliday, G.M.3
  • 96
    • 27844554819 scopus 로고    scopus 로고
    • Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults
    • Hyun D.H., Lee M., Halliwell B., Jenner P. Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults. Journal of Neuroscience Research 2005, 82:232-244.
    • (2005) Journal of Neuroscience Research , vol.82 , pp. 232-244
    • Hyun, D.H.1    Lee, M.2    Halliwell, B.3    Jenner, P.4
  • 100
    • 72649092390 scopus 로고    scopus 로고
    • Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process
    • Isobe C., Abe T., Terayama Y. Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process. Neuroscience Letters 2010, 469:159-163.
    • (2010) Neuroscience Letters , vol.469 , pp. 159-163
    • Isobe, C.1    Abe, T.2    Terayama, Y.3
  • 101
    • 0034001572 scopus 로고    scopus 로고
    • Mechanisms of toxicity, clinical features, and management of diquat poisoning: a review
    • Jones G.M., Vale J.A. Mechanisms of toxicity, clinical features, and management of diquat poisoning: a review. Journal of Toxicology Clinical Toxicology 2000, 38:123-128.
    • (2000) Journal of Toxicology Clinical Toxicology , vol.38 , pp. 123-128
    • Jones, G.M.1    Vale, J.A.2
  • 103
    • 77952545692 scopus 로고    scopus 로고
    • Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration
    • Kachroo A., Irizarry M.C., Schwarzschild M.A. Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration. Experimental Neurology 2010, 223:657-661.
    • (2010) Experimental Neurology , vol.223 , pp. 657-661
    • Kachroo, A.1    Irizarry, M.C.2    Schwarzschild, M.A.3
  • 108
    • 33644610520 scopus 로고    scopus 로고
    • The genetics of Parkinson disease: implications for neurological care
    • Klein C., Schlossmacher M.G. The genetics of Parkinson disease: implications for neurological care. Nature Clinical Practice Neurology 2006, 2:136-146.
    • (2006) Nature Clinical Practice Neurology , vol.2 , pp. 136-146
    • Klein, C.1    Schlossmacher, M.G.2
  • 110
    • 57649210194 scopus 로고    scopus 로고
    • Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration
    • Knott A.B., Bossy-Wetzel E. Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration. Annals of the New York Academy of Sciences 2008, 1147:283-292.
    • (2008) Annals of the New York Academy of Sciences , vol.1147 , pp. 283-292
    • Knott, A.B.1    Bossy-Wetzel, E.2
  • 111
    • 33646351299 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
    • Kraytsberg Y., Kudryavtseva E., McKee A.C., Geula C., Kowall N.W., Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nature Genetics 2006, 38:518-520.
    • (2006) Nature Genetics , vol.38 , pp. 518-520
    • Kraytsberg, Y.1    Kudryavtseva, E.2    McKee, A.C.3    Geula, C.4    Kowall, N.W.5    Khrapko, K.6
  • 113
    • 0026484964 scopus 로고
    • Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson Disease Research Group
    • Krige D., Carroll M.T., Cooper J.M., Marsden C.D., Schapira A.H. Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson Disease Research Group. Annals of Neurology 1992, 32:782-788.
    • (1992) Annals of Neurology , vol.32 , pp. 782-788
    • Krige, D.1    Carroll, M.T.2    Cooper, J.M.3    Marsden, C.D.4    Schapira, A.H.5
  • 118
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston J.W., Ballard P., Tetrud J.W., Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983, 219:979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 119
    • 0021263249 scopus 로고
    • 1-Methyl-4-phenylpyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra
    • Langston J.W., Irwin I., Langston E.B., Forno L.S. 1-Methyl-4-phenylpyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra. Neuroscience Letters 1984, 48:87-92.
    • (1984) Neuroscience Letters , vol.48 , pp. 87-92
    • Langston, J.W.1    Irwin, I.2    Langston, E.B.3    Forno, L.S.4
  • 120
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston J.W., Forno L.S., Tetrud J., Reeves A.G., Kaplan J.A., Karluk D. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Annals of Neurology 1999, 46:598-605.
    • (1999) Annals of Neurology , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 121
    • 33750361540 scopus 로고    scopus 로고
    • A century-old debate on protein aggregation and neurodegeneration enters the clinic
    • Lansbury P.T., Lashuel H.A. A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature 2006, 443:774-779.
    • (2006) Nature , vol.443 , pp. 774-779
    • Lansbury, P.T.1    Lashuel, H.A.2
  • 122
    • 34748826792 scopus 로고    scopus 로고
    • Localization of alpha-synuclein to mitochondria within midbrain of mice
    • Li W.W., Yang R., Guo J.C., Ren H.M., Zha X.L., Cheng J.S., Cai D.F. Localization of alpha-synuclein to mitochondria within midbrain of mice. Neuroreport 2007, 18:1543-1546.
    • (2007) Neuroreport , vol.18 , pp. 1543-1546
    • Li, W.W.1    Yang, R.2    Guo, J.C.3    Ren, H.M.4    Zha, X.L.5    Cheng, J.S.6    Cai, D.F.7
  • 123
    • 33846460819 scopus 로고    scopus 로고
    • Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease
    • Liang C.L., Wang T.T., Luby-Phelps K., German D.C. Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease. Experimental Neurology 2007, 203:370-380.
    • (2007) Experimental Neurology , vol.203 , pp. 370-380
    • Liang, C.L.1    Wang, T.T.2    Luby-Phelps, K.3    German, D.C.4
  • 126
    • 76849117517 scopus 로고    scopus 로고
    • Genome-wide microarray analysis of the differential neuroprotective effects of antioxidants in neuroblastoma cells overexpressing the familial Parkinson's disease alpha-synuclein A53T mutation
    • Ma L., Cao T.T., Kandpal G., Warren L., Fred Hess J., Seabrook G.R., Ray W.J. Genome-wide microarray analysis of the differential neuroprotective effects of antioxidants in neuroblastoma cells overexpressing the familial Parkinson's disease alpha-synuclein A53T mutation. Neurochemical Research 2010, 35:130-142.
    • (2010) Neurochemical Research , vol.35 , pp. 130-142
    • Ma, L.1    Cao, T.T.2    Kandpal, G.3    Warren, L.4    Fred Hess, J.5    Seabrook, G.R.6    Ray, W.J.7
  • 128
    • 34548741834 scopus 로고    scopus 로고
    • RAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease
    • Manfredsson F.P., Burger C., Sullivan L.F., Muzyczka N., Lewin A.S., Mandel R.J. rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease. Experimental Neurology 2007, 207:289-301.
    • (2007) Experimental Neurology , vol.207 , pp. 289-301
    • Manfredsson, F.P.1    Burger, C.2    Sullivan, L.F.3    Muzyczka, N.4    Lewin, A.S.5    Mandel, R.J.6
  • 129
    • 0021137683 scopus 로고
    • Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism
    • Markey S.P., Johannessen J.N., Chiueh C.C., Burns R.S., Herkenham M.A. Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism. Nature 1984, 311:464-467.
    • (1984) Nature , vol.311 , pp. 464-467
    • Markey, S.P.1    Johannessen, J.N.2    Chiueh, C.C.3    Burns, R.S.4    Herkenham, M.A.5
  • 132
    • 57049143140 scopus 로고    scopus 로고
    • Mitochondria in neuroplasticity and neurological disorders
    • Mattson M.P., Gleichmann M., Cheng A. Mitochondria in neuroplasticity and neurological disorders. Neuron 2008, 60:748-766.
    • (2008) Neuron , vol.60 , pp. 748-766
    • Mattson, M.P.1    Gleichmann, M.2    Cheng, A.3
  • 134
    • 84859699540 scopus 로고    scopus 로고
    • Animal models of the non-motor features of Parkinson's disease
    • McDowell K., Chesselet M.F. Animal models of the non-motor features of Parkinson's disease. Neurobiology of Disease 2012, 46:597-606.
    • (2012) Neurobiology of Disease , vol.46 , pp. 597-606
    • McDowell, K.1    Chesselet, M.F.2
  • 141
    • 0024829856 scopus 로고
    • Acute exposure to maneb alters some behavioral functions in the mouse
    • Morato G.S., Lemos T., Takahashi R.N. Acute exposure to maneb alters some behavioral functions in the mouse. Neurotoxicology and Teratology 1989, 11:421-425.
    • (1989) Neurotoxicology and Teratology , vol.11 , pp. 421-425
    • Morato, G.S.1    Lemos, T.2    Takahashi, R.N.3
  • 142
    • 78650025189 scopus 로고    scopus 로고
    • Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2
    • Mortiboys H., Johansen K.K., Aasly J.O., Bandmann O. Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2. Neurology 2010, 75:2017-2020.
    • (2010) Neurology , vol.75 , pp. 2017-2020
    • Mortiboys, H.1    Johansen, K.K.2    Aasly, J.O.3    Bandmann, O.4
  • 145
    • 33846471122 scopus 로고    scopus 로고
    • Proteasome-independent functions of ubiquitin in endocytosis and signaling
    • Mukhopadhyay D., Riezman H. Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 2007, 315:201-205.
    • (2007) Science , vol.315 , pp. 201-205
    • Mukhopadhyay, D.1    Riezman, H.2
  • 146
    • 0037426566 scopus 로고    scopus 로고
    • Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease
    • Muller T., Buttner T., Gholipour A.F., Kuhn W. Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease. Neuroscience Letters 2003, 341:201-204.
    • (2003) Neuroscience Letters , vol.341 , pp. 201-204
    • Muller, T.1    Buttner, T.2    Gholipour, A.F.3    Kuhn, W.4
  • 148
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy M.P. How mitochondria produce reactive oxygen species. The Biochemical Journal 2009, 417:1-13.
    • (2009) The Biochemical Journal , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 151
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra D., Tanaka A., Suen D.F., Youle R.J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. The Journal of Cell Biology 2008, 183:795-803.
    • (2008) The Journal of Cell Biology , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 153
    • 57649178442 scopus 로고    scopus 로고
    • Oxidative stress and energy crises in neuronal dysfunction
    • Nicholls D.G. Oxidative stress and energy crises in neuronal dysfunction. Annals of the New York Academy of Sciences 2008, 1147:53-60.
    • (2008) Annals of the New York Academy of Sciences , vol.1147 , pp. 53-60
    • Nicholls, D.G.1
  • 154
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Nicklas W.J., Vyas I., Heikkila R.E. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sciences 1985, 36:2503-2508.
    • (1985) Life Sciences , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heikkila, R.E.3
  • 155
    • 84863728713 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via dynamin-like protein
    • Niu J., Yu M., Wang C., Xu Z. Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via dynamin-like protein. Journal of Neurochemistry 2012, 122:650-658.
    • (2012) Journal of Neurochemistry , vol.122 , pp. 650-658
    • Niu, J.1    Yu, M.2    Wang, C.3    Xu, Z.4
  • 158
    • 0030710487 scopus 로고    scopus 로고
    • Oxidative damage and fragmentation of mitochondrial DNA in cellular apoptosis
    • Ozawa T. Oxidative damage and fragmentation of mitochondrial DNA in cellular apoptosis. Bioscience Reports 1997, 17:237-250.
    • (1997) Bioscience Reports , vol.17 , pp. 237-250
    • Ozawa, T.1
  • 163
    • 57749194390 scopus 로고    scopus 로고
    • The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process
    • Park J., Lee G., Chung J. The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. Biochemical and Biophysical Research Communications 2009, 378:518-523.
    • (2009) Biochemical and Biophysical Research Communications , vol.378 , pp. 518-523
    • Park, J.1    Lee, G.2    Chung, J.3
  • 164
    • 41749104745 scopus 로고    scopus 로고
    • Complex I deficiency in Parkinson's disease frontal cortex
    • Parker W.D., Parks J.K., Swerdlow R.H. Complex I deficiency in Parkinson's disease frontal cortex. Brain Research 2008, 1189:215-218.
    • (2008) Brain Research , vol.1189 , pp. 215-218
    • Parker, W.D.1    Parks, J.K.2    Swerdlow, R.H.3
  • 166
    • 0033521095 scopus 로고    scopus 로고
    • Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease
    • Pennathur S., Jackson-Lewis V., Przedborski S., Heinecke J.W. Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease. The Journal of Biological Chemistry 1999, 274:34621-34628.
    • (1999) The Journal of Biological Chemistry , vol.274 , pp. 34621-34628
    • Pennathur, S.1    Jackson-Lewis, V.2    Przedborski, S.3    Heinecke, J.W.4
  • 170
    • 28844439032 scopus 로고    scopus 로고
    • Proteomic analysis of parkin knockout mice: alterations in energy metabolism protein handling and synaptic function
    • Periquet M., Corti O., Jacquier S., Brice A. Proteomic analysis of parkin knockout mice: alterations in energy metabolism protein handling and synaptic function. Journal of Neurochemistry 2005, 95:1259-1276.
    • (2005) Journal of Neurochemistry , vol.95 , pp. 1259-1276
    • Periquet, M.1    Corti, O.2    Jacquier, S.3    Brice, A.4
  • 173
    • 84859422737 scopus 로고    scopus 로고
    • Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP(+)-induced mitochondrial dysfunctions in neuronal cells
    • Piao Y., Kim H.G., Oh M.S., Pak Y.K. Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP(+)-induced mitochondrial dysfunctions in neuronal cells. Biochimica et Biophysica Acta 2012, 1820:577-585.
    • (2012) Biochimica et Biophysica Acta , vol.1820 , pp. 577-585
    • Piao, Y.1    Kim, H.G.2    Oh, M.S.3    Pak, Y.K.4
  • 175
    • 0029965334 scopus 로고    scopus 로고
    • Apamin-sensitive Ca(2+)-activated K+ channels regulate pacemaker activity in nigral dopamine neurons
    • Ping H.X., Shepard P.D. Apamin-sensitive Ca(2+)-activated K+ channels regulate pacemaker activity in nigral dopamine neurons. Neuroreport 1996, 7:809-814.
    • (1996) Neuroreport , vol.7 , pp. 809-814
    • Ping, H.X.1    Shepard, P.D.2
  • 178
    • 14744305520 scopus 로고    scopus 로고
    • Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice - a model of familial Parkinson's disease
    • Poon H.F., Frasier M., Shreve N., Calabrese V., Wolozin B., Butterfield D.A. Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice - a model of familial Parkinson's disease. Neurobiology of Disease 2005, 18:492-498.
    • (2005) Neurobiology of Disease , vol.18 , pp. 492-498
    • Poon, H.F.1    Frasier, M.2    Shreve, N.3    Calabrese, V.4    Wolozin, B.5    Butterfield, D.A.6
  • 180
    • 34547127902 scopus 로고    scopus 로고
    • PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
    • Pridgeon J.W., Olzmann J.A., Chin L.S., Li L. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biology 2007, 5:e172.
    • (2007) PLoS Biology , vol.5
    • Pridgeon, J.W.1    Olzmann, J.A.2    Chin, L.S.3    Li, L.4
  • 184
    • 0022516015 scopus 로고
    • Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism
    • Ramsay R.R., Salach J.I., Dadgar J., Singer T.P. Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism. Biochemical and Biophysical Research Communications 1986, 135:269-275.
    • (1986) Biochemical and Biophysical Research Communications , vol.135 , pp. 269-275
    • Ramsay, R.R.1    Salach, J.I.2    Dadgar, J.3    Singer, T.P.4
  • 190
    • 84866164284 scopus 로고    scopus 로고
    • Alpha-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease
    • Ritz B., Rhodes S.L., Bordelon Y., Bronstein J. Alpha-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease. PloS One 2012, 7:e36199.
    • (2012) PloS One , vol.7
    • Ritz, B.1    Rhodes, S.L.2    Bordelon, Y.3    Bronstein, J.4
  • 192
    • 0025247726 scopus 로고
    • Dopamine neurons of the monkey midbrain: contingencies of responses to active touch during self-initiated arm movements
    • Romo R., Schultz W. Dopamine neurons of the monkey midbrain: contingencies of responses to active touch during self-initiated arm movements. Journal of Neurophysiology 1990, 63:592-606.
    • (1990) Journal of Neurophysiology , vol.63 , pp. 592-606
    • Romo, R.1    Schultz, W.2
  • 194
    • 77955594704 scopus 로고    scopus 로고
    • Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways
    • Saini N., Oelhafen S., Hua H., Georgiev O., Schaffner W., Bueler H. Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways. Neurobiology of Disease 2010, 40:82-92.
    • (2010) Neurobiology of Disease , vol.40 , pp. 82-92
    • Saini, N.1    Oelhafen, S.2    Hua, H.3    Georgiev, O.4    Schaffner, W.5    Bueler, H.6
  • 195
    • 33745908586 scopus 로고    scopus 로고
    • Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats
    • Saint-Pierre M., Tremblay M.E., Sik A., Gross R.E., Cicchetti F. Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats. Journal of Neurochemistry 2006, 98:760-772.
    • (2006) Journal of Neurochemistry , vol.98 , pp. 760-772
    • Saint-Pierre, M.1    Tremblay, M.E.2    Sik, A.3    Gross, R.E.4    Cicchetti, F.5
  • 199
    • 79959305691 scopus 로고    scopus 로고
    • Mitochondria: the next (neurode)generation
    • Schon E.A., Przedborski S. Mitochondria: the next (neurode)generation. Neuron 2011, 70:1033-1053.
    • (2011) Neuron , vol.70 , pp. 1033-1053
    • Schon, E.A.1    Przedborski, S.2
  • 200
    • 44649150145 scopus 로고    scopus 로고
    • Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells
    • Shavali S., Brown-Borg H.M., Ebadi M., Porter J. Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells. Neuroscience Letters 2008, 439:125-128.
    • (2008) Neuroscience Letters , vol.439 , pp. 125-128
    • Shavali, S.1    Brown-Borg, H.M.2    Ebadi, M.3    Porter, J.4
  • 202
    • 0037847451 scopus 로고    scopus 로고
    • Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats
    • Shimizu K., Matsubara K., Ohtaki K., Fujimaru S., Saito O., Shiono H. Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats. Brain Research 2003, 976:243-252.
    • (2003) Brain Research , vol.976 , pp. 243-252
    • Shimizu, K.1    Matsubara, K.2    Ohtaki, K.3    Fujimaru, S.4    Saito, O.5    Shiono, H.6
  • 204
    • 0345451597 scopus 로고    scopus 로고
    • Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients
    • Shults C.W., Beal M.F., Fontaine D., Nakano K., Haas R.H. Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients. Neurology 1998, 50:793-795.
    • (1998) Neurology , vol.50 , pp. 793-795
    • Shults, C.W.1    Beal, M.F.2    Fontaine, D.3    Nakano, K.4    Haas, R.H.5
  • 209
    • 1542617769 scopus 로고    scopus 로고
    • Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP
    • Song D.D., Shults C.W., Sisk A., Rockenstein E., Masliah E Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP. Experimental Neurology 2004, 186:158-172.
    • (2004) Experimental Neurology , vol.186 , pp. 158-172
    • Song, D.D.1    Shults, C.W.2    Sisk, A.3    Rockenstein, E.4    Masliah, E.5
  • 210
    • 84864759870 scopus 로고    scopus 로고
    • Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat
    • Sonia Angeline M., Chaterjee P., Anand K., Ambasta R.K., Kumar P. Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat. Neuroscience 2012, 220:291-301.
    • (2012) Neuroscience , vol.220 , pp. 291-301
    • Sonia Angeline, M.1    Chaterjee, P.2    Anand, K.3    Ambasta, R.K.4    Kumar, P.5
  • 211
    • 56349133547 scopus 로고    scopus 로고
    • Positioning mitochondrial plasticity within cellular signaling cascades
    • Soubannier V., McBride H.M. Positioning mitochondrial plasticity within cellular signaling cascades. Biochimica et Biophysica Acta 2009, 1793:154-170.
    • (2009) Biochimica et Biophysica Acta , vol.1793 , pp. 154-170
    • Soubannier, V.1    McBride, H.M.2
  • 212
    • 0034531475 scopus 로고    scopus 로고
    • The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy
    • Spillantini M.G., Goedert M. The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Annals of the New York Academy of Sciences 2000, 920:16-27.
    • (2000) Annals of the New York Academy of Sciences , vol.920 , pp. 16-27
    • Spillantini, M.G.1    Goedert, M.2
  • 214
    • 57649233079 scopus 로고    scopus 로고
    • The role of mitochondria in reactive oxygen species metabolism and signaling
    • Starkov A.A. The role of mitochondria in reactive oxygen species metabolism and signaling. Annals of the New York Academy of Sciences 2008, 1147:37-52.
    • (2008) Annals of the New York Academy of Sciences , vol.1147 , pp. 37-52
    • Starkov, A.A.1
  • 217
    • 84870013071 scopus 로고    scopus 로고
    • Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy
    • Sun Y., Vashisht A.A., Tchieu J., Wohlschlegel J.A., Dreier L. Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy. The Journal of Biological Chemistry 2012, 287:40652-40660.
    • (2012) The Journal of Biological Chemistry , vol.287 , pp. 40652-40660
    • Sun, Y.1    Vashisht, A.A.2    Tchieu, J.3    Wohlschlegel, J.A.4    Dreier, L.5
  • 218
    • 34548657565 scopus 로고    scopus 로고
    • Calcium, ageing, and neuronal vulnerability in Parkinson's disease
    • Surmeier D.J. Calcium, ageing, and neuronal vulnerability in Parkinson's disease. Lancet Neurology 2007, 6:933-938.
    • (2007) Lancet Neurology , vol.6 , pp. 933-938
    • Surmeier, D.J.1
  • 219
    • 81255149611 scopus 로고    scopus 로고
    • The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease
    • Surmeier D.J., Guzman J.N., Sanchez-Padilla J., Schumacker PT The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease. Neuroscience 2011, 198:221-231.
    • (2011) Neuroscience , vol.198 , pp. 221-231
    • Surmeier, D.J.1    Guzman, J.N.2    Sanchez-Padilla, J.3    Schumacker, P.T.4
  • 225
    • 0036778511 scopus 로고    scopus 로고
    • Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype
    • Thiruchelvam M., Richfield E.K., Goodman B.M., Baggs R.B., Cory-Slechta D.A. Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype. Neurotoxicology 2002, 23:621-633.
    • (2002) Neurotoxicology , vol.23 , pp. 621-633
    • Thiruchelvam, M.1    Richfield, E.K.2    Goodman, B.M.3    Baggs, R.B.4    Cory-Slechta, D.A.5
  • 226
    • 20444471551 scopus 로고    scopus 로고
    • Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype
    • Thiruchelvam M., Prokopenko O., Cory-Slechta D.A., Buckley B., Mirochnitchenko O. Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. The Journal of Biological Chemistry 2005, 280:22530-22539.
    • (2005) The Journal of Biological Chemistry , vol.280 , pp. 22530-22539
    • Thiruchelvam, M.1    Prokopenko, O.2    Cory-Slechta, D.A.3    Buckley, B.4    Mirochnitchenko, O.5
  • 229
    • 34548620297 scopus 로고    scopus 로고
    • Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation
    • Uversky V.N. Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation. Journal of Neurochemistry 2007, 103:17-37.
    • (2007) Journal of Neurochemistry , vol.103 , pp. 17-37
    • Uversky, V.N.1
  • 232
    • 0028171396 scopus 로고
    • Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in Parkinson's disease
    • Varastet M., Riche D., Maziere M., Hantraye P Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in Parkinson's disease. Neuroscience 1994, 63:47-56.
    • (1994) Neuroscience , vol.63 , pp. 47-56
    • Varastet, M.1    Riche, D.2    Maziere, M.3    Hantraye, P.4
  • 235
    • 33745143950 scopus 로고    scopus 로고
    • Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease
    • Bronstein JM
    • Wang X.F., Li S., Chou A.P., Bronstein JM Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease. Neurobiology of Disease 2006, 23:198-205.
    • (2006) Neurobiology of Disease , vol.23 , pp. 198-205
    • Wang, X.F.1    Li, S.2    Chou, A.P.3
  • 236
    • 35349030746 scopus 로고    scopus 로고
    • PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c
    • Wang H.L., Chou A.H., Yeh T.H., Li A.H., Chen Y.L., Kuo Y.L., Tsai S.R., Yu S.T. PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c. Neurobiology of Disease 2007, 28:216-226.
    • (2007) Neurobiology of Disease , vol.28 , pp. 216-226
    • Wang, H.L.1    Chou, A.H.2    Yeh, T.H.3    Li, A.H.4    Chen, Y.L.5    Kuo, Y.L.6    Tsai, S.R.7    Yu, S.T.8
  • 237
    • 79954616687 scopus 로고    scopus 로고
    • PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons
    • Wang H.L., Chou A.H., Wu A.S., Chen S.Y., Weng Y.H., Kao Y.C., Yeh T.H., Chu P.J., Lu C.S. PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochimica et Biophysica Acta 2011, 1812:674-684.
    • (2011) Biochimica et Biophysica Acta , vol.1812 , pp. 674-684
    • Wang, H.L.1    Chou, A.H.2    Wu, A.S.3    Chen, S.Y.4    Weng, Y.H.5    Kao, Y.C.6    Yeh, T.H.7    Chu, P.J.8    Lu, C.S.9
  • 241
    • 0034118103 scopus 로고    scopus 로고
    • Coupled oscillator model of the dopaminergic neuron of the substantia nigra
    • Wilson C.J., Callaway J.C. Coupled oscillator model of the dopaminergic neuron of the substantia nigra. Journal of Neurophysiology 2000, 83:3084-3100.
    • (2000) Journal of Neurophysiology , vol.83 , pp. 3084-3100
    • Wilson, C.J.1    Callaway, J.C.2
  • 242
  • 243
    • 38549169530 scopus 로고    scopus 로고
    • The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
    • Winklhofer K.F., Tatzelt J., Haass C. The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. The EMBO Journal 2008, 27:336-349.
    • (2008) The EMBO Journal , vol.27 , pp. 336-349
    • Winklhofer, K.F.1    Tatzelt, J.2    Haass, C.3
  • 245
    • 84867234462 scopus 로고    scopus 로고
    • Central nervous system damage due to acute paraquat poisoning: a neuroimaging study with 3.0T MRI
    • Wu B.L., Song B., Tian S.Z., Huo S.H., Cui C.X., Guo Y.S., Liu H.J. Central nervous system damage due to acute paraquat poisoning: a neuroimaging study with 3.0T MRI. Neurotoxicology 2012, 33(5):1330-1337.
    • (2012) Neurotoxicology , vol.33 , Issue.5 , pp. 1330-1337
    • Wu, B.L.1    Song, B.2    Tian, S.Z.3    Huo, S.H.4    Cui, C.X.5    Guo, Y.S.6    Liu, H.J.7
  • 246
    • 28844448703 scopus 로고    scopus 로고
    • The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the dopaminergic pathogenesis
    • Yang W., Tiffany-Castiglioni E. The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the dopaminergic pathogenesis. Journal of Toxicology and Environmental Health Part A 2005, 68:1939-1961.
    • (2005) Journal of Toxicology and Environmental Health Part A , vol.68 , pp. 1939-1961
    • Yang, W.1    Tiffany-Castiglioni, E.2
  • 248
    • 35748954034 scopus 로고    scopus 로고
    • Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice
    • Yang W., Chen L., Ding Y., Zhuang X., Kang U.J. Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice. Human Molecular Genetics 2007, 16:2900-2910.
    • (2007) Human Molecular Genetics , vol.16 , pp. 2900-2910
    • Yang, W.1    Chen, L.2    Ding, Y.3    Zhuang, X.4    Kang, U.J.5
  • 252
    • 79960826207 scopus 로고    scopus 로고
    • The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
    • Yu W., Sun Y., Guo S., Lu B. The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Human Molecular Genetics 2011, 20:3227-3240.
    • (2011) Human Molecular Genetics , vol.20 , pp. 3227-3240
    • Yu, W.1    Sun, Y.2    Guo, S.3    Lu, B.4
  • 253
    • 0036235608 scopus 로고    scopus 로고
    • Paraquat- and diquat-induced oxygen radical generation and lipid peroxidation in rat brain microsomes
    • Yumino K., Kawakami I., Tamura M., Hayashi T., Nakamura M. Paraquat- and diquat-induced oxygen radical generation and lipid peroxidation in rat brain microsomes. Journal of Biochemistry 2002, 131:565-570.
    • (2002) Journal of Biochemistry , vol.131 , pp. 565-570
    • Yumino, K.1    Kawakami, I.2    Tamura, M.3    Hayashi, T.4    Nakamura, M.5
  • 255
    • 0037265974 scopus 로고    scopus 로고
    • Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction
    • Zhang J., Fitsanakis V.A., Gu G., Jing D., Ao M., Amarnath V., Montine T.J. Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction. Journal of Neurochemistry 2003, 84:336-346.
    • (2003) Journal of Neurochemistry , vol.84 , pp. 336-346
    • Zhang, J.1    Fitsanakis, V.A.2    Gu, G.3    Jing, D.4    Ao, M.5    Amarnath, V.6    Montine, T.J.7
  • 257
    • 56049093847 scopus 로고    scopus 로고
    • Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody
    • Zhang L., Zhang C., Zhu Y., Cai Q., Chan P., Ueda K., Yu S., Yang H. Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody. Brain Research 2008, 1244:40-52.
    • (2008) Brain Research , vol.1244 , pp. 40-52
    • Zhang, L.1    Zhang, C.2    Zhu, Y.3    Cai, Q.4    Chan, P.5    Ueda, K.6    Yu, S.7    Yang, H.8
  • 259
    • 54449096831 scopus 로고    scopus 로고
    • Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation
    • Zhong N., Xu J. Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation. Human Molecular Genetics 2008, 17:3357-3367.
    • (2008) Human Molecular Genetics , vol.17 , pp. 3357-3367
    • Zhong, N.1    Xu, J.2
  • 260
    • 4444225471 scopus 로고    scopus 로고
    • Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson's disease
    • Zhou Y., Shie F.S., Piccardo P., Montine T.J., Zhang J. Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson's disease. Neuroscience 2004, 128:281-291.
    • (2004) Neuroscience , vol.128 , pp. 281-291
    • Zhou, Y.1    Shie, F.S.2    Piccardo, P.3    Montine, T.J.4    Zhang, J.5


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