Fever in adult ICUs: An interrupted time series analysis

Critical Care Medicine

Volumn 41, Issue 8, 2013, Pages 1863-1869

  Niven, Daniel J ^a   Stelfox, Henry T ^a,b   Shahpori, Reza ^a   Laupland, Kevin B ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Bloodstream infection; Fever; Incidence; Temperature; Thermometer; Time series

Indexed keywords

ADULT; ARTICLE; BLOOD CULTURE; BLOODSTREAM INFECTION; FEMALE; FEVER; HUMAN; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TEMPERATURE; VENTILATOR ASSOCIATED PNEUMONIA;

ALBERTA; ANTI-BACTERIAL AGENTS; BACTEREMIA; BACTERIOLOGICAL TECHNIQUES; COHORT STUDIES; DRUG UTILIZATION; FEMALE; FEVER; HOSPITAL MORTALITY; HUMANS; INCIDENCE; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PNEUMONIA, VENTILATOR-ASSOCIATED; RETROSPECTIVE STUDIES; THERMOMETERS;

EID: 84880947068     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31828a43b2     Document Type: Article

References (33)

1. Laupland KB: Fever in the critically ill medical patient. Crit Care Med 2009; 37(7 Suppl):S273-S278
2. O'Grady NP, Barie PS, Bartlett JG, et al; American College of Critical Care Medicine; Infectious Diseases Society of America: Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Crit Care Med 2008; 36:1330-1349
3. Laupland KB, Shahpori R, Kirkpatrick AW, et al: Occurrence and outcome of fever in critically ill adults. Crit Care Med 2008; 36:1531-1535
4. Barie PS, Hydo LJ, Eachempati SR: Causes and consequences of fever complicating critical surgical illness. Surg Infect (Larchmt) 2004; 5:145-159
5. Laupland KB, Zahar JR, Adrie C, et al: Determinants of temperature abnormalities and influence on outcome of critical illness. Crit Care Med 2012; 40:145-151
6. Young PJ, Saxena M, Beasley R, et al. Early peak temperature and mortality in critically ill patients with or without infection. Intensive Care Med 2012; 38:437-444.
7. Lee BH, Inui D, Suh GY, et al; Fever and Antipyretic in Critically ill patients Evaluation (FACE) Study Group: Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: Multi-centered prospective observational study. Crit Care 2012; 16:R33
8. Gozzoli V, Schöttker P, Suter PM, et al: Is it worth treating fever in intensive care unit patients? Preliminary results from a randomized trial of the effect of external cooling. Arch Intern Med 2001; 161:121-123
9. Schulman CI, Namias N, Doherty J, et al: The effect of antipyretic therapy upon outcomes in critically ill patients: A randomized, prospective study. Surg Infect (Larchmt) 2005; 6:369-375
10. Morris PE, Promes JT, Guntupalli KK, et al: A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults. Crit Care 2010; 14:R125
11. Niven DJ, Stelfox HT, Leger C, et al. Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: A pilot randomized clinical trial. J Crit Care 2012; doi:10.1016/j. jcrc.2012.08.015.
12. Circiumaru B, Baldock G, Cohen J: A prospective study of fever in the intensive care unit. Intensive Care Med 1999; 25:668-673
13. Peres Bota D, Lopes Ferreira F, Mélot C, et al: Body temperature alterations in the critically ill. Intensive Care Med 2004; 30:811-816
14. Brilli RJ, Spevetz A, Branson RD, et al; American College of Critical Care Medicine Task Force on Models of Critical Care Delivery. The American College of Critical Care Medicine Guidelines for the Defintion of an Intensivist and the Practice of Critical Care Medicine: Critical care delivery in the intensive care unit: Defining clinical roles and the best practice model. Crit Care Med 2001; 29:2007-2019
15. Shahpori R, de Los Angeles A, Laupland K: Information management framework: A model for clinical departments. Stud Health Technol Inform 2009; 143:81-86
16. Leal J, Gregson DB, Ross T, et al: Development of a novel electronic surveillance system for monitoring of bloodstream infections. Infect Control Hosp Epidemiol 2010; 31:740-747
17. Myny D, De Waele J, Defloor T, et al: Temporal scanner thermometry: A new method of core temperature estimation in ICU patients. Scott Med J 2005; 50:15-18
18. Niven DJ, Shahpori R, Stelfox HT, et al. Management of febrile critically ill adults: A retrospective assessment of regional practice. Ther Hypothermia Temp Manag 2011; 1:99-104.
19. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13:818-829
20. Laupland KB, Kirkpatrick AW, Kortbeek JB, et al: Long-term mortality outcome associated with prolonged admission to the ICU. Chest 2006; 129:954-959
21. Esmail R, Duchscherer G, Giesbrecht J, et al: Prevention of ventilatorassociated pneumonia in the calgary health region: A Canadian success story! Healthc Q 2008; 11(3 Spec No.):129-136
22. Wagner AK, Soumerai SB, Zhang F, et al: Segmented regression analysis of interrupted time series studies in medication use research. J Clin Pharm Ther 2002; 27:299-309
23. Berthiaume LR, Peets AD, Schmidt U, et al: Time series analysis of use patterns for common invasive technologies in critically ill patients. J Crit Care 2009; 24:471.e9-471.14
24. Madden JM, Soumerai SB, Lieu TA, et al; Health maintenance organization: Effects of a law against early postpartum discharge on newborn follow-up, adverse events, and HMO expenditures. N Engl J Med 2002; 347:2031-2038
25. Kimberger O, Cohen D, Illievich U, et al: Temporal artery versus bladder thermometry during perioperative and intensive care unit monitoring. Anesth Analg 2007; 105:1042-7, table of contents
26. Stelfox HT, Straus SE, Ghali WA, et al: Temporal artery versus bladder thermometry during adult medical-surgical intensive care monitoring: An observational study. BMC Anesthesiol 2010; 10:13
27. Durbin J. Testing for serial correlation in least-squares regressions when some of the regressors are lagged dependent variables. Econometrica 1970; 38:410-421.
28. Ljung G, Box G. On a measure of a lack of fit in time series models. Biometrika 1978; 65:297-303.
29. Cochrane D, Orcutt G. Application of least squares regression to relationships containing auto-correlated error terms. J Am Stat Assoc 1949; 44:32-61.
30. World Health Organization Collaborating Centre for Drug Statistics Methodology. Available at: http://www.whocc.no/atc-ddd-index/. Accessed August 31, 2012.
31. Rivers E, Nguyen B, Havstad S, et al; Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377
32. Kumar A, Roberts D, Wood KE, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589-1596
33. Coburn B, Morris AM, Tomlinson G, et al: Does this adult patient with suspected bacteremia require blood cultures? JAMA 2012; 308:502-511