The Efficacy of an Immunoisolating Membrane System for Islet Xenotransplantation in Minipigs

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Neufeld, Tova ^a   Ludwig, Barbara ^b   Barkai, Uriel ^a,b   Weir, Gordon C ^c   Colton, Clark K ^d   Evron, Yoav ^a   Balyura, Maria ^a,b   Yavriyants, Karina ^a   Zimermann, Baruch ^a   Azarov, Dmitri ^a   Maimon, Shiri ^a   Shabtay, Noa ^a   Rozenshtein, Tania ^a   Lorber, Dana ^a   Steffen, Anja ^b   Willenz, Udi ^e   Bloch, Konstantine ^f   Vardi, Pnina ^f   Taube, Ran ^g   de Vos, Paul ^h   Lewis, Eli C ^g   Bornstein, Stefan R ^b   Rotem, Avi ^a   more..

^a Kiryat Arie   (Israel)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c JOSLIN DIABETES CENTER   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e Lahav Research Institute   (Israel)

^f TEL AVIV UNIVERSITY   (Israel)

^g BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^h UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; POLITEF;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL MEMBRANE; CONTROLLED STUDY; DIABETES MELLITUS; EQUIPMENT DESIGN; IMMOBILIZED CELL; IMMUNOISOLATING MEMBRANE; IMPLANT DELIVERY DEVICE; INSULIN RELEASE; MALE; MEMBRANE PERMEABILITY; MINIPIG; NONHUMAN; OXYGEN CONCENTRATION; PANCREAS ISLET TRANSPLANTATION; RAT; XENOTRANSPLANTATION;

ANIMALS; BIOMASS; DIABETES MELLITUS, EXPERIMENTAL; DIFFUSION; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MEMBRANES, ARTIFICIAL; OXYGEN; RATS; SWINE; SWINE, MINIATURE; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84880986383     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070150     Document Type: Article

References (31)

1. Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, et al. (2012) Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care 35: 1436-1445.
2. Thompson DM, Meloche M, Ao Z, Paty B, Keown P, et al. (2011) Reduced progression of diabetic microvascular complications with islet cell transplantation compared with intensive medical therapy. Transplantation 91: 373-378.
3. Bellin MD, Barton FB, Heitman A, Harmon JV, Kandaswamy R, et al. (2012) Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes. Am J Transplant 12: 1576-1583.
4. CITR Research Group (2009) 2007 update on allogeneic islet transplantation from the Collaborative Islet Transplant Registry (CITR). Cell Transplant 18: 753-767.
5. Ludwig B, Ludwig S, Steffen A, Saeger HD, Bornstein SR, (2010) Islet versus pancreas transplantation in type 1 diabetes: competitive or complementary? Curr Diab Rep 10: 506-511.
6. Dufrane D, Goebbels RM, Saliez A, Guiot Y, Gianello P, (2006) Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates: proof of concept. Transplantation 81: 1345-1353.
7. Sun Y, Ma X, Zhou D, Vacek I, Sun AM, (1996) Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression. J Clin Invest 98: 1417-1422.
8. Elliott RB, Escobar L, Calafiore R, Basta G, Garkavenko O, et al. (2005) Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys. Transplant Proc 37: 466-469.
9. Gray DW, (1997) Encapsulated islet cells: the role of direct and indirect presentation and the relevance to xenotransplantation and autoimmune recurrence. Br Med Bull 53: 777-788.
10. Gray DW, (2001) An overview of the immune system with specific reference to membrane encapsulation and islet transplantation. Ann N Y Acad Sci 944: 226-239.
11. Komoda H, Miyagawa S, Kubo T, Kitano E, Kitamura H, et al. (2004) A study of the xenoantigenicity of adult pig islets cells. Xenotransplantation 11: 237-246.
12. Tam SK, de Haan BJ, Faas MM, Halle JP, Yahia L, et al. (2009) Adsorption of human immunoglobulin to implantable alginate-poly-L-lysine microcapsules: effect of microcapsule composition. J Biomed Mater Res A 89: 609-615.
13. Dufrane D, Goebbels RM, Gianello P, (2010) Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression. Transplantation 90: 1054-1062.
14. Ludwig B, Zimerman B, Steffen A, Yavriants K, Azarov D, et al. (2010) A novel device for islet transplantation providing immune protection and oxygen supply. Horm Metab Res 42: 918-922.
15. Barkai U, Weir GC, Colton CK, Ludwig B, Bornstein SR, et al. (2013) Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant. doi:dx.doi.org/10.3727/096368912X657341.
16. Kuzmina A, Hadad U, Fujinaga K, Taube R, (2012) Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1. Virology 426: 152-161.
17. Hyder A, Laue C, Schrezenmeir J, (2005) Effect of the immunosuppressive regime of Edmonton protocol on the long-term in vitro insulin secretion from islets of two different species and age categories. Toxicol In Vitro 19: 541-546.
18. Lohmann T, List C, Lamesch P, Kohlhaw K, Wenzke M, et al. (2000) Diabetes mellitus and islet cell specific autoimmunity as adverse effects of immunsuppressive therapy by FK506/tacrolimus. Exp Clin Endocrinol Diabetes 108: 347-352.
19. Biarnes M, Montolio M, Nacher V, Raurell M, Soler J, et al. (2002) Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 51: 66-72.
20. Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, et al. (2006) International trial of the Edmonton protocol for islet transplantation. N Engl J Med 355: 1318-1330.
21. Carlsson PO, Palm F, Andersson A, Liss P, (2001) Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. Diabetes 50: 489-495.
22. Jansson L, (1994) The regulation of pancreatic islet blood flow. Diabetes Metab Rev 10: 407-416.
23. Jansson L, Bodin B, Kallskog O, Andersson A, (2005) Duct ligation and pancreatic islet blood flow in rats: physiological growth of islets does not affect islet blood perfusion. Eur J Endocrinol 153: 345-351.
24. Lehmann R, Zuellig RA, Kugelmeier P, Baenninger PB, Moritz W, et al. (2007) Superiority of small islets in human islet transplantation. Diabetes 56: 594-603.
25. McCall M, Shapiro AM, (2012) Update on islet transplantation. Cold Spring Harb Perspect Med 2: a007823 doi:10.1101/cshperspect.a007823.
26. Dulong JL, Legallais C, (2007) A theoretical study of oxygen transfer including cell necrosis for the design of a bioartificial pancreas. Biotechnol Bioeng 96: 990-998.
27. Storrs R, Dorian R, King SR, Lakey J, Rilo H, (2001) Preclinical development of the Islet Sheet. Ann N Y Acad Sci 944: 252-266.
28. Ludwig B, Ziegler CG, Schally AV, Richter C, Steffen A, et al. (2010) Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets. Proc Natl Acad Sci U S A 107: 12623-12628.
29. de Groot M, Schuurs TA, Keizer PP, Fekken S, Leuvenink HG, et al. (2003) Response of encapsulated rat pancreatic islets to hypoxia. Cell Transplant 12: 867-875.
30. Cooper DK, Koren E, Oriol R, (1994) Clinical potential of xenotransplantation. Transplant Proc 26: 1331-1332.
31. Specke V, Plesker R, Wood J, Coulibaly C, Suling K, et al. (2009) No in vivo infection of triple immunosuppressed non-human primates after inoculation with high titers of porcine endogenous retroviruses. Xenotransplantation 16: 34-44.