Clinical and experimental studies regarding the expression and diagnostic value of carcinoembryonic antigen-related cell adhesion molecule 1 in non-small-cell lung cancer

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Zhou, Mu qing ^a   Du, Yan ^a   Liu, Yi wen ^a   Wang, Ying zhi ^a   He, Yi qing ^a   Yang, Cui xia ^a   Wang, Wen juan ^a   Gao, Feng ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Carcinoembryonic antigen related cell adhesion molecule 1; Enzyme linked immunosorbent assay; Non small cell lung carcinomas; Receiver operating characteristic curve

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1 L ISOFORM; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1 S ISOFORM; MESSENGER RNA; UNCLASSIFIED DRUG; CD66 ANTIGENS; CELL ADHESION MOLECULE; ISOPROTEIN; LEUKOCYTE ANTIGEN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CLINICAL STUDY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MALE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; AREA UNDER THE CURVE; BIOSYNTHESIS; BLOOD; CARCINOMA, NON-SMALL-CELL LUNG; DIAGNOSTIC USE; LUNG NEOPLASMS; METABOLISM; MIDDLE AGED;

ADULT; AGED; ANTIGENS, CD; AREA UNDER CURVE; CARCINOMA, NON-SMALL-CELL LUNG; CELL ADHESION MOLECULES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROTEIN ISOFORMS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ROC CURVE; TUMOR MARKERS, BIOLOGICAL;

EID: 84880946443     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-359     Document Type: Article

References (43)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Canc J Clin 2011, 61:69-90.
2. Gray-Owen SD, Blumberg RS. CEACAM1: contact-dependent control of immunity. Nat Rev Immunol 2006, 6:433-446. 10.1038/nri1864, 16724098.
3. Yokoyama S, Chen CJ, Nguyen T, Shively JE. Role of CEACAM1 isoforms in an in vivo model of mammary morphogenesis: mutational analysis of the cytoplasmic domain of CEACAM1-4S reveals key residues involved in lumen formation. Oncogene 2007, 26:7637-7646. 10.1038/sj.onc.1210577, 17546042.
4. Gu A, Tsark W, Holmes KV, Shively JE. Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res 2009, 315:1668-1682. 10.1016/j.yexcr.2009.02.026, 2745895, 19285068.
5. Klaile E, Müller MM, Kannicht C, Singer BB, Lucka L. CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration. J Cell Sci 2005, 118:5513-5524. 10.1242/jcs.02660, 16291724.
6. Abou-Rjaily GA, Lee SJ, May D, Al-Share QY, DeAngelis AM, Ruch RJ, Neumaier M, Kalthoff H, Lin S-H, Najjar SM. CEACAM1 modulates epidermal growth factor receptor-mediated cell proliferation. J Clin Invest 2004, 114:944-952. 518664, 15467833.
7. Scheffrahn I, Singer BB, Sigmundsson K, Lucka L, Obrink B. Control of density-dependent, cell state-specific signal transduction by the cell adhesion molecule CEACAM1, and its influence on cell cycle regulation. Exp Cell Res 2005, 307:427-435. 10.1016/j.yexcr.2005.03.030, 15950623.
8. Müller MM, Singer BB, Klaile E, Öbrink B, Lucka L. Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells. Blood 2005, 105:3925-3934. 10.1182/blood-2004-09-3618, 15687237.
9. Muller MM, Klaile E, Vorontsova O, Singer BB, Obrink B. Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. J Cell Biol 2009, 187:569-581. 10.1083/jcb.200904150, 2779222, 19948503.
10. Busch C, Hanssen TA, Wagener C, OB B. Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition. Hum Pathol 2002, 33:290-298. 10.1053/hupa.2002.32218, 11979369.
11. Sundberg U, Beauchemin N, Öbrink B. The cytoplasmic domain of CEACAM1-L controls its lateral localization and the organization of desmosomes in polarized epithelial cells. J Cell Sci 2004, 117:1091-1104. 10.1242/jcs.00944, 14970258.
12. Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, Grunert F, Blumberg RS, Kuroki M, Skubitz KM, Bates PA. Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site. Blood 2001, 98:1469-1479. 10.1182/blood.V98.5.1469, 11520797.
13. Song J, Cao Z, Yoon J, Nam S, Kim S, Lee J, Park W. Genetic alterations and expression pattern of CEACAM1 in colorectal adenomas and cancers. Pathol Oncol Res 2010, 17:67-74.
14. Tanaka K, Hinoda Y, Takahashi H, Sakamoto H, Nakajima Y, Imai K. Decreased expression of biliary glycoprotein in hepatocellular carcinomas. Int J Canc 1997, 74:15-19.
15. Bamberger AM, Kappes H, Methner C, Rieck G, Brümmer J, Wagener C, Löning T, Milde-Langosch K. Expression of the adhesion molecule CEACAM1 (CD66a, BGP, C-CAM) in breast cancer is associated with the expression of the tumor-suppressor genes Rb, Rb2, and p27. Virchows Arch 2002, 440:139-144. 10.1007/s00428-001-0554-0, 11964043.
16. Kammerer R, Riesenberg R, Weiler C, Lohrmann J, Schleypen J, Zimmermann W. The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma. J Pathol 2004, 204:258-267. 10.1002/path.1657, 15476270.
17. Tilki D, Irmak S, Oliveira-Ferrer L, Hauschild J, Miethe K, Atakaya H, Hammerer P, Friedrich MG, Schuch G, Galalae R, et al. CEA-related cell adhesion molecule-1 is involved in angiogenic switch in prostate cancer. Oncogene 2006, 25:4965-4974. 10.1038/sj.onc.1209514, 16568082.
18. Hsieh J, Luo W, Song W, Wang Y, Kleinerman D, Van N, Lin S. Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches. Canc Res 1995, 55:190-197.
19. Markel G, Ortenberg R, Seidman R, Sapoznik S, Koren-Morag N, Besser MJ, Bar J, Shapira R, Kubi A, Nardini G, et al. Systemic dysregulation of CEACAM1 in melanoma patients. Canc Immunol Immunother 2010, 59:365-374.
20. Liu W, Wei W, Winer D, Bamberger AM, Bamberger C, Wagener C, Ezzat S, Asa SL. CEACAM1 impedes thyroid cancer growth but promotes invasiveness: a putative mechanism for early metastases. Oncogene 2006, 26:2747-2758.
21. Simeone DM, Ji B, Banerjee M, Arumugam T, Li D, Anderson MA, Bamberger AM, Greenson J, Brand RE, Ramachandran V, Logsdon CD. CEACAM1, a novel serum biomarker for pancreatic cancer. Pancreas 2007, 34:436-443. 10.1097/MPA.0b013e3180333ae3, 17446843.
22. Sivan S, Suzan F, Rona O, Tamar H, Vivian B, Tamar P, Jacob S, Gal M, Michal L. Serum CEACAM1 correlates with disease progression and survival in malignant melanoma patients. Clin Dev Immunol 2010, 59:215-230.
23. Laack E, Nikbakht H, Peters A, Kugler C, Jasiewicz Y, Edler L, Brümmer J, Schumacher U, Hossfeld D. Expression of CEACAM1 in adenocarcinoma of the lung: a factor of independent prognostic significance. J Clin Oncol 2002, 20:4279-4284. 10.1200/JCO.2002.08.067, 12409325.
24. Dango S, Sienel W, Schreiber M, Stremmel C, Kirschbaum A, Pantel K, Passlick B. Elevated expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is associated with increased angiogenic potential in non-small-cell lung cancer. Lung Canc 2008, 60:426-433.
25. Lee MK, Kim JH, Lee CH, Kim JM, Kang CD, Kim YD, Choi KU, Kim HW, Kim JY, Park do Y, Sol MY. Clinicopathological significance of BGP expression in non-small-cell lung carcinoma: relationship with histological type, microvessel density and patients' survival. Pathology 2006, 38:555-560. 10.1080/00313020601024029, 17393985.
26. Th MI, Schult-Kronefeld O, Burkholder I, Schuch G, Andritzky B, Kastendieck H, Edler L, Wagener C, Bokemeyer C, Schumacher U. Expression of CEACAM-1 in pulmonary adenocarcinomas and their metastases. Anticancer Res 2009, 29:249-254.
27. Zhou XH. Statistical methods in diagnestie medicine. 2002, New York: Wiley & Sons Interscience, MCCLISH DK.
28. Obuchowski NA, Lieber ML, Wians FH. ROC curves in clinical chemistry: Uses, misuses, and possible solutions. Clin Chem 2004, 50:1118-1125. 10.1373/clinchem.2004.031823, 15142978.
29. Zhou C-J, Liu B, Zhu K-X, Zhang Q-H, Zhang T-G, Xu W-H, Wang H-B, Yu W-H, Qu Y-D, Wang H-J, et al. The different expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and possible roles in gastric carcinomas. Pathol Res Pract 2009, 205:483-489. 10.1016/j.prp.2009.01.006, 19243897.
30. Sienel W, Dango S, Woelfle U, Morresi-Hauf A, Wagener C, Brümmer J, Mutschler W, Passlick B, Pantel K. Elevated expression of carcinoembryonic antigen-related cell adhesion molecule 1 promotes progression of non-small cell lung cancer. Clin Canc Res 2003, 9:2260-2266.
31. Wang L, Lin SH, Wu WG, Kemp BL, Walsh GL, Hong WK, Mao L. C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers. Clin Canc Res 2000, 6:2988.
32. Gaur S, Shively JE, Yen Y, Gaur RK. Altered splicing of CEACAM1 in breast cancer: Identification of regulatory sequences that control splicing of CEACAM1 into long or short cytoplasmic domain isoforms. Mol Canc 2008, 7:1-12.
33. Kuespert K, Pils S, Hauck C. CEACAMs: their role in physiology and pathophysiology. Curr Opin Cell Biol 2006, 18:565-571. 10.1016/j.ceb.2006.08.008, 16919437.
34. Nouvion A-L, Oubaha M, LeBlanc S, Davis EC, Jastrow H, Kammerer R, Breton V, Turbide C, Ergun S, Gratton J-P, Beauchemin N. CEACAM1: a key regulator of vascular permeability. J Cell Sci 2010, 123:4221-4230. 10.1242/jcs.073635, 21081647.
35. Ieda J, Yokoyama S, Tamura K, Takifuji K, Hotta T, Matsuda K, Oku Y, Nasu T, Kiriyama S, Yamamoto N, et al. Re-expression of CEACAM1 long cytoplasmic domain isoform is associated with invasion and migration of colorectal cancer. Int J Canc 2011, 129:1351-1361.
36. Draberova L, Cerna H, Brodska H, Boubelik M, Watt SM, Stanners CP, Draber P. Soluble isoforms of CEACAM1 containing the A2 domain: increased serum levels in patients with obstructive jaundice and differences in 3-fucosyl-N-acetyl-lactosamine moiety. Immunology 2000, 101:279-287. 10.1046/j.1365-2567.2000.00113.x, 2327077, 11012782.
37. Svenberg T, Wahren B, Hammarstrom S. Elevated serum levels of a biliary glycoprotein (BGP I) in patients with liver or biliary tract disease. Clin Exp Immunol 1979, 36:317-325. 1537735, 477033.
38. Ergun S, Kilik N, Ziegeler G, Hansen A, Nollau P, Gotze J, Wurmbach JH, Horst A, Weil J, Fernando M, Wagener C. CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. Mol Cell 2000, 5:311-320. 10.1016/S1097-2765(00)80426-8, 10882072.
39. Nittka S, Bohm C, Zentgraf H, Neumaier M. The CEACAM1-mediated apoptosis pathway is activated by CEA and triggers dual cleavage of CEACAM1. Oncogene 2008, 27:3721-3728. 10.1038/sj.onc.1211033, 18278069.
40. Tilki D, Singer BB, Shariat SF, Behrend A, Fernando M, Irmak S, Buchner A, Hooper AT, Stief CG, Reich O, Ergün S. CEACAM1: A Novel Urinary Marker for Bladder Cancer Detection. Eur Urol 2010, 57:648-654. 10.1016/j.eururo.2009.05.040, 19487071.
41. Ohwada A, Takahashi H, Nagaoka I, Kira S. Biliary glycoprotein mRNA expression is increased in primary lung cancer, especially in squamous cell carcinoma. Am J Respir Cell Mol Biol 1994, 11:214-220. 10.1165/ajrcmb.11.2.8049082, 8049082.
42. Singer BB, Scheffrahn I, Heymann R, Sigmundsson K, Kammerer R, Obrink B. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. J Immunol 2002, 168:5139-5146.
43. Guo J-Q, Yu W-H, Wang H-J, Liu B, Zhu K-X, Zhang Q-H, Zhang T-G, Xu W-H, Wang H-B, Wu H-L, Zhou C-J. Different expression patterns of CEACAM1 and its impacts on Angiogenesis in Gastric Nonneoplastic and Neoplastic Lesions. Ann Surg Oncol 2012, 19:365-374.