메뉴 건너뛰기




Volumn 22, Issue 8, 2013, Pages 1409-1425

Distinct immunomodulatory and migratory mechanisms underpin the therapeutic potential of human mesenchymal stem cells in autoimmune demyelination

Author keywords

Cell migration; Experimental autoimmune encephalomyelitis (EAE); Immunomodulation; Mesenchymal stem cells (MSCs); Multiple sclerosis (MS)

Indexed keywords

CYTOKINE; MITOGENIC AGENT;

EID: 84880996557     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368912X657620     Document Type: Article
Times cited : (79)

References (76)
  • 1
    • 34247231682 scopus 로고    scopus 로고
    • Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collageninduced arthritis
    • Augello, A.; Tasso, R.; Negrini, S. M.; Cancedda, R.; Pennesi, G. Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collageninduced arthritis. Arthritis Rheum. 56(4):1175-1186; 2007.
    • (2007) Arthritis Rheum , vol.56 , Issue.4 , pp. 1175-1186
    • Augello, A.1    Tasso, R.2    Negrini, S.M.3    Cancedda, R.4    Pennesi, G.5
  • 2
    • 84861574208 scopus 로고    scopus 로고
    • Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models
    • Bai, L.; Lennon, D. P.; Caplan, A. I.; DeChant, A.; Hecker, J.; Kranso, J.; Zaremba, A.; Miller, R. H. Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models. Nat. Neurosci. 15(6):868-870; 2012.
    • (2012) Nat. Neurosci , vol.15 , Issue.6 , pp. 868-870
    • Bai, L.1    Lennon, D.P.2    Caplan, A.I.3    Dechant, A.4    Hecker, J.5    Kranso, J.6    Zaremba, A.7    Miller, R.H.8
  • 3
    • 65649113921 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis
    • Bai, L.; Lennon, D. P.; Eaton, V.; Maier, K.; Caplan, A. I.; Miller, S. D.; Miller, R. H. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia 57(11):1192-1203; 2009.
    • (2009) Glia , vol.57 , Issue.11 , pp. 1192-1203
    • Bai, L.1    Lennon, D.P.2    Eaton, V.3    Maier, K.4    Caplan, A.I.5    Miller, S.D.6    Miller, R.H.7
  • 4
    • 83755188640 scopus 로고    scopus 로고
    • Comparison of chemokine and receptor gene expression between Wharton's jelly and bone marrow-derived mesenchymal stromal cells
    • Balasubramanian, S.; Venugopal, P.; Sundarraj, S.; Zakaria, Z.; Majumdar, A. S.; Ta, M. Comparison of chemokine and receptor gene expression between Wharton's jelly and bone marrow-derived mesenchymal stromal cells. Cytotherapy 14(1):26-33; 2012.
    • (2012) Cytotherapy , vol.14 , Issue.1 , pp. 26-33
    • Balasubramanian, S.1    Venugopal, P.2    Sundarraj, S.3    Zakaria, Z.4    Majumdar, A.S.5    Ta, M.6
  • 6
    • 0031882899 scopus 로고    scopus 로고
    • Expression purification, and encephalitogenicity of recombinant human myelin oligodendrocyte glycoprotein
    • Bettadapura, J.; Menon, K. K.; Moritz, S.; Liu, J.; Bernard, C. C,Expression purification, and encephalitogenicity of recombinant human myelin oligodendrocyte glycoprotein. J. Neurochem. 70(4):1593-1599; 1998.
    • (1998) J. Neurochem , vol.70 , Issue.4 , pp. 1593-1599
    • Bettadapura, J.1    Menon, K.K.2    Moritz, S.3    Liu, J.4    Bernard, C.C.5
  • 7
    • 0038523790 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoproteinspecific T-cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
    • Bettelli, E.; Pagany, M.; Weiner, H. L.; Linington, C.; Sobel, R. A.; Kuchroo, V. K. Myelin oligodendrocyte glycoproteinspecific T-cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J. Exp. Med. 197(9): 1073-1081; 2003.
    • (2003) J. Exp. Med , vol.197 , Issue.9 , pp. 1073-1081
    • Bettelli, E.1    Pagany, M.2    Weiner, H.L.3    Linington, C.4    Sobel, R.A.5    Kuchroo, V.K.6
  • 8
    • 14944339174 scopus 로고    scopus 로고
    • Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness
    • Beyth, S.; Borovsky, Z.; Mevorach, D.; Liebergall, M.; Gazit, Z.; Aslan, H.; Galun, E.; Rachmilewitz, J. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 105(5): 2214-2219; 2005.
    • (2005) Blood , vol.105 , Issue.5 , pp. 2214-2219
    • Beyth, S.1    Borovsky, Z.2    Mevorach, D.3    Liebergall, M.4    Gazit, Z.5    Aslan, H.6    Galun, E.7    Rachmilewitz, J.8
  • 9
    • 42749084909 scopus 로고    scopus 로고
    • Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro
    • Bochev, I.; Elmadjian, G.; Kyurkchiev, D.; Tzvetanov, L.; Altankova, I.; Tivchev, P.; Kyurkchiev, S. Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro. Cell Biol. Int. 32(4):384-393; 2008.
    • (2008) Cell Biol. Int , vol.32 , Issue.4 , pp. 384-393
    • Bochev, I.1    Elmadjian, G.2    Kyurkchiev, D.3    Tzvetanov, L.4    Altankova, I.5    Tivchev, P.6    Kyurkchiev, S.7
  • 10
    • 57449096881 scopus 로고    scopus 로고
    • Molecular trafficking mechanisms of multipotent mesenchymal stem cells derived from human bone marrow and placenta
    • Brooke, G.; Tong, H.; Levesque, J. P.; Atkinson, K. Molecular trafficking mechanisms of multipotent mesenchymal stem cells derived from human bone marrow and placenta. Stem Cells Dev. 17(5):929-940; 2008.
    • (2008) Stem Cells Dev , vol.17 , Issue.5 , pp. 929-940
    • Brooke, G.1    Tong, H.2    Levesque, J.P.3    Atkinson, K.4
  • 11
    • 79955402680 scopus 로고    scopus 로고
    • Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis
    • Chang, J. W.; Hung, S. P.; Wu, H. H.; Wu, W. M.; Yang, A. H.; Tsai, H. L.; Yang, L. Y.; Lee, O. K. Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis. Cell Transplant. 20(2):245-257; 2011.
    • (2011) Cell Transplant , vol.20 , Issue.2 , pp. 245-257
    • Chang, J.W.1    Hung, S.P.2    Wu, H.H.3    Wu, W.M.4    Yang, A.H.5    Tsai, H.L.6    Yang, L.Y.7    Lee, O.K.8
  • 12
    • 70350718157 scopus 로고    scopus 로고
    • Cutting edge: Natalizumab blocks adhesion but not initial contact of human T-cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis
    • Coisne, C.; Mao, W.; Engelhardt, B. Cutting edge: Natalizumab blocks adhesion but not initial contact of human T-cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis. J. Immunol. 182(10):5909-5913; 2009.
    • (2009) J. Immunol , vol.182 , Issue.10 , pp. 5909-5913
    • Coisne, C.1    Mao, W.2    Engelhardt, B.3
  • 13
    • 47249111609 scopus 로고    scopus 로고
    • Chemokine signaling and integrin activation in lymphocyte migration into the inflamed brain
    • Constantin, G. Chemokine signaling and integrin activation in lymphocyte migration into the inflamed brain. J. Neuroimmunol. 198(1-2):20-26; 2008.
    • (2008) J. Neuroimmunol , vol.198 , Issue.1-2 , pp. 20-26
    • Constantin, G.1
  • 17
    • 33846648734 scopus 로고    scopus 로고
    • Human mesenchymal stem cells constitutively express chemokines and chemokine receptors: That can be upregulated by cytokines, IFN-b, and copaxone
    • Croitoru-Lamoury, J.; Lamoury, F. M.; Zaunders, J. J.; Veas, L. A.; Brew, B. J. Human mesenchymal stem cells constitutively express chemokines and chemokine receptors: that can be upregulated by cytokines, IFN-b, and copaxone. J. Interferon Cytokine Res. 27(1):53-64; 2007.
    • (2007) J. Interferon Cytokine Res , vol.27 , Issue.1 , pp. 53-64
    • Croitoru-Lamoury, J.1    Lamoury, F.M.2    Zaunders, J.J.3    Veas, L.A.4    Brew, B.J.5
  • 18
    • 33745503987 scopus 로고    scopus 로고
    • Mesenchymal stem cells reside in virtually all postnatal organs and tissues
    • Da Silva Meirelles, L.; Chagastelles, P. C.; Nardi, N. B. Mesenchymal stem cells reside in virtually all postnatal organs and tissues. J. Cell Sci. 119(Pt 11):2204-2213; 2006.
    • (2006) J. Cell Sci , vol.119 , Issue.PART 11 , pp. 2204-2213
    • Da Silva Meirelles, L.1    Chagastelles, P.C.2    Nardi, N.B.3
  • 19
    • 0030690228 scopus 로고    scopus 로고
    • Requirement for CD44 in activated T-cell extravasation into an inflammatory site
    • De Grendele, H. C.; Estess, P.; Siegelman, M. H. Requirement for CD44 in activated T-cell extravasation into an inflammatory site. Science 278(5338):672-675; 1997.
    • (1997) Science , vol.278 , Issue.5338 , pp. 672-675
    • de Grendele, H.C.1    Estess, P.2    Siegelman, M.H.3
  • 20
    • 0141862027 scopus 로고    scopus 로고
    • Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow
    • De Ugarte, D. A.; Alfonso, Z.; Zuk, P. A.; Elbarbary, A.; Zhu, M.; Ashjian, P.; Benhaim, P.; Hedrick, M. H.; Fraser, J. K. Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol. Lett. 89(2-3):267-270; 2003.
    • (2003) Immunol. Lett , vol.89 , Issue.2-3 , pp. 267-270
    • de Ugarte, D.A.1    Alfonso, Z.2    Zuk, P.A.3    Elbarbary, A.4    Zhu, M.5    Ashjian, P.6    Benhaim, P.7    Hedrick, M.H.8    Fraser, J.K.9
  • 22
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola, M.; Carlo-Stella, C.; Magni, M.; Milanesi, M.; Longoni, P. D.; Matteucci, P.; Grisanti, S.; Gianni, A. M. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99(10):3838-3843; 2002.
    • (2002) Blood , vol.99 , Issue.10 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6    Grisanti, S.7    Gianni, A.M.8
  • 24
    • 34249781999 scopus 로고    scopus 로고
    • Pathogenesis of axonal and neuronal damage in multiple sclerosis
    • Dutta, R.; Trapp, B. D. Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology 68(22 suppl 3): S22-S31; 2007.
    • (2007) Neurology , vol.68 , Issue.22 SUPPL. 3
    • Dutta, R.1    Trapp, B.D.2
  • 25
    • 42649124913 scopus 로고    scopus 로고
    • Not always the bad guys: B-cells as regulators of autoimmune pathology
    • Fillatreau, S.; Gray, D.; Anderton, S. M. Not always the bad guys: B-cells as regulators of autoimmune pathology. Nat. Rev. Immunol. 8(5):391-397; 2008.
    • (2008) Nat. Rev. Immunol , vol.8 , Issue.5 , pp. 391-397
    • Fillatreau, S.1    Gray, D.2    Anderton, S.M.3
  • 28
    • 65649149328 scopus 로고    scopus 로고
    • Activation of signal transducers and activators of transcription 3 and focal adhesion kinase by stromal cell-derived factor 1 is required for migration of human mesenchymal stem cells in response to tumor cell-conditioned medium
    • Gao, H.; Priebe, W.; Glod, J.; Banerjee, D. Activation of signal transducers and activators of transcription 3 and focal adhesion kinase by stromal cell-derived factor 1 is required for migration of human mesenchymal stem cells in response to tumor cell-conditioned medium. Stem Cells 27(4):857-865; 2009.
    • (2009) Stem Cells , vol.27 , Issue.4 , pp. 857-865
    • Gao, H.1    Priebe, W.2    Glod, J.3    Banerjee, D.4
  • 31
    • 55549121533 scopus 로고    scopus 로고
    • Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection, and with sparse CNS infiltration
    • Gordon, D.; Pavlovska, G.; Glover, C. P.; Uney, J. B.; Wraith, D.; Scolding, N. J. Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection, and with sparse CNS infiltration. Neurosci. Lett. 448(1):71-73; 2008.
    • (2008) Neurosci. Lett , vol.448 , Issue.1 , pp. 71-73
    • Gordon, D.1    Pavlovska, G.2    Glover, C.P.3    Uney, J.B.4    Wraith, D.5    Scolding, N.J.6
  • 32
    • 78049348334 scopus 로고    scopus 로고
    • Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis
    • Gordon, D.; Pavlovska, G.; Uney, J. B.; Wraith, D. C.; Scolding, N. J. Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis. J. Neuropathol. Exp. Neurol. 69(11):1087-1095; 2010.
    • (2010) J. Neuropathol. Exp. Neurol , vol.69 , Issue.11 , pp. 1087-1095
    • Gordon, D.1    Pavlovska, G.2    Uney, J.B.3    Wraith, D.C.4    Scolding, N.J.5
  • 33
    • 33847039191 scopus 로고    scopus 로고
    • Contact-dependent induction of regulatory antigen-presenting cells by human mesenchymal stem cells is mediated via STAT3 signaling
    • Gur-Wahnon, D.; Borovsky, Z.; Beyth, S.; Liebergall, M.; Rachmilewitz, J. Contact-dependent induction of regulatory antigen-presenting cells by human mesenchymal stem cells is mediated via STAT3 signaling. Exp. Hematol. 35(3):426-433; 2007.
    • (2007) Exp. Hematol , vol.35 , Issue.3 , pp. 426-433
    • Gur-Wahnon, D.1    Borovsky, Z.2    Beyth, S.3    Liebergall, M.4    Rachmilewitz, J.5
  • 34
    • 77952944054 scopus 로고    scopus 로고
    • Interferon-g and tumor necrosis factor-a differentially affect cytokine expression and migration properties of mesenchymal stem cells
    • Hemeda, H.; Jakob, M.; Ludwig, A. K.; Giebel, B.; Lang, S.; Brandau, S. Interferon-g and tumor necrosis factor-a differentially affect cytokine expression and migration properties of mesenchymal stem cells. Stem Cells Dev. 19(5):693-706; 2010.
    • (2010) Stem Cells Dev , vol.19 , Issue.5 , pp. 693-706
    • Hemeda, H.1    Jakob, M.2    Ludwig, A.K.3    Giebel, B.4    Lang, S.5    Brandau, S.6
  • 35
    • 78650173034 scopus 로고    scopus 로고
    • The blood- brain barrier, chemokines and multiple sclerosis
    • Holman, D. W.; Klein, R. S.; Ransohoff, R. M. The blood- brain barrier, chemokines and multiple sclerosis. Biochim. Biophys. Acta 1812(2):220-230; 2012.
    • (2012) Biochim. Biophys. Acta , vol.1812 , Issue.2 , pp. 220-230
    • Holman, D.W.1    Klein, R.S.2    Ransohoff, R.M.3
  • 36
    • 33745489036 scopus 로고    scopus 로고
    • Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors
    • Honczarenko, M.; Le, Y.; Swierkowski, M.; Ghiran, I.; Glodek, A. M.; Silberstein, L. E. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells 24(4):1030-1041; 2006.
    • (2006) Stem Cells , vol.24 , Issue.4 , pp. 1030-1041
    • Honczarenko, M.1    Le, Y.2    Swierkowski, M.3    Ghiran, I.4    Glodek, A.M.5    Silberstein, L.E.6
  • 37
    • 70249108406 scopus 로고    scopus 로고
    • Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrowderived mesenchymal stem cells
    • Ivanova-Todorova, E.; Bochev, I.; Mourdjeva, M.; Dimitrov, R.; Bukarev, D.; Kyurkchiev, S.; Tivchev, P.; Altunkova, I.; Kyurkchiev, D. S. Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrowderived mesenchymal stem cells. Immunol. Lett. 126(1-2): 37-42; 2009.
    • (2009) Immunol. Lett , vol.126 , Issue.1-2 , pp. 37-42
    • Ivanova-Todorova, E.1    Bochev, I.2    Mourdjeva, M.3    Dimitrov, R.4    Bukarev, D.5    Kyurkchiev, S.6    Tivchev, P.7    Altunkova, I.8    Kyurkchiev, D.S.9
  • 38
    • 60849136593 scopus 로고    scopus 로고
    • Mesenchymal stem cell homing: The devil is in the details
    • Karp, J. M.; Leng Teo, G. S. Mesenchymal stem cell homing: The devil is in the details. Cell Stem Cell 4(3):206-216; 2009.
    • (2009) Cell Stem Cell , vol.4 , Issue.3 , pp. 206-216
    • Karp, J.M.1    Leng Teo, G.S.2
  • 40
    • 33745437684 scopus 로고    scopus 로고
    • Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    • Kern, S.; Eichler, H.; Stoeve, J.; Kluter, H.; Bieback, K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24(5):1294-1301; 2006.
    • (2006) Stem Cells , vol.24 , Issue.5 , pp. 1294-1301
    • Kern, S.1    Eichler, H.2    Stoeve, J.3    Kluter, H.4    Bieback, K.5
  • 41
    • 64149094052 scopus 로고    scopus 로고
    • Immunomodulatory treatment strategies in multiple sclerosis
    • Kieseier, B. C.; Wiendl, H.; Leussink, V. I.; Stuve, O. Immunomodulatory treatment strategies in multiple sclerosis. J. Neurol. 255(Suppl 6):15-21; 2008.
    • (2008) J. Neurol , vol.255 , Issue.SUPPL. 6 , pp. 15-21
    • Kieseier, B.C.1    Wiendl, H.2    Leussink, V.I.3    Stuve, O.4
  • 42
    • 80052487336 scopus 로고    scopus 로고
    • Mesenchymal stromal cell 'licensing': A multistep process
    • Krampera, M. Mesenchymal stromal cell 'licensing': A multistep process. Leukemia 25(9):1408-1414; 2011.
    • (2011) Leukemia , vol.25 , Issue.9 , pp. 1408-1414
    • Krampera, M.1
  • 43
    • 0038204193 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigenspecific T-cells to their cognate peptide
    • Krampera, M.; Glennie, S.; Dyson, J.; Scott, D.; Laylor, R.; Simpson, E.; Dazzi, F. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigenspecific T-cells to their cognate peptide. Blood 101(9): 3722-3729; 2003.
    • (2003) Blood , vol.101 , Issue.9 , pp. 3722-3729
    • Krampera, M.1    Glennie, S.2    Dyson, J.3    Scott, D.4    Laylor, R.5    Simpson, E.6    Dazzi, F.7
  • 44
    • 36849059595 scopus 로고    scopus 로고
    • Bone homing of mesenchymal stem cells by ectopic {alpha}4 integrin expression
    • Kumar, S.; Ponnazhagan, S. Bone homing of mesenchymal stem cells by ectopic {alpha}4 integrin expression. FASEB J. 21(14):3917-3927; 2007.
    • (2007) FASEB J , vol.21 , Issue.14 , pp. 3917-3927
    • Kumar, S.1    Ponnazhagan, S.2
  • 47
    • 67649171661 scopus 로고    scopus 로고
    • Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    • Lee, R. H.; Pulin, A. A.; Seo, M. J.; Kota, D. J.; Ylostalo, J.; Larson, B. L.; Semprun-Prieto, L.; Delafontaine, P.; Prockop, D. J. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 5(1):54-63; 2009.
    • (2009) Cell Stem Cell , vol.5 , Issue.1 , pp. 54-63
    • Lee, R.H.1    Pulin, A.A.2    Seo, M.J.3    Kota, D.J.4    Ylostalo, J.5    Larson, B.L.6    Semprun-Prieto, L.7    Delafontaine, P.8    Prockop, D.J.9
  • 49
    • 84858123362 scopus 로고    scopus 로고
    • Targeted intra-arterial transplantation of stem cells to the injured CNS is more effective than intravenous administration: Engraftment is dependent on cell type and adhesion molecule expression
    • Lundberg, J.; Sodersten, E.; Sundstrom, E.; Le Blanc, K.; Andersson, T.; Hermanson, O.; Holmin, S. Targeted intra-arterial transplantation of stem cells to the injured CNS is more effective than intravenous administration: Engraftment is dependent on cell type and adhesion molecule expression. Cell Transplant. 21(1):333-343; 2012.
    • (2012) Cell Transplant , vol.21 , Issue.1 , pp. 333-343
    • Lundberg, J.1    Sodersten, E.2    Sundstrom, E.3    Le Blanc, K.4    Andersson, T.5    Hermanson, O.6    Holmin, S.7
  • 50
    • 0036312179 scopus 로고    scopus 로고
    • Critical role of antigen-specific antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoprotein
    • Lyons, J. A.; Ramsbottom, M. J.; Cross, A. H. Critical role of antigen-specific antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoprotein. Eur. J. Immunol. 32(7):1905-1913; 2002.
    • (2002) Eur. J. Immunol , vol.32 , Issue.7 , pp. 1905-1913
    • Lyons, J.A.1    Ramsbottom, M.J.2    Cross, A.H.3
  • 51
    • 59249086198 scopus 로고    scopus 로고
    • Functions and molecular mechanisms of the CD47-SIRPa signalling pathway
    • Matozaki, T.; Murata, Y.; Okazawa, H.; Ohnishi, H. Functions and molecular mechanisms of the CD47-SIRPa signalling pathway. Trends Cell Biol. 19(2):72-80; 2009.
    • (2009) Trends Cell Biol , vol.19 , Issue.2 , pp. 72-80
    • Matozaki, T.1    Murata, Y.2    Okazawa, H.3    Ohnishi, H.4
  • 52
    • 33845755785 scopus 로고    scopus 로고
    • Multiple sclerosis: A battle between destruction and repair
    • McQualter, J. L.; Bernard, C. C. Multiple sclerosis: A battle between destruction and repair. J. Neurochem. 100(2):295-306; 2007.
    • (2007) J. Neurochem , vol.100 , Issue.2 , pp. 295-306
    • McQualter, J.L.1    Bernard, C.C.2
  • 53
    • 0035476518 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor: A new putative therapeutic target in multiple sclerosis
    • McQualter, J. L.; Darwiche, R.; Ewing, C.; Onuki, M.; Kay, T. W.; Hamilton, J. A.; Reid, H. H.; Bernard, C. C. Granulocyte macrophage colony-stimulating factor: A new putative therapeutic target in multiple sclerosis. J. Exp. Med. 194(7):873-882; 2001.
    • (2001) J. Exp. Med , vol.194 , Issue.7 , pp. 873-882
    • McQualter, J.L.1    Darwiche, R.2    Ewing, C.3    Onuki, M.4    Kay, T.W.5    Hamilton, J.A.6    Reid, H.H.7    Bernard, C.C.8
  • 55
    • 40949099450 scopus 로고    scopus 로고
    • Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials
    • Noel, D.; Caton, D.; Roche, S.; Bony, C.; Lehmann, S.; Casteilla, L.; Jorgensen, C.; Cousin, B. Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials. Exp. Cell Res. 314(7):1575-1584; 2008.
    • (2008) Exp. Cell Res , vol.314 , Issue.7 , pp. 1575-1584
    • Noel, D.1    Caton, D.2    Roche, S.3    Bony, C.4    Lehmann, S.5    Casteilla, L.6    Jorgensen, C.7    Cousin, B.8
  • 57
    • 81755184012 scopus 로고    scopus 로고
    • Cytokines and effector T-cell subsets causing autoimmune CNS disease
    • Petermann, F.; Korn, T. Cytokines and effector T-cell subsets causing autoimmune CNS disease. FEBS Lett. 585(23):3747-3757; 2011.
    • (2011) FEBS Lett , vol.585 , Issue.23 , pp. 3747-3757
    • Petermann, F.1    Korn, T.2
  • 60
    • 77949308137 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines, IFN-g and TNF-a, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially
    • Prasanna, S. J.; Gopalakrishnan, D.; Shankar, S. R.; Vasandan, A. B. Pro-inflammatory cytokines, IFN-g and TNF-a, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially. PLoS One 5(2):e9016; 2010.
    • (2010) PLoS One , vol.5 , Issue.2
    • Prasanna, S.J.1    Gopalakrishnan, D.2    Shankar, S.R.3    Vasandan, A.B.4
  • 61
    • 70349883762 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis
    • Rafei, M.; Birman, E.; Forner, K.; Galipeau, J. Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis. Mol. Ther. 17(10):1799-1803; 2009.
    • (2009) Mol. Ther , vol.17 , Issue.10 , pp. 1799-1803
    • Rafei, M.1    Birman, E.2    Forner, K.3    Galipeau, J.4
  • 63
    • 34848851890 scopus 로고    scopus 로고
    • Mesenchymal stem cells fail to trigger effector functions of cytotoxic T-lymphocytes
    • Rasmusson, I.; Uhlin, M.; Le Blanc, K.; Levitsky, V. Mesenchymal stem cells fail to trigger effector functions of cytotoxic T-lymphocytes. J. Leukoc. Biol. 82(4):887-893; 2007.
    • (2007) J. Leukoc. Biol , vol.82 , Issue.4 , pp. 887-893
    • Rasmusson, I.1    Uhlin, M.2    Le Blanc, K.3    Levitsky, V.4
  • 64
    • 79953701030 scopus 로고    scopus 로고
    • Vascular inflammation in central nervous system diseases: Adhesion receptors controlling leukocyte-endothelial interactions
    • Rossi, B.; Angiari, S.; Zenaro, E.; Budui, S. L.; Constantin, G. Vascular inflammation in central nervous system diseases: Adhesion receptors controlling leukocyte-endothelial interactions. J. Leukoc. Biol. 89(4):539-556; 2011.
    • (2011) J. Leukoc. Biol , vol.89 , Issue.4 , pp. 539-556
    • Rossi, B.1    Angiari, S.2    Zenaro, E.3    Budui, S.L.4    Constantin, G.5
  • 65
    • 84863171061 scopus 로고    scopus 로고
    • Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferation
    • Sajic, M.; Hunt, D. P.; Lee, W.; Compston, D. A.; Schweimer, J. V.; Gregson, N. A.; Chandran, S.; Smith, K. J. Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferation. PLoS One 7(2):e30708; 2012.
    • (2012) PLoS One , vol.7 , Issue.2
    • Sajic, M.1    Hunt, D.P.2    Lee, W.3    Compston, D.A.4    Schweimer, J.V.5    Gregson, N.A.6    Chandran, S.7    Smith, K.J.8
  • 66
    • 77649298684 scopus 로고    scopus 로고
    • Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis
    • Schurgers, E.; Kelchtermans, H.; Mitera, T.; Geboes, L.; Matthys, P. Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis Arthritis. Res. Ther. 12(1):R31; 2010.
    • (2010) Arthritis. Res. Ther , vol.12 , Issue.1
    • Schurgers, E.1    Kelchtermans, H.2    Mitera, T.3    Geboes, L.4    Matthys, P.5
  • 68
    • 79751504754 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Mechanisms of inflammation
    • Singer, N. G.; Caplan, A. I. Mesenchymal stem cells: Mechanisms of inflammation. Annu. Rev. Pathol. 6:457-478; 2011.
    • (2011) Annu. Rev. Pathol , vol.6 , pp. 457-478
    • Singer, N.G.1    Caplan, A.I.2
  • 70
    • 70849093289 scopus 로고    scopus 로고
    • In vitro study of matrix metalloproteinase/ tissue inhibitor of metalloproteinase production by mesenchymal stromal cells in response to inflammatory cytokines: The role of their migration in injured tissues
    • Tondreau, T.; Meuleman, N.; Stamatopoulos, B.; De Bruyn, C.; Delforge, A.; Dejeneffe, M.; Martiat, P.; Bron, D.; Lagneaux, L. In vitro study of matrix metalloproteinase/ tissue inhibitor of metalloproteinase production by mesenchymal stromal cells in response to inflammatory cytokines: The role of their migration in injured tissues. Cytotherapy 11(5):559-569; 2009.
    • (2009) Cytotherapy , vol.11 , Issue.5 , pp. 559-569
    • Tondreau, T.1    Meuleman, N.2    Stamatopoulos, B.3    de Bruyn, C.4    Delforge, A.5    Dejeneffe, M.6    Martiat, P.7    Bron, D.8    Lagneaux, L.9
  • 71
    • 0037442264 scopus 로고    scopus 로고
    • Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation
    • Tse, W. T.; Pendleton, J. D.; Beyer, W. M.; Egalka, M. C.; Guinan, E. C. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation. Transplantation 75(3):389-397; 2003.
    • (2003) Transplantation , vol.75 , Issue.3 , pp. 389-397
    • Tse, W.T.1    Pendleton, J.D.2    Beyer, W.M.3    Egalka, M.C.4    Guinan, E.C.5
  • 72
    • 78649859841 scopus 로고    scopus 로고
    • Why should mesenchymal stem cells (MSCs) cure autoimmune diseases
    • Uccelli, A.; Prockop, D. J. Why should mesenchymal stem cells (MSCs) cure autoimmune diseases? Curr. Opin. Immunol. 22(6):768-774; 2010.
    • (2010) Curr. Opin. Immunol , vol.22 , Issue.6 , pp. 768-774
    • Uccelli, A.1    Prockop, D.J.2
  • 74
    • 33644827383 scopus 로고    scopus 로고
    • Bone-marrow haematopoieticstem-cell niches
    • Wilson, A.; Trumpp, A. Bone-marrow haematopoieticstem-cell niches. Nat. Rev. Immunol. 6(2):93-106; 2006.
    • (2006) Nat. Rev. Immunol , vol.6 , Issue.2 , pp. 93-106
    • Wilson, A.1    Trumpp, A.2
  • 76
    • 33745496833 scopus 로고    scopus 로고
    • The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix
    • Zhu, H.; Mitsuhashi, N.; Klein, A.; Barsky, L. W.; Weinberg, K.; Barr, M. L.; Demetriou, A.; Wu, G. D. The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells 24(4):928-935; 2006.
    • (2006) Stem Cells , vol.24 , Issue.4 , pp. 928-935
    • Zhu, H.1    Mitsuhashi, N.2    Klein, A.3    Barsky, L.W.4    Weinberg, K.5    Barr, M.L.6    Demetriou, A.7    Wu, G.D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.